prof. dr. A.J.R. (Albert) Heck
A.J.R.Heck@uu.nl
Gegenereerd op 2017-11-22 13:24:22


Chair
Biomolecular Mass Spectrometry and Proteomics
Endowed by Chemistry and Pharmaceutical Sciences
Date of appointment 01.09.1998
Inaugural lecture date 22.10.1999
Profile

Albert Heck (b. 1964) is a leading expert in protein mass spectrometry. His group develops and implements innovative mass spectrometric methods for the more efficient and detailed characterization of proteins in relation to their biological function. In short, Heck applies protein mass spectrometry to problems in proteomics, glycoproteomics and in structural biology.

Albert Heck received multiple awards, such as the KNCV Golden Medal (2001), the Descartes Huygens Award de la Republique Francaise (2007), NGI Distinguished Visiting Scientist (2010-2011), the Life Science Award of the German Mass Spectrometry Society (2010), the HUPO Discovery Award in Proteomic Sciences (2013), the EuPA Pioneer in Proteomics Award (2014) and the American Chemical Society ‘Frank H. Field and Joe L. Franklin Award for Outstanding Achievements in Mass Spectrometry’ (2015). In 2017, Albert Heck has been awarded with the Spinoza Award, the most important award in the field of Science in the Netherlands.

The research of Heck focuses on the development and implementation of innovative mass spectrometric methods for the more efficient and detailed characterization of proteins in relation to their biological function. The emphasis is on the structural characterization of proteins and posttranslational modifications as well as the investigation of protein complexes and protein interactions important in e.g. protein folding, protein ligand binding, and the formation of tertiary and quaternary structures. In short we apply protein mass spectrometry to problem in proteomics and in structural biology. As scientific director, myself and my group play a pivotal role in the Netherlands Proteomics Centre, which focuses on developing proteomics technologies, focused on protein expression quantification, membrane protein proteomics, post-translational modifications, protein networks, highthroughput protein analysis and biomarkers.

The Heck laboratory has a track record in proteomics and especially in the analysis of protein post-translational modifications. We introduced TiO2 as enrichment material for the targeted analysis of phosphopeptides, and implemented this technique into a miniaturized on-line automatic system, and on a micro-chip device. We introduced the use of a protease named LysN, that in conjunction with ETD provides unique sequence ladders, that are straightforward to interpret and allow facile de novo sequencing and improve the analysis of protein phosphorylation.We also have an extensive track-record in quantitative proteomics, introducing metabolic stable isotope labeling in multicellular organisms such as Drosophila and C. elegans, using SILAC for studying stem cell and B cell differentiation, and stable isotope labeling by using chemical approaches. The latter method we most recently also implemented to follow differential pTyr phosphorylation in differentiating stem cells.

The Heck laboratory is also a pioneer in macromolecular or native mass spectrometry, which enable the analysis of intact protein assemblies by mass spectrometry. The Heck group evelops mass spectrometers dedicated for this work and applies these technologies to study the structure and dynamics of for instance transcription complexes and virus assembly.

Key recent references

1. Krijgsveld J, et al. (2003) Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics.  Nat Biotechnol 21:927-931.

2. Heck AJ (2008) Native mass spectrometry: a bridge between interactomics and structural biology.  Nature Methods 5:927-933.

3. Van Hoof D, et al. (2009) Phosphorylation dynamics during early differentiation of human embryonic stem cells.  Cell Stem Cell 5:214-226.

4. Uetrecht C, Barbu IM, Shoemaker GK, van Duijn E, & Heck AJ (2011) Interrogating viral capsid assembly with ion mobility-mass spectrometry.  Nature Chem 3:126-132.

5. de Lau W, et al. (2011) Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.  Nature 476:293-297.

6. Li VS, et al. (2012) Wnt Signaling through Inhibition of beta-Catenin Degradation in an Intact Axin1 Complex.  Cell 149:1245-1256.

7. Koo BK, et al. (2012) Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.  Nature 488:665-669.

8. Rose RJ, Damoc E, Denisov E, Makarov A, & Heck AJ (2012) High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies.  Nature Methods 9:1084-1086.

9. Peng M, et al. (2012) Protease bias in absolute protein quantitation.  Nature Methods 9:524-525.

10. Ringrose JH, et al. (2013) Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity.  Nature Commun 4:1408.

11. Altelaar AF, Munoz J, & Heck AJ (2013) Next-generation proteomics: towards an integrative view of proteome dynamics.  Nature Rev Genet 14:35-48.

12. Pijnappel WW, et al. (2013) A central role for TFIID in the pluripotent transcription circuitry.  Nature 495:516-519.

 

