Ing. A.J. (Arwin) Brouwer

Research and Education Assistant
Chemical Biology and Drug Discovery
a.j.brouwer@uu.nl

Brouwer, Arwin J.; Herrero Álvarez, Natalia; Ciaffoni, Adriano; van de Langemheen, Helmus; Liskamp, Rob M. J. “Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides” Bioorganic & Medicinal Chemistry, 2016, 24, 3429-3435.

Pukin, Aliaksei V.; Brouwer, Arwin J.; Koomen, Leonie; Quarles van Ufford, H. C.; Kemmink, Johan; de Mol, Nico J.; Pieters, Roland J. “Thiourea-based spacers in potent divalent inhibitors of Pseudomonas aeruginosa virulence lectin LecA” Organic & Biomolecular Chemistry, 2015, 13, 10923-10928.

Dubiella, Christian; Cui, Haissi; Gersch, Malte; Brouwer, Arwin J.; Sieber, Stephan A.; Krüger, Achim; Liskamp, Rob M. J.; Groll, Michael. “Selective immunoproteasome inhibition by ligand-induced active site collapse” Angewandte Chemie Int. Ed. 2014, 53, 11969-11973.

Brouwer, Arwin J.; van de Langemheen, Helmus; Liskamp, Rob M. J. “Synthesis of the TACO Scaffold as a New Selectively Deprotectable Conformationally Restricted Triazacyclophane Based Scaffold” Organic Letters, 2014, 16, 3106-3109.
 
Brouwer, Arwin J.; van de Langemheen, Helmus; Liskamp, Rob M. J. “Expedient synthesis of a novel asymmetric selectively deprotectable derivative of the ATAC scaffold” Tetrahedron, 2014, 70, 4002-4007.
 
Tschan, Serena; Brouwer, Arwin J.; Werkhoven, Paul R.; Jonker, Anika M.; Wagner, Lena; Knittel, Sarah; Nigel Aminake, Makoah; Pradel, Gabriele; Joanny, Fanny; Liskamp, Rob M. J.; Mordmüller, Benjamin. “Broad spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors” Antimicrobial Agents and Chemotherapy, 2013, 57, 3576-3584.
 
Mulder, Gwenn E.; Quarles van Ufford H (Linda). C.; Ameijde, Jeroen van; Brouwer, Arwin J.; Kruijtzer, John A. W.; Liskamp, Rob M. J. ”Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries” Organic & Biomolecular Chemistry, 2013, 11, 2676-2684.
 
Vosyka, Oliver; Vinothkumar, Kutti R.; Küttler, Eliane V.; Brouwer, Arwin J.; Liskamp, Rob M. J. Verhelst, Steven H. L. “Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay” Proceedings of the National Academy of Sciences of the United States of America, 2013, 110, 1-6.
 
Brouwer, Arwin J.; Jonker, Anika; Werkhoven, Paul; Kuo, Ethan; Li, Nan; Gallastegui, Nerea; Kemmink, Johan; Florea, Bogdan I.; Groll, Michael; Overkleeft, Herman S.; Liskamp, Rob M. J. “Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors” Journal of Medicinal Chemistry, 2012, 55, 10995-11003.
 
van de Langemheen, Helmus; Brouwer, Arwin J.; Kemmink, Johan; Kruijtzer, John A. W.; Liskamp, Rob M. J. “Synthesis of Cyclic Peptides Containing a Thioester Handle for Native Chemical Ligation” Journal of Organic Chemistry, 2012, 77, 10058-10064.
 
Brouwer, Arwin J.; Liskamp, Rob M. J. ”A simple large scale synthesis of Cbz-taurylsulfonyl azide.” Synlett, 2011,
 
Brouwer, Arwin J.; Ceylan, Tarik; Jonker, Anika M.; van der Linden, Tima; Liskamp, Rob M. J. “Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap.” Bioorganic & Medicinal Chemistry, 2011, 19, 2397-2406.
 
