The research activities of Anne Keirse are primarily focused on the law of obligations, with emphasis on the field of Dutch and European tort law, Dutch and European contract law, law of damages, prevention and mitigation of damage.

Comparative research is a key component of her research method, with particular focus on the various European legal systems. Anne Keirse further expands her research through incorporating results from other disciplines.

In her research, she is particularly interested in utilizing the law of obligation, not only for the purpose of retrospectively sanctioning socially undesirable behavior, but also, to promote the use of private law in facilitating socially desirable behavior in the future. Anne Keirse subscribes to the maxim that prevention is better than cure.