Gegenereerd op 2017-11-22 13:24:22
All publications
  2017 - Scholarly publications
Montersino, Stefania, Te Poele, Evelien, Orru, Roberto, Westphal, Adrie H, Barendregt, Arjan, Heck, Albert J R, van der Geize, Robert, Dijkhuizen, Lubbert, Mattevi, Andrea & van Berkel, Willem J H (2017). 3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor. Frontiers in Microbiology, 8.
Lebesgue, Nicolas, Megyeri, Márton, Cristobal Gonzalez de Durana, Alba, Scholten, Arjen, Chuartzman, Silvia G, Voichek, Yoav, Scheltema, Richard A, Mohammed, Shabaz, Futerman, Anthony H, Schuldiner, Maya, Heck, Albert J R & Lemeer, Simone (03.02.2017). Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis. Journal of Proteome Research, 16 (2), (pp. 571-582) (12 p.).
Mahmoudi, Tokameh, Boj, Sylvia F, Hatzis, Pantelis, Li, Vivian S W, Taouatas, Nadia, Vries, Robert G J, Teunissen, Hans, Begthel, Harry, Korving, Jeroen, Mohammed, Shabaz, Heck, Albert J R & Clevers, Hans (2017). Correction - The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis. PLoS Biology, 15 (2).
Mäkelä, Miia R, Bouzid, Ourdia, Ruiz-Robleto, J., Post, Harm, Peng, Mao, Heck, Albert, Altelaar, Maarten & de Vries, Ronald P (07.02.2017). Cultivation of Podospora anserina on soybean hulls results in an efficient enzyme cocktail for plant biomass hydrolysis. BMC Biotechnology, 37 (B), (pp. 162-171) (10 p.). Copyright © 2017 Elsevier B.V. All rights reserved..
Wang, Guanbo, de Jong, Rob N, van den Bremer, Ewald T J, Parren, Paul W H I & Heck, Albert J R (2017). Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry. Analytical Chemistry, 89 (9), (pp. 4793–4797).
Yang, Yang, Franc, Vojtech & Heck, Albert J R (2017). Glycoproteomics - A Balance between High-Throughput and In-Depth Analysis. Trends in Biotechnology, 35 (7), (pp. 598-609). Copyright © 2017 Elsevier Ltd. All rights reserved..
van de Waterbeemd, Michiel, Fort, Kyle L, Boll, Dmitriy, Reinhardt-Szyba, Maria, Routh, Andrew, Makarov, Alexander & Heck, Albert J R (23.01.2017). High-fidelity mass analysis unveils heterogeneity in intact ribosomal particles. Nature Methods, 14, (pp. 283-286) (4 p.).
Tak, Tamar, Wijten, Patrick, Heeres, Marjolein, Pickkers, Peter, Scholten, Arjen, Heck, Albert J R, Vrisekoop, Nienke, Leenen, Luke P, Borghans, Jos Eacute A M, Tesselaar, Kiki & Koenderman, Leo (2017). Human CD62L(dim) Neutrophils Identified as a Separate Subset by Proteome Profiling and In Vivo Pulse-Chase Labelling. Blood, 129 (26), (pp. 3476-3485). Copyright © 2017 American Society of Hematology..
van Ooijen, Michiel P, Jong, Victor L, Eijkemans, Marinus J C, Heck, Albert J R, Andeweg, Arno C, Binai, Nadine A & van den Ham, Henk-Jan (2017). Identification of differentially expressed peptides in high-throughput proteomics data. Briefings in Bioinformatics, 2017, (pp. 1-11). © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com..
van Riel, Wilhelmina E, Rai, Ankit, Bianchi, Sarah, Katrukha, Eugene A, Liu, Qingyang, Heck, Albert Jr, Hoogenraad, Casper C, Steinmetz, Michel O, Kapitein, Lukas C & Akhmanova, Anna (2017). Kinesin-4 KIF21B is a potent microtubule pausing factor. eLife, 6 (30 p.).
Jiang, Kai, Rezabkova, Lenka, Hua, Shasha, Liu, Qingyang, Capitani, Guido, Altelaar, Maarten, Heck, Albert J R, Kammerer, Richard A, Steinmetz, Michel O & Akhmanova, Anna (2017). Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nature Cell Biology, 19 (5), (pp. 480-492) (13 p.).
Liu, Fan, Lössl, Philip, Scheltema, Richard, Viner, Rosa & Heck, Albert J R (2017). Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature Communications, 8.
Cristobal Gonzalez de Durana, Alba, van den Toorn, Henk W P, van de Wetering, Marc, Clevers, Hans, Heck, Albert J R & Mohammed, Shabaz (03.01.2017). Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell Reports, 18 (1), (pp. 263-274) (12 p.). Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved..
Leestemaker, Yves, de Jong, Annemieke, Witting, Katharina F, Penning, Renske, Schuurman, Karianne, Rodenko, Boris, Zaal, Esther A, van de Kooij, Bert, Laufer, Stefan, Heck, Albert J R, Borst, Jannie, Scheper, Wiep, Berkers, Celia R & Ovaa, Huib (22.06.2017). Proteasome Activation by Small Molecules. Cell Chemical Biology, 24 (6), (pp. 725-736.e7). Copyright © 2017 Elsevier Ltd. All rights reserved..
Franc, Vojtech, Yang, Yang & Heck, Albert J R (2017). Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N-, O-, and C-Glycosylation. Analytical Chemistry, 89 (6), (pp. 3483–3491).
Frese, Christian K, Mikhaylova, Marina, Stucchi, Riccardo, Gautier, Violette, Liu, Qingyang, Mohammed, Shabaz, Heck, Albert J R, Altelaar, A F Maarten & Hoogenraad, Casper C (07.02.2017). Quantitative Map of Proteome Dynamics during Neuronal Differentiation. Cell Reports, 18 (6), (pp. 1527-1542) (16 p.). Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved..
De Nardis, Camilla, Lössl, Philip, Van Den Biggelaar, Maartje, Madoori, Pramod K., Leloup, Nadia, Mertens, Koen, Heck, Albert J R & Gros, Piet (20.01.2017). Recombinant expression of the full-length ectodomain of LDL receptor-related protein 1 (LRP1) unravels phdependent conformational changes and the stoichiometry of binding with receptor-associated protein (RAP). Journal of Biological Chemistry, 292 (3), (pp. 912-924) (13 p.).
Yang, Yang, Wang, Guanbo, Song, Ting, Lebrilla, Carlito B & Heck, Albert J R (14.02.2017). Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches. mAbs, (pp. 1-8) (8 p.).
van de Waterbeemd, Michiel, Llauró, Aida, Snijder, Joost, Valbuena, Alejandro, Rodríguez-Huete, Alicia, Fuertes, Miguel Angel, de Pablo, Pedro J, Mateu, Mauricio G & Heck, Albert J R (2017). Structural Analysis of a Temperature-Induced Transition in a Viral Capsid Probed by HDX-MS. Biophysical Journal, 112 (6), (pp. 1157-1165) (9 p.). Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved..
Sasaki, Eita, Böhringer, Daniel, van de Waterbeemd, Michiel, Leibundgut, Marc, Zschoche, Reinhard, Heck, Albert J R, Ban, Nenad & Hilvert, Donald (2017). Structure and assembly of scalable porous protein cages. Nature Communications, 8.
Snijder, Joost, Schuller, Jan M, Wiegard, Anika, Lössl, Philip, Schmelling, Nicolas, Axmann, Ilka M, Plitzko, Jürgen M, Förster, Friedrich & Heck, Albert J R (17.03.2017). Structures of the cyanobacterial circadian oscillator frozen in a fully assembled state. Science, 355 (6330), (pp. 1181-1184) (4 p.). Copyright © 2017, American Association for the Advancement of Science..
Tsiatsiani, Liana, Akeroyd, Michiel, Olsthoorn, Maurien & Heck, Albert J R (01.08.2017). The Aspergillus niger Prolyl endoprotease (An-PEP) for hydrogen-deuterium exchange mass spectrometry and protein structural studies. Analytical Chemistry, 89, (pp. 7966-7973).
Vega, Francisco M, Gautier, Violette, Fernandez-Ponce, Cecilia M, Extremera, M J, Altelaar, A F M, Millan, Jaime, Tellez, Juan C, Hernandez-Campos, Jose A, Conejero, Rosario, Bolivar, Jorge, Pardal, Ricardo, Garcia-Cózar, Francisco J, Aguado, Enrique, Heck, Albert J R & Duran-Ruiz, Mª Carmen (20.02.2017). The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo. Journal of Molecular and Cellular Cardiology, 105, (pp. 12-23) (12 p.). Copyright © 2017 Elsevier Ltd. All rights reserved..
Snijder, Joost, Radtke, Kerstin, Anderson, Fenja, Scholtes, Luella, Corradini, Eleonora, Baines, Joel, Heck, Albert J R, Wuite, Gijs J L, Sodeik, Beate & Roos, Wouter H (05.04.2017). The vertex specific proteins pUL17 and pUL25 mechanically reinforce Herpes Simplex Virus capsids. Journal of Virology, 91 (10). Copyright © 2017 American Society for Microbiology..
Cristobal Gonzalez de Durana, Alba, Marino, Fabio, Post, Harm, van den Toorn, Henk W P, Mohammed, Shabaz & Heck, Albert J R (24.02.2017). Toward an Optimized Workflow for Middle-Down Proteomics. Analytical Chemistry, 89 (6), (pp. 3318-3325) (8 p.).
  2016 - Scholarly publications
Gagarinov, Ivan A, Li, Tiehai, Sastre Torano, Javier, Caval, Tomislav, Srivastava, Apoorva D, Kruijtzer, John A W, Heck, Albert J R & Boons, Geert-Jan (21.12.2016). A Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri- and Tetra-Antennary N-Glycans from a Common Precursor. Journal of the American Chemical Society (8 p.).
Liepe, Juliane, Marino, Fabio, Sidney, John, Jeko, Anita, Bunting, Daniel E, Sette, Alessandro, Kloetzel, Peter M, Stumpf, Michael P H, Heck, Albert J R & Mishto, Michele (2016). A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science, 354 (6310), (pp. 354-358) (5 p.). Copyright © 2016, American Association for the Advancement of Science..
Alpízar, Adán, Marino, Fabio, Ramos-Fernández, Antonio, Lombardía, Manuel, Jeko, Anita, Pazos, Florencio, Paradela, Alberto, Santiago, César, Heck, Albert J R & Marcilla, Miguel (05.12.2016). A molecular basis for the presentation of phosphorylated peptides by HLA-B antigens. Molecular and Cellular Proteomics Copyright © 2016, The American Society for Biochemistry and Molecular Biology..
de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine & Parren, Paul W H I (2016). A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface. PLoS Biology, 14 (1), (pp. e1002344).
Soni, Siddarth, Raaijmakers, Antonia J A, Raaijmakers, Linsey M, Damen, J Mirjam A, van Stuijvenberg, Leonie, Vos, Marc A, Heck, Albert J R, van Veen, Toon A B & Scholten, Arjen (2016). A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins. PLoS One, 11 (5).
Waaijers, Selma, Muñoz, Javier, Berends, Christian, Ramalho, João J, Goerdayal, Soenita S, Low, Teck Y, Zoumaro-Djayoon, Adja D, Hoffmann, Michael, Koorman, Thijs, Tas, Roderick P, Harterink, Martin, Seelk, Stefanie, Kerver - Stumpfova, J, Hoogenraad, Casper C, Bossinger, Olaf, Tursun, Baris, van den Heuvel, Sander, Heck, Albert J R & Boxem, Mike (09.08.2016). A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biology, 14.
Marino, Fabio, Mommen, Geert P M, Jeko, Anita, Meiring, Hugo D, van Gaans-van den Brink, Jacqueline A M, Scheltema, Richard A, van Els, Cécile A C M & Heck, Albert J R (2016). Arginine (Di)methylated Human Leukocyte Antigen Class I Peptides Are Favorably Presented by HLA-B*07. Journal of Proteome Research (11 p.).
Snijder, Joost, Kononova, Olga, Barbu, Ioana M, Uetrecht, Charlotte, Rurup, W Frederik, Koay, Melissa S T, Burnley, Rebecca J, Cornelissen, Jeroen J L M, Roos, Wouter H, Barsegov, Valeri, Wuite, Gijs J L & Heck, Albert J R (07.07.2016). Assembly and Mechanical Properties of the Cargo-Free and Cargo-Loaded Bacterial Nanocompartment Encapsulin. Biomacromolecules
Schmidlin, Thierry, Garrigues, Luc, Lane, Catherine S, Mulder, T Celine, van Doorn, Sander, Post, Harm, de Graaf, Erik L, Lemeer, Simone, Heck, Albert J R & Altelaar, A F Maarten (2016). Assessment of SRM, MRM(3) and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer. Proteomics, 16 (15-16), (pp. 2193–2205). This article is protected by copyright. All rights reserved..
Zuko, Amila, Oguro-Ando, Asami, Post, Harm, Taggenbrock, Renske L R E, van Dijk, Roland E, Altelaar, A F Maarten, Heck, Albert J R, Petrenko, Alexander G, van der Zwaag, Bert, Shimoda, Yasushi, Pasterkamp, R J & Burbach, J P H (2016). Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis. Frontiers in Molecular Neuroscience, 9.
van Heesbeen, Roy G H P, Raaijmakers, Jonne A, Tanenbaum, Marvin E, Halim, Vincentius A, Lelieveld, Daphne, Lieftink, Cor, Heck, Albert J R, Egan, David A & Medema, René H (29.06.2016). Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation. Chromosoma
Anvarian, Zeinab, Nojima, Hisashi, van Kappel, Eline C, Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y, van Scherpenzeel, Revina C, Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean-Paul, Rüdiger, Stefan G D & Maurice, Madelon M (2016). Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network. Nature Structural and Molecular Biology, 23, (pp. 324-332) (9 p.).
Lössl, Philip, Brunner, Andrea M, Liu, Fan, Leney, Aneika C, Yamashita, Masami, Scheltema, Richard A & Heck, Albert J R (27.07.2016). Deciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System. ACS central science, 2 (7), (pp. 445-455) (11 p.).
Lebesgue, Nicolas, da Costa, Gonçalo, Ribeiro, Raquel Mesquita, Ribeiro-Silva, Cristina, Martins, Gabriel G, Matranga, Valeria, Scholten, Arjen, Cordeiro, Carlos, Heck, Albert J R & Santos, Romana (27.02.2016). Deciphering the molecular mechanisms underlying sea urchin reversible adhesion - A quantitative proteomics approach. Journal of Proteomics, 138, (pp. 61-71) (11 p.). Copyright © 2016 Elsevier B.V. All rights reserved..
Kaplan, M., Narasimhan, Siddarth, de Heus, Cilia, Mance, Deni, van Doorn, Sander, Houben, Klaartje, Popov-Celeketic, Dusan, Damman, Reinier, Katrukha, Eugene A, Jain, Purvi, Geerts, Willie J C, Heck, Albert J R, Folkers, Gert E, Kapitein, Lukas C, Lemeer, Simone, van Bergen En Henegouwen, Paul M P & Baldus, Marc (17.11.2016). EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR. Cell, 167 (5), (pp. 1241-1251.e11) (11 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
van de Waterbeemd, Michiel, Snijder, Joost, Tsvetkova, Irina B, Dragnea, Bogdan G, Cornelissen, Jeroen J & Heck, Albert J R (29.02.2016). Examining the Heterogeneous Genome Content of Multipartite Viruses BMV and CCMV by Native Mass Spectrometry. Journal of the American Society for Mass Spectrometry
Yang, Yang, Liu, Fan, Franc, Vojtech, Halim, Liem Andhyk, Schellekens, Huub & Heck, Albert J R (08.11.2016). Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity. Nature Communications, 7, (pp. 13397).
Fort, Kyle L, Dyachenko, Andrey, Potel, Clement M, Corradini, Eleonora, Marino, Fabio, Barendregt, Arjan, Makarov, Alexander A, Scheltema, Richard Alexander & Heck, Albert J R (13.01.2016). Implementation of UV-photodissociation on a benchtop Q Exactive mass spectrometer and its application to phospho-proteomics. Analytical Chemistry, 88 (4), (pp. 2303-2310) (8 p.).
Liu, Qingyang, Liu, Fan, Yu, Ka Lou, Tas, Roderick, Grigoriev, Ilya, Remmelzwaal, Sanne, Marques, Andrea, Kapitein, Lukas C, Heck, Albert J R & Akhmanova, Anna (15.08.2016). MICAL3 flavoprotein monooxygenase forms a complex with centralspindlin and regulates cytokinesis. Journal of Biological Chemistry (23 p.). Copyright © 2016, The American Society for Biochemistry and Molecular Biology..
Wang, Guanbo, de Jong, Rob N, van den Bremer, Ewald T J, Beurskens, Frank J, Labrijn, Aran F, Ugurlar, D., Gros, Piet, Schuurman, Janine, Parren, Paul W H I & Heck, Albert J R (15.06.2016). Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen. Molecular Cell, 63, (pp. 1-11) (11 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
Guerreiro, Ana C L, Penning, Renske, Raaijmakers, Linsey M, Axman, Ilka M, Heck, Albert J R & Altelaar, A F Maarten (29.04.2016). Monitoring light/dark association dynamics of multi-protein complexes in cyanobacteria using size exclusion chromatography-based proteomics. Journal of Proteomics, 142, (pp. 33-44) (12 p.). Copyright © 2016 Elsevier B.V. All rights reserved..
Portegijs, Vincent, Fielmich, Lars-Eric, Galli, Matilde, Schmidt, Ruben, Munoz Peralta, Javier, van Mourik, Tim, Akhmanova, Anna, Heck, Albert J R, Boxem, Mike & van den Heuvel, Sander (2016). Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans. PLoS Genetics, 12 (10), (pp. 1-32) (32 p.).
Leney, Aneika C & Heck, Albert J R (01.12.2016). Native Mass Spectrometry - What is in the Name?. Journal of the American Society for Mass Spectrometry
Schuller, Jan M, Beck, Florian, Lössl, Philip, Heck, Albert J R & Förster, Friedrich (05.02.2016). Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited. FEBS Letters, 590 (5), (pp. 595-604). This article is protected by copyright. All rights reserved..
Tsiatsiani, Liana, Giansanti, Piero, Scheltema, Richard A., van den Toorn, Henk, Overall, Christopher M., Altelaar, A.F. Maarten & Heck, Albert J.R. (21.11.2016). Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics. Journal of Proteome Research
Lebesgue, Nicolas, da Costa, Gonçalo, Ribeiro, Raquel Mesquita, Ribeiro-Silva, Cristina, Martins, Gabriel G, Matranga, Valeria, Scholten, Arjen, Cordeiro, Carlos, Heck, Albert J R & Santos, Romana (2016). Proteomic dataset of the sea urchin Paracentrotus lividus adhesive organs and secreted adhesive. Data in Brief, 7, (pp. 1497-505) (9 p.).
Barasa, Benjamin A, van Oirschot, Brigitte A, Bianchi, Paola, van Solinge, Wouter W, Heck, Albert J R, van Wijk, Richard & Slijper, Monique (05.07.2016). Proteomics reveals reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients. Proteomics - Clinical Applications This article is protected by copyright. All rights reserved..
Chiang, David Y, Heck, Albert J R, Dobrev, Dobromir & Wehrens, Xander H T (20.09.2016). Regulating the regulator - Insights into the cardiac protein phosphatase 1 interactome. Journal of Molecular and Cellular Cardiology Copyright © 2016. Published by Elsevier Ltd..
Post, Harm, Penning, Renske, Fitzpatrick, Martin, Garrigues, L.B., Wu, W., Mac Gillavry, H.D., Hoogenraad, C.C., Heck, A.J.R. & Altelaar, A.F.M. (28.11.2016). Robust, Sensitive, and Automated Phosphopeptide Enrichment Optimized for Low Sample Amounts Applied to Primary Hippocampal Neurons. Journal of Proteome Research
Mommen, Geert P M, Marino, Fabio, Meiring, Hugo D, Poelen, Martien C M, van Gaans-van den Brink, Jacqueline A M, Mohammed, Shabaz, Heck, Albert J R & van Els, Cecile A C M (13.01.2016). Sampling from the proteome to the HLA-DR ligandome proceeds via high specificity. Molecular and Cellular Proteomics Copyright © 2016, The American Society for Biochemistry and Molecular Biology..
Giansanti, Piero, Tsiatsiani, Liana, Low, Teck Yew & Heck, Albert J R (2016). Six alternative proteases for mass spectrometry-based proteomics beyond trypsin. Nature Protocols, 11 (5), (pp. 993-1006) (14 p.).
Pronker, M.F., Lemstra, Suzanne, Snijder, J., Heck, A.J.R., Thies - Weesie, Dominique, Pasterkamp, R Jeroen & Janssen, B.J.C. (06.12.2016). Structural basis of myelin-associated glycoprotein adhesion and signalling. Nature Communications, 7, (pp. 1-13) (13 p.).
Burgers, Pepijn P, Bruystens, Jessica, Burnley, Rebecca J, Nikolaev, Viacheslav O, Keshwani, Malik, Wu, Jian, Janssen, Bert J C, Taylor, Susan S, Heck, Albert J R & Scholten, Arjen (2016). Structure of smAKAP and its regulation by PKA-mediated phosphorylation. The FEBS journal This article is protected by copyright. All rights reserved..
Tamara, Sem, Dyachenko, Andrey, Fort, Kyle L, Makarov, Alexander A, Scheltema, Richard A & Heck, Albert J R (31.08.2016). Symmetry of Charge Partitioning in Collisional and UV Photon-Induced Dissociation of Protein Assemblies. Journal of the American Chemical Society, 138 (34), (pp. 10860-10868) (9 p.).
Bouchet, Benjamin P, Gough, Rosemarie E, Ammon, York-Christoph, van de Willige, Dieudonnée, Post, Harm, Jacquemet, Guillaume, Altelaar, Maarten, Heck, Albert Jr, Goult, Ben T & Akhmanova, Anna (13.07.2016). Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions. eLife, 5.
Lössl, Philip, van de Waterbeemd, Michiel & Heck, Albert Jr (2016). The diverse and expanding role of mass spectrometry in structural and molecular biology. EMBO Journal © 2016 The Authors. Published under the terms of the CC BY NC ND 4.0 license..
  2015 - Scholarly publications
Burgers, Pepijn P, van der Heyden, Marcel A G, Kok, Bart, Heck, Albert J R & Scholten, Arjen (13.01.2015). A systematic evaluation of protein kinase a-a-kinase anchoring protein interaction motifs. Biochemistry, 54 (1), (pp. 11-21) (11 p.).
Giansanti, Piero, Aye, Thin Thin, van den Toorn, Henk, Peng, Mao, van Breukelen, Bas & Heck, Albert J R (10.06.2015). An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas. Cell Reports, 11 (11), (pp. 1834-1843) (10 p.). Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved..
Weiss, Victor U., Bereszcazk, Jessica Z., Havlik, Marlene, Kallinger, Peter, Gösler, Irene, Kumar, Mohit, Blaas, Dieter, Marchetti-Deschmann, Martina, Heck, Albert J R, Szymanski, Wladyslaw W. & Allmaier, Günter (01.09.2015). Analysis of a Common Cold Virus and Its Subviral Particles by Gas-Phase Electrophoretic Mobility Molecular Analysis and Native Mass Spectrometry. Analytical Chemistry, 87 (17), (pp. 8709-8717) (9 p.).
McNulty, Reginald, Lokareddy, Ravi Kumar, Roy, Ankoor, Yang, Yang, Lander, Gabriel C., Heck, Albert J R, Johnson, John E. & Cingolani, Gino (18.05.2015). Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. Journal of Molecular Biology, 427 (20), (pp. 3285-3299) (15 p.).
Brunner, Andrea M., Lössl, Philip, Liu, Fan, Huguet, Romain, Mullen, Christopher, Yamashita, Masami, Zabrouskov, Vlad, Makarov, Alexander, Altelaar, A. F Maarten & Heck, Albert J R (21.04.2015). Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization. Analytical Chemistry, 87 (8), (pp. 4152-4158) (7 p.).
Shakiba, Nika, White, Carl A, Lipsitz, Yonatan Y, Yachie-Kinoshita, Ayako, Tonge, Peter D, Hussein, Samer M I, Puri, Mira C, Elbaz, Judith, Morrissey-Scoot, James, Li, Mira, Munoz Peralta, Javier, Benevento, Marco, Rogers, Ian M, Hanna, Jacob H, Heck, Albert J R, Wollscheid, Bernd, Nagy, Andras & Zandstra, Peter W (16.06.2015). CD24 tracks divergent pluripotent states in mouse and human cells. Nature Communications, 6 (11 p.).
Corradini, Eleonora, Klaasse, Gruson, Leurs, Ulrike, Heck, Albert J R, Martin, Nathaniel I. & Scholten, Arjen (16.07.2015). Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach. Molecular BioSystems, 11 (10), (pp. 2786-2797) (12 p.).
Snijder, Joost, Van De Waterbeemd, Michiel, Glover, Matthew S., Shi, Liuqing, Clemmer, David E. & Heck, Albert J R (2015). Conformational landscape and pathway of disulfide bond reduction of human alpha defensin. Protein Science, 24 (8), (pp. 1264-1271) (8 p.).
Vogel, Celia J., Smit, Marjon A., Maddalo, Gianluca, Possik, Patricia A., Sparidans, Rolf W., van der Burg, Sjoerd H., Verdegaal, Els M., Heck, Albert J R, Samatar, Ahmed A., Beijnen, Jos H., Altelaar, A. F Maarten & Peeper, Daniel S. (01.01.2015). Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell and Melanoma Research, 28 (3), (pp. 307-317) (11 p.).
Hussein, Samer M I, Puri, Mira C, Tonge, Peter D, Benevento, Marco, Corso, Andrew J, Clancy, Jennifer L, Mosbergen, Rowland, Li, Mira, Lee, Dong-Sung, Cloonan, Nicole, Wood, David L A, Munoz, Javier, Middleton, Robert, Korn, Othmar, Patel, Hardip R, White, Carl A, Shin, Jong-Yeon, Gauthier, Maely E, Cao, Kim-Anh Lê, Kim, Jong-Il, Mar, Jessica C, Shakiba, Nika, Ritchie, William, Rasko, John E J, Grimmond, Sean M, Zandstra, Peter W, Wells, Christine A, Preiss, Thomas, Seo, Jeong-Sun, Heck, Albert J R, Rogers, Ian M & Nagy, Andras (30.07.2015). Corrigendum: Genome-wide characterization of the routes to pluripotency. Nature, 523 (7562).
Magliozzi, Roberto, Peng, Mao, Mohammed, Shabaz, Guardavaccaro, Daniele, Heck, Albert J R & Low, Teck Yew (01.09.2015). Datasets from an interaction proteomics screen for substrates of the SCFβTrCP ubiquitin ligase. Data in Brief, 4, (pp. 229-234) (6 p.).
Welling, Maaike, Chen, Hsu Hsin, Munoz Peralta, Javier, Musheev, Michael U., Kester, Lennart, Junker, Jan Philipp, Mischerikow, Nikolai, Arbab, Mandana, Kuijk, Ewart, Silberstein, Lev, Kharchenko, Peter V., Geens, Mieke, Niehrs, Christof, Van De Velde, Hilde, Van Oudenaarden, Alexander, Heck, Albert J R & Geijsen, Niels (01.07.2015). DAZL regulates Tet1 translation in murine embryonic stem cells. EMBO Reports, 16 (7), (pp. 791-802) (12 p.).
Balluff, Benjamin, Frese, Christian K., Maier, Stefan K., Schöne, Cédrik, Kuster, Bernhard, Schmitt, Manfred, Aubele, Michaela, Höfler, Heinz, Deelder, André M., Heck, Albert J R, Hogendoorn, Pancras C W, Morreau, Johannes, Altelaar, A. F Maarten, Walch, Axel & McDonnell, Liam A. (01.01.2015). De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. Journal of Pathology, 235 (1), (pp. 3-13) (11 p.).
Evaristo, Geisa P C, Pinkse, Martijn W H, Chen, Tianbao, Wang, Lei, Mohammed, Shabaz, Heck, Albert J R, Mathes, Isabella, Lottspeich, Friedrich, Shaw, Chris, Albar, Juan Pablo & Verhaert, Peter D E M (01.09.2015). De novo sequencing of two novel peptides homologous to calcitonin-like peptides, from skin secretion of the Chinese Frog, Odorrana schmackeri. EuPA Open Proteomics, 8, (pp. 157-166) (10 p.).
Schmidlin, Thierry, Boender, Arjen J., Frese, Christian K., Heck, Albert J R, Adan, Roger A H & Altelaar, A. F Maarten (06.10.2015). Diet-Induced Neuropeptide Expression - Feasibility of Quantifying Extended and Highly Charged Endogenous Peptide Sequences by Selected Reaction Monitoring. Analytical Chemistry, 87 (19), (pp. 9966-9973) (8 p.).
Marino, Fabio, Bern, Marshall, Mommen, Geert P M, Leney, Aneika C, van Gaans-van den Brink, Jacqueline A M, Bonvin, Alexandre M J J, Becker, Christopher, van Els, Cécile A C M & Heck, Albert J R (19.08.2015). Extended O-GlcNAc on HLA Class-I-Bound Peptides. Journal of the American Chemical Society, (pp. 10922–10925).
Benevento, Marco, Tonge, Peter D., Puri, Mira C., Nagy, Andras, Heck, Albert J R & Munoz Peralta, Javier (01.09.2015). Fluctuations in histone H4 isoforms during cellular reprogramming monitored by middle-down proteomics. Proteomics, 15 (18), (pp. 3219-3231) (13 p.).
Heck, Albert J R (2015). Gaining weight in structural biology - Applications of mass spectrometry in protein science. Protein Science, 24 (8), (pp. 1173-1175) (3 p.).
Zeqiraj, Elton, Tian, Lei, Piggott, Christopher A., Pillon, Monica C., Duffy, Nicole M., Ceccarelli, Derek F., Keszei, Alexander F A, Lorenzen, Kristina, Kurinov, Igor, Orlicky, Stephen, Gish, Gerald D., Heck, Albert J R, Guarné, Alba, Greenberg, Roger A. & Sicheri, Frank (17.09.2015). Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Molecular Cell, 59 (6), (pp. 970-983) (14 p.).
Corradini, Eleonora, Burgers, Pepijn P., Plank, Michael, Heck, Albert J R & Scholten, Arjen (20.03.2015). Huntingtin-Associated Protein 1 (HAP1) is a cGMP-dependent Kinase Anchoring Protein (GKAP) specific for the cGMP-dependent protein kinase Iβ isoform. Journal of Biological Chemistry, 290 (12), (pp. 7887-7896) (10 p.).
