Publications
2023
Scholarly publications
Seesing, M. F. J., Janssen, H. J. B., Geraedts, T. C. M., Weijs, T. J., van Ark, I., Leusink-Muis, T., Folkerts, G., Garssen, J., Ruurda, J. P., Nieuwenhuijzen, G. A. P., van Hillegersberg, R., & Luyer, M. D. P. (2023). Exploring the Modulatory Effect of High-Fat Nutrition on Lipopolysaccharide-Induced Acute Lung Injury in Vagotomized Rats and the Role of the Vagus Nerve. Nutrients, 15(10), [2327]. https://doi.org/10.3390/nu15102327
2022
Scholarly publications
Pelgrim, C. E., van Ark, I., van Berkum, R. E., Schuitemaker-Borneman, A. M., Flier, I., Leusink-Muis, T., Janbazacyabar, H., Diks, M. A. P., Gosker, H. R., Kelders, M. C. J. M., Langen, R. C. J., Schols, A. M. W. J., Hageman, R. J. J., Braber, S., Garssen, J., Folkerts, G., van Helvoort, A., & Kraneveld, A. D. (2022). Effects of a nutritional intervention on impaired behavior and cognitive function in an emphysematous murine model of COPD with endotoxin-induced lung inflammation. Frontiers in Nutrition, 9, [1010989]. https://doi.org/10.3389/fnut.2022.1010989
Wang, L., van Iersel, L. E. J., Pelgrim, C. E., Lu, J., van Ark, I., Leusink-Muis, T., Gosker, H. R., Langen, R. C. J., Schols, A. M. W. J., Argilés, J. M., van Helvoort, A., Kraneveld, A. D., Garssen, J., Henricks, P. A. J., Folkerts, G., & Braber, S. (2022). Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies. Cells, 11(18), 1-20. [2893]. https://doi.org/10.3390/cells11182893
Wang, L., Pelgrim, C. E., Peralta Marzal, L. N., Korver, S., van Ark, I., Leusink-Muis, T., van Helvoort, A., Keshavarian, A., Kraneveld, A. D., Garssen, J., Henricks, P. A. J., Folkerts, G., & Braber, S. (2022). Changes in intestinal homeostasis and immunity in a cigarette smoke- and LPS-induced murine model for COPD: the lung-gut axis. American journal of physiology. Lung cellular and molecular physiology, 323(3), L266-L280. https://doi.org/10.1152/ajplung.00486.2021
Pelgrim, C. E., Wang, L., Peralta Marzal, L. N., Korver, S., van Ark, I., Leusink-Muis, T., Braber, S., Folkerts, G., Garssen, J., van Helvoort, A., & Kraneveld, A. D. (2022). Increased exploration and hyperlocomotion in a cigarette smoke and LPS induced murine model of COPD: linking pulmonary and systemic inflammation with the brain. American journal of physiology. Lung cellular and molecular physiology, 323(3), L251-L265. https://doi.org/10.1152/ajplung.00485.2021
Pelgrim, C. E., van Ark, I., Leusink-Muis, T., Brans, M. A. D., Braber, S., Garssen, J., van Helvoort, A., Kraneveld, A. D., & Folkerts, G. (2022). Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy. Journal of Pharmacological and Toxicological Methods, 114, 1-7. [107156]. https://doi.org/10.1016/j.vascn.2022.107156
2021
Scholarly publications
Janbazacyabar, H., van Bergenhenegouwen, J., Garssen, J., Leusink-Muis, T., Ark, I. V., van Daal, M. T., Folkerts, G., & Braber, S. (2021). Prenatal and Postnatal Cigarette Smoke Exposure Is Associated With Increased Risk of Exacerbated Allergic Airway Immune Responses: A Preclinical Mouse Model. Frontiers in Immunology, 12, 1-14. [797376]. https://doi.org/10.3389/fimmu.2021.797376
Toutounchi, N. S., Braber, S., Hogenkamp, A., Varasteh, S., Cai, Y., Wehkamp, T., Tims, S., Leusink-Muis, T., van Ark, I., Wiertsema, S., Stahl, B., Kraneveld, A. D., Garssen, J., Folkerts, G., & Van’T Land, B. (2021). Human milk oligosaccharide 3′-gl improves influenza-specific vaccination responsiveness and immunity after deoxynivalenol exposure in preclinical models. Nutrients, 13(9), [3190]. https://doi.org/10.3390/nu13093190