Rijkers, Dirk T. S.; Merkx, Remco; Yim, Cheng-Bin; Brouwer, Arwin J.; Liskamp, Rob M. J. “'Sulfo-click' for ligation as well as for site-specific conjugation with peptides, fluorophores, and metal chelators.” Journal of Peptide Science, 2010, 16, 1-5.
 
Brouwer, Arwin J.; Ceylan, Tarik; van der Linden, Tima; Liskamp, Rob M. J. “Synthesis of β-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors.” Tetrahedron Letters, 2009, 50, 3391-3393.
 
Brouwer, Arwin J.; Elgersma, R. C.; Jagondzinska, M.; Rijkers, D. T. S.; Liskamp, R. M. J. "Delayed Fibril Formation of Amylin(20-29) by Incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis" Bioorganic & Medicinal Chemistry Letters, 2008, 18, 78-84.
 
Brouwer, Arwin J.; Bunschoten, Anton; Liskamp, R. M. J. "Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors." Bioorganic & Medicinal Chemistry, 2007, 15, 6985-6993.
 
Dijkgraaf, Ingrid; Rijnders, Anneloes Y.; Soede, Annemieke; Dechesne, Annemarie C.; Van Esse, G. Wilma; Brouwer, Arwin J.; Corstens, Frans H. M.; Boerman, Otto C.; Rijkers, Dirk T. S.; Liskamp, Rob M. J. "Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes." Organic & Biomolecular Chemistry, 2007, 5, 935-944.
 
Liskamp, Rob M. J.; Rijkers, Dirk T. S.; Pieters, Roland J.; Brouwer, Arwin J.; Joosten, John A. F. "Dendrimers multivalently substituted with active groups as pharmaceutical or diagnostic agents." Eur. Pat. Appl. 2006, 23pp. EP  1733742.
 
Elgersma, Ronald C.; Meijneke, Tania; de Jong, Remco; Brouwer, Arwin J.; Posthuma, George; Rijkers, Dirk T. S.; Liskamp, Rob M. J. " Synthesis and structural investigations of N-alkylated β-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials." Organic & Biomolecular Chemistry, 2006, 4, 3587-3597.
 
Brouwer, Arwin J.; Merkx, Remco; Dabrowska, Katarzyna; Rijkers, Dirk T. S.; Liskamp, Rob M. J. "Synthesis and applications of β-aminoethanesulfonyl azides." Synthesis, 2006, 455-460.
 
Rijkers, Dirk T. S.; van Esse, G. Wilma; Merkx, Remco; Brouwer, Arwin J.; Jacobs, Hans J. F.; Pieters, Roland J.; Liskamp, Rob M. J. "Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry." Chemical Communications, 2005, 4581-4583. 
 
Joosten, John A. F.; Tholen, Niels T. H.; El Maate, Fatna Ait; Brouwer, Arwin J.; van Esse, G. Wilma; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Pieters, Roland J. "High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition". European Journal of Organic Chemistry, 2005, 3182-3185.
 
Merkx, Remco; Brouwer, Arwin J.; Rijkers, Dirk T. S.; Liskamp, Rob M. J. “Highly Efficient Coupling of b-Substituted Aminoethane Sulfonyl Azides with Thio Acids, toward a New Chemical Ligation Reaction.” Organic Letters, 2005, 7, 1125-1128.
 
Brouwer, Arwin J.; Liskamp, Rob M. J. “Synthesis of Novel Dendrimeric Systems Containing NLO Ligands.” European Journal of Organic Chemistry, 2005, 487-495.
 
Brouwer, Arwin J.; Monnee, Menno C. F.; Liskamp, Rob M. J. “Synthesis, Screening and Evaluation of a Combined Library of Tweezer- and Tripodal Synthetic Receptors.QSAR & Combinatorial Science, 2004, 23, 546-559.
 
Brouwer, Arwin J.; Liskamp, Rob M. J. “Synthesis of Cyclic Peptidosulfonamides by Ring-Closing Metathesis.” Journal of Organic Chemistry, 2004, 69, 3662-3668.
 