Götzke, Hansjörg, Muheim, Claudio, Altelaar, A.F. Maarten, Heck, Albert J.R., Maddalo, Gianluca & Daley, Daniel O. (01.01.2015). Identification of putative substrates for the periplasmic chaperone YfgM in Escherichia coli using quantitative proteomics. Molecular and Cellular Proteomics, 14 (1), (pp. 216-226) (11 p.).
Liu, Fan & Heck, Albert J R (01.12.2015). Interrogating the architecture of protein assemblies and protein interaction networks by cross-linking mass spectrometry. Current Opinion in Structural Biology, 35, (pp. 100-108) (9 p.).
Gautier, Violette, Boumeester, Anja J., Lössl, Philip & Heck, Albert J R (01.08.2015). Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics. Proteomics, 15 (16), (pp. 2756-2765) (10 p.).
Martinez-Rucobo, Fuensanta W., Kohler, Rebecca, van de Waterbeemd, Michiel, Heck, Albert J R, Hemann, Matthias, Herzog, Franz, Stark, Holger & Cramer, Patrick (18.06.2015). Molecular Basis of Transcription-Coupled Pre-mRNA Capping. Molecular Cell, 58 (6), (pp. 1079-1089) (11 p.).
Zhao, Qian, Ding, Yu, Deng, Zhangshuang, Lee, On Yi, Gao, Peng, Chen, Pin, Rose, Rebecca J., Zhao, Hong, Zhang, Zhehao, Tao, Xin Pei, Heck, Albert J R, Kao, Richard & Yang, Dan (01.07.2015). Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin i. Chemical Science, 6 (7), (pp. 4124-4130) (7 p.).
Dondelinger, Yves, Jouan-Lanhouet, Sandrine, Divert, Tatyana, Theatre, Emilie, Bertin, John, Gough, Peter J, Giansanti, Piero, Heck, Albert J R, Dejardin, Emmanuel, Vandenabeele, Peter & Bertrand, Mathieu J M (02.09.2015). NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. Molecular Cell Copyright © 2015 Elsevier Inc. All rights reserved..
Heck, Albert John Roeland (2015). Nico M. M. Nibbering (1938-2014). Angewandte Chemie-International Edition
Raaijmakers, Linsey M., Giansanti, Piero, Possik, Patricia A., Mueller, Judith, Peeper, Daniel S., Heck, Albert J R & Altelaar, A. F Maarten (02.10.2015). PhosphoPath - Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks. Journal of Proteome Research, 14 (10), (pp. 4332-4341) (10 p.).
Liu, Fan, Rijkers, Dirk T S, Post, Harm & Heck, Albert J R (2015). Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature Methods, (pp. 1179-1184).
Isogai, Tadamoto, Van Der Kammen, Rob, Goerdayal, Soenita S., Heck, Albert J. R., Altelaar, A. F. Maarten & Innocenti, Metello (01.04.2015). Proteomic analyses uncover a new function and mode of action for mouse homolog of diaphanous 2 (mDia2). Molecular and Cellular Proteomics, 14 (4), (pp. 1064-1078) (15 p.).
Tsiatsiani, Liana & Heck, Albert J R (01.07.2015). Proteomics beyond trypsin. The FEBS journal, 282 (14), (pp. 2612-2626) (15 p.).
Binai, Nadine A., Marino, Fabio, Soendergaard, Peter, Bache, Nicolai, Mohammed, Shabaz & Heck, Albert J R (01.01.2015). Rapid analyses of proteomes and interactomes using an integrated solid-phase extraction-liquid chromatography-MS/ms system. Journal of Proteome Research, 14 (2), (pp. 977-985) (9 p.).
The, Inge, Ruijtenberg, Suzan, Bouchet, Benjamin P, Cristobal Gonzalez de Durana, Alba, Prinsen, Martine B W, van Mourik, Tim, Koreth, John, Xu, Huihong, Heck, Albert J R, Akhmanova, Anna, Cuppen, Edwin, Boxem, Mike, Munoz Murillo, Ara & van den Heuvel, Sander (2015). Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells. Nature Communications, 6, (pp. 5906).
Low, Teck Yew & Heck, Albert Jr (16.11.2015). Reconciling proteomics with next generation sequencing. Current Opinion in Chemical Biology, 30, (pp. 14-20) (7 p.).
Corradini, Eleonora, Heck, Albert J R & Scholten, Arjen (01.01.2015). Separation of PKA and PKG signaling nodes by chemical proteomics. Methods in Molecular Biology, 1294, (pp. 191-201) (11 p.).
De Graaf, Erik L., Kaplon, Joanna, Mohammed, Shabaz, Vereijken, Lisette A M, Duarte, Daniel P., Redondo Gallego, Laura, Heck, Albert J R, Peeper, Daniel S. & Altelaar, A. F Maarten (02.07.2015). Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence. Journal of Proteome Research, 14 (7), (pp. 2906-2914) (9 p.).
Benoit, Isabelle, Zhou, Miaomiao, Duarte, Alexandra Vivas, Downes, Damien J., Todd, Richard B., Kloezen, Wendy, Post, Harm, Heck, Albert J. R., Altelaar, A. F. Maarten & de Vries, Ronald P. (28.08.2015). Spatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization. Scientific Reports, 5 (13 p.).
Peng, Mao, Aye, Thin Thin, Snel, Berend, Van Breukelen, Bas, Scholten, Arjen & Heck, Albert J R (02.07.2015). Spatial Organization in Protein Kinase A Signaling Emerged at the Base of Animal Evolution. Journal of Proteome Research, 14 (7), (pp. 2976-2987) (12 p.).
Dyachenko, Andrey, Wang, Guanbo, Belov, Mike, Makarov, Alexander, De Jong, Rob N., Van Den Bremer, Ewald T J, Parren, Paul W H I & Heck, Albert J R (16.06.2015). Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector. Analytical Chemistry, 87 (12), (pp. 6095-6102) (8 p.).
Selvan, Nithya, Mariappa, Daniel, Van Den Toorn, Henk W P, Heck, Albert J R, Ferenbach, Andrew T. & Van Aalten, Daan M F (08.05.2015). The early metazoan Trichoplax adhaerens possesses a functional O-GlcNAc system. Journal of Biological Chemistry, 290 (19), (pp. 11969-11982) (14 p.).
Glas, Marjolein, Bart Van Den Berg Van Saparoea, H., McLaughlin, Stephen H., Roseboom, Winfried, Liu, Fan, Koningstein, Gregory M., Fish, Alexander, Den Blaauwen, Tanneke, Heck, Albert J R, De Jong, Luitzen, Bitter, Wilbert, De Esch, Iwan J P & Luirink, Joen (28.08.2015). The soluble periplasmic domains of Escherichia coli cell division proteins FtsQ/FtsB/FtsL form a trimeric complex with submicromolar affinity. Journal of Biological Chemistry, 290 (35), (pp. 21498-21509) (12 p.).
Patyshakuliyeva, Aleksandrina, Post, Harm, Zhou, Miaomiao, Jurak, Edita, Heck, Albert J R, Hildén, Kristiina S., Kabel, Mirjam A., Mäkelä, Miia R., Altelaar, Maarten A F & De Vries, Ronald P. (01.08.2015). Uncovering the abilities of Agaricus bisporus to degrade plant biomass throughout its life cycle. Environmental Microbiology, 17 (8), (pp. 3098-3109) (12 p.).
Patyshakuliyeva, Aleksandrina, Harm, Post, Zhou, Miaomiao, Jurak, Edita, Heck, Albert J.R., Hildén, Kristiina S., Kabel, Mirjam A., Mäkelä, Miia R., Altelaar, Maarten A.F. & De Vries, Ronald P. (01.06.2015). Unraveling the abilities of agaricus bisporus to degrade plant biomass throughout its life cycle. Acta Microbiologica et Immunologica Hungarica, 62, (pp. 198) (1 p.).
  2014 - Scholarly publications
Benevento, Marco, Di Palma, Serena, Snijder, Joost, Moyer, Crystal L, Reddy, Vijay S, Nemerow, Glen R & Heck, Albert J R (18.04.2014). Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics. Journal of Biological Chemistry, 289 (16), (pp. 11421-30) (10 p.).
Corradini, Eleonora, Vallur, Raghavan, Raaijmakers, Linsey M, Feil, Susanne, Feil, Robert, Heck, Albert J R & Scholten, Arjen (2014). Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse. Molecular and Cellular Proteomics, 13 (8), (pp. 2004-2016) (13 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Snijder, Joost & Heck, Albert J R (2014). Analytical approaches for size and mass analysis of large protein assemblies. Annual Review of Analytical Chemistry, 7, (pp. 43-64) (22 p.).
Kelstrup, Christian D, Frese, Christian, Heck, Albert J R, Olsen, Jesper V & Nielsen, Michael L (2014). Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID). Molecular and Cellular Proteomics, 13 (8), (pp. 1914-24) (11 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Veesler, David, Khayat, Reza, Krishnamurthy, Srinath, Snijder, Joost, Huang, Rick K, Heck, Albert J R, Anand, Ganesh S & Johnson, John E (04.02.2014). Architecture of a dsDNA viral capsid in complex with its maturation protease. Structure with Folding & design, 22 (2), (pp. 230-7) (8 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
Bereszczak, Jessica Z, Watts, Norman R, Wingfield, Paul T, Steven, Alasdair C & Heck, Albert J R (2014). Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry. Protein Science, 23 (7), (pp. 884-96) (13 p.). © 2014 The Protein Society..
Lössl, Philip, Snijder, Joost & Heck, Albert J R (2014). Boundaries of mass resolution in native mass spectrometry. Journal of the American Society for Mass Spectrometry, 25 (6), (pp. 906-17) (12 p.).
Marino, Fabio, Cristobal, Alba, Binai, Nadine A, Bache, Nicolai, Heck, Albert J R & Mohammed, Shabaz (21.12.2014). Characterization and usage of the EASY-spray technology as part of an online 2D SCX-RP ultra-high pressure system. The Analyst, 139 (24), (pp. 6520-8) (9 p.).
Matheron, Lucrece, van den Toorn, Henk, Heck, Albert J R & Mohammed, Shabaz (19.08.2014). Characterization of biases in phosphopeptide enrichment by Ti(4+)-immobilized metal affinity chromatography and TiO2 using a massive synthetic library and human cell digests. Analytical Chemistry, 86 (16), (pp. 8312-20) (9 p.).
Diebolder, Christoph A., Beurskens, Frank J., De Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., Van De Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet & Parren, Paul W. H. I. (2014). Complement is activated by IgG hexamers assembled at the cell surface. Science, 343 (6176), (pp. 1260-1263) (4 p.).
Guerreiro, Ana C L, Benevento, Marco, Lehmann, Robert, van Breukelen, Bas, Post, Harm, Giansanti, Piero, Altelaar, Adrianus, Axmann, Ilka M & Heck, Albert J R (2014). Daily rhythms in the cyanobacterium synechococcus elongatus probed by high-resolution mass spectrometry-based proteomics reveals a small defined set of cyclic proteins. Molecular and Cellular Proteomics, 13 (8), (pp. 2042-2055) (14 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Chen, Hsu-Hsin, Welling, Maaike, Bloch, Donald B, Muñoz, Javier, Mientjes, Edwin, Chen, Xinjie, Tramp, Cody, Wu, Jie, Yabuuchi, Akiko, Chou, Yu-Fen, Buecker, Christa, Krainer, Adrian, Willemsen, Rob, Heck, Albert J & Geijsen, Niels (11.11.2014). DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells. Stem Cell Reports, 3 (5), (pp. 892-904) (13 p.).
Snijder, Joost, van de Waterbeemd, Michiel, Damoc, Eugen, Denisov, Eduard, Grinfeld, Dmitry, Bennett, Antonette, Agbandje-McKenna, Mavis, Makarov, Alexander & Heck, Albert J R (2014). Defining the stoichiometry and cargo load of viral and bacterial nanoparticles by Orbitrap mass spectrometry. Journal of the American Chemical Society, 136 (20), (pp. 7295-9) (5 p.).
Magliozzi, Roberto, Kim, Jihoon, Low, Teck Yew, Heck, Albert J R & Guardavaccaro, Daniele (2014). Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. Journal of Biological Chemistry, 289 (40), (pp. 27400-9) (10 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Rosati, Sara, Yang, Yang, Barendregt, Arjan & Heck, Albert J R (2014). Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry. Nature Protocols, 9 (4), (pp. 967-76) (10 p.).
Giansanti, Piero, Preisinger, Christian, Huber, Kilian V M, Gridling, Manuela, Superti-Furga, Giulio, Bennett, Keiryn L & Heck, Albert J R (18.07.2014). Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics. ACS Chemical Biology, 9 (7), (pp. 1490-1498) (9 p.).
Mommen, Geert P M, Frese, Christian K, Meiring, Hugo D, van Gaans-van den Brink, Jacqueline, de Jong, Ad P J M, van Els, Cécile A C M & Heck, Albert J R (2014). Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD). Proceedings of the National Academy of Sciences of the United States of America, 111 (12), (pp. 4507-12) (6 p.).
Liu, Fan, van Breukelen, Bas & Heck, Albert J R (2014). Facilitating protein disulfide mapping by a combination of pepsin digestion, electron transfer higher energy dissociation (EThcD), and a dedicated search algorithm SlinkS. Molecular and Cellular Proteomics, 13 (10), (pp. 2776-86) (11 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Vlaming, Hanneke, van Welsem, Tibor, de Graaf, Erik L, Ontoso, David, Altelaar, A F Maarten, San-Segundo, Pedro A, Heck, Albert J R & van Leeuwen, Fred (2014). Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo. EMBO Reports, 15 (10), (pp. 1077-84) (8 p.). © 2014 The Authors..
Vlaming, Hanneke, van Welsem, Tibor, de Graaf, Erik L, Ontoso, David, Altelaar, A F Maarten, San-Segundo, Pedro A, Heck, Albert J R & van Leeuwen, Fred (2014). Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo (Corrigendum). EMBO Reports, 15 (11), (pp. 1220-1221) (2 p.). © 2014 The Authors..
Muñoz, Javier & Heck, Albert J R (2014). From the human genome to the human proteome. Angewandte Chemie-International Edition, 53 (41), (pp. 10864-6) (3 p.).
Hussein, Samer M I, Puri, Mira C, Tonge, Peter D, Benevento, Marco, Corso, Andrew J, Clancy, Jennifer L, Mosbergen, Rowland, Li, Mira, Lee, Dong-Sung, Cloonan, Nicole, Wood, David L A, Munoz, Javier, Middleton, Robert, Korn, Othmar, Patel, Hardip R, White, Carl A, Shin, Jong-Yeon, Gauthier, Maely E, Lê Cao, Kim-Anh, Kim, Jong-Il, Mar, Jessica C, Shakiba, Nika, Ritchie, William, Rasko, John E J, Grimmond, Sean M, Zandstra, Peter W, Wells, Christine A, Preiss, Thomas, Seo, Jeong-Sun, Heck, Albert J R, Rogers, Ian M & Nagy, Andras (11.12.2014). Genome-wide characterization of the routes to pluripotency. Nature, 516 (7530), (pp. 198-206) (9 p.).
Peng, Mao, Scholten, Arjen, Heck, Albert J R & van Breukelen, Bas (03.01.2014). Identification of Enriched PTM Crosstalk Motifs from Large-Scale Experimental Data Sets. Journal of Proteome Research, 13 (1), (pp. 249-259) (11 p.).
Snijder, Joost, Burnley, Rebecca J, Wiegard, Anika, Melquiond, Adrien S J, Bonvin, Alexandre M J J, Axmann, Ilka M & Heck, Albert J R (28.01.2014). Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction. Proceedings of the National Academy of Sciences of the United States of America, 111 (4), (pp. 1379-84) (6 p.).
Jiang, Kai, Hua, Shasha, Mohan, Renu, Grigoriev, Ilya, Yau, Kah Wai, Liu, Qingyang, Katrukha, Eugene A, Altelaar, A F Maarten, Heck, Albert J R, Hoogenraad, Casper C & Akhmanova, Anna (10.02.2014). Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Developmental Cell, 28 (3), (pp. 295-309) (15 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
de Graaf, Erik L, Kaplon, Joanna, Zhou, Houjiang, Heck, Albert J R, Peeper, Daniel S & Altelaar, A.F.M. (2014). Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence. Molecular and Cellular Proteomics, 13 (8), (pp. 2089-2100) (12 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Yates, John R, Mohammed, Shabaz & Heck, Albert J R (04.02.2014). Phosphoproteomics. Analytical Chemistry, 86 (3), (pp. 1313).
Kleppe, Rune, Rosati, Sara, Jorge-Finnigan, Ana, Alvira, Sara, Ghorbani, Sadaf, Haavik, Jan, Valpuesta, José María, Heck, Albert J R & Martinez, Aurora (2014). Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Molecular and Cellular Proteomics, 13 (8), (pp. 2017-30) (14 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Raijmakers, Reinout, Olsen, Jesper V, Aebersold, Ruedi & Heck, Albert J R (2014). PRIME-XS, a European infrastructure for proteomics. Molecular and Cellular Proteomics, 13 (8), (pp. 1901-4) (4 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
D'Annibale, Sara, Kim, Jihoon, Magliozzi, Roberto, Low, Teck Yew, Mohammed, Shabaz, Heck, Albert J R & Guardavaccaro, Daniele (2014). Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division. Journal of Biological Chemistry, 289 (11), (pp. 7730-7) (8 p.).
Castano-Cerezo, Sara, Bernal, Vicente, Post, Harm, Fuhrer, Tobias, Cappadona, Salvatore, Sanchez-Diaz, Nerea C., Sauer, Uwe, Heck, Albert J. R., Altelaar, A. F. Maarten & Canovas, Manuel (2014). Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli. Molecular Systems Biology, 10 (11) (15 p.).
Benevento, Marco, Tonge, Peter D, Puri, Mira C, Hussein, Samer M I, Cloonan, Nicole, Wood, David L, Grimmond, Sean M, Nagy, Andras, Munoz, Javier & Heck, Albert J R (2014). Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks. Nature Communications, 5 (11 p.).
Binai, Nadine A, Bisschops, Markus M M, van Breukelen, Bas, Mohammed, Shabaz, Loeff, Luuk, Pronk, Jack T, Heck, Albert J R, Daran-Lapujade, Pascale & Slijper, Monique (01.08.2014). Proteome adaptation of Saccharomyces cerevisiae to severe calorie restriction in Retentostat cultures. Journal of Proteome Research, 13 (8), (pp. 3542-3553) (12 p.).
Paardekooper Overman, Jeroen, Yi, Jae-Sung, Bonetti, Monica, Soulsby, Matthew, Preisinger, Christian, Stokes, Matthew P, Hui, Li, Silva, Jeffrey C, Overvoorde, John, Giansanti, Piero, Heck, Albert J R, Kontaridis, Maria I, den Hertog, Jeroen & Bennett, Anton M (2014). PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice. Molecular and Cellular Biology, 34 (15), (pp. 2874-2889) (16 p.). Copyright © 2014, American Society for Microbiology. All Rights Reserved..
Walzer, Mathias, Pernas, Lucia Espona, Nasso, Sara, Bittremieux, Wout, Nahnsen, Sven, Kelchtermans, Pieter, Pichler, Peter, van den Toorn, Henk W P, Staes, An, Vandenbussche, Jonathan, Mazanek, Michael, Taus, Thomas, Scheltema, Richard A, Kelstrup, Christian D, Gatto, Laurent, van Breukelen, Bas, Aiche, Stephan, Valkenborg, Dirk, Laukens, Kris, Lilley, Kathryn S, Olsen, Jesper V, Heck, Albert J R, Mechtler, Karl, Aebersold, Ruedi, Gevaert, Kris, Vizcaíno, Juan Antonio, Hermjakob, Henning, Kohlbacher, Oliver & Martens, Lennart (2014). qcML - an exchange format for quality control metrics from mass spectrometry experiments. Molecular and Cellular Proteomics, 13 (8), (pp. 1905-13) (9 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
van Holten, Thijs C, Bleijerveld, Onno B, Wijten, Patrick, de Groot, Philip G, Heck, Albert J R, Barendrecht, Arjan D, Merkx, Tesy H, Scholten, Arjen & Roest, Mark (01.07.2014). Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets. Cardiovascular Research, 103 (1), (pp. 140-146) (7 p.). Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com..
Staals, Raymond H J, Zhu, Yifan, Taylor, David W, Kornfeld, Jack E, Sharma, Kundan, Barendregt, Arjan, Koehorst, Jasper J, Vlot, Marnix, Neupane, Nirajan, Varossieau, Koen, Sakamoto, Keiko, Suzuki, Takehiro, Dohmae, Naoshi, Yokoyama, Shigeyuki, Schaap, Peter J, Urlaub, Henning, Heck, Albert J R, Nogales, Eva, Doudna, Jennifer A, Shinkai, Akeo & van der Oost, John (20.11.2014). RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus. Molecular Cell, 56 (4), (pp. 518-30) (13 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
Smit, Marjon A, Maddalo, Gianluca, Greig, Kylie, Raaijmakers, Linsey M, Possik, Patricia A, van Breukelen, Bas, Cappadona, Salvatore, Heck, Albert Jr, Altelaar, Adrianus & Peeper, Daniel S (2014). ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma. Molecular Systems Biology, 10 (12), (pp. 772) (1 p.). © 2014 The Authors. Published under the terms of the CC BY 4.0 license..
Rurup, W Frederik, Snijder, Joost, Koay, Melissa S T, Heck, Albert J R & Cornelissen, Jeroen J L M (2014). Self-sorting of foreign proteins in a bacterial nanocompartment. Journal of the American Chemical Society, 136 (10), (pp. 3828-32) (5 p.).
Klaubauf, Sylvia, Narang, Hari Mander, Post, Harm, Zhou, Miaomiao, Brunner, Kurt, Mach-Aigner, Astrid R, Mach, Robert L, Heck, Albert J R, Altelaar, A F Maarten & de Vries, Ronald P (2014). Similar is not the same - Differences in the function of the (hemi-)cellulolytic regulator XlnR (Xlr1/Xyr1) in filamentous fungi. Fungal Genetics and Biology, 72, (pp. 73-81) (9 p.). Copyright © 2014 Elsevier Inc. All rights reserved..
van de Waterbeemd, Michiel, Lössl, Philip, Gautier, Violette, Marino, Fabio, Yamashita, Masami, Conti, Elena, Scholten, Arjen & Heck, Albert J R (01.09.2014). Simultaneous assessment of kinetic, site-specific, and structural aspects of enzymatic protein phosphorylation. Angewandte Chemie-International Edition, 53 (36), (pp. 9660-4) (5 p.). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
de Graaf, Erik L, Giansanti, Piero, Altelaar, A F Maarten & Heck, Albert J R (2014). Single-step enrichment by Ti4+-IMAC and label-free quantitation enables in-depth monitoring of phosphorylation dynamics with high reproducibility and temporal resolution. Molecular and Cellular Proteomics, 13 (9), (pp. 2426-2434) (9 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Bereszczak, Jessica Z, Havlik, Marlene, Weiss, Victor U, Marchetti-Deschmann, Martina, van Duijn, Esther, Watts, Norman R, Wingfield, Paul T, Allmaier, Guenter, Steven, Alasdair C & Heck, Albert J R (2014). Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry - morphology selective binding of Fabs to hepatitis B virus capsids. Fresenius Zeitschrift fur Analytische Chemie, 406 (5), (pp. 1437-46) (10 p.).
Clancy, Jennifer L, Patel, Hardip R, Hussein, Samer M I, Tonge, Peter D, Cloonan, Nicole, Corso, Andrew J, Li, Mira, Lee, Dong-Sung, Shin, Jong-Yeon, Wong, Justin J L, Bailey, Charles G, Benevento, Marco, Munoz, Javier, Chuah, Aaron, Wood, David, Rasko, John E J, Heck, Albert J R, Grimmond, Sean M, Rogers, Ian M, Seo, Jeong-Sun, Wells, Christine A, Puri, Mira C, Nagy, Andras & Preiss, Thomas (2014). Small RNA changes en route to distinct cellular states of induced pluripotency. Nature Communications, 5 (9 p.).
Thompson, Natalie J, Merdanovic, Melisa, Ehrmann, Michael, van Duijn, Esther & Heck, Albert J R (04.02.2014). Substrate occupancy at the onset of oligomeric transitions of DegP. Structure with Folding & design, 22 (2), (pp. 281-90) (10 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
Snijder, Joost, Benevento, Marco, Moyer, Crystal L, Reddy, Vijay, Nemerow, Glen R & Heck, Albert J R (2014). The cleaved N-terminus of pVI binds peripentonal hexons in mature adenovirus. Journal of Molecular Biology, 426 (9), (pp. 1971-9) (9 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
Kim, Jihoon, D'Annibale, Sara, Magliozzi, Roberto, Low, Teck Yew, Jansen, Petra, Shaltiel, Indra A, Mohammed, Shabaz, Heck, Albert J R, Medema, Rene H & Guardavaccaro, Daniele (15.11.2014). USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response. Molecular and Cellular Biology, 34 (22), (pp. 4177-85) (9 p.). Copyright © 2014, American Society for Microbiology. All Rights Reserved..
  2013 - Scholarly publications
Srivastava, S.K., Ruigrok, V.J.B., Thompson, N.J., Trilling, A.K., Heck, A.J.R., van Rijn, C, Beekwilder, M.J. & Jongsma, M.A. (2013). 16 kDa heat shock protein from heat-inactivated Mycobacterium tuberculosis is a homodimer - suitability for diagnostic applications with specific llama VHH monoclonals. PLoS One, 8 (5) (11 p.).
Pijnappel, W.W.M., Esch, D., Baltissen, M.P.A., Wu, G., Mischerikow, N., Bergsma, A., van der Wal, E., Han, D.W., vom Bruch, H., Moritz, S., Lijnzaad, P., Altelaar, A.F.M., Sameith, K., Zaehres, H., Heck, A.J.R., Holstege, F.C.P., Scholer, H.R. & Timmers, H.T.M. (2013). A central role for TFIID in the pluripotent transcription circuitry. Nature, 495, (pp. 516-519) (4 p.).
Marx, H., Lemeer, S., Schliep, J.E., Matheron, L.I., Mohammed, S., Cox, J., Mann, M., Heck, A.J.R. & Kuster, B. (2013). A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics. Nature Biotechnology, 31, (pp. 557-564) (8 p.).
Yang, Y., Barendregt, A., Kamerling, J.P. & Heck, A.J.R. (2013). Analyzing Protein Micro-Heterogeneity in Chicken Ovalbumin by High-Resolution Native Mass Spectrometry Exposes Qualitatively and Semi-Quantitatively 59 Proteoforms. Analytical Chemistry, 85, (pp. 12037-12045) (9 p.).
Altelaar, A.F.M., Frese, C.K., Preisinger, C., Hennrich, M.L., Schram, A.W., Timmers, H.T.M., Heck, A.J.R. & Mohammed, S. (2013). Benchmarking stable isotope labeling based quantitative proteomics. Journal of Proteomics, 88, (pp. 14-26) (13 p.). This article is part of a Special Issue entitled: New Horizons and Applications for Proteomics [EuPA 2012]..
Frese, C., Nolting, D., Altelaar, A.F.M., Griep-Raming, J., Mohammed, S. & Heck, A.J.R. (2013). Characterization of Electron Transfer Dissociation in the Orbitrap Velos HCD Cell. Journal of the American Society for Mass Spectrometry, 24 (11), (pp. 1663-1670) (8 p.).
Halim, V.A., Alvarez Fernandez, M., Xu, Y.J., Aprelia, M., van den Toorn, H.W.P., Heck, A.J.R., Mohammed, S. & Medema, R.H. (2013). Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response. Science Signaling, 6 (272), (pp. 1-10) (10 p.).
Thompson, Natalie J, Hendriks, Linda J A, de Kruif, John, Throsby, Mark & Heck, Albert J R (20.12.2013). Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry. mAbs, 6 (1), (pp. 197-203) (7 p.).
Magliozzi, R., Low, T.Y., Weijts, B.G.M.W., Cheng, T., Spanjaard, E., Mohammed, S., van Veen, A., Ovaa, H., de Rooij, J., Zwartkruis, G.J.T., Bos, J.L., de Bruin, A. & Heck, A.J.R. (2013). Control of Epithelial Cell Migration and Invasion by the IKKβ- and CK1α-Mediated Degradation of RAPGEF2. Developmental Cell, 27, (pp. 574-585) (12 p.).
Ringrose, J.H., van den Toorn, H.W.P., Eitel, M., Post, H., Neerincx, P.B.T., Schierwater, B., Altelaar, A.F.M. & Heck, A.J.R. (2013). Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity. Nature Communications, 4.
Krijgsheld, P., Nitsche, B.M., Post, H., Levin, A.M., Muller, W.H., Heck, A.J.R., Ram, A.F., Altelaar, A.F.M. & Wösten, H.A.B. (2013). Deletion of flbA results in increased secretome complexity and reduced secretion heterogeneity in colonies of Aspergillus niger. Journal of Proteome Research, 12 (4), (pp. 1808-1819) (12 p.).
Scholten, A. & Heck, A.J.R. (2013). Determining Protein Concentrations of the Human Ventricular Proteome. Methods in Molecular Biology, 1005, (pp. 11-24) (14 p.).
Chin, P.T.K., van der Linden, Marte, van Harten, E.J., Barendregt, A., Rood, M.T.M., Koster, A.J., van Leeuwen, F.W.B., de Mello Donega, C., Heck, A.J.R. & Meijerink, A. (2013). Enhanced luminescence of Ag nanoclusters via surface modification. Nanotechnology, 24 (7).
Bereszczak, J.Z., Rose, R.J., van Duijn, E., Watts, N.R., Wingfield, P.T., Steven, A.C. & Heck, A.J.R. (2013). Epitope-distal Effects Accompany the Binding of Two Distinct Antibodies to Hepatitis B Virus Capsids. Journal of the American Chemical Society, 135, (pp. 6504-6512) (9 p.).
Berends, C.W.H., Muñoz, J., Portegijs, V.C., Schmidt, R., Grigoriev, I.S., Boxem, M., Akhmanova, A.S., Heck, A.J.R. & van den Heuvel, S. (2013). F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Molecular Biology of the Cell, 24 (14), (pp. 2201-2215) (15 p.).