Janbazacyabar, H., van Daal, M., Leusink-Muis, T., van Ark, I., Garssen, J., Folkerts, G., van Bergenhenegouwen, J., & Braber, S. (2021). The Effects of Maternal Smoking on Pregnancy and Offspring: Possible Role for EGF? Frontiers in Cell and Developmental Biology, 9, 1-15. [680902]. https://doi.org/10.3389/fcell.2021.680902
Wang, L., Pelgrim, C. E., Swart, D. H., Krenning, G., van der Graaf, A. C., Kraneveld, A. D., Leusink-Muis, T., van Ark, I., Garssen, J., Folkerts, G., & Braber, S. (2021). SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure. International Journal of Molecular Sciences, 22(9), 1-17. [4991]. https://doi.org/10.3390/ijms22094991
Ayechu-Muruzabal, V., Xiao, L., Wehkamp, T., van Ark, I., Hoogendoorn, E. J., Leusink-Muis, T., Folkerts, G., Garssen, J., Willemsen, L. E. M., & Van’T Land, B. (2021). A fermented milk matrix containing postbiotics supports th1-and th17-type immunity in vitro and modulates the influenza-specific vaccination response in vivo in association with altered serum galectin ratios. Vaccines, 9(3), 1-17. [254]. https://doi.org/10.3390/vaccines9030254
2020
Scholarly publications
Ghiamati Yazdi, F., Zakeri, A., Ark, I. V., Leusink-Muis, T., Braber, S., Soleimanian-Zad, S., & Folkerts, G. (2020). Crude Turmeric Extract Improves the Suppressive Effects of Lactobacillus rhamnosus GG on Allergic Inflammation in a Murine Model of House Dust Mite-Induced Asthma. Frontiers in Immunology, 11, [1092]. https://doi.org/10.3389/fimmu.2020.01092
2019
Scholarly publications
Xiao, L., Engen, P. A., Leusink-Muis, T., Van Ark, I., Stahl, B., Overbeek, S. A., Garssen, J., Naqib, A., Green, S. J., Keshavarzian, A., Folkerts, G., & Van’t Land, B. (2019). The combination of 2-fucosyllactose with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides that enhance influenza vaccine responses is associated with mucosal immune regulation in mice. Journal of Nutrition, 149(5), 856-869. https://doi.org/10.1093/jn/nxz006
Kumawat, K., Geerdink, R. J., Hennus, M. P., Roda, M. A., Van Ark, I., Leusink-Muis, T., Folkerts, G., Van Oort-Jansen, A., Mazharian, A., Watson, S. P., Coenjaerts, F. E., Bont, L., & Meyaard, L. (2019). LAIR-1 limits neutrophilic airway inflammation. Frontiers in Immunology, 10(APR), [842]. https://doi.org/10.3389/fimmu.2019.00842
Janbazacyabar, H., van Bergenhenegouwen, J., Verheijden, K. A. T., Leusink-Muis, T., van Helvoort, A., Garssen, J., Folkerts, G., & Braber, S. (2019). Non-digestible oligosaccharides partially prevent the development of LPS-induced lung emphysema in mice. PharmaNutrition, 10, [100163]. https://doi.org/10.1016/j.phanu.2019.100163
2018
Scholarly publications
Xiao, L., Van't Land, B., Engen, P. A., Naqib, A., Green, S. J., Nato, A., Leusink-Muis, T., Garssen, J., Keshavarzian, A., Stahl, B., & Folkerts, G. (2018). Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice. Scientific Reports, 8(1), [3829]. https://doi.org/10.1038/s41598-018-22052-y
Xiao, L., Leusink-Muis, T., Kettelarij, N., van Ark, I., Blijenberg, B., Hesen, N. A., Stahl, B., Overbeek, S. A., Garssen, J., Folkerts, G., & Van't Land, B. (2018). Human Milk Oligosaccharide 2'-Fucosyllactose Improves Innate and Adaptive Immunity in an Influenza-Specific Murine Vaccination Model. Frontiers in Immunology, 9, [452]. https://doi.org/10.3389/fimmu.2018.00452