Liskamp, Rob M. J.; Brouwer, Arwin J.; Chamorro, Cristina; Monnee, Menno F.; Opatz, Till; Pieters, Roland J.; Rijkers, Dirk T. S.; Van Zoelen, Dirk-Jan. “From Synthetic Receptors Toward Synthetic Antibodies.”Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003.
 
Brouwer, Arwin J.; Mulders, Suzanne J. E.; Liskamp, Rob M. J. “Convergent Synthesis and Diversity of Amino Acid based Dendrimers.” European Journal of Organic Chemistry, 2001, 10, 1903-1915.
 
Monnee, Menno C. F.; Brouwer, Arwin J.; Verbeek, Linda M.; van Wageningen, Andre M.; Liskamp, Rob M. J. “Bio-inspired Synthetic Receptor Molecules towards Mimicry of Vancomycin.” Bioorganic & Medicinal Chemistry Letters, 2001, 11, 1521-5.
 
Liskamp, Rob M. J.; Kruijtzer, John A. W.; Hofmeyer, Lovina J. F.; Boeijen, Astrid; Brouwer, Arwin J.; Monnee, Menno C. F.“Peptide Transformation and Synthesis of Oligopeptidomimetics.” Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9-14, 2001, 232-233.
 
Monnee, Menno C. F.; Marijne, Michael F.; Brouwer, Arwin J.; Liskamp, Rob M. J. “A Practical Solid Phase Synthesis of Oligopeptidosulfonamide Foldamers. Tetrahedron Letters, 2000, 41, 7991-7995, Tetrahedron Letters 2001, 42, 965.
 
Brouwer, Arwin J.; Monnee, Menno C. F.; Liskamp, Rob M. J. “An Efficient Synthesis of N-protected b-aminoethanesulfonyl Chlorides: Versatile Building Blocks for the Synthesis of Oligopeptidosulfonamides. Synthesis, 2000, 11, 1579-1584.
 
Brouwer, Arwin J.; van der Linden, Heiko J.; Liskamp, Rob M. J. “Combinatorial Chemistry for Ligand Development in Catalysis: Synthesis and Catalysis Screening of Peptidosulfonamide Tweezers on the Solid Phase. Journal of Organic Chemistry, 2000, 65, 1750-1757.
 
Gossage, Robert A.; Jastrzebski, Johann T. B. H.; Van Ameijde, Jeroen; Mulders, Suzanne J. E.; Brouwer, Arwin J.; Liskamp, Rob M. J.; Van Koten, Gerard. “Synthesis and Catalytic Application of Amino Acid based Dendritic Macromolecules. Tetrahedron Letters, 1999, 40, 1413-1416.
 
Lowik, Dennis W. P. M.; Weingarten, M. David; Broekema, Matthias; Brouwer, Arwin J.; Still, W. Clark; Liskamp, Rob. M. J. “Tweezers with Different Bite: Increasing the Affinity of Synthetic Receptors by Varying the Hinge Part. Angewandte Chemie, International Edition, 1998, 37, 1846-1850.
 
Mulders, Suzanne J. E.; Brouwer, Arwin J.; Kimkes, Peter; Sudholter, Ernst J. R.; Liskamp, Rob M. J. “Sizing of Amino Acid based Dendrimers in Langmuir Monolayers. Journal of the Chemical Society, Perkin Transactions 2, 1998, 7, 1535-1538.
 
Mulders, Suzanne J. E.; Brouwer, Arwin J.; Liskamp, Rob M. J. “Molecular Diversity of Novel Amino Acid based Dendrimers.Tetrahedron Letters, 1997, 38, 3085-3088.
 
Mulders, Suzanne J. E.; Brouwer, Arwin J.; van der Meer, Peter G. J.; Liskamp, Rob M. J. "Synthesis of a Novel Amino Acid based Dendrimer. Tetrahedron Letters, 1997, 38, 631-634.