Di Palma, S., Zoumaro-Djayoon, A.D., Peng, M, Post, H., Preisinger, C., Munoz, J & Heck, A.J.R. (2013). Finding the same needles in the haystack? A comparison of phosphotyrosine peptides enriched by immuno-affinity precipitation and metal-based affinity chromatography. Journal of Proteomics, 91, (pp. 331-337) (7 p.).
Tseng, Y.H., Uetrecht, C., Yang, S.C., Barendregt, A., Heck, A.J.R. & Peng, W.P. (2013). Game-Theory-Based Search Engine to Automate the Mass Assignment in Complex Native Electrospray Mass Spectra. Analytical Chemistry, 85, (pp. 11275-11283) (9 p.).
Wijten, P., van Holten, T.C., Woo, L.L., Bleijerveld, O.B., Roest, M., Heck, A.J.R. & Scholten, A. (2013). High precision platelet releasate definition by quantitative reversed protein profiling--Brief report. Arteriosclerosis, Thrombosis, and Vascular Biology, 33, (pp. 1635-1638) (4 p.).
Rose, R.J., Damoc, E., Denisov, E. & Heck, A.J.R. (2013). High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies. Nature Methods, 9 (11), (pp. 1084-1086) (3 p.).
Jones, E.A., Schmitz, N., Waaijer, C.J.F., Frese, C., van Remoortere, A., van Zeijl, R.J.M., Heck, A.J.R., Hogendoorn, P.C.W., Deelder, A.M., Altelaar, A.F.M., Bovée, J.V.M.G. & McDonnell, L.A. (2013). Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors. Journal of Proteome Research, 12, (pp. 1847-1855) (9 p.).
Haberkant, P., Raijmakers, R., Wildwater, M., Sachsenheimer, T., Brügger, B., Maeda, K., Houweling, M., Gavin, A-C, Schultz, C., van Meer, G., Heck, A.J.R. & Holthuis, J.C.M. (2013). In vivo profiling and visualization of cellular protein–lipid interactions using bifunctional fatty acids. Angewandte Chemie-International Edition, 52, (pp. 4033-4038) (6 p.).
Rosati, S, van den Bremer, E.T.J., Schuurman, J., Parren, P.W.H.I., Kamerling, J.P. & Heck, A.J.R. (2013). In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap. mAbs, 5 (6), (pp. 917-924) (8 p.).
Giansanti, P., Stokes, M.P., Silva, J.C., Scholten, A. & Heck, A.J.R. (2013). Interrogating cAMP-dependent kinase signaling in jurkat T cells via a protein kinase A targeted immune-precipitation phosphoproteomics approach. Molecular and Cellular Proteomics, 12 (11), (pp. 3350-3359) (10 p.).
Mommen, G.P.M., Meiring, H.D., Heck, A.J.R. & de Jong, A.P.J.M. (2013). Mixed-Bed Ion Exchange Chromatography Employing a Salt-Free pH Gradient for Improved Sensitivity and Compatibility in MudPIT. Analytical Chemistry, 85, (pp. 6608-6616) (9 p.).
Esposito, G., Garvey, M., Alverdi, V., Pettirossi, F., Corazza, A., Fogolari, F., Polano, M., Mangione, P.P., Giorgetti, S., Stoppini, M., Rekas, A., Bellotti, V., Heck, A.J.R. & Carver, J.A. (2013). Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers. Journal of Biological Chemistry, 288 (24), (pp. 17844-17858) (15 p.).
Rose, R.J., van Berkel, P.H.C., van den Bremer, E.T.J., Labrijn, A.F., Vink, T., Schuurman, J., Heck, A.J.R. & Parren, P.W.H.I. (2013). Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG. mAbs, 5 (2), (pp. 219-228) (10 p.).
Altelaar, A.F.M., Munoz-Peralta, J. & Heck, A.J.R. (2013). Next-generation proteomics: towards an integrative view of proteome dynamics. Nature Reviews Genetics, 14, (pp. 35-48) (14 p.).
Ekkebus, R., van Kasteren, S.I., Kulathu, Y., Scholten, A., Berlin, I., Geurink, P.P., de Jong, A., Goerdayal, S.S., Neefjes, J., Heck, A.J.R., Komander, D. & Ovaa, H. (2013). On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases. Journal of the American Chemical Society, 135 (8), (pp. 2867-2870) (4 p.).
Thompson, N.J., Rosati, S & Heck, A.J.R. (2013). Performing native mass spectrometry analysis on therapeutic antibodies. ImmunoMethods, 65 (1), (pp. 11-17) (7 p.).
Scholten, A., Preisinger, C., Corradini, E., Bourgonje, V.J.A., Hennrich, M.L., van Veen, T.A.B., Swaminathan, P.D., Joiner, M.L., Vos, M.A., Anderson, M.E. & Heck, A.J.R. (2013). Phosphoproteomics study based on in vivo inhibition reveals sites of calmodulin-dependent protein kinase II regulation in the heart. Journal of the American Heart Association, 2 (4), (pp. e000318) (11 p.).
Snijder, J., Uetrecht, C., Rose, R.J., Sanchez-Eugenia, R., Marti, G.A., Agirre, J., Guérin, D.M.A., Wuite, G.J.L., Heck, A.J.R. & Roos, W.H. (2013). Probing the biophysical interplay between a viral genome and its capsid. Nature Chemistry, 5, (pp. 502-509) (8 p.).
Frese, C., Boender, A.J., Mohammed, S., Heck, A.J.R., Adan, R.A.H. & Altelaar, A.F.M. (2013). Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry. Analytical Chemistry, 85 (7), (pp. 4594-4604) (11 p.). http://www.ncbi.nlm.nih.gov/pubmed/23581470.
Low, T.Y., van Heesch, S.A.A.C., van den Toorn, H.W.P., Giansanti, P., Cristobal, A., Toonen, P., Schafer, S., Hübner, N., van Breukelen, B., Mohammed, S., Cuppen, E.P.J.G. & Heck, A.J.R. (2013). Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis. Cell Reports, 5 (5), (pp. 1469-1478) (10 p.). http://linkinghub.elsevier.com/retrieve/pii/S2211-1247(13)00640-2.
Meijer, L.A.T., Zhou, H., Chan, O.Y.A., Altelaar, A.F.M., Hennrich, M.L., Mohammed, S., Bos, J.L. & Heck, A.J.R. (2013). Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Molecular BioSystems, 9, (pp. 732-749) (18 p.).
Zhang, H., Zhou, H., Berke, L., Heck, A.J.R., Mohammed, S., Scheres, B.J.G. & Menke, F.L.H. (2013). Quantitative phosphoproteomics after auxin-stimulated lateral root induction identifies an SNX1 protein phosphorylation site required for growth. Molecular and Cellular Proteomics, 12, (pp. 1158-1169) (12 p.).
Zhou, H., Ye, M., Dong, J., Corradini, E., Cristobal, A., Heck, A.J.R., zou, H. & Mohammed, S. (2013). Robust phosphoproteome enrichment using monodisperse microsphere-based immobilized titanium (IV) ion affinity chromatography. Nature Protocols, 8, (pp. 461-480) (20 p.).
de Graaf, E.L., Vermeij, W.P., de Waard, M.C., Rijksen, Y., van der Pluijm, I., Hoogenraad, C.C., Hoeijmakers, J.H.J., Altelaar, A.F.M. & Heck, A.J.R. (2013). Spatio-temperal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum. Molecular and Cellular Proteomics, 12 (5), (pp. 1350-1362) (13 p.).
Staals, R.H.J., Agari, Y., Maki-Yonekura, S., Zhu, Y., Taylor, D.W., van Duijn, E., Barendregt, A., Vlot, M.C., Koehorst, J.J., Sakamoto, K., Masuda, A., Dohmae, N., Schaap, P.J., Doudna, J.A., Heck, A.J.R., Yonekura, K., van der Oost, J. & Shinkai, A. (2013). Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus. Molecular Cell, 52 (1), (pp. 135-145) (11 p.).
Snijder, J., Rose, R.J., Veesler, D., Johnson, J.A. & Heck, A.J.R. (2013). Studying 18 MDa Virus Assemblies with Native Mass Spectrometry. Angewandte Chemie-International Edition, 52 (14), (pp. 4020-4023) (4 p.).
Bleijerveld, O.B., van Holten, T.C., Preisinger, C., van der Smagt, J.J., Farndale, R.W., Kleefstra, T., Willemsen, M.H., Urbanus, R.T, de Groot, Ph.G., Heck, A.J.R., Roest, M. & Scholten, A. (2013). Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (7), (pp. 1538-1543) (6 p.). http://www.ncbi.nlm.nih.gov/pubmed/23619296.
Mellacheruvu, D., Wright, Z., Couzens, A.L., Low, T.Y., Halim, V.A., Heck, A.J.R., Mohammed, S. & Nesvizhskii, A. (2013). The CRAPome: a contaminant repository for affinity purification–mass spectrometry data. Nature Methods, 10, (pp. 730-736) (7 p.).
Thompson, N.J., Rosati, S, Rose, R.J. & Heck, A.J.R. (2013). The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis. Chemical Communications, 49 (6), (pp. 538-548) (11 p.).
Zhou, H., Di Palma, S., Preisinger, C., Peng, M, Polat, A.N., Heck, A.J.R. & Mohammed, S. (2013). Toward a comprehensive characterization of a human cancer cell phosphoproteome. Journal of Proteome Research, 12, (pp. 260-271) (12 p.).
Frese, C., Zhou, H., Taus, T., Altelaar, A.F.M., Mechtler, K., Heck, A.J.R. & Mohammed, S. (2013). Unambiguous Phosphosite Localization using Electron-Transfer/Higher-Energy Collision Dissociation (EThcD). Journal of Proteome Research, 12, (pp. 1520-1525) (6 p.).
Hennrich, M.L., Marino, F., Groenewold, V., Kops, G.J.P.L., Mohammed, S. & Heck, A.J.R. (2013). Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1. Journal of Proteome Research, 12, (pp. 2214-2224) (11 p.).
Pollo-Oliveira, L., Post, H., Acencio, M.L., Lemke, N., van den Toorn, H.W.P., Tragante Do O, V., Heck, A.J.R., Altelaar, A.F.M. & Yatsuda, A.P. (2013). Unravelling the Neospora caninum secretome through the secreted fraction (ESA) and quantification of the discharged tachyzoite using high-resolution mass spectrometry-based proteomics. Parasites and Vectors, 6 (1), (pp. 335) (14 p.).
  2012 - Scholarly publications
Smith, A.B., Lopez-Villarejo, J., Diago-Navarro, E., Mitchenall, L.A., Barendregt, A., Heck, A.J.R., Lemonnier, M., Maxwell, A. & Diaz-Orejas, R. (2012). A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions. PLoS One, 7 (9), (pp. 46499) (1 p.).
Burgers, P.P., Ma, Y., Margarucci, L., Mackey, M., van der Heyden, M.A.G., Ellisman, M., Scholten, A., Taylor, S.S. & Heck, A.J.R. (2012). A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane. Journal of Biological Chemistry, 287 (52), (pp. 43789-43797) (9 p.).
Kovanich, D., Cappadona, S., Raijmakers, R., Mohammed, S., Scholten, A. & Heck, A.J.R. (2012). Applications of stable isotope dimethyl labeling in quantitative proteomics. Fresenius Zeitschrift fur Analytische Chemie, 404 (4), (pp. 991-1009) (19 p.).
Lindhoud, S., van den Berg, W.A.M., van den Heuvel, R.H.H., Heck, A.J.R., van Mierlo, C.P.M. & van Berkel, W.J.H. (2012). Cofactor binding protects flavodoxin against oxidative stress. PLoS One, 7 (7).
Kukrer, B., Barbu, I.M., Copps, J., Hogan, P., Taylor, S.S., van Duijn, E. & Heck, A.J.R. (2012). Conformational isomers of calcineurin follow distinct dissociation pathways. Journal of the American Society for Mass Spectrometry, 23, (pp. 1534-1543) (10 p.).
Kruiswijk, F., Yuniati, L., Low, T.Y., Lim, R., Bolder, R., Mohammed, S., Proud, C.G., Heck, A.J.R. & Pagano, M. (2012). Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Science Signaling, 5 (227), (pp. 1-12) (12 p.).
van Noort, V., Seebacher, J., Bader, S., Mohammed, S., Vonkova, I., Betts, M.J., Kuhner, S., Kumar, R., Maier, T., O'Flaherty, M.C., Rybin, V., Schmeisky, A., Yus, E., Stulke, J., Serrano, L., Russell, R.B., Heck, A.J.R., Bork, P. & Gavin, A-C (2012). Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. Molecular Systems Biology, 8 (571).
Cappadona, S., Baker, P.R., Cutillas, P., Heck, A.J.R. & van Breukelen, B. (2012). Current challenges in software solutions for mass spectrometry-based quantitative proteomics. Amino Acids, 43, (pp. 1087-1108) (22 p.).
Altelaar, A.F.M., Navarro, D., Boekhorst, J., van Breukelen, B., Snel, B., Mohammed, S. & Heck, A.J.R. (2012). Database independent proteomics analysis of the ostrich and human proteome. Proceedings of the National Academy of Sciences of the United States of America, 109, (pp. 407-412) (6 p.).
Bleijerveld, O.B., Wijten, P., Cappadona, S., McClellan, E.A., Polat, A.N., Raijmakers, R., Sels, J.W., Colle, L.B., Grasso, S., van den Toorn, H.W.P., van Breukelen, B., Stubbs, A., Pasterkamp, G., Heck, A.J.R., Hoefer, I.E. & Scholten, A. (2012). Deep Proteome Profiling of Circulating Granulocytes Reveals Bactericidal/Permeability-Increasing Protein as a Biomarker for Severe Atherosclerotic Coronary Stenosis. Journal of Proteome Research, 11, (pp. 5235-5244) (10 p.).
Raijmakers, R., Beers, J.J.B.C., El-Azzouny, M., Visser, N.F.C., Bozic, B., Pruijn, G.J.M. & Heck, A.J.R. (2012). Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients. Arthritis Research and Therapy, 14.
Polat, A.N., Kraiczek, K., Heck, A.J.R., Raijmakers, R. & Mohammed, S. (2012). Fully automated isotopic dimethyl labeling and phosphopeptide enrichment using a microfluidic HPLC phosphochip. Fresenius Zeitschrift fur Analytische Chemie, 404, (pp. 2507-2512) (6 p.).
Preisinger, C., Schwarz, J. P., Bleijerveld, O.B., Corradini, E., Muller, P.J., Anderson, K.I., Kolch, W., Scholten, A. & Heck, A.J.R. (2012). Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells. Leukemia, 27, (pp. 743-746) (4 p.).
Cristobal, A., Hennrich, M.L., Giansanti, P., Goerdayal, S.S., Heck, A.J.R. & Mohammed, S. (2012). In-house construction of a UHPLC system enabling the identification of over 4000 protein groups in a single analysis. The Analyst, 137, (pp. 3541-3548) (8 p.).
Choukrallah, M.A., Kobi, D., Martianov, I., Pijnappel, W.W.M., Mischerikow, N., Ye, T., Heck, A.J.R., Timmers, H.T.M. & Davidson, I. (2012). Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome. Nucleic Acids Research, 40 (4), (pp. 1446-1459) (14 p.).
Glatter, T., Ludwig, C., Ahrne, E., Aebersold, R., Heck, A.J.R. & Schmidt, A. (2012). Large-scale quantitative assessment of different in-solution protein digestion protocols reveals superior cleavage efficiency of tandem Lys-C/trypsin proteolysis over trypsin digestion. Journal of Proteome Research, 11, (pp. 5145-5156) (12 p.).
Bensimon, A., Heck, A.J.R. & Aebersold, R. (2012). Mass spectrometry-based proteomics and network biology. Annual Review of Biochemistry, 81, (pp. 379-405) (27 p.).
van Duijn, E., Barbu, I.M., Barendregt, A., Jore, M.M., Wiedenheft, B., Lundgren, M., Westra, E.R., Brouns, S.J.J., Doudna, J.A., van der Oost, J. & Heck, A.J.R. (2012). Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Molecular and Cellular Proteomics, 11, (pp. 1430-1441) (12 p.).
Nenci, S., Piano, V., Rosati, S, Aliverti, A., Pandini, V., Fraaije, M.W., Heck, A.J.R., Edmondson, D.E. & Mattevi, A. (2012). Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis. Proceedings of the National Academy of Sciences of the United States of America, 109 (46), (pp. 18791-18796) (6 p.).
Kovanich, D., Aye, T.T., Heck, A.J.R. & Scholten, A. (2012). Probing the specificity of protein-protein interactions by quantitative chemical proteomics. Chemical Proteomics (pp. 167-181) (15 p.).
Peng, M, Ms. Taouatas, N., Cappadona, S., van Breukelen, B., Mohammed, S., Scholten, A. & Heck, A.J.R. (2012). Protease bias in absolute protein quantitation. Nature Methods, 9 (6), (pp. 524-525) (2 p.).
Rosati, S, Thompson, N.J., Barendregt, A., Hendriks, L.J.A., Bakker, A.B.H., De Kruif, J., Throsby, M., van Duijn, E. & Heck, A.J.R. (2012). Qualitative and semiquantitative analysis of composite mixtures of antibodies by native mass spectrometry. Analytical Chemistry, 84, (pp. 7227-7232) (6 p.).
Di Palma, S., Hennrich, M.L., Heck, A.J.R. & Mohammed, S. (2012). Recent advances in peptide separation by multidimensional liquid chromatography for proteome analysis. Journal of Proteomics, 75, (pp. 3791-3813) (23 p.).
Aye, T.T., Soni, S., van Veen, T.A.B., van der Heyden, M.A.G., Cappadona, S., Varro, A., de Weger, R.A., de Jonge, N., Vos, M.A., Heck, A.J.R. & Scholten, A. (2012). Reorganized PKA-AKAP associations in the failing human heart. Journal of Molecular and Cellular Cardiology, 52 (2), (pp. 511-518) (8 p.).
Krijgsheld, P., Wosten, H.A.B., Altelaar, A.F.M., Post, H., Ringrose, J.H., Muller, W.H. & Heck, A.J.R. (30.03.2012). Spatially resolving the microtome within the mycelium of the cell factory Aspergillus niger. onbekend Philipps-Universitaet Marburg, Germany, 11th European Conference on Fungal Genetics.
Krijgsheld, P., Altelaar, A.F.M., Post, H., Ringrose, J.H., Muller, W.H., Heck, A.J.R. & Wösten, H.A.B. (2012). Spatially resolving the secretome within the mycelium of the cell factory Aspergillus niger. Journal of Proteome Research, 11 (5), (pp. 2807-2818) (12 p.).
Bereszczak, J.Z., Barbu, I.M., Tan, M., Xia, M., Jiang, X., van Duijn, E. & Heck, A.J.R. (2012). Structure, stability and dynamics of norovirus P domain derived protein complexes studied by native mass spectrometry. Journal of Structural Biology, 177, (pp. 273-282) (10 p.).
Zoumaro-Djayoon, A.D., Heck, A.J.R. & Munoz, J (2012). Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis. ImmunoMethods, 56 (2), (pp. 268-274) (7 p.).
Mithoe, S.C., Boersema, P.J., Berke, L., Snel, B., Heck, A.J.R. & Menke, F.L.H. (2012). Targeted quantitative phosphoproteomics approach for the detection of phospho-tyrosine signaling in plants. Journal of Proteome Research, 11, (pp. 438-448) (11 p.).
Munoz-Peralta, J., Stange, D.J., Schepers, A.G., van de Wetering, M., Itzkovitz, S., Volckmann, R, Kung, K.S., Koster, J., Radulescu, S., Myant, K., Versteeg, R., Sansom, O.J., Barker, Nick, van Oudenaarden, A., Mohammed, S., Heck, A.J.R. & Clevers, H.C. (2012). The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO Journal, 31 (14), (pp. 3079-3091) (13 p.).
Cote, R.G., Griss, J., Dianes, J.A., Wang, R., Wright, J.C., van den Toorn, H.W.P., van Breukelen, B., Heck, A.J.R., Hulstaert, N., Martens, L., Reisinger, F., Csordas, A., Ovelleiro, D., Perez-Rivevol, Y., Barsnes, H., Hermjakob, H. & Vizcaino, J.A. (2012). The PRoteomics IDEntification (PRIDE) Converter 2 Framework: An Improved Suite of Tools to Facilitate Data Submission to the PRIDE Database and the ProteomeXchange Consortium. Molecular and Cellular Proteomics, 12, (pp. 1682-1689) (8 p.).
Munoz, J, Low, T.Y., Kok, Y.J., Chin, A., Frese, C., Ding, V., Choo, A. & Heck, A.J.R. (2012). The quantitative proteomes of human induced pluripotent stem cells and embryonic stem cells. Molecular Systems Biology, 7 (550).
Moreno-Cordoba, I, Diago-Navarro, E., Barendregt, A., Heck, A.J.R., Alfonso, C., Diaz-Orejas, R., Nieto, C. & Espinosa, M. (2012). The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target. Proteins: Structure, Function and Genetics, 80 (7), (pp. 1834-1846) (13 p.).
Frese, C.K., Altelaar, A.F.M., van den Toorn, H.W.P., Nolting, D., Griep-Raming, J., Heck, A.J.R. & Mohammed, S. (2012). Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry. Analytical Chemistry, 84, (pp. 9668-9673) (6 p.).
Altelaar, A.F.M. & Heck, A.J.R. (2012). Trends in ultrasensitive proteomics. Current Opinion in Chemical Biology, 16, (pp. 206-213) (8 p.).
Hennrich, M.L., van den Toorn, H.W.P., Groenewold, V., Heck, A.J.R. & Mohammed, S. (2012). Ultra acidic strong cation exchange enabling the efficient enrichment of basic phosphopeptides. Analytical Chemistry, 84, (pp. 1804-1808) (5 p.).
Mommen, G.P.M., van de Waterbeemd, B., Meiring, H.D., Kersten, G., Heck, A.J.R. & de Jong, A.P.J.M. (2012). Unbiased selective isolation of protein N-terminal peptides from complex proteome samples using phospho tagging (PTAG) and TiO(2)-based depletion. Molecular and Cellular Proteomics, 9, (pp. 832-842) (11 p.).
Low, T.Y., Magliozzi, R. & Heck, A.J.R. (2012). Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics. Proteomics, 13 (3-4), (pp. 526-537) (12 p.).
Aye, T.T., Low, T.Y., Bjorlykke, Y, Barsnes, H., Heck, A.J.R. & Berven, F.S. (2012). Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins. Analytical Chemistry, 84, (pp. 4999-5006) (8 p.).
Li, V.S.W., Boersema, P.J., Low, T.Y., Gerlach, J.P., Mohammed, S., Heck, A.J.R., Maurice, M.M. & Clevers, H.C. (2012). Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex. Cell, 149, (pp. 1245-1256) (12 p.).
Di Palma, S., Mohammed, S. & Heck, A.J.R. (2012). ZIC-cHILIC as a fractionation method for sensitive and powerful shotgun proteomics. Nature Protocols, 7 (11), (pp. 2041-2055) (15 p.).
  2011 - Scholarly publications
Abrahams, Jan-Pieter, Apweiler, Rolf, Balling, Rudi, Bertero, Michela G, Bujnicki, Janusz M, Chayen, Naomi E, Chène, Patrick, Corthals, Gary L, Dyląg, Tomasz, Förster, Friedrich, Heck, Albert J R, Henderson, Peter J F, Herwig, Ralf, Jehenson, Philippe, Kokalj, Sasa Jenko, Laue, Ernest, Legrain, Pierre, Martens, Lennart, Migliorini, Cristiano, Musacchio, Andrea, Podobnik, Marjetka, Schertler, Gebhard F X, Schreiber, Gideon, Sixma, Titia K, Smit, August B, Stuart, David, Svergun, Dmitri I & Taussig, Michael J (2011). "4D Biology for health and disease" workshop report. Biotechnology Journal, 28 (4), (pp. 291-3) (3 p.). Copyright © 2010. Published by Elsevier B.V. All rights reserved..
Galli, M., Munoz, J, Portegijs, V.C., Boxem, M., Grill, S.W., Heck, A.J.R. & van den Heuvel, S.J.L. (2011). aPKC phosphorylates NuMa-related LIN-5 to position the mitotic spindle during asymmetric division. Nature Cell Biology, 13 (9), (pp. 1132-1138) (7 p.).
Margarucci, L., Roest, M., Preisinger, C., Bleijerveld, O.B., van Holten, T.C., Heck, A.J.R. & Scholten, A. (2011). Collagen stimulation of platelets induces a rapid spatial response of cAMP and cGMP signaling scaffolds. Molecular BioSystems, 7, (pp. 2311-2319) (9 p.).
Garcia-Alles, L.F., Giacometti, G., Versluis, C., Maveyraud, L., de Paepe, D., Guiard, J., Tranier, S., Gilleron, M., Prandi, J., Hanau, D., Heck, A.J.R., Mori, L., de Libero, G., Puzo, G., Mourey, L. & de la Salle, H. (2011). Crystal structure of human CD1e reveals a groove suited for lipid-exchange processess. Proceedings of the National Academy of Sciences of the United States of America, 108 (32), (pp. 13230-13235) (6 p.).
Cappadona, S., Munoz, J, Spee, W.P.E., Low, T.Y., Mohammed, S., van Breukelen, B. & Heck, A.J.R. (2011). Deconvolution of overlapping isotopic clusters improves quantification of stable isotope-labeled peptides. Journal of Proteomics, 74 (10), (pp. 2204-2209) (6 p.).
Brasch, M., de la Escosura, A., Ma, Y., Uetrecht, C., Heck, A.J.R., Torres, T. & Cornelissen, J.J.L.M. (2011). Encapsulation of phthalocyanine supramolecular stacks into virus-like particles. Journal of the American Chemical Society, 133 (18), (pp. 6878-6881) (4 p.).
Zhou, H., Low, T.Y., Hennrich, M.L., van den Toorn, H.W.P., Schwend, T.A., zou, H., Mohammed, S. & Heck, A.J.R. (2011). Enhancing the identification of phosphopeptides from putative basophilic kinase substrates using Ti (IV) based IMAC enrichment. Molecular and Cellular Proteomics, 10 (10).
Boekhorst, J., Boersema, P.J., Tops, B.B.J., van Breukelen, B., Heck, A.J.R. & Snel, B. (2011). Evaluating experimental bias and completeness in comparative phosphoproteomics analysis. PLoS One, 6 (8), (pp. 23276) (1 p.).
Di Palma, S., Raijmakers, R., Heck, A.J.R. & Mohammed, S. (2011). Evaluation of the deuterium isotope effect in zwitterionic hydrophilic interaction liquid chromatography separations for implementation in a quantitative proteomic approach. Analytical Chemistry, 83 (21), (pp. 8352-8356) (5 p.).
Di Palma, S., Stange, D., van de Wetering, M., Clevers, H.C., Heck, A.J.R. & Mohammed, S. (2011). Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. Journal of Proteome Research, 10 (8), (pp. 3814-3819) (6 p.).
Vogels, M.W., van Balkom, B.W.M., Kaloyanova, D.V., Batenburg, J.J., Heck, A.J.R., Helms, J.B., Rottier, P.J.M. & de Haan, C.A.M. (2011). Identification of host factors involved in coronavirus replication by quantitative proteomics analysis. Proteomics, 11 (1), (pp. 64-80) (17 p.).
Frese, C.K., Altelaar, A.F.M., Hennrich, M.L., Nolting, D., Zeller, M., Griep-Raming, J., Heck, A.J.R. & Mohammed, S. (2011). Improved peptide identification by targeted fragmentation using CID, HCD and ETD on an LTQ-Orbitrap Velos. Journal of Proteome Research, 10 (5), (pp. 2377-2388) (12 p.).
Hennrich, M.L., Groenewold, V., Kops, G.J.P.L., Heck, A.J.R. & Mohammed, S. (2011). Improving depth in phosphoproteomics by using a strong cation exchange-weak anion exchange-reversed phase multidimensional separation approach. Analytical Chemistry, 83 (18), (pp. 7137-7143) (7 p.).
de Graaf, E.L., Altelaar, A.F.M., van Breukelen, B., Mohammed, S. & Heck, A.J.R. (2011). Improving SRM assay development: a global comparison between triple quadrupole, ion trap, and higher energy CID peptide fragmentation spectra. Journal of Proteome Research, 10 (9), (pp. 4334-4341) (8 p.).
Scholten, A., Mohammed, S., Low, T.Y., Zanivan, S., van Veen, A.A.B., Delanghe, B. & Heck, A.J.R. (2011). In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse. Molecular and Cellular Proteomics, 10 (10), (pp. O111.008474) (1 p.).
Tseng, Y.H., Uetrecht, C., Heck, A.J.R. & Peng, W.P. (2011). Interpreting the charge state assignment in electrospray mass spectra of bioparticles. Analytical Chemistry, 83 (6), (pp. 1960-1968) (9 p.).
Uetrecht, C., Barbu, I.M., Shoemaker, G.K., van Duijn, E. & Heck, A.J.R. (2011). Interrogating viral capsid assembly with ion mobility-mass spectrometry. Nature Chemistry, 3 (2), (pp. 126-132) (7 p.).
Zoumaro-Djayoon, A.D., Ding, V., Foong, L.Y., Choo, A., Heck, A.J.R. & Munoz, J (2011). Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling. Proteomics, 11 (20), (pp. 3962-3971) (10 p.).
de Lau, W., Low, T.Y., Kujala, P., Peters, P.J., Schasfoort, R.B.M., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A.J.R. & Clevers, H.C. (2011). Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature, 476 (7360), (pp. 293-297) (5 p.).
Uetrecht, C. & Heck, A.J.R. (2011). Modern biomolecular mass spectrometry and its role in studying virus structure, dynamics, and assembly. Angewandte Chemie-International Edition, 50, (pp. 8248-8262) (15 p.).
Blattner, C., Jennebach, S., Herzog, F., Mayer, A., Cheung, A.C., Witte, G., Lorenzen, K., Hopfner, K.P., Heck, A.J.R., Aebersold, R. & Cramer, P. (2011). Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes and Development, 25 (19), (pp. 2093-2105) (13 p.).
Monti, M.C., Cohen, S.X., Fish, A., Winterwerp, H.H., Barendregt, A., Friedhoff, P., Perrakis, A., Heck, A.J.R., Sixma, T.K., van den Heuvel, R.H.H. & Lebbink, J.H. (2011). Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS. Nucleic Acids Research, 39 (18), (pp. 8052-8064) (13 p.).
Karagoz, Elif, dos santos Duarte, Afonso, Ippel, Hans, Uetrecht, Charlotte, Sinnige, Tessa, Van Rosmalen, Martijn, Hausmann, J., Heck, Albert J. R., Boelens, Rolf & Rüdiger, Stefan G. D. (11.01.2011). N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proceedings of the National Academy of Sciences of the United States of America, 108 (2), (pp. 580-585) (6 p.).
Karagöz, G.E., dos santos Duarte, A.M., Ippel, J.H., Uetrecht, C., Sinnige, T., van Rosmalen, M., Hausmann, J., Heck, A.J.R., Boelens, R. & Rüdiger, S.G.D. (2011). N-terminal domain of human Hsp90 triggers binding to the co-chaperone p23. Proceedings of the National Academy of Sciences of the United States of America, 108 (2), (pp. 580-585) (6 p.).