Verheijden, K. A. T., Braber, S., Leusink-Muis, T., Jeurink, P. V., Thijssen, S., Kraneveld, A. D., Garssen, J., Folkerts, G., & Willemsen, L. E. M. (2018). The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma. Frontiers in Immunology, 9, [2419]. https://doi.org/10.3389/fimmu.2018.02419
2017
Scholarly publications
Abbring, S., Verheijden, K. A. T., Diks, M. A. P., Leusink - Muis, T., Hols, G., Baars, T., Garssen, J., & van Esch, B. C. A. M. (2017). Raw Cow's Milk Prevents the Development of Airway Inflammation in a Murine House Dust Mite-Induced Asthma Model. Frontiers in Immunology, 8, 1045. https://doi.org/10.3389/fimmu.2017.01045
2016
Scholarly publications
Verheijden, K. A. T., Braber, S., Leusink-Muis, T., Thijssen, S., Boon, L., Kraneveld, A. D., Garssen, J., Folkerts, G., & Willemsen, L. E. M. (2016). Regulatory T cell depletion abolishes the protective effect of dietary galactooligosaccharides on eosinophilic airway inflammation in house dust mite-induced asthma. Allergy: European Journal of Allergy and Clinical Immunology, 71, 229-230. https://doi.org/10.1111/all.12972
Verheijden, K. A., Braber, S., Leusink-Muis, T., Thijssen, S., Boon, L., Kraneveld, A. D., Garssen, J., Folkerts, G., & Willemsen, L. E. (2016). Regulatory T Cell Depletion Abolishes the Protective Effect of Dietary Galacto-Oligosaccharides on Eosinophilic Airway Inflammation in House Dust Mite-Induced Asthma in Mice. Journal of Nutrition, 146(4), 831-837. https://doi.org/10.3945/jn.115.224402
Verheijden, K. A. T., Willemsen, L. E. M., Braber, S., Leusink-Muis, T., Jeurink, P. V., Garssen, J., Kraneveld, A. D., & Folkerts, G. (2016). The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V. European Journal of Nutrition, 55(3), 1141-1151. https://doi.org/10.1007/s00394-015-0928-8
2015
Scholarly publications
Verheijden, K. A. T., Willemsen, L. E. M., Braber, S., Leusink-Muis, T., Delsing, D. J. M., Garssen, J., Kraneveld, A. D., & Folkerts, G. (2015). Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model. Respiratory Research, 16, 17. https://doi.org/10.1186/s12931-015-0171-0
2014
Scholarly publications
Vos, A. P., Nato, A. N., Bastiaans, J., Leusink-Muis, T., Stahl, B., Garssen, J., & Folkerts, G. (2014). Early supplementation of non-obese diabetic mice with oligosaccharides isolated from human milk reduces spontaneous autoimmune diabetes development later in life. Gastroenterology, 146(5), 840. https://doi.org/10.1016/S0016-5085(14)63052-3
Bezemer, G., Van Ark, I., Leusink Muis, T., Kraneveld, A., Garssen, J., & Folkerts, G. (2014). Acetate is more effective than a glucocorticoid steroid at preventing and reducing neutrophilic airway inflammation in a cigarette smoke induced mouse model for copd. Basic & Clinical Pharmacology & Toxicology, 115, 285.
2013
Scholarly publications
van Noort, J. M., Bsibsi, M., Nacken, P. J., Gerritsen, W. H., Amor, S., Holtman, I. R., Boddeke, E., van Ark, I., Leusink-Muis, A., Folkerts, G., Hennink, W. E., & Amidi, M. (2013). Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles. Biomaterials, 34(3), 831-40.
2006
Scholarly publications
ten Broeke, R., de Crom, R., van Haperen, R., Verweij, V. G. M., Leusink-Muis, A., van Ark, I., de Clerck, F., Nijkamp, F. P., & Folkerts, G. (2006). Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. Respiratory Research, 7.
de Vries, A., Engels, F., Henricks, P. A. J., Leusink-Muis, A., McGregor, G. P., Braun, A., Groneberg, D. A., Dessing, M. C., Nijkamp, F. P., & Fischer, A. (2006). Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. Clinical and Experimental Allergy, 36, 1192-1200.