van Dooren, S.H., Raijmakers, R., Pluk, H., Lokate, A.M.C., Koemans, T.S., Spanjers, R.E., Heck, A.J.R., Boelens, W.C., van Venrooij, W.J. & Pruijn, G.J.M. (2011). Oxidative stress-induced modifications of histidyl-tRNA synthetase affect its tRNA aminoacylation activity but not its immunoreactivity. Biochemistry and Cell Biology, 89 (6), (pp. 545-553) (9 p.).
Baclayon, M, Shoemaker, G.K., Uetrecht, C., Crawford, S.E., Estes, M.K., Prasad, B.V.V., Heck, A.J.R., Wuite, G.J.L. & Roos, W.H. (2011). Prestress strengthens the shell of norwalk virus nanoparticles. Nano Letters, 9 (11), (pp. 4865-4869) (5 p.).
Wijte, D., van Baar, B.L.M., Heck, A.J.R. & Altelaar, A.F.M. (2011). Probing the proteome response to toluene exposure in the solvent tolerant pseudomonas putida S12. Journal of Proteome Research, 10 (2), (pp. 394-403) (10 p.).
de Vos, D, Frederiks, F., Terweij, M., Welsem, T., Verzijlbergen, K.F., Iachina, E., de Graaf, E.L., Altelaar, A.F.M., Oudgenoeg, G., Heck, A.J.R., Krijgsveld, J., Bakker, B.M. & van Leeuwen, F. (2011). Progressive methylation of ageing histones by Dot1 functions as a timer. EMBO Reports, 12 (9), (pp. 956-962) (7 p.).
Bleijerveld, O.B., Brakenhoff, R.H., Schaaij-Visser, B.M., Damen, J.M.A., Altelaar, A.F.M., Heck, A.J.R., Leemans, C.R. & Slijper, M. (2011). Protein signatures associated with tumor cell dissemination in head and neck cancer. Journal of Proteomics, 74 (4), (pp. 558-566) (9 p.).
Rose, R.J., Labrijn, A.F., van den Bremer, E.T.J., Loverix, S., Lasters, I., van Berkel, P.H.C., van de Winkel, J.G.J., Schuurman, J., Parren, P.W.H.I. & Heck, A.J.R. (2011). Quantitative analysis of the interaction strength and dynamics of human IgG4 half molecules by native mass spectrometry. Structure with Folding & design, 19 (9), (pp. 1274-1282) (9 p.).
Vogels, M.W., van Balkom, B.W.M., Heck, A.J.R., de Haan, C.A.M., Rottier, P.J.M., Batenburg, J.J., Kaloyanova, D.V. & Helms, J.B. (2011). Quantitative proteomic identification of host factors involved in the Salmonella syphimuruim infectin cycle. Proteomics, 11, (pp. 4477-4491) (14 p.).
Wiedenheft, B., van Duijn, E., Bultema, J.B., Waghmare, S.P., Zhou, K., Barendregt, A., Westphal, W., Heck, A.J.R., Boekema, E.J., Dickman, M.J. & Doudna, J.A. (2011). RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proceedings of the National Academy of Sciences of the United States of America, 108 (25), (pp. 10092-10097) (6 p.).
van den Toorn, H.W.P., Munoz, J, Mohammed, S., Raijmakers, R., Heck, A.J.R. & van Breukelen, B. (2011). RockerBox: analysis and filtering of massive proteomics search results. Journal of Proteome Research, 10 (3), (pp. 1420-1424) (5 p.).
Snijder, J., Rose, R.J., Raijmakers, R. & Heck, A.J.R. (2011). Site-specific methionine oxidation in calmodulin affects structural integrity and interaction with Ca2+/calmodulin-dependent protein kinase II. Journal of Structural Biology, 174 (1), (pp. 187-195) (9 p.).
Labrijn, A.F., Rispens, T., Meesters, J., Rose, R.J., den Bleker, T.H., Loverix, S., van den Bremer, E.T.J., Neijssen, J., Vink, T., Lasters, I., Aalberse, R.C., Heck, A.J.R., van de Winkel, J.G.J., Schuurman, J. & Parren, P.W.H.I. (2011). Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength. Journal of Immunology, 187 (6), (pp. 3238-3246) (9 p.).
Mohammed, S. & Heck, A.J.R. (2011). Strong cation exchange (SCX) based analytical mehtods for the targeted analysis of protein post-translational modifications. Current Opinion in Biotechnology, 22, (pp. 9-16) (8 p.).
Jore, M.M., Lundgren, M., van Duijn, E., Bultema, J.B., Waghmare, S.P., Wiedenheft, B., Pul, U., Wurm, R., Wagner, R., Beijer, M.R., Barendregt, A., Zhou, K., Snijders, A.P.L., Dickman, M.J., Doudna, J.A., Boekema, E.J., Heck, A.J.R., van der Oost, J. & Brouns, S.J.J. (2011). Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature Structural and Molecular Biology, 18 (5), (pp. 529-536) (8 p.).
Garcia-Alles, L.F., Collmann, A., Versluis, C., Lindner, B., Guiard, J., Maveyraud, L., Huc, E., Im, J.S., Sansano, S., Brando, T., Julien, S., Prandi, J., Gilleron, M., Porcelli, S.A., de la Salle, H., Heck, A.J.R., Mori, L., Puzo, G., Mourey, L. & de Libero, G. (2011). Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids. Proceedings of the National Academy of Sciences of the United States of America, 108 (43), (pp. 17755-17760) (6 p.).
Mischerikow, N. & Heck, A.J.R. (2011). Targeted large-scale analysis of protein acetylation. Proteomics, 11 (4), (pp. 571-589) (19 p.).
Helbig, A.O., Daran-Lapujade, P., van Maris, A.J., de Hulster, E.A., de Ridder, D., Pronk, J.T., Heck, A.J.R. & Slijper, M. (2011). The diversity of protein turnover and abundance under nitrogen-limited steady-state conditions in Saccharomyces cerevisiae. Molecular BioSystems, 7 (12), (pp. 3313-3326) (14 p.).
Ding, V.M., Boersema, P.J., Foong, L.Y., Preisinger, C., Koh, G., Natarajan, S., Lee, D.Y., Boekhorst, J., Snel, B., Lemeer, S.M., Heck, A.J.R. & Choo, A. (2011). Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS One, 6 (3), (pp. 17538) (1 p.).
Di Palma, S., Boersema, P.J., Heck, A.J.R. & Mohammed, S. (2011). Zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC and ZIC-cHILIC) provide high resolution separation and increase sensitivity in proteome analysis. Analytical Chemistry, 83 (9), (pp. 3440-3447) (8 p.).
  2011 - Professional publications
Pinkse, M.W.H., Lemeer, S.M. & Heck, A.J.R. (2011). A protocol on the use of titanium dioxide chromatography for phosphoproteomics. Gel free proteomics; Methods in Molecular Biology (pp. 215-228) (14 p.). Springer.
Ms. Taouatas, N., Mohammed, S. & Heck, A.J.R. (2011). Exploring new proteome space: combining Lys-N proteolytic digestion and strong cation exchange (SCX) separation in peptide-centric MS-driven proteomics. Gel free proteomics: Methods in Molecular Biology (pp. 157-167) (11 p.). Springer.
Munoz, J & Heck, A.J.R. (2011). Quantitative proteome and phosphoproteome analysis of human pluripotent stem cells. Human pluripotent stem cells; methods in molecular biology (pp. 297-312) (16 p.). Springer.
  2010 - Scholarly publications
Fu, C-Y, Uetrecht, C., Kang, S., Morais, M.C., Heck, A.J.R., Walter, M.R. & Prevelige, P.E. (2010). A docking model based on mass spectrometric and biochemical data describes phage packaging motor incorporation. Molecular and Cellular Proteomics, 9, (pp. 1764-1773) (10 p.).
Brettschneider, C., Rose, R.J., Hertel, S., Axmann, I.M., Heck, A.J.R. & Kollmann, M. (2010). A sequestration feedback determines dynamics and temperature entrainment of the KaiABC circadian clock. Molecular Systems Biology, 6.
Raijmakers, R., Neerincx, P.B.T., Mohammed, S. & Heck, A.J.R. (2010). Cleavage specificities of the brother and sister proteases Lys-C and Lys-N. Chemical Communications, 46, (pp. 8827-8829) (3 p.).
Mischerikow, N., Altelaar, A.F.M., Navarro Herrero, J.D., Mohammed, S. & Heck, A.J.R. (2010). Comparative assessment of site assignments in CID and electron transfer dissociation spectra of phosphopeptides discloses limited relocation of phosphate groups. Molecular and Cellular Proteomics, 9, (pp. 2140-2148) (9 p.).
Girardi, E., Wang, J., Mac, T.T., Versluis, C., Bhowruth, V., Besra, G., Heck, A.J.R., van Rhijn, I. & Zajonc, D.M. (2010). Crystal structure of bovine CD1b3 with endogenously bound ligands. Journal of Immunology, 185, (pp. 376-386) (11 p.).
Hennrich, M.L., Mohammed, S., Altelaar, A.F.M. & Heck, A.J.R. (2010). Dimethyl isotope labeling assisted de novo peptide sequencing. Journal of the American Society for Mass Spectrometry, 12, (pp. 1957-1965) (9 p.).
Staals, R.H.J, Bronkhorst, A.W., Schilders, G., Slomovic, S., Schuster, G., Heck, A.J.R., Raijmakers, R. & Pruijn, G.J.M. (2010). Dis3-like 1: a novel exoribonuclease associated with the human exosome. EMBO Journal, 29 (14), (pp. 2358-2367) (10 p.).
Schaaij-Visser, B.M., Bremmer, J.F., Braakhuis, B.J.M., Heck, A.J.R., Slijper, M., van der Waal, I. & Brakenhoff, R.H. (2010). Evaluation of cornulin, keratin 4, keratin 13 expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. Oral Oncology, 46, (pp. 123-127) (5 p.).
Ms. Taouatas, N., Heck, A.J.R. & Mohammed, S. (2010). Evaluation of metalloendopeptidase Lys-N protease performance under different sample handling conditions. Journal of Proteome Research, 9, (pp. 4282-4288) (7 p.).
Raijmakers, R., Kraiczek, K., de Jong, A.P., Mohammed, S. & Heck, A.J.R. (2010). Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Analytical Chemistry, 82 (3), (pp. 824-832) (9 p.).
Helbig, A.O., Heck, A.J.R. & Slijper, M. (2010). Exploring the membrane proteome--challenges and analytical strategies. Journal of Proteomics, 73, (pp. 868-878) (11 p.).
Mischerikow, N., van Nierop, P., Li, K.W., Bernstein, H.G., Smit, A.B., Heck, A.J.R. & Altelaar, A.F.M. (2010). Gaining efficiency by parallel quantification and identification of iTRAQ-labeled peptides using HCD and decision tree guided CID/ETD on an LTQ Orbitrap Orbitrap. The Analyst, 135, (pp. 2643-2652) (10 p.).
Frederiks, F., Welsem, T., Oudgenoeg, G., Heck, A.J.R., Janzen, C.J. & van Leeuwen, F. (2010). Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferase of Trypanosoma brucei. Journal of Cell Science, 123, (pp. 4019-4023) (5 p.).
Oberprieler, N.G., Lemeer, S.M., kalland, M.E., Torgersen, K.M., Heck, A.J.R. & Tasken, K. (2010). High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells. Blood, 116 (13), (pp. 2253-2265) (13 p.).
van Hoof, D., Dormeyer, W., Braam, S.R., Passier, R., Monshouwer-Kloots, J., Heck, A.J.R., Krijgsveld, J. & Mummery, C.L. (2010). Identification of Cell Surface Proteins for Antibody-Based Selection of Human Embryonic Stem Cell-Derived Cardiomyocytes. Journal of Proteome Research, 9 (3), (pp. 1610-1618) (9 p.). J AR.
Spedale, G., Mischerikow, N., Heck, A.J.R., Timmers, H.T.M. & Pijnappel, W.W.M. (2010). Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex. Journal of Biological Chemistry, 285 (30), (pp. 22793-22799) (7 p.).
Uetrecht, C., Rose, R.J., van Duijn, E., Lorenzen, K. & Heck, A.J.R. (2010). Ion mobility mass spectrometry of proteins and protein assemblies. Chemical Society Reviews, 39, (pp. 1633-1655) (23 p.).
van Breukelen, B., Georgiou, A., Drugan, M.M., Ms. Taouatas, N., Mohammed, S. & Heck, A.J.R. (2010). LysNDeNovo: an algorithm enabling de novo sequencing of Lys-N generated peptides fragmented by electron transfer dissociation. Rapid Communications in Mass Spectrometry, 10, (pp. 1196-1201) (6 p.).
Ng, S.S., Boersema, P.J., Mohammed, S., Heck, A.J.R. & Clevers, H.C. (2010). MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biological Chemistry, 391 (2-3), (pp. 171-180) (10 p.).
van Beers, J.B.C., Raijmakers, R., Alexander, L-E, Stammen-Vogelzangs, J., Lokate, A.M.C., Heck, A.J.R., Schasfoort, R.B.M. & Pruijn, G.J.M. (2010). Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance. Arthritis Research and Therapy, 12 (6).
Kukrer, B., Filipe, V., van Duijn, E., Kasper, P.T., Vreeken, R.J., Heck, A.J.R. & Jiskoot, W. (2010). Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography. Pharmaceutical Research, 27, (pp. 2197-2204) (8 p.).
Buschow, S.I., van Balkom, B.W.M., Aalberts, M., Heck, A.J.R., Wauben, M.H.M. & Stoorvogel, W. (2010). MHC class II-associated proteins in B-cells exosomes and potential functional implications for exosome biogenesis. Immunology and Cell Biology, 88 (8), (pp. 851-856) (6 p.).
Mortensen, P., Gouw, J.W., Olsen, J.V., Ong, S-E, Rigbolt, K.T.G., Bunkenborg, J., Cox, J., Foster, L.J., Heck, A.J.R., Blagoev, B., Andersen, J.S. & Mann, M. (2010). MSQuant, an open source platform for mass spectrometry-based quantitative proteomics. Journal of Proteome Research, 9, (pp. 393-403) (11 p.).
Hoogenraad, C.C., Popa, I.L., Futai, K., Martinez Sanchez, E., Wulf, P.S., van Vlijmen, T., Dortland, B., Oorschot, V.M.J., Govers, R., Monti, M., Heck, A.J.R., Sheng, M., Klumperman, J., Rehmann, H., Jaarsma, D., Kapitein, L.C. & van der Sluijs, P. (2010). Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biology, 8 (1), (pp. e1000283) (1 p.).
Shoemaker, G.K., van Duijn, E., Crawford, S.E., Uetrecht, C., Baclayon, M, Roos, W.H., Wuite, G.J.L., Estes, M.K., Prasad, B.V.V. & Heck, A.J.R. (2010). Norwalk virus assembly and stability monitored by mass spectrometry. Molecular and Cellular Proteomics, 9, (pp. 1742-1751) (10 p.).
Barbu, I.M., Smith, D.F., van Breukelen, B., van der Burgt, Y.E.M., Duursma, M.C., Heck, A.J.R., Heeren, R.M.A. & Krijgsveld, J. (2010). On-the-fly targeted selection of labeled peptides in liquid chromatography/mass spectrometry based quantitative proteomics. Rapid Communications in Mass Spectrometry, 24, (pp. 239-241) (3 p.).
Alpert, A.J., Petritis, K., Kangas, L., Smith, R.D., Mechtler, K., Mitulovic, G., Mohammed, S. & Heck, A.J.R. (2010). Peptide orientation affects selectivity in ion-exchange chromatography. Analytical Chemistry, 82 (12), (pp. 5253-5259) (7 p.).
Helbig, A.O., Rosati, S, Pijnappel, W.W.M., van Breukelen, B., Timmers, H.T.M., Mohammed, S., Slijper, M. & Heck, A.J.R. (2010). Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels. BMC Genomics, 11, (pp. 685) (15 p.).
Lau, N.C., Mulder, K.W., Brenkman, A.B., Mohammed, S., van den Broek, N.J.F., Heck, A.J.R. & Timmers, H.T.M. (2010). Phosphorylation of Not4p Functions Parallel to BUR2 to Regulate Resistance to Cellular Stresses in Saccharomyces cerevisiae. PLoS One, 5 (4), (pp. e9864) (1 p.).
Koschubs, T., Lorenzen, K., Baumli, S., Sandstrom, S., Heck, A.J.R. & Cramer, P. (2010). Preparation and topology of the Mediator middle module. Nucleic Acids Research, 38 (10), (pp. 3186-3195) (10 p.).
Helbig, A.O., Gauci, S., Raijmakers, R., van Breukelen, B., Slijper, M., Mohammed, S. & Heck, A.J.R. (2010). Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome. Molecular and Cellular Proteomics, 9, (pp. 928-939) (12 p.).
Schaaij-Visser, B.M., Brakenhoff, R.H., Leemans, C.R., Heck, A.J.R. & Slijper, M. (2010). Protein biomarker discovery for head and neck cancer. Journal of Proteomics, 73, (pp. 1790-1803) (14 p.).
Aye, T.T., Scholten, A., Ms. Taouatas, N., Varro, A., van Veen, T.A.B., Vos, M.A. & Heck, A.J.R. (2010). Proteome-wide protein concentrations in the human heart. Molecular BioSystems, 6 (10), (pp. 1917-1927) (11 p.).
Pelletier, S., Schuurman, K.G., Berkers, C.R., Ovaa, H., Heck, A.J.R. & Raijmakers, R. (2010). Quantifying cross-tissue diversity in proteasome complexes by mass spectrometry. Molecular BioSystems, 6, (pp. 1450-1453) (4 p.).
van Gestel, R.A., van Solinge, W.W., van den Toorn, H.W.P., Rijksen, G., Heck, A.J.R., van Wijk, R. & Slijper, M. (2010). Quantitative erythrocyte membrane proteome analysis with Blue-native/SDS PAGE. Journal of Proteomics, 73, (pp. 456-465) (10 p.).
Gouw, J.W., Krijgsveld, J. & Heck, A.J.R. (2010). Quantitative proteomics by metabolic labeling of model organisms. Molecular and Cellular Proteomics, 9, (pp. 11-24) (14 p.).
Alvarez Fernandez, M., Halim, V.A.H., Krenning, L., Aprelia, M., Mohammed, S., Heck, A.J.R. & Medema, R.H. (2010). Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. EMBO Reports, 11, (pp. 452-458) (7 p.).
Christis, C., Fullaondo, A., Schildknegt, D., Mkrtchian, S., Heck, A.J.R. & Braakman, L.J. (2010). Regulated increase in folding capacity prevents unfolded protein stress in the ER. Journal of Cell Science, 123 (5), (pp. 787-794) (8 p.). Cited By (since 1996): 1.
Geiger, S.R., Lorenzen, K., Schreieck, A., Hanecker, P., Kostrewa, D., Heck, A.J.R. & Cramer, P. (2010). RNA polymerase I contains a TFIIF related DNA binding subcomplex. Molecular Cell, 39, (pp. 583-594) (12 p.).
Hah, N., Kolkman, A., Ruhl, D.D., Pijnappel, W.W.M., Heck, A.J.R., Timmers, H.T.M. & Kraus, W.L. (2010). Role for BAF57 in cell cycle-dependent transcriptional regulation by the SWI/SNF chromatin remodeling complex. Cancer Research, 70, (pp. 4402-4411) (10 p.).
Kovanich, D., van der Heyden, M.A.G., Aye, T.T., van Veen, A.A.B., Heck, A.J.R. & Scholten, A. (2010). Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. ChemBioChem, 11 (7), (pp. 963-971) (9 p.).
Roos, W.H., Gibbons, M.M., Arkhipov, A., Uetrecht, C., Watts, N.R., Wingfield, P.T., Steven, A.C., Heck, A.J.R., Schulten, K., Klug, W.S. & Wuite, G.J.L. (2010). Squeezing protein shells: how continuum elastic models, molecular dynamics simulations, and experiments coalesce at the nanoscale. Biophysical Journal, 99, (pp. 1175-1181) (7 p.).
Wu, H., Sun, L, Blombach, F., Brouns, S.J.J., Snijders, A.P.L., Lorenzen, K., van den Heuvel, R.H.H., Heck, A.J.R., Fu, S., Li, X., Zhang, X.C. & van der Oost, J. (2010). Structure of the ribosome associating GTPase HflX. Proteins: Structure, Function and Genetics, 15 (78), (pp. 705-713) (9 p.).
Uetrecht, C., Watts, N.R., Stahl, S.J., Wingfield, P.T., Steven, A.C. & Heck, A.J.R. (2010). Subunit exchange rates in Hepatitis B virus capsids are geometry- and temperature-dependent. Physical Chemistry Chemical Physics, 12, (pp. 13368-13371) (4 p.).
Raijmakers, R., Pelletier, S., Gouw, J.W., Rumpel, K., Heck, A.J.R. & Dadvar, P. (2010). Target profiling of a small library of phosphodiesterase 5 (PDE5) inhibitors using chemical proteomics. ChemMedChem, 5, (pp. 1927-1936) (10 p.).
Wit, N.C.J., Heck, A.J.R. & Thornton, S. (2010). The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome. Reproductive Sciences, 17, (pp. 40-46) (7 p.).
Kim, S., Mischerikow, N., Bandeira, N., Navarro Herrero, J.D., Wich, L., Mohammed, S., Heck, A.J.R. & Pevzner, P.A. (2010). The generating function of CID, ETD, and CID/ETD pairs of tandem Mass Spectra: applications to Database search. Molecular and Cellular Proteomics, 9, (pp. 2840-2852) (13 p.).
van Gestel, R.A., Rijken, P.J., Surinova, S., O'Flaherty, M., Heck, A.J.R., Killian, J.A., de Kroon, A.I.P.M. & Slijper, M. (2010). The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; An unexpected effect of cardiolipin in α-ketoglutarate dehydrogenase and prohibitin complexes. Journal of Proteomics, 73 (4), (pp. 806-814) (9 p.). Cited By (since 1996): 1 Eighth International Conference on Teaching Statistics.
Mahmoudi, T., Ms. Taouatas, N., Mohammed, S., Heck, A.J.R. & Clevers, H.C. (2010). The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4//β-Catenin Coactivators essential for intestinal homeostasis. PLoS Biology, 8 (11), (pp. e1000539) (1 p.).
Tops, B.B.J., Gauci, S., Heck, A.J.R. & Krijgsveld, J. (2010). Worms from venus and mars: proteomics profiling of sexual differences in Caenorhabditis elegans using in vivo 15N isotope labeling. Journal of Proteome Research, 9, (pp. 341-351) (11 p.).
  2010 - Professional publications
Heck, A.J.R. (2010). At the interface of interaction proteomics and structural biology. Molecular and Cellular Proteomics, 9, (pp. 1633-1633) (1 p.).
  2009 - Scholarly publications
Dadvar, P., O'Flaherty, M.C., Scholten, A., Rumpel, K. & Heck, A.J.R. (2009). A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124. Molecular BioSystems (5), (pp. 472-482) (11 p.).
Diago-Navarro, E., Kamphuis, M.B., Boelens, R., Barendregt, A., Heck, A.J.R., van den Heuvel, R.H.H. & Diaz-Orejas, R. (2009). A mutagenic analysis of the RNase mechanism of the bacterial Kid toxin by mass spectrometry. The FEBS journal (276), (pp. 4973-4986) (14 p.).
Helbig, A.O., de Groot, M.J.L., van Gestel, R.A., Mohammed, S., Hulster, E.A.F., van Luttik, M.A.H., Daran-Lapujade, P., Pronk, J.T., Heck, A.J.R. & Slijper, M. (2009). A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics (9), (pp. 4787-4798) (12 p.).
Sneekes, E.J., Han, J., Elliot, M., Ausio, J., Swart, R., Heck, A.J.R. & Borchers, C. (2009). Accurate molecular weight analysis of histones using FFE and RP-HPLC on monolithic capillary columns. Journal of Separation Science (32), (pp. 2691-2698) (8 p.).
de Vries, E., Bakker, N., Krijgsveld, J., Knox, D.P., Heck, A.J.R. & Yatsuda, A.P. (2009). An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs. Veterinary Research, 40, (pp. 41) (11 p.).
Raijmakers, R., Heck, A.J.R. & Mohammed, S. (2009). Assessing biological variation and protein processing in primary human leukocytes by automated multiplex stable isotope labeling coupled to 2 dimensional peptide separation. Molecular BioSystems (5), (pp. 992-1003) (12 p.).
van Duijn, E., Barendregt, A., Synowsky, S.A., Versluis, C. & Heck, A.J.R. (2009). Chaperonin complexes monitored by ion mobility mass spectrometry. Journal of the American Chemical Society (131), (pp. 1452-1459) (8 p.).
Synowsky, S.A., van Wijk, M., Raijmakers, R. & Heck, A.J.R. (2009). Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes. Journal of Molecular Biology (385), (pp. 1300-1313) (14 p.).
Schaaij-Visser, B.M., Brakenhoff, R.H., Jansen, J.W.A., O'Flaherty, M.C., Smeets, S.J., Heck, A.J.R. & Slijper, M. (2009). Comparative proteome analysis to explore p53 pathway disruption in head and neck carcinogenesis. Journal of Proteomics (72), (pp. 803-814) (12 p.).
Schaaij-Visser, B.M., Graveland, A.P., Gauci, S., Braakhuis, B.J.M., Buijze, M., Heck, A.J.R., Kuik, D.J., Bloemena, E., Leemans, C.R., Slijper, M. & Brakenhoff, R.H. (2009). Differential Proteomics Identifies Protein Biomarkers that predict local relapse of head and neck squamous cell carcinomas. Clinical Cancer Research (15), (pp. 7666-7675) (10 p.).
Hennrich, M.L., Boersema, P.J., van den Toorn, H.W.P., Mischerikow, N., Heck, A.J.R. & Mohammed, S. (2009). Effect of chemical modifications on peptide fragmentation behavior upon electron transfer induced dissociation. Analytical Chemistry, 81 (18), (pp. 7814-7822) (9 p.).
van Anken, E., Pena, F., Hafkemeijer, N., Christis, C., Romijn, E.P., Grauschopf, U., Oorschot, V.M.J., Pertel, T., Engels, S., Ora, A., Lastun, V., Glockshuber, R., Klumperman, J., Heck, A.J.R., Luban, J. & Braakman, I. (2009). Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1. Proceedings of the National Academy of Sciences of the United States of America, 106 (40), (pp. 17019-17024) (6 p.).
Leferink, N.G.H., van Duijn, E., Barendregt, A., Heck, A.J.R. & van Berkel, W.J.H. (2009). Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C. Plant Physiology (150), (pp. 596-605) (10 p.).
Lau, N.C., Kolkman, A., van Schaik, F.M.A., Mulder, K.W., Pijnappel, W.W.M., Heck, A.J.R. & Timmers, H.T.M. (2009). Human Ccr4-Not complexes contain variable deadenylase subunits. Biochemical Journal, 422, (pp. 443-453) (11 p.).
Altelaar, A.F.M., Mohammed, S., Brans, M.A., Adan, R.A.H. & Heck, A.J.R. (2009). Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis. Journal of Proteome Research, 8 (2), (pp. 870-876) (7 p.).
Gouw, J.W., Pinkse, M.W.H., Vos, H.R., Moshkin, Y.M., Verrijzer, C.P., Heck, A.J.R. & Krijgsveld, J. (2009). In vivo stable isotope labeling of fruit flies reveals post-transcriptional regulation in the maternal-to-zygotic transition. Molecular and Cellular Proteomics, 8 (7), (pp. 1566-1578) (13 p.).
Mischerikow, N., Spedale, G., Altelaar, A.F.M., Timmers, H.T.M., Pijnappel, W.W.M. & Heck, A.J.R. (2009). In-depth profiling of post-translational modifications on the related transcription factor complexes TFIID and SAGA. Journal of Proteome Research, 8 (11), (pp. 5020-5030) (11 p.).
Gauci, S., Helbig, A.O., Slijper, M., Krijgsveld, J., Heck, A.J.R. & Mohammed, S. (2009). Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Analytical Chemistry (81), (pp. 4493-4501) (9 p.).
Pinkse, M.W.H., Rijkers, D.T.S., Dostmann, W.R.G. & Heck, A.J.R. (2009). Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. Journal of Biological Chemistry (284), (pp. 16354-16368) (15 p.).
Boersema, P.J., Raijmakers, R., Lemeer, S.M., Mohammed, S. & Heck, A.J.R. (2009). Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nature Protocols (4), (pp. 484-494) (11 p.).
Gauci, S., Veenhoff, L.M., Heck, A.J.R. & Krijgsveld, J. (2009). Orthogonal separation techniques for the characterization of the yeast nuclear proteome. Journal of Proteome Research (8), (pp. 3451-3463) (13 p.).
Munoz-Peralta, J. & Heck, A.J.R. (2009). Perspectives in stem cell proteomics. Genome Medicine, 1, (pp. 45-45) (1 p.).
Dadvar, P., Kovanich, D., Folkers, G.E., Rumpel, K., Raijmakers, R. & Heck, A.J.R. (2009). Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors. ChemBioChem (10), (pp. 2654-2662) (9 p.).
Boersema, P.J., Mohammed, S. & Heck, A.J.R. (2009). Phosphopeptide fragmentation and analysis by mass spectrometry. Journal of Mass Spectrometry (44), (pp. 861-878) (18 p.).
van Hoof, D., Munoz-Peralta, J., Braam, S.R., Pinkse, M.W.H., Linding, R., Heck, A.J.R., Mummery, C.L. & Krijgsveld, J. (2009). Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell, 5 (2), (pp. 214-226) (13 p.).
Rodriguez, H., Snyder, M., Uhlen, M., Andrews, P., Beavis, R., Borchers, C., Chalkley, R.J., Cho, S.Y., Cottingham, K., Dunn, M., Dylag, T., Edgar, R., Hare, P., Heck, A.J.R., Hirsch, R.F., Kennedy, K., Kolar, P., Kraus, H-J, Mallick, P., Nesvizhskii, A., Ping, P., Ponten, F., Yang, L., Yates, J.R., Stein, S.E., Hermjakob, H., Kinsinger, C.R. & Apweiler, R. (2009). Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles. Journal of Proteome Research (8), (pp. 3689-3692) (4 p.).
Bantscheff, M., Scholten, A. & Heck, A.J.R. (2009). Revealing promiscuous drug-target interactions by chemical proteomics. Drug Discovery Today: Technologies (14), (pp. 1021-1029) (9 p.).
Aye, T.T., Mohammed, S., van den Toorn, H.W.P., van Veen, T.A.B., van der Heyden, M.A.G., Scholten, A. & Heck, A.J.R. (2009). Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Molecular and Cellular Proteomics, 8 (5), (pp. 1016-1028) (13 p.).
Munoz-Peralta, J. & Heck, A.J.R. (2009). Snapshots of kinase activities. Nature Biotechnology (27), (pp. 912-913) (2 p.).
van Breukelen, B., van den Toorn, H.W.P., Drugan, M.M. & Heck, A.J.R. (2009). StatQuant: a post-quantification analysis toolbox for improving quantitative mass spectrometry. BMC Bioinformatics (25), (pp. 1472-1473) (2 p.).
Boersema, P.J., Ms. Taouatas, N., Altelaar, A.F.M., Gouw, J.W., Ross, P.L., Pappin, D.J., Heck, A.J.R. & Mohammed, S. (2009). Straightforward and de novo peptide sequencing by MALDI-MS/MS using a Lys-N metalloendopeptidase. Molecular and Cellular Proteomics (8), (pp. 650-660) (11 p.).
Ms. Taouatas, N., Altelaar, A.F.M., Drugan, M.M., Helbig, A.O., Mohammed, S. & Heck, A.J.R. (2009). Strong cation exchange-based fractionation of Lys-N-generated peptides facilitates the targeted analysis of post-translational modifications. Molecular and Cellular Proteomics (8), (pp. 190-200) (11 p.).
Mahmoudi, T., Ms. Taouatas, N., Mohammed, S., Heck, A.J.R. & Clevers, J.C. (2009). The kinase TNIK is an essential activator of Wnt target genes. EMBO Journal, 28 (21), (pp. 3329-3340) (12 p.).
Lemeer, S.M. & Heck, A.J.R. (2009). The phosphoproteomics data explosion. Current Opinion in Chemical Biology (13), (pp. 414-420) (7 p.).
  2008 - Scholarly publications
Mohammed, S., Lorenzen, K., Kerkhoven, R., van Breukelen, B., Vannini, A., Cramer, P. & Heck, A.J.R. (2008). ) Multiplexed proteomics mapping of yeast RNA polymerase II and III allows near-complete sequence coverage and reveals several novel phosphorylation sites. Analytical Chemistry, 80 (10), (pp. 3584-3592) (9 p.).
Gouw, J.W., Tops, B.B.J., Mortensen, P., Heck, A.J.R. & Krijgsveld, J. (2008). ) Optimizing identification and quantitation of 15N-labeled proteins in comparative proteomics. Analytical Chemistry, 80 (20), (pp. 7796-7803) (8 p.).
Scholten, A., Aye, T.T. & Heck, A.J.R. (2008). A Multi-Angular Mass Spectrometric View at Cyclic Nucleotide Dependent Protein Kinases. Mass Spectrometry Reviews, 27, (pp. 331-353) (23 p.).
Dormeyer, W., van Hoof, D., Mummery, C.L., Krijgsveld, J. & Heck, A.J.R. (2008). A practical guide for the identification of membrane and plasma membrane proteins in human embryonic stem cells and human embryonal carcinoma cells. Proteomics, 8, (pp. 4036-4053) (18 p.).
van Vlijmen, T., Vleugel, M.M., Evers, M., Mohammed, S., Wulf, P.S., Heck, A.J.R., Hoogenraad, C.C. & van der Sluijs, P. (2008). A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. The FEBS journal, 582, (pp. 2838-2842) (5 p.).
Gauci, S., van Breukelen, B., Lemeer, S.M., Krijgsveld, J. & Heck, A.J.R. (2008). A versatile peptide pI calculator for phosphorylated and N-terminal acetylated peptides experimentally tested using peptide isoelectric focusing. Proteomics, 8 (23-24), (pp. 4898-4906) (9 p.). J EC.
Laoukili, J., Alvarez, M., Meijer, L.A.T., Stahl, M., Mohammed, S., Kleij, L., Heck, A.J.R. & Medema, R.H. (2008). Activation of FoxM1 during G2 requires CyclinA/Cdk-dependent relief of auto-repression by the FoxM1 N-terminal domain. Molecular and Cellular Biology, 28 (9), (pp. 3076-3087) (12 p.).
Hellemond, E.W., Mazon, H.F.M., Heck, A.J.R., van den Heuvel, R.H.H., Heuts, D.P.H.M., Janssen, D.B. & Fraaije, M.W. (2008). ADP competes with FAD binding in putrescine oxidase. Journal of Biological Chemistry, 283 (42), (pp. 28259-28264) (6 p.).
Raijmakers, R., Berkers, C.R., de Jong, G.J., Ovaa, H., Heck, A.J.R. & Mohammed, S. (2008). Automated online sequential isotope labeling for protein quantitation applied to proteasome tissue specific diversity. Molecular and Cellular Proteomics, 7, (pp. 1755-1762) (8 p.).
Alverdi, V., Mazon, H.F.M., Versluis, C., Hemrika, W., Esposito, G., van den Heuvel, R.H.H., Scholten, A. & Heck, A.J.R. (2008). cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain. Journal of Molecular Biology, 375, (pp. 1380-1393) (14 p.).
Mohammed, S., Kraiczek, K., Pinkse, M.W.H., Lemeer, S.M., Benschop, J.J. & Heck, A.J.R. (2008). Chip based enrichment and nanoLC MS/MS analysis of phosphopeptides from whole lysates. Journal of Proteome Research, 7, (pp. 1565-1571) (7 p.).
Lemeer, S.M., Jopling, J.C., Gouw, J.W., Mohammed, S., Heck, A.J.R. & Slijper, M. (2008). Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Molecular and Cellular Proteomics, 7, (pp. 2176-2187) (12 p.).
Boekhorst, J., van Breukelen, B., Heck, A.J.R. & Snel, B. (2008). Comparative phosphoproteomics reveals evolutionary and functional conservation of phosphorylation across eukaryotes. Genome Biology, 9, (pp. R144.1-R144.9) (9 p.).
van Werven, F.J., van Bakel, H.H.M.J., van Teeffelen, H.A.A.M., Altelaar, A.F.M., Groot Koerkamp, M.J.A., Heck, A.J.R., Holstege, F.C.P. & Timmers, H.T.M. (2008). Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes and Development, 22, (pp. 2359-2369) (11 p.).
Jin, X., Mazon, H.F.M., van den Heuvel, R.H.H., Heck, A.J.R., Janssen, D.B. & Fraaije, M.W. (2008). Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process. The FEBS journal, 275, (pp. 5191-5200) (10 p.).
Lorenzen, K., Olia, A.S., Uetrecht, C., Cingolani, G. & Heck, A.J.R. (2008). Determination of stoichiometry and conformational changes in the first step of the P22 tail assembly. Journal of Molecular Biology, 379, (pp. 385-396) (12 p.).
van Hoof, D., Braam, S.R., Dormeyer, W., Heck, A.J.R., Krijgsveld, J. & Mummery, C.L. (2008). Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile. Stem Cells, 26, (pp. 2777-2781) (5 p.).
Uetrecht, C., Versluis, C., Watts, N.R., Roos, W.H., Wuite, G.J.L., Wingfield, P.T., Steven, A.C. & Heck, A.J.R. (2008). High Resolution Mass Spectrometry of Viral Assemblies: Molecular Compositions and Stability of Dimorphic Hepatitis B Virus Capsids. Proceedings of the National Academy of Sciences of the United States of America, 105 (27), (pp. 9216-9229) (14 p.).
Ringrose, J.H., van Solinge, W.W., Mohammed, S., O'Flaherty, M.C., van Wijk, H.A., Heck, A.J.R. & Slijper, M. (2008). Highly efficient depletion strategy for the two most abundant erythrocyte soluble proteins improves proteome coverage dramatically. Journal of Proteome Research, 7, (pp. 3060-3063) (4 p.).
Pinkse, M.W.H., Mohammed, S., Gouw, J.W., van Breukelen, B., Vos, H.R. & Heck, A.J.R. (2008). Highly Robust, Automated, and Sensitive Online TiO2-Based Phosphoproteomics Applied To Study Endogenous Phosphorylation in Drosophila melanogaster. Journal of Proteome Research, 7, (pp. 687-697) (11 p.).
Boersema, P.J., Mohammed, S. & Heck, A.J.R. (2008). Hydrophilic Interaction liquid chromatography (HILIC) in proteomics. Fresenius Zeitschrift fur Analytische Chemie, 391, (pp. 151-159) (9 p.).
Moonen, M.J.H., Synowsky, S.A., van den Berg, W.A.M., Westphal, A.H., Heck, A.J.R., van den Heuvel, R.H.H., Fraaije, M.W. & van Berkel, W.J.H. (2008). Hydroquinone Dioxygenase from Pseudomonas fluorescens ACB: A Novel Member of the Family of Non-Heme Iron(II)-Dependent Dioxygenases. Journal of Bacteriology, 190 (15), (pp. 5199-5209) (11 p.).
Sneekes, E.J., Damen, J.M.A., Swart, R. & Heck, A.J.R. (2008). Isoform separation of a multi-acetylated protein using capillary polystyrene-divinylbenzene monolithic columns. Journal of Chromatography, 1194, (pp. 199-204) (6 p.).
Heck, A.J.R. (2008). Native mass spectrometry: a bridge between interactomics and structural biology. Nature Methods, 5 (11), (pp. 927-933) (7 p.).
Lemeer, S.M., Pinkse, M.W.H., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M. & Heck, A.J.R. (2008). Online automated in vivo zebrafish phosphoproteomics: From large-scale analysis down to a single embryo. Journal of Proteome Research, 7 (4), (pp. 1555-1564) (10 p.). J PR 1st International Immunonutrition Workshop.
Dormeyer, W., van Hoof, D., Braam, S.R., Heck, A.J.R., Mummery, C.L. & Krijgsveld, J. (2008). Plasma membrane proteomics of human embryonic stem cells and human embryonal carcinoma cells. Journal of Proteome Research, 7, (pp. 2936-2951) (16 p.).
Heck, A.J.R., Mummery, C.L., Whetton, A., Oh, S., Lee, B., Pera, M., Lemischka, I. & Krijgsveld, J. (2008). Proteome biology of stem cells. Molecular and Cellular Proteomics, 7 (1), (pp. 204-205) (2 p.).
Krijgsveld, J., Whetton, A.D., Lee, B., Lemischka, I., Oh, S., Mummery, C.L. & Heck, A.J.R. (2008). Proteome Biology of Stem Cells: A New Joint HUPO and ISSCR Initiative. Molecular and Cellular Proteomics, 7.1, (pp. 204-205) (2 p.).
Mousson, F., Kolkman, A., Pijnappel, W.W.M., Timmers, H.T.M. & Heck, A.J.R. (2008). Quantitative proteomics reveals regulation of dynamic components within TATA-binding protein (TBP) transcription complexes. Molecular and Cellular Proteomics, 7.5, (pp. 845-852) (8 p.).
Rojas, R., van Vlijmen, T., Mardones, G.A., Prabhu, Y., Rojas, A.L., Mohammed, S., Heck, A.J.R., Raposo, G., van der Sluijs, P. & Bonifacino, J.S. (2008). Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. Journal of Cell Biology, 183 (3), (pp. 513-526) (14 p.).
Stelzer, W., Poschner, B.C., Stalz, H., Heck, A.J.R. & Langosch, D. (2008). Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange. Biophysical Journal, 95 (3), (pp. 1326-1335) (10 p.).
Uetrecht, C., Versluis, C., Watts, N.R., Wingfield, P.T., Steven, A.C. & Heck, A.J.R. (2008). Stability and Shape of Hepatitis B Virus Capsids in vacuo. Angewandte Chemie-International Edition, 47 (33), (pp. 6247-6251) (5 p.).
Kitagawa, N., Mazon, H.F.M. & Heck, A.J.R. (2008). Stoichiometry of the peripheral stalk subunits E and G of Yeast V1-ATPase determined by mass spectrometry. Journal of Biological Chemistry, 283 (6), (pp. 3329-3337) (9 p.).
Ms. Taouatas, N., Drugan, M.M., Mohammed, S. & Heck, A.J.R. (2008). Straightforward ladder sequencing of peptides using a Lys-N metalloendopeptidase. Nature Methods, 5 (5), (pp. 405-407) (3 p.).
Zhang, Z., Zheng, Y, Mazon, H.F.M., Milgrom, E., Kitagawa, N., Kish-Trier, E., Heck, A.J.R., Kane, P.M. & Wilkens, S. (2008). Structure of the Yeast Vacuolar ATPase. Journal of Biological Chemistry, 283 (51), (pp. 35983-35995) (13 p.).
Carol-Visser, N.F.C. & Heck, A.J.R. (2008). Surface plasmon resonance – mass spectrometry in proteomics. Expert Review Proteomics, 5 (3), (pp. 425-433) (9 p.).
Whetton, A.D., Williamson, A.J.K., Krijgsveld, J., Lee, B.H., Lemischka, I., Oh, S., Pera, M., Mummery, C.L. & Heck, A.J.R. (2008). The time is right; Proteome Biology of Stem Cells. Cell Stem Cell, 2 (3), (pp. 215-217) (3 p.).
Synowsky, S.A. & Heck, A.J.R. (2008). The yeast Ski complex is a hetero-tetramer. Protein Science, 17, (pp. 119-125) (7 p.).
Geels, R.B.J., Calmat, S., Heck, A.J.R., van der Vies, S.M. & Heeren, R.M.A. (2008). Thermal activation of the co-chaperonins GroES and gp31 probed by mass spectrometry. Rapid Communications in Mass Spectrometry, 22, (pp. 3633-3641) (9 p.).
Boersema, P.J., Aye, T.T., van Veen, T.A.B., Heck, A.J.R. & Mohammed, S. (2008). Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates. Proteomics, 8, (pp. 4624-4632) (9 p.).
  2008 - Professional publications
Gavin, A-C, Aebersold, R. & Heck, A.J.R. (2008). ) Meeting Report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome Biology. Molecular and Cellular Proteomics, 7.11, (pp. 2288-2291) (4 p.).
  2007 - Scholarly publications
Brunner, E., Ahrens, C.H., Mohanty, S., Baetschmann, H., Loevenich, S., Potthast, F., Deutsch, E.W., Panse, C., de Lichtenberg, U., Rinner, O., Lee, H., Pedrioli, P.G.A., Malmstrom, J., Koehler, K., Schrimpf, S., Krijgsveld, J., Kregenow, F., Heck, A.J.R., Hafen, E., Schlapbach, R. & Aebersold, R. (2007). A high quality catalog of the Drosophila melanogaster proteome. Nature Biotechnology, 25 (5), (pp. 576-583) (8 p.).
van Hoof, D., Pinkse, M.W.H., Ward-van Oostwaard, D., Mummery, C.L., Heck, A.J.R. & Krijgsveld, J. (2007). An experimental correction for arginine-to-proline conversion artifacts in SILAC-based quantitative proteomics. Nature Methods, 4 (9), (pp. 677-678) (2 p.).
Mihalca, R., van der Burgt, Y.E.M., Heck, A.J.R. & Heeren, R.M.A. (2007). Disulfide bond cleavages observed in SORI-CIS of three nonapeptides complexed with divalent transition-metal cations. Journal of Mass Spectrometry, 42, (pp. 450-458) (9 p.).
Scholten, A., van Veen, A.A.B., Vos, M.A. & Heck, A.J.R. (2007). Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue. Journal of Proteome Research, 6 (5), (pp. 1705-1717) (13 p.).
Lemeer, S.M., Ruijtenbeek, R., Pinkse, M.W.H., Jopling, J.C., Heck, A.J.R., den Hertog, J. & Slijper, M. (2007). Endogenous phosphotyrosine signaling in zebrafish embryos. Molecular and Cellular Proteomics
Boersema, P.J., Divecha, N, Heck, A.J.R. & Mohammed, S. (2007). Evaluation and Optimization of ZIC-HILIC-RP as an alternative MudPIT Strategy. Journal of Proteome Research, 6, (pp. 937-946) (10 p.).
Kamphuis, M.B., Monti, M.C., van den Heuvel, R.H.H., Santos-Sierra, S., Folkers, G.E., Lemonnier, M., Diaz-Orejas, R., Heck, A.J.R. & Boelens, R. (2007). Interactions between the toxin kid of the bacterial parD system and the antitoxins Kis and MazE. Proteins: Structure, Function and Genetics, 67, (pp. 219-231) (13 p.).
Monti, M.C., Hernandez-Arriaga, A.M., Kamphuis, M.B., Lopez-Villarejo, J., Heck, A.J.R., Boelens, R., Diaz-Orejas, R. & van den Heuvel, R.H.H. (2007). Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promotor region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers. Nucleic Acids Research, 35 (5), (pp. 1737-1749) (13 p.).
van Duijn, E., Heck, A.J.R. & van der Vies, S.M. (2007). Inter-ring communication allows the GroEL chaperonin complex to distinguish between different substrates. Protein Science, 16, (pp. 956-965) (10 p.).
Stanley, W.A., Versluis, C., Schultz, C., Heck, A.J.R. & Wilmanns, M. (2007). Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay. Archives of Biochemistry and Biophysics, 461, (pp. 50-58) (9 p.).
Poliakov, A., van Duijn, E., Lander, G., Fu, C., Johnson, J.E., Prevelige, P.E. & Heck, A.J.R. (2007). Macromolecular mass spectrometry and electron microscopy as complementary tools for investigation of the hereogeneity of bacteriophage portal assemblies. Journal of Structural Biology, 157, (pp. 371-383) (13 p.).
Lorenzen, K., Versluis, C., van Duijn, E., van den Heuvel, R.H.H. & Heck, A.J.R. (2007). Optimizing macromolecular tandem mass spectrometry of large non covalent complexes using heavy collision gases. International Journal of Mass Spectrometry, 268, (pp. 198-206) (9 p.).
Lemeer, S.M., Jopling, J.C., Ruijtenbeek, R., Slijper, M., Heck, A.J.R. & den Hertog, J. (2007). Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. PLoS One, 7, (pp. e581) (1 p.).
Orchard, S., Heck, A.J.R., Uhlen, M. & Ping, P. (2007). Publication committee Meeting HUPO 5th Annual World congress. Proteomics, 7, (pp. 1009-1011) (3 p.).
Benschop, J.J., Mohammed, S., O'Flaherty, M.C., Heck, A.J.R., Slijper, M. & Menke, F.L.H. (2007). Quantitative phospho-proteomics of early elicitor signalling in Arabidopsis. Molecular and Cellular Proteomics, Feb 21 (E).
de Groot, M.J.L., Daran-Lapujade, P., van Breukelen, B., Knijnenburg, T.A., Hulster, E.A.F., Reinders, M.J.T., Pronk, J.T., Heck, A.J.R. & Slijper, M. (2007). Quantitative proteomics and transcriptomics of anaerobic and aerobic yeast cultures reveals post-transcriptional regulation of key cellular processes. Microbiology, 153, (pp. 3864-3878) (15 p.).
Lorenzen, K., Vannini, A., Cramer, P. & Heck, A.J.R. (2007). Structural biology of RNA polymerase III: mass spectrometry elucidates subcomplex architecture. Structure with Folding & design, 15, (pp. 1237-1245) (9 p.).
Kool, J., Reubsaet, J.L.E., Wesseldijk, F., Maravilha, R.T., Pinkse, M.W.H., D'Santos, C.S., van Hilten, J.J., Zijlstra, F.J. & Heck, A.J.R. (2007). Suction blister fluid as potential body fluid for biomarker proteins. Proteomics, 7, (pp. 3638-3650) (13 p.).
Dormeyer, W., Mohammed, S., van Breukelen, B., Krijgsveld, J. & Heck, A.J.R. (2007). Targeted Analysis of Protein Termini. Journal of Proteome Research
Daran-Lapujade, P., Rossell, S., van Gulik, W.M., van Luttik, M.A.H., de Groot, M.J.L., Slijper, M., Heck, A.J.R., Daran, J-M, de Winde, J.H., Westerhoff, H.V., Pronk, J.T. & Bakker, B.M. (2007). The fluxes through glycolytic enzymes in S. cerevisiae are predominantly regulated at posttranscriptional levels. Proceedings of the National Academy of Sciences of the United States of America, 104 (40), (pp. 15753-15758) (6 p.).
Scholten, A., Fuss, H., Heck, A.J.R. & Dostmann, W.R.G. (2007). The hinge region operates as a stability switch in cGMP-dependent protein kinase I. The FEBS journal, 274, (pp. 2274-2286) (13 p.).
Taylor, C.F., Paton, N.W., Lilley, K.S., Binz, P-A, Julian, R.K., Jones, A.R., Zhu, W., Apweiler, R., Aebersold, R., Deutsch, E.W., Dunn, M.J., Heck, A.J.R., Leitner, A., Macht, M., Mann, M., Martens, L., Neubert, T.A., Patterson, S.D., Ping, P., Seymour, S.L., Souda, P, Tsugita, A., Vandekerckhove, J., Vondriska, T.M., Whitelegge, J.P., Wilkins, M.R., Xenarios, I., Yates, J.R. & Hermjakob, H. (2007). The minimum information about a proteomics experiment (MIAPE). Nature Biotechnology, 25 (8), (pp. 887-893) (7 p.).
Mazon, H.F.M., Gabor, K., Leys, D., Heck, A.J.R. & van der Oost, J. (2007). Transcriptional activation by CprK1 is regulated by protein structural changes induced by effector binding and redox state. Journal of Biological Chemistry, 282 (15), (pp. 11281-11290) (10 p.).
  2006 - Scholarly publications
van Hoof, D., Passier, R., Ward-van Oostwaard, D., Pinkse, M.W.H., Heck, A.J.R., Hosman - Mummery, C.L. & Krijgsveld, J. (2006). A quest for human and mouse embryonic stem cell-specific proteins. Molecular and Cellular Proteomics, 5, (pp. 1261-1273) (13 p.).
Halstead, J.R., Van Rheenen, J., Snel, M.H.J., Meeuws, S., Mohammed, S., De Santos, C.S., Heck, A.J.R., Jalink, K. & Divecha, N (2006). A role for Ptdlns(4,5)P2 and PIP5Kα in regulating stress-induced apoptosis. Current Biology, 16, (pp. 1850-1856) (7 p.).
Scholten, A., Carol-Visser, N.F.C., van den Heuvel, R.H.H. & Heck, A.J.R. (2006). Analysis of protein-protein interaction surfaces usinga combination of efficient lysine acetylation and nanoLC-MALDI-MS/MS applied to the E9:Im9 bacteriotoxin-immunity protein complex. Journal of the American Society for Mass Spectrometry, 17, (pp. 983-994) (12 p.).
Scholten, A., Poh, M.K., van Veen, A.A.B., van Breukelen, B., Vos, M.A. & Heck, A.J.R. (2006). Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP. Journal of Proteome Research, 5 (6), (pp. 1435-1447) (13 p.).
Kleinnijenhuis, A.J., Mihalca, R., Heeren, R.M.A. & Heck, A.J.R. (2006). Atypical behavior in the electron capture induced dissociation of biologically relevant transition metal ion complexes of the peptide hormone oxytocin. International Journal of Mass Spectrometry, 253, (pp. 217-224) (8 p.).
Siebert, H.-C., Born, K., André, S., Frank, M., Kaltner, H., von der Lieth, C.-W., Heck, A.J.R., Jiménez-Barbero, J., Kopitz, J. & Gabius, H.-J. (2006). Carbohydrate Chain of Ganglioside GM1 as a Ligand: Identification of the Binding Strategies of Three 15 mer Peptides and Their Divergence from the Binding Modes of Growth-Regulatory Galectin-1 and Cholera Toxin. Chemistry-A European Journal, 12, (pp. 388-402) (14 p.).
Mihalca, R., van der Burgt, Y.E.M., McDonnell, L.A., Duursma, M., Cerjak, I, Heck, A.J.R. & Heeren, R.M.A. (2006). Combined infrared multiphoton dissociation and electron-capture dissociation using co-linear and overlapping beams in Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 20, (pp. 1838-1844) (7 p.).
Boumann, H.A., Gubbens, J, Koorengevel, M.C., Oh, C-S., Martin, C.E., Heck, A.J.R., Patton-Vogt, J., Henry, S.A., de Kruijff, B. & de Kroon, A.I.P.M. (2006). Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote. Molecular Biology of the Cell, 17, (pp. 1006-1017) (12 p.).
Geels, R.B.J., van der Vies, S.M., Heck, A.J.R. & Heeren, R.M.A. (2006). Electron capture dissociation as structural probe for noncovalent gas-phase protein assemblies. Analytical Chemistry, 20, (pp. 7191-7196) (6 p.).
van Hoof, D., Mummery, C.L., Heck, A.J.R. & Krijgsveld, J. (2006). Embryonic stem cell proteomics. Expert Review of Proteomics, 3 (4), (pp. 427-437) (11 p.).
van Hoof, D., Krijgsveld, J., Hosman - Mummery, C.L. & Heck, A.J.R. (2006). Embryonic Stem Cell Proteomics; seeking human and mouse embryonic stem cell-specific proteins. BioForum Europe, 10, (pp. 42-43) (2 p.).
Garcia-Alles, L.F., Versluis, C., Maveyraud, L., Vallina, A.T., Sansano, S., Bello, N.F., Gober, H-J, Guillet, V., De la Salle, H., Puzo, G., Mori, L., Heck, A.J.R., De Libero, G. & Mourey, L. (2006). Endogenous phosphatidylcholine and an long spacer ligand stabilize the lipid-binding groove of CD1b. EMBO Journal, 25, (pp. 3684-3692) (9 p.).
Pinkse, M.W.H. & Heck, A.J.R. (2006). Essential enrichment strategies in phosphoproteomics. Drug Discovery Today: Technologies, 3, (pp. 331-337) (7 p.).
Gavin, A-C & Heck, A.J.R. (2006). Expanding the frontiers in proteomics. Drug Discovery Today: Technologies, 3, (pp. 315-316) (2 p.).
Dirksen, E.H.C., Cloos, J, Braakhuis, B.J.M., Brakenhoff, R.H., Heck, A.J.R. & Slijper, M. (2006). Human Lymphoblastoid proteome analysis reveals a role for the inhibitor of acetyltransferases complex in DNA double-strand break response. Cancer Research, 3, (pp. 1473-1480) (8 p.).
Yatsuda, A.P., Bakker, N., Krijgsveld, J., Knox, D.P., Heck, A.J.R. & de Vries, E. (2006). Identification of secreted cysteine proteases from the parasitic nematode Haemonchus contortus detected by biotinylated inhibitors. Infection and Immunity, 74, (pp. 1989-1993) (5 p.).
van den Heuvel, R.H.H., van Duijn, E., Mazon, H.F.M., Synowsky, S.A., Lorenzen, K., Versluis, C., Brouns, S.J.J., Langridge, D., Van der Oost, J., Hoyes, J. & Heck, A.J.R. (2006). Improving the performance of a Quadrupole Time-of-Flight instrument for Macromolecular Mass Spectrometry. Analytical Chemistry, 78, (pp. 7473-7483) (11 p.).
Krijgsveld, J., Gauci, S., Dormeyer, W. & Heck, A.J.R. (2006). In-Gel isoelectric focusing of peptides as a tool for improved protein identification. Journal of Proteome Research, 5, (pp. 1721-1730) (10 p.).
Dirksen, E.H.C., Pinkse, M.W.H., Rijkers, D.T.S., Cloos, J, Liskamp, R.M.J., Slijper, M. & Heck, A.J.R. (2006). Investigating the dynamic nature of the interactions between nuclear proteins and histones upon DNA damage using an immobilized peptide chemical proteomics approach. Journal of Proteome Research, 5, (pp. 2380-2388) (9 p.).
van Duijn, E. & Heck, A.J.R. (2006). Mass spectrometric analysis of intact macromolecular chaperone complexes. Drug Discovery Today: Technologies, 3, (pp. 21-27) (7 p.).
Jones, D.R., Bultsma, Y., Keune, W-J., Halstead, J.R., Elouarrat, D., Mohammed, S., Heck, A.J.R., De Santos, C.S. & Divecha, N (2006). Nuclear Ptdlns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Molecular Cell, 23, (pp. 685-695) (11 p.).
Synowsky, S.A., van den Heuvel, R.H.H., Mohammed, S., Pijnappel, P.W. & Heck, A.J.R. (2006). Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex. Molecular and Cellular Proteomics, 5, (pp. 1581-1592) (12 p.).
Eman, M.R., Regan-Klapisz, E.E., Pinkse, M.W.H., Koop, I.M., Haverkamp, J., Heck, A.J.R., Verkleij, A.J. & Post, J.A. (2006). Protein expression dynamics during replicative senescence of endothelial cells studied by 2-D difference in-gel electrophoresis. Electrophoresis, 27, (pp. 1669-1682) (14 p.).
Kolkman, A., Daran-Lapujade, P., Fullaondo, A., Olsthoorn, M.M.A., Pronk, J.T., Slijper, M. & Heck, A.J.R. (2006). Proteome analysis of yeast response to various nutrient limitations. Molecular Systems Biology
Wijte, D., de Jong, A.L., Mol, M.A.E., Van Baar, B.L.M. & Heck, A.J.R. (2006). ProteomeIQ Blue, a potent post-stain for the visualization and subsequent Mass Spectrometry based identification of fluorescent stained proteins on 2D-gels. Journal of Proteome Research, 5, (pp. 2033-2038) (6 p.).
van Breukelen, B., Barendregt, A., Heck, A.J.R. & van den Heuvel, R.H.H. (2006). Resolving stoichiometries and oligomeric states of glutamate synthase protein complexes with curve fitting and simulation of electrospray mass spectra. Rapid Communications in Mass Spectrometry, 20, (pp. 2490-2496) (7 p.).
Poot, A.J., Ruijter, E., Nuijens, T., Dirksen, E.H.C., Heck, A.J.R., Slijper, M., Rijkers, D.T.S. & Liskamp, R.M.J. (2006). Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides. Proteomics, 6, (pp. 6394-6399) (6 p.).
Meiring, H.D., Soethout, E.C., Poelen, M.C.M., Mooibroek, D., Hoogerbrugge, R., Timmermans, H., Boog, C.J., Heck, A.J.R., de Jong, A.P.J.M. & van Els, C.A.C.M. (2006). Stable Isotope Tagging of Epitopes. Molecular and Cellular Proteomics, 5, (pp. 902-913) (12 p.).
van Duijn, E., Simmons, D.A., van den Heuvel, R.H.H., Bakkes, P.J., van Heerikhuizen, H., Heeren, R.M.A., Robinson, C.V., van der Vies, S.M. & Heck, A.J.R. (2006). Tandem Mass Spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans Ring. Journal of the American Chemical Society, 128, (pp. 4694-4702) (9 p.).
  2005 - Scholarly publications
Kranenburg, O., Gent, Y.Y.J., Romijn, E.P., Voest, E.E., Heck, A.J.R. & Gebbink, M.F.B.G. (2005). Amyloid-beta-stimulated plasminogen activation by tissue-type plasminogen activator results in processing of neuroendocrine factors. Neuroscience, 131, (pp. 877-886) (10 p.).
Catalina Caballero, M.I., Fischer, M.J.E., Dekker, F.J., Liskamp, R.M.J. & Heck, A.J.R. (2005). Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study. Journal of the American Society for Mass Spectrometry, 16, (pp. 1039-1051) (13 p.).
van den Heuvel, R.H.H., Tahallah, N., Kamerbeek, N.M., Fraaije, M.W., van Berkel, W.J.H., Janssen, D.B. & Heck, A.J.R. (2005). Coenzyme Binding during Catalysis Is Beneficial for the Stability of 4-Hydroxyacetophenone Monooxygenase. Journal of Biological Chemistry, 280 (37), (pp. 32115-32121) (6 p.).
Kolkman, A., Olsthoorn, M.M.A., Heeremans, C.E.M., Heck, A.J.R. & Slijper, M. (2005). Comparative Proteome Analysis of Saccharomyces cerevisiae grown in chemostat cultures limited for glucose or ethanol. Molecular and Cellular Proteomics, 4, (pp. 1-11) (11 p.).
Catalina Caballero, M.I., van den Heuvel, R.H.H., van Duijn, E. & Heck, A.J.R. (2005). Decharging of Globular Proteins and Protein Complexes in Electrospray. Chemistry-A European Journal, 11, (pp. 960-968) (9 p.).
Andre, S., Kaltner, H., Lensch, M., Russwurm, R., Siebert, H.-C., Fallsehr, C., Tajkhorshid, E., Heck, A.J.R., Von Knebel Doeberitz, M., Gabius, H.-J. & Kopitz, J. (2005). Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM in silico and in vitro on human neuroblastoma cells. International Journal of Cancer, 114, (pp. 46-57) (12 p.).