2004
Scholarly publications
ten Broeke, R., Leusink-Muis, A., Hilberdink, R., van Ark, I., van den Worm, E., Villain, M., de Clerck, F., Blalock, J. E., Nijkamp, F. P., & Folkerts, G. (2004). Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Laboratory Investigation, 84, 29-40.
https://dspace.library.uu.nl/bitstream/handle/1874/14957/folkerts_04_specific_modulation.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/14957/folkerts_04_specific_modulation.pdf?sequence=1
2003
Scholarly publications
ten Broeke, R., Brandhorst, M. C., Leusink-Muis, A., Villain, M., de Clerck, F., Blalock, J. E., Nijkamp, F. P., & Folkerts, G. (2003). Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. European Journal of Pharmacology, 476, 151-157.
Arts, J. H. E., Bloksma, M. A., Leusink-Muis, A., & Kuper, C. F. (2003). Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats. Toxicology and Applied Pharmacology, 187, 38-49.
2002
Scholarly publications
Haag, M., Leusink-Muis, A., le Bouquin, R., Nijkamp, F. P., Lugnier, A., Frossard, N., Folkerts, G., & Pons, F. (2002). Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma. Archives of Toxicology, 76, 621-627.
de Vries, A., Engels, G. M. H., Henricks, P. A. J., Leusink-Muis, A., Fischer, K., & Nijkamp, F. P. (2002). Antibodies directed against nerve growth factor inhibit the acute bronchoconstriction due to allergen challenge in guinea-pig. Clinical and Experimental Allergy, 32, 325-328.
Michielsen, C., Zeamari, S., Leusink-Muis, A., Vos, J. G., & Bloksma, M. A. (2002). The environmental pollutant hexachlorobenzene causes eosinophilic and granulomatous inflammation and in vitro airways hyperreactivity in the Brown Norway rat. Archives of Toxicology, 76, 236-247.
2001
Scholarly publications
Michielsen, C. P. P. C., Leusink-Muis, A., Vos, J. G., & Bloksma, M. A. (2001). Hexachlorobenzene-induced eosinophilic and granulomatous lung inflammation is associated with in vivo airways hyperresponsiveness in the Brown Norway rat. Toxicology and Applied Pharmacology, 172, 11-20.
Michielsen, C. P. P. C., Leusink-Muis, A., Vos, J. G., & Bloksma, M. A. (2001). Hexachlorobenzene-induced eosinophilic and granulomatous lung inflammation Is associated with in vivo airways hyperresponssiveness in the Brown Norway rat. Toxicology and Applied Pharmacology, 172, 11-20.
ten Broeke, R., Folkerts, G., Leusink-Muis, A., van der Linde, H. J., Villain, M., Manion, M., de Clerck, F., Blalock, J. E., & Nijkamp, F. P. (2001). Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB Journal, 15, 1831-1833.
2000
Other output
Smit, J. J., Folkerts, G., Leusink-Muis, A., Sandvold, M. L., Myhren, F., & Nijkamp, F. P. (2000). A derivative of methylprednisolone, P4114, is more potent in suppressing the ovalbumin-induced bronchoconstriction in guinea pigs. 248-248. Abstract from Unknown event, Asilomar, USA.
ten Broeke, R., Folkerts, G., Leusink-Muis, A., Manion, M., Villain, M., de Clerck, F., Blalock, J. E., & Nijkamp, F. P. (2000). Complementary peptides to EF hand of calmodulin modulate airway responsiveness and [Ca2+]1 and nitric oxide production by guinea pig tracheal epithelial cells. 46-46. Abstract from Unknown event, Asilomar, USA.
Folkerts, G., Leusink-Muis, A., Sandvold, M. L., Myhren, F., & Nijkamp, F. P. (2000). The acute allergen-induced bronchoconstriction in guinea pigs is prevented by aerosols with P4114, a derivative of methylpredisolone (MP). 559s. Abstract from Unknown event, Asilomar, USA.