Kolkman, A., Slijper, M. & Heck, A.J.R. (2005). Development and application of proteomics technologies in Saccharomyces cerevisiae. Trends in Biotechnology, 23 (12), (pp. 598-604) (6 p.).
van der Veken, P., Dirksen, E.H.C., Ruijter, E., Elgersma, R.C., Heck, A.J.R., Rijkers, D.T.S., Slijper, M. & Liskamp, R.M.J. (2005). Development of a Novel Chemical Probe for the Selective Enrichment of Phosphorylated Serine- and Threonine-Containing Peptides. ChemBioChem, 6, (pp. 2271-2280) (9 p.).
Groen, A.J., Lemeer, S.M., van der Wijk, T., Overvoorde, J., Heck, A.J.R., Ostman, A., Barford, D., Slijper, M. & den Hertog, J. (2005). Differential Oxidation of Protein-tyrosine Phosphatases. Journal of Biological Chemistry, 280 (11), (pp. 10298-10304) (6 p.).
Kleinnijenhuis, A.J., Heck, A.J.R., Duursma, M.C. & Heeren, R.M.A. (2005). Does Double Electron Capture Lead to the Formation of Biradicals? An ECD-SORI-CID Study on Lacticin 481. Journal of the American Society for Mass Spectrometry, (pp. 2261-2270) (9 p.).
Kolkman, A., Dirksen, E.H.C., Slijper, M. & Heck, A.J.R. (2005). Double Standards in Quantitative Proteomics. Molecular and Cellular Proteomics, 4, (pp. 255-266) (11 p.).
Römpp, A., Mihalca, R., Taban, I., Heck, A.J.R., Kleinnijenhuis, A.J., McDonnell, L.A., Mize, T.H. & Heeren, R.M.A. (2005). Examples of FTICR-MS developments: from ion physics to remote acces biochemical mass spectrometry. European Journal of Mass Spectrometry, 11, (pp. 443-456) (14 p.).
Romijn, E.P., Christis, C., Wieffer, M., Gouw, J.W., Fullaondo, A., van der Sluijs, P., Braakman, L.J. & Heck, A.J.R. (2005). Expression Clustering Reveals Detailed Co-expression Patterns of Functionally Related Proteins during B Cell Differentiation. Molecular and Cellular Proteomics, 4, (pp. 1297-1310) (13 p.).
Rodriguez, P., Bonte, E., Krijgsveld, J., Kolodziej, K.E., Guyot, B., Heck, A.J.R., Vyas, P., de Boer, E., Grosveld, F. & Strouboulis, J. (2005). GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO Journal, 24 (13), (pp. 2354-2366) (12 p.).
van der Knaap, J.A., Prasphanth Kumar, B.R., Moshkin, Y.M., Langenberg, K., Krijgsveld, J., Heck, A.J.R., Karch, F. & Verrijzer, C.P. (2005). GMP Synthetase Stimulates Histone H2B Deubiquitylation by the Epigenetic Silencer USP7. Molecular Cell, 17, (pp. 695-707) (12 p.).
Kruithof, C.A., Casado Lacabra, M.A., Guillena, G., Egmond, M.R., van der Kerk-van Hoof, A.C., Heck, A.J.R., Klein Gebbink, R.J.M. & van Koten, G. (2005). Lipase Active-Site-Directed Anchoring of Organometallics:Metallopincer/Protein Hybrids. Chemistry-A European Journal, 11, (pp. 6869-6877) (8 p.).
van Balkom, Bas W M, van Gestel, Renske A, Brouwers, Jos F H M, Krijgsveld, Jeroen, Tielens, Aloysius G M, Heck, Albert J R & van Hellemond, Jaap J (15.06.2005). Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome. Journal of Proteome Research, 4 (3), (pp. 958-966) (9 p.).
van den Bremer, E.T.J., Keeble, A.H., Kleanthous, C. & Heck, A.J.R. (2005). Metal induced selectivity in phosphate ion binding in E9 Dnase. Chemical Communications, 9, (pp. 1137-1139) (3 p.).
van Duijn, E., Bakkes, P.J., Heeren, R.M.A., van den Heuvel, R.H.H., van Heerikhuizen, H., van der Vies, S.M. & Heck, A.J.R. (2005). Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry. Nature Methods, 2 (5), (pp. 371-376) (5 p.).
Neeft, M.A., Wieffer, M., de Jong, A.S., Negroiu, G., Metz, C.H.G., van Loon, A., Griffith, J.M., Krijgsveld, J., Wulffraat, N.M., Koch, H., Heck, A.J.R., Brose, N., Kleijmeer, M.J. & van der Sluijs, P. (2005). Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Molecular Biology of the Cell, 16 (2), (pp. 731-741) (11 p.).
de Mol, N.J., Catalina Caballero, M.I., Dekker, F.J., Fischer, M.J.E., Heck, A.J.R. & Liskamp, R.M.J. (2005). Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM based ligand binding to Syk tandem SH2. ChemBioChem, 6, (pp. 2261-2270) (10 p.).
van den Heuvel, R.H.H., Gato, S., Versluis, C., Gerbaux, P., Kleanthous, C. & Heck, A.J.R. (2005). Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry. Nucleic Acids Research, 33 (10) (7 p.).
Brandon, E.F.A., van Ooijen, R.D., Sparidans, R.W., Lazaro, L.L., Heck, A.J.R., Beijnen, J.H. & Schellens, J.H.M. (2005). Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry. Journal of Mass Spectrometry, 40 (6), (pp. 821-831) (11 p.).
  2005 - Professional publications
van den Bremer, E.T.J. & Heck, A.J.R. (2005). Mass Spectrometry: Protein Conformational Analysis and Molecular Recognition. In W. Jiskoot & D.J.A. Crommelin (Eds.), Methods for Structural Analysis of Protein Pharmaceuticals (29 p.). Arlington: AAPS Press.
Romijn, E.P. & Heck, A.J.R. (2005). Mass Spectrometry: Proteomics. In W. Jiskoot & D.J.A. Crommelin (Eds.), Methods for Structural Analysis of Protein Pharmaceuticals (35 p.). Arlington: AAPS Press.
  2004 - Scholarly publications
de Mol, N.J., Catalina Caballero, M.I., Fischer, M.J.E., Broutin, I., Maier, C.S. & Heck, A.J.R. (2004). Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain. Biochimica et Biophysica Acta - Proteins and Proteomics, 1700 (1), (pp. 53-64) (12 p.).
Mohrmann, L., Langenberg, K., Krijgsveld, J., Kal, A.J., Heck, A.J.R. & Verrijzer, C.P. (2004). Differential Targeting of Two Distinct SWI/SNF-Related Drosophila Chromatin-Remodeling Complexes. Molecular and Cellular Biology, (pp. 3077-3088) (12 p.).
van den Bremer, E.T.J., Keeble, A.H., Jiskoot, W., Spelbrink, R.E.J., Maier, C.S., Hoek, A., Visser, A.J.W.G., James, R., Moore, G.R., Kleanthous, C. & Heck, A.J.R. (2004). Distinct conformational stability and functional activity of four highly homologous endonuclease colicins. Protein Science, 13, (pp. 1391-1401) (11 p.).
Mihalca, R., Kleinnijenhuis, A.J., McDonnell, L.A., Heck, A.J.R. & Heeren, R.M.A. (2004). Electron Capture Dissociation at Low Temperatures Reveals Selective Dissociations. Journal of the American Society for Mass Spectrometry, 15, (pp. 1869-1873) (5 p.).
Iovan Avram, D., Romijn, E.P., Pap, E.H.W., Heck, A.J.R. & Wirtz, K.W.A. (2004). Identification of proteins in activated human neutrophils susceptible to tyrosyl radical attack. A proteomic study using a tyrosylating fluorophore. Proteomics, 4, (pp. 2397-2407) (11 p.).
Heck, A.J.R. & van den Heuvel, R.H.H. (2004). Investigation of intact protein complexes by Mass Spectrometry. Mass Spectrometry Reviews, 23, (pp. 368-389) (22 p.).
van den Bremer, E.T.J., Keeble, A.H., Visser, A.J.W.G., Hoek, A., Kleanthous, C., Heck, A.J.R. & Jiskoot, W. (2004). Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease. Biochemistry, 43, (pp. 4347-4355) (9 p.).
van den Heuvel, R.H.H. & Heck, A.J.R. (2004). Mass spectrometry as a novel tool in protein structural biology. Spectroscopy Europe, 16 (2), (pp. 6-13) (8 p.).
Heck, A.J.R. & Krijgsveld, J. (2004). Mass spectrometry-based quantitative proteomics. Expert Review Proteomics, 1 (3), (pp. 317-326) (10 p.).
van den Heuvel, R.H.H. & Heck, A.J.R. (2004). Native protein mass spectrometry: from intact oligomers to functional machineries. Current Opinion in Chemical Biology (8), (pp. 519-526) (8 p.).
Ridder, A.N.J.A., Spelbrink, R.E.J., Demmers, J.A.A., Rijkers, D.T.S., Liskamp, R.M.J., Brunner, J., Heck, A.J.R., de Kruijff, B. & Killian, J.A. (2004). Photo-crosslinking analysis of preferential interactions between a transmembrane peptide and matching lipids. Biochemistry, 43, (pp. 4482-4489) (18 p.).
Catalina Caballero, M.I., de Mol, N.J., Fischer, M.J.E. & Heck, A.J.R. (2004). Probing factors affecting the gas phase stabilities of noncovalent complexes formed by peptides bound to the Grb2 SH2 domain protein. Physical Chemistry Chemical Physics, 6, (pp. 2572-2579) (8 p.).
Pinkse, M.W.H. & Heck, A.J.R. (2004). Probing Noncovalent Protein-Ligand Interactions of the cGMP-Dependent Protein Kinase Using Electrospray Ionization Time of Flight Mass Spectrometrie. Journal of the American Society for Mass Spectrometry, 15, (pp. 1392-1399) (8 p.).
Beumer, J.H., Rosing, H., Hillebrand, MJ, Nan-Offeringa, LG, Foley, K, Yule, SM, Heck, A.J.R., Schellens, J.H.M. & Beijnen, J.H. (2004). Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 18 (23), (pp. 2839-48) (10 p.).
Krijgsveld, J. & Heck, A.J.R. (2004). Quantitative proteomics by metabolic labeling with stable isotopes. DDT: TARGETS Elsevier, 3, (pp. 11-15) (5 p.).
Pinkse, M.W.H., Uitto, P.M., Hilhorst, M.J., Ooms, B. & Heck, A.J.R. (2004). Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns. Analytical Chemistry, 76, (pp. 3935-3943) (9 p.).
van den Heuvel, R.H.H., Westphal, A.H., Heck, A.J.R., Walsh, M.A., Rovida, S., van Berkel, W.J.H. & Mattevi, A. (2004). Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action. Journal of Biological Chemistry, 279, (pp. 12860-12867) (8 p.).
Boumann, H.A., de Kruijff, B., Heck, A.J.R. & de Kroon, A.I.P.M. (2004). The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. FEBS Letters, 569, (pp. 173-177) (5 p.).
Boumann, H.A., Chin, P.T.K., Heck, A.J.R., de Kruijff, B. & de Kroon, A.I.P.M. (2004). The yeast phospholipid N-methyltransferases catalyzing the synthesis of phosphatidylcholine preferentially convert di-C16:1 substrates both in vivo and in vitro. Journal of Biological Chemistry, 279, (pp. 40314-40319) (6 p.).
Kol, M.A., Kuster, D.W.D., Boumann, H.A., de Cock, J.J.P.A., Heck, A.J.R., de Kruijff, B. & de Kroon, A.I.P.M. (2004). Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli. Biochimica et Biophysica Acta, 1636, (pp. 205-212) (8 p.).
Heck, A.J.R. & Jorgensen, T.J.D. (2004). Vancomycin in vacuo. International Journal of Mass Spectrometry, 236, (pp. 11-23) (13 p.).
  2004 - Professional publications
Iovan Avram, D., Romijn, E.P., Heck, A.J.R. & Wirtz, K.W.A. (2004). Activation of human neutrophils leads to the cross-linking of tyrosyl radicals to endogenous anti-inflamatory and anti-bacterial proteins. Application of a tyrosylating fluorophore. NATO Science Series, Series I, Life and Behavioural Sciences, vol. 358 (pp. 32-39) (8 p.). Amsterdam: IOS Press.
  2003 - Scholarly publications
Blokland, M.H., Sterk, S.S., van Ginkel, L.A., Stephany, R.W. & Heck, A.J.R. (2003). Analysis for endogenous and recombinant porcine somatotropine in serum. Analytica Chimica Acta, 483, (pp. 201-206) (6 p.).
Yatsuda, A.P., Krijgsveld, J., Cornelissen, A.W.C.A., Heck, A.J.R. & de Vries, E. (2003). Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition. Journal of Biological Chemistry, 278 (19), (pp. 16941-16951) (11 p.).
de Boer, E., Rodriguez, P., Bonte, E., Krijgsveld, J., Katsantoni, E., Heck, A.J.R., Grosveld, F. & Strouboulis, J. (2003). Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 100 (13), (pp. 7480-7485) (6 p.).
Bonnici, P.J., Breukink, E.J. & Heck, A.J.R. (2003). Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics. Chemistry-A European Journal, 9, (pp. 1556-1565) (10 p.).
Kopitz, J., André, S., Von Reitzenstein, C., Versluis, C., Kaltner, H., Pieters, R.J., Wasano, K., Kuwabara, I., Liu, F-T., Cantz, M., Heck, A.J.R. & Gabius, H.-J. (2003). Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Oncogene, 22, (pp. 6277-6288) (12 p.).
Breukink, E.J., van Heusden, H.E., Bonnici, P.J., Swiezewska, E., Brunner, L., Walker, S.M., Heck, A.J.R. & de Kruijff, B. (2003). Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes. Journal of Biological Chemistry, 278, (pp. 19898-19903) (6 p.).
Kleinnijenhuis, A.J., Duursma, M.C., Breukink, E.J., Heeren, R.M.A. & Heck, A.J.R. (2003). Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation. Analytical Chemistry, 75, (pp. 3219-3225) (7 p.).
Houtman, R., Krijgsveld, J., Kool, M., Romijn, E.P., Redegeld, F.A.M., Nijkamp, F.P., Heck, A.J.R. & Humphery-Smith, I. (2003). Lung proteome alterations in a mouse model for nonallergic asthma. Proteomics, 3, (pp. 2008-2018) (11 p.).
Pinkse, M.W.H., Maier, C.S., Kim, J.I., Oh, B.H. & Heck, A.J.R. (2003). Macromolecular assembly of Helicobacter pylori urease investigated by mass spectrometry. Journal of Mass Spectrometry, 38, (pp. 315--320) (1 p.).
Krijgsveld, J., Ketting, R.F., Mahmoudi, T., Johansen, J., Artal-Sanz, M., Verrijzer, C.P. & Heck, A.J.R. (2003). Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nature Biotechnology, 21 (8), (pp. 927-931) (5 p.).
Romijn, E.P., Krijgsveld, J. & Heck, A.J.R. (2003). Recent liquid chromatographic-(tandem) mass spectrometric applications in proteomics. Journal of Chromatography, 1000, (pp. 589-608) (20 p.).
van Anken, E., Romijn, E.P., Maggioni, M.C., Mezghrani, A., Sitia, R., Braakman, L.J. & Heck, A.J.R. (2003). Sequential Waves of Functionally Related Proteins Are Expressed When B Cells Prepare for Antibody Secretion. Immunity, 18, (pp. 243-253) (11 p.).
Catalina Caballero, M.I., Dekker, F.J., Liskamp, R.M.J., Versluis, C., Maier, C.S. & Heck, A.J.R. (2003). Structural analysis of high affinity divalent phosphopeptide hybrids of spleen tyrosine kinase. International Journal of Mass Spectrometry, 228, (pp. 879-890) (12 p.).
de Wit, N.J.C., Vatish, M., Heck, A.J.R. & Thornton, S. (2003). The application of proteomics to fetal and maternal medicine. Fetal and Maternal Medicine Review, 14, (pp. 47-55) (9 p.).
Boumann, H.A., Damen, J.M.A., Versluis, C., Heck, A.J.R., de Kruijff, B. & de Kroon, A.I.P.M. (2003). The two biosynthetic routes leading to posphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling. Biochemistry, 42, (pp. 3054-3059) (6 p.).
  2002 - Scholarly publications
Heck, A.J.R., Maier, C.S., Tahallah, N., Bossi, R.T., Aliverti, A., Zanetti, G., Ferrari, D., Rizzi, M. & Mattevi, A. (2002). An unprecedented covalent modification of NADP+ revealed by atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase. Biochemistry, 41, (pp. 8807-8818) (12 p.).
Siebert, H.-C., Lü, S.-Y., Frank, M., Kramer, J., Wechselberger, R.W., Joosten, J., André, S., Rittenhouse-Olson, K., Roy, R., von der Lieth, C.-W., Kaptein, R., Vliegenthart, J.F.G., Heck, A.J.R. & Gabius, H.-J. (2002). Analysis of protein-carbohydrate interaction at the lower size limit of the protein part (15-mer peptide) by NMR Spectroscopy, electrospray ionization mass spectrometry and molecular modeling. Biochemistry, 41, (pp. 9707-9717) (10 p.).
Heck, A.J.R. & Maier, C.S. (2002). Biomolecular mass spectrometry related to drug research. In H. van der Goot (Eds.), Proceedings of 13th Noordwijkerhout-Camerino symposium trends in drug research (pp. 81-94) (13 p.).
Ruijtenbeek, R., Versluis, C., Heck, A.J.R., Redegeld, F.A.M., Nijkamp, F.P. & Liskamp, R.M.J. (2002). Characterization of a phosphorylated peptide and peptoid and peptoid-peptide hybrids by mass spectrometry. Journal of Mass Spectrometry, 37, (pp. 47-55) (9 p.).
Tahallah, N., van den Heuvel, R.H.H., van den Berg, W.A.M., Maier, C.S., van Berkel, W.J.H. & Heck, A.J.R. (2002). Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase. Journal of Biological Chemistry, 277, (pp. 36425-36432) (7 p.).
de Brouwer, A.P.M., Versluis, C., Westermann, J., Roelofsen, B., Heck, A.J.R. & Wirtz, K.W.A. (2002). Determination of the stability of the noncovalent phospholipid transfer protein-lipid complex by electrospray time-of-flight mass spectrometry. Biochemistry, 41, (pp. 8013-8018) (5 p.).
Demmers, J.A.A., Rijkers, D.T.S., Haverkamp, J., Killian, J.A. & Heck, A.J.R. (2002). Factors affecting gas-phase deuterium scrambling in peptide ions and their implications for protein structure determination. Journal of the American Chemical Society, 124, (pp. 11191-11198) (7 p.).
Corbellini, F., Fiammengo, R., Timmerman, P., Crego-Calama, M., Versluis, K., Heck, A.J.R., Luyten, I. & Reinhoudt, D.N. (2002). Guest encapsulation and self-assembly of molecular capsules in polar solvents via multiple ionic interactions. Journal of the American Chemical Society, 124, (pp. 6569-6575) (6 p.).
Vollmerhaus, P.J., Tempels, F.W.A., Kettenes-van den Bosch, J.J. & Heck, A.J.R. (2002). Molecular interactions of glycopeptide antibiotics investigated by affinity capillary electrophoresis and bioaffinity electrospray ionization-mass spectrometry. Electrophoresis, 23, (pp. 868-879) (11 p.).
Fiammengo, R., Timmerman, P., Huskens, J., Versluis, K., Heck, A.J.R. & Reinhoudt, D.N. (2002). Non-covalent synthesis of calix[4]arene-cappes porpyrins in polar solvents via ionic interactions. Tetrahedron, 58, (pp. 757-764) (7 p.).
van den Bremer, E.T.J., Jiskoot, W., James, R., Moore, G.R., Kleanthous, C., Heck, A.J.R. & Maier, C.S. (2002). Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry. Protein Science, 11, (pp. 1738-1752) (15 p.).
Surroca, Y., Haverkamp, J. & Heck, A.J.R. (2002). Towards the understanding of molecular mechanisms in the early stages of heat-induced aggregation of beta-lactoglobulin AB. Journal of Chromatography, 970, (pp. 275-285) (10 p.).
Jeric, I., Versluis, C., Horvat, S. & Heck, A.J.R. (2002). Tracing glycoprotein structures: electron ionization tandem mass spectrometric analysis of sugar-peptide adducts. Journal of Mass Spectrometry, 37, (pp. 803-811) (8 p.).
  2001 - Scholarly publications
Farine, S., Versluis, C., Bonnici, P.J., Heck, A.J.R., L'homme, C., Puigserver, A. & Biagini, A. (2001). Application of high performance anion exchange chromtography to study invertase-catalysed hydrolysis of sucrose and formation of intermediate fructan products. Applied Microbiology and Biotechnology, 55, (pp. 55-60) (6 p.).
Waterval, J.C.M., Hommels, G., Bestebreurtje, P., Versluis, C., Heck, A.J.R., Bult, A. & Underberg, W.J.M. (2001). Capillary electrophoresis bioanalysis of therapeutically active peptides with UV and mass spectrometric detection after on-capillary preconcentration. Electrophoresis, 22, (pp. 2709-2716) (8 p.).
Bonnici, P.J., Damen, J.M.A., Waterval, J.C.M. & Heck, A.J.R. (2001). Formation and efficacy of vancomycin group glycopeptide antibiotic stereoisomers studied by capillary electrophoresis and bioaffinity mass spectrometry. Analytical Biochemistry, 290, (pp. 292-301) (10 p.).
Demmers, J.A.A., van Duijn, E., Haverkamp, J., Greathouse, D.V., Koeppe II, R.E., Heck, A.J.R. & Killian, J.A. (2001). Interfacial positioning and stability of transmembrane peptides in lipid bilayers studied by combining hydrogen/deuterium exchange and mass spectrometry. Journal of Biological Chemistry, 276, (pp. 34501-34508) (8 p.).
Morris, L.A., Jaspars, M., Kettenes-van den Bosch, J.J., Versluis, C., Heck, A.J.R., Kelly, S.M. & Price, N.C. (2001). Metal binding of Lissoclinum patella metabolites. Part 1: Patellamides A, C and ulithiacyclamide. Tetrahedron, 57, (pp. 3185-3197) (13 p.).
Morris, L.A., Milne, B.F., Jaspars, M., Kettenes-van den Bosch, J.J., Versluis, C., Heck, A.J.R., Kelly, S.M. & Price, N.C. (2001). Metal binding of Lissoclinum patella metabolites. Part 2: Lissoclinamides 9 and 10. Tetrahedron, 57, (pp. 3199-3207) (9 p.).
Versluis, C., van der Staaij, A., Stokvis, E., Heck, A.J.R. & de Craene, B. (2001). Metastable Ion Formation and Disparate Charge Separation in the Gas-Phase Dissection of Protein Assemblies studied by Orthogonal Time-of-Flight Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 12, (pp. 329-336) (8 p.).
Heck, A.J.R., Bonnici, P.J., Breukink, E.J., Morris, D. & Wills, M. (2001). Modification and inhibition of vancomycin group antibiotics by formaldehyde and acetaldehyde. Chemistry-A European Journal, 7, (pp. 910-916) (7 p.).
Versluis, C. & Heck, A.J.R. (2001). On the gas-phase dissociation of hemoglobin. International Journal of Mass Spectrometry, 210/211, (pp. 637-649) (13 p.).
Cadee, J.A., van Steenbergen, M.J., Versluis, C., Heck, A.J.R., Underberg, W.J.M., den Otter, W., Jiskoot, W. & Hennink, W.E. (2001). Oxidation of Recombinant Human interleukin-2 by Potassium Peroxodisulfate. Pharmaceutical Research, 18, (pp. 1461-1467) (7 p.).
Waterval, J.C.M., Bestebreurtje, P., Lingeman, H., Versluis, C., Heck, A.J.R., Bult, A. & Underberg, W.J.M. (2001). Robust and cost-effective capillary electrophoresis-mass spectrometry interfaces suitable for combination with on-line analyte preconcentration. Electrophoresis, 22, (pp. 2701-2708) (8 p.).
Farine, S., Versluis, C., Bonnici, P.J., Heck, A.J.R., Peschet, J.L., Puigserver, A. & Biagini, A. (2001). Separation and identification of enzymatic sucrose hydrolysis products by high-performance anion-exchange chromatography with pulsed amperometric detection. Journal of Chromatography, 920, (pp. 299-308) (10 p.).
Roscic, M., Versluis, C., Kleinnijenhuis, A.J., Horvat, S. & Heck, A.J.R. (2001). The early glycation products of the Maillard reaction: mass spectrometric characterization of novel imidazolidinones derived from an opioid pentapeptide and glucose. Rapid Communications in Mass Spectrometry, 15, (pp. 1022-1029) (8 p.).
Tahalla, N., Pinkse, M.W.H., Maier, C.S. & Heck, A.J.R. (2001). The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-f-flight instrument. Rapid Communications in Mass Spectrometry, 15, (pp. 596-601) (6 p.).
  2000 - Scholarly publications
van Dongen, W.D. & Heck, A.J.R. (2000). Binding of selected carbohydrates to apo-concanavalin A studied by electrospray ionazation mass spectrometry. The Analyst, 125, (pp. 583-589) (7 p.).
Stokvis, E., Clugston, S.L., Honek, J.F. & Heck, A.J.R. (2000). Characterization of Glyoxalase I (E.coli)-Inhibitor Interactions by Electrospray Time-of-Flight Mass Spectrometry and Enzyme Kinetic Analysis. Journal of Protein Chemistry, 19, (pp. 389-397) (9 p.).
van Berkel, W.J.H., van den Heuvel, R.H.H., Versluis, C. & Heck, A.J.R. (2000). Detection of intact megaDalton protein assemblies of vanillyl-alcohol oxidase by mass spectrometry. Protein Science, 9, (pp. 435-439) (5 p.).
Demmers, J.A.A., Haverkamp, J., Heck, A.J.R., Koeppe, R.E. & Killian, J.A. (2000). Electrospray ionazation mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics to transmembrane peptides in lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America, 97, (pp. 3189-3194) (6 p.).
Nuijen, B., Bouma, M., Henrar, R.E.C., Floriano, P., Jimeno, J.M., Talsma, H., Kettenes-van den Bosch, J.J., Heck, A.J.R., Bult, A. & Beijnen, J.H. (2000). Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumour agent aplidine. PDA Journal of Pharmaceutical Science and Technology, 54 (3), (pp. 193-208) (16 p.).
Nuijen, B., Bouma, M., Henrar, R.E.C., Floriano, P., Jimeno, J.M., Talsma, H., Kettenes-van den Bosch, J.J., Heck, A.J.R., Bult, A. & Beijnen, J.H. (2000). Related Articles Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine. PDA Journal of Pharmaceutical Science and Technology, 54, (pp. 193-208) (16 p.).
van Maanen, M.J., Doesburg Smits, K., Damen, J.M.A., Heck, A.J.R. & Beijnen, J.H. (2000). Stability of thioTEPA and its metabolites, TEPA, monochloroTEPA and thioTEPA-mercapturate, in plasma and urine. International Journal of Pharmaceutics, 200, (pp. 187-194) (8 p.).
Kenny, J.A., Versluis, C., Heck, A.J.R., Walsgrove, T. & Wills, M. (2000). The detection of intermediates in the rythenium (II) catalysed asymmetric hydrogenation of ketones using electrospray ionisation mass spectrometry. Chemical Communications, (pp. 99-100) (2 p.).
Staroske, T., O'Brien, D.P., Jorgensen, T.J.D.J., Roepstorff, P., Williams, D.H. & Heck, A.J.R. (2000). The formation of Heterodimers by Vancomycin Group Antibiotics. Chemistry-A European Journal, 6, (pp. 504-509) (6 p.).
  1999 - Scholarly publications
van Maanen, M.J., Tijhof, I.M., Damen, J.M.A., Versluis, C., Kettenes-van den Bosch, J.J., Heck, A.J.R., Rodenhuis, S. & Beijnen, J.H. (1999). A search for new metabolites of N,N',N"-triethylenethiophosphoramide. Cancer Research, 59, (pp. 4720-4724) (4 p.).
Silva, C.M.L., Duarte, M.F., Mira, M.L., Florincio, M.H., Versluis, C. & Heck, A.J.R. (1999). Copper and iron interactions with angiotensin - converting enzyme inhibitors. A study by FAB / MS study. Rapid Communications in Mass Spectrometry, 13, (pp. 1098-1103) (6 p.).
van der Kerk-van Hoof, A.C. & Heck, A.J.R. (1999). Covalent and Non-covalent Dissociations of Gas-phase Complexes of Avoparcin and Bacterial Receptor Mimicking Precursor Peptides Studied by Collisionally Activated Decomposition Mass Spectrometry. Journal of Mass Spectrometry, 34, (pp. 813-819) (7 p.).
Lafitte, D., Heck, A.J.R., Hill, T.J., Jumel, K., Harding, S.E. & Derrick, P.J. (1999). Evidence of noncovalent dimerization of calmodulin. Biochemistry International, 261, (pp. 337-344) (7 p.).
van der Kerk-van Hoof, A.C. & Heck, A.J.R. (1999). Interactions of - and -avoparcin with bacterial cell-wall receptor-mimicking peptides studied by electrospray ionization mass spectrometry. Journal of Antimicrobial Chemotherapy, 44, (pp. 593-599) (7 p.).
Heck, A.J.R. (1999). Mass spectrometry : Ion Imaging Using Mass Spectrometry. In J.C. Lindon, G.E. Tranter & J.L. Holmes (Eds.), Encyclopedia of Spectroscopy and Spectrometry Academic Press.
Neyer, D.W., Heck, A.J.R. & Chandler, D.W. (1999). Photodissociation of N2O : J-dependent anisotropy revealed in N2 photofragment images. Chemical Physics, 110, (pp. 3411-3417) (7 p.).
Neyer, D.W., Heck, A.J.R., Chandler, D.W., Teule, J.M. & Janssen, M.H.M. (1999). Speed-dependent alignment and angular distributions of O 1D2 from the ultraviolet photodissociation of N20. Journal of Physical Chemistry A, 103, (pp. 10388-10397) (10 p.).
Jorgensen, T.J.D.J., Staroske, T., Roepstorff, P., Williams, D.H. & Heck, A.J.R. (1999). Subtle differences in molecular recognition between modified glycopeptide antibiotics and bacterial receptor peptides identified by electrospray ionization mass spectrometry. Journal of the Chemical Society, Perkin Transactions 2, 9, (pp. 1859-1863) (5 p.).
Smith, A.R.C., Heck, A.J.R., Kenny, J.A., Kettenes-van den Bosch, J.J. & Wills, M. (1999). Synthesis and electrospray mass spectrometric studies on a chiral, non-racemic, phosphoramide receptor molecule. Tetrahedron Asymmetry, 10, (pp. 3267-3271) (5 p.).
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Gegenereerd op 2017-11-22 13:24:22

Eiwitten aan het werk - de fascinerende wereld van proteomics

Deze video laat de fascinerende wereld van proteomics zien, onderzoek aan de eiwitten die aan de basis van al het leven staan. De video is gemaakt voor het lab van prof. dr. Albert Heck van de Universiteit Utrecht en het Netherlands Proteomics Centre.

Proteomics is het op grote schaal onderzoeken van eiwitten, essentiële moleculen die een belangrijk deel vormen van alle levende organismes. Het onderzoeken van eiwitten kan ons helpen om ziektes beter te begrijpen en betere medicijnen te ontwikkelen, maar leert ons ook waarom sommige planten beter tegen droogte kunnen en hoe we micro-organismen efficiënt kunnen bestrijden.

De video is mogelijk gemaakt door de input van de onderzoekers van het Heck lab en financiële steun van het Utrechts Instituut voor Farmaceutische Wetenschappen (UIPS).

 

 

Project:
H2020 FET-OPEN MSMed
01.12.2015 to 10.12.2019
General project description 

Novel EU-funded collaborative proteomics project to bring proteomics to clinical application


 


Novel proteomic technologies that are so robust and powerful that they can be used in every biological laboratory and in every clinic are expected as results of the currently starting research consortium MSmed. The European Commis­sion is co-funding the project with 3.7 Million Euros for four years starting Dec. 1, 2015 within the research line “Future and Emerging Technologies” under the Horizon 2020 Pro­gramme. MSmed will automate workflows in mass spectrometric analysis for proteomics re­search to prepare them for high-throughput clinical application.

Role Researcher Funding
EU grant
Project members UU
Project:
Institute for Chemical Immunology
01.01.2014 to 31.12.2023
General project description 

The Institute for Chemical Immunlogy is an NWO Gravitation project coordinator by Leiden University. It will define and exploit a new field termed chemical immunology and train a novel generation of interdisciplinary scientists. It aims to promote academic excellence; with economic and clinical translation of new treatment options for a large population of patients that currently only have limited treatment options.

Role Researcher Funding
Utrecht University
Project members UU
External project members:
  • prof. dr. Sjaak Neefjes (NKI; coordinator)
  • prof. dr. Hermen Overkleeft (LU)
  • prof. dr. Carl Figdor (RU)
  • prof. dr. Ton Schumacher (NKI)
Project:
Proteins At Work
01.01.2014 to 30.06.2019
General project description 

Proteins At Work is a project in the NWO National Roadmap for Large-Scale Research Facilities programme which encourages the establishment or improvement of large research facilities with which the Netherlands can assume an important position internationally. Proteins At Work will make high-level technology, equipment and expertise for studying proteins in cells and tissues available to the biological and biomedical researchers in the Netherlands. The Proteins At Work programme is a collaboration between Utrecht University, the UMC Utrecht, the Hubrecht Institute, the Erasmus MC Rotterdam and the Netherlands Cancer Institute and is coordinated by prof. dr. Albert Heck.

Role Researcher Funding
NWO grant
Project members UU
External project members:
  • prof. dr. Roland Kanaar (Erasmuc MC)
  • dr. Jeroen Demmers (Erasmus MC)
  • dr. Harm-Jan Vos (UMCU)
  • prof. dr. Rene Medema (NKI)
  • prof. dr. Hans Clevers (Hubrecht Institute)

Completed projects

Project:
ManiFold 01.09.2012 to 31.08.2016
General project description

ManiFold is an Innovative Doctoral Programme organised by members of the Bijvoet Center for Biomolecular Research and its Graduate Research School, at Utrecht University in the Netherlands. The European Union selected the most innovative doctoral programmes in Europe for funding in the prestigious Marie-Curie Initial Training Networks scheme. ManiFold was the only Innovative Doctoral Programme in the Life Sciences funded in 2012.

 
Role Researcher Funding
EU grant
Project members UU
Project:
PRIME-XS 01.02.2011 to 31.01.2015
General project description

PRIME-XS provides European Union funded access to an infrastructure of state-of-the-art proteomics technology to the biological and biomedical research community in Europe. European researchers who would like to use proteomics technology for their research can apply with a research proposal on this website. PRIME-XS is a consortium of twelve partners, all leading in the field of proteomics. In addition to providing access, we develop new technologies to better aid the research community in answering current day scientific questions, and organize courses and meetings.

 
Role Researcher Funding
EU grant
Project members UU
External project members:
  • Flemish Institute for Biotechnology
  • University of Zurich
  • Eidgenössische Technische Hochschule Zurich
  • University of Copenhagen
  • Center for Genomic Regulation
  • University of Cambridge
  • Research Institute of Molecular Pathology
  • Commissariat à l'énergie atomique
  • Eberhard Karls Universität Tübingen
  • European Bioinformatics Institute
  • Max Planck Institute of Biochemistry
Gegenereerd op 2017-11-22 13:24:23
Additional functions and activities
  • Editorial board member scientific journals: Molecular and Cellular Proteomics [2005-present]; Molecular BioSystems [2008-present]; J Proteome Research [2008-present]; RSC Molecular BioSystems [2008-2015], Editor [2015-present]; Mass Spectrom Reviews [2009-present]; ChemBioChem [2010-present]; ACS Analytical Chemistry [2015-present]
  • Scientific Advisory Board Member “ERA-Instrument Infrastructures for the Life Sciences” [2008-present] 
  • Scientific Advisory Board Member “University of Victoria Genome-BC Proteomics Centre” [2007-2012]
  • Scientific Advisory Board (SAB) EU FP7 Program Prospects (2009-2013), SAB EU FP7 Program Eurotrans (2010-2014).
  • SAB “Institut de Pharmacologie et de Biologie Structurale”, Toulouse, (2012-2016)
  • Wellcome Trust Reviewer Principle Research Fellowship (2014, 2015)
  • SAB Inotrem, Paris, a company specializing in the development of novel treatments in the field of inflammatory diseases
  • Scientific Advisory Board Member Max Planck Institute of Biochemistry, Martinsried (2015-2018).
  • Advisory Board Member "Limburg INvesteert in haar Kenniseconomie" (LINK) (2016-).
  • Lid Programmaraad Chemistry of Life, Top Sector Chemie
Gegenereerd op 2017-11-22 13:24:23
Full name
prof. dr. A.J.R. Heck Contact details
Hugo R. Kruytgebouw

Padualaan 8
Room O603
3584 CH  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 6797
Phone number (department) +31 30 253 5871
Postal address
Postbus 80.082
3508 TB    UTRECHT
The Netherlands
Gegenereerd op 2017-11-22 13:24:23
Last updated 09.10.2017