1999
Scholarly publications
Leusink-Muis, A., Folkerts, G., Sandvold, M. L., Myhren, F., & Nijkamp, F. P. (1999). P4112 and P4114, derivatives of betamethasone and methylprednisolone, respectively, are more potent in reducing rat peritoneal cell numbers and activity. In H. E. Neffen, & C. E. Baena-Cagnani (Eds.), VXI World congress of Asthma (pp. 23-26). Monduzzi editore S.p.A..
Leusink-Muis, A., ten Broeke, R., Folkerts, G., de Clerck, F., & Nijkamp, F. P. (1999). Betametasone prevents virus-induced airway inflammation but not airway hyperresponsiveness in guinea pigs. Clinical and Experimental Allergy, 29(suppl. 2), 82-85.
van Heuven-Nolsen, D., de Kimpe, J. J., Leusink-Muis, A., van Ark, I., Savelkoul, T. J. F., Beems, R. B., van Oosterhout, A. J. M., & Nijkamp, F. P. (1999). Opposite role of interferon-gamma and interleukin-4 on the regulation of blood pressure in mice. Biochemical and Biophysical Research Communications, 254, 816-820.
Scheerens, H., Buckley, T. L., Leusink-Muis, A., Garssen, J., Dormans, J., Nijkamp, F. P., & van Loveren, H. (1999). Long-term topical exposure to toluene diisocyanate in mice leads to antibody production and in vivo airway hyperresponsiveness 3 h after intranasal challenge. American Journal of Respiratory and Critical Care Medicine, 159, 1074-1080.
Other output
Leusink-Muis, A., Broeke, R. T., Folkerts, G., De Clerck, F., & Nijkamp, F. P. (1999). Betamethasone prevents virus-induced airway inflammation but not airway hyperresponsiveness in guinea pigs. 82-85.
Folkerts, G., Leusink-Muis, A., ten Broeke, R., de Clerck, F., & Nijkamp, F. P. (1999). Potential links between virus-induced and allergen-induced airway inflammation and airway hyperresponsiveness in animal models. 1-2. Abstract from Unknown event, Asilomar, USA.
Leusink-Muis, A., Folkerts, G., Sandvold, M. L., Myhren, F., & Nijkamp, F. P. (1999). P4112 and P4114, derivates of betamethasone and methulprednisolone, respectively, are more potent in reducing rat peritoneal cell numbers and activity. 134-134. Abstract from Unknown event, Asilomar, USA.
ten Broeke, R., Folkerts, G., van der Linde, H. J., Leusink-Muis, A., Blalock, J. E., de Clerck, F., & Nijkamp, F. P. (1999). In vitro effects of the EF hand-binding peptides CALP1 and CALP2 on guinea pig tracheal tubes. 126-126. Abstract from Unknown event, Asilomar, USA.
ten Broeke, R., Folkerts, G., van der Linde, H. J., Leusink-Muis, A., Blalock, J. E., de Clerck, F., & Nijkamp, F. P. (1999). Modulation of guinea pig tracheal responsiveness by EF hand-binding calcium-like peptides CALP-1 and CALP-2. A398-A398. Abstract from Unknown event, Asilomar, USA.
1997
Other output
Scheerens, H., Buckley, T. L., Leusink-Muis, A., Scheerens, J., van Loveren, H., & Nijkamp, F. P. (1997). Mast cell activation and tracheal hyperreactivity are dissociated events in a model for toluene diisocyanate-induced asthma. A158-A158. Abstract from Unknown event, Asilomar, USA.
Scheerens, H., Buckley, T. L., Leusink-Muis, A., & Nijkamp, F. P. (1997). Long term topical exposure to toluene diisocyanate leads to IgE production and in vivo airway hyperreactivity in mice. A259-A259. Abstract from Unknown event, Asilomar, USA.
1996
Other output
Scheerens, H., Buckley, T. L., Leusink-Muis, A., van Loveren, H., & Nijkamp, F. P. (1996). Sensory neuropeptides are essential for the toluene diisocyanate-induced tracheal hyperreactivity in the mouse.. Abstract from Unknown event, Asilomar, USA.