Dr. A.I.P.M. (Toon) de Kroon

Dr. A.I.P.M. (Toon) de Kroon

Associate Professor
Membrane Biochemistry & Biophysics
+31 30 253 3424
a.i.p.m.dekroon@uu.nl

Publications

2021

Scholarly publications

Renne, M. F., Bao, X., Hokken, M. W., Bierhuizen, A. S., Hermansson, M., Sprenger, R. R., Ewing, T. A., Ma, X., Cox, R. C., Brouwers, J. F., De Smet, C. H., Ejsing, C. S., & de Kroon, A. I. (2021). Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids. EMBO Journal, 41(2), 1-16. [e106837]. https://doi.org/10.15252/embj.2020106837
Bao, X., Koorengevel, M. C., Groot Koerkamp, M. J. A., Homavar, A., Weijn, A., Crielaard, S., Renne, M. F., Lorent, J. H., Geerts, W. J. C., Surma, M. A., Mari, M., Holstege, F. C. P., Klose, C., & de Kroon, A. I. P. M. (2021). Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast. EMBO Journal, 40(20), 1-26. [e107966]. https://doi.org/10.15252/embj.2021107966

2020

Scholarly publications

Renne, M. F., Bao, X., & de Kroon, A. I. P. M. (2020). Water soluble lipid precursor contaminants in yeast culture medium ingredients. FEMS Yeast Research, 20(5), [foaa029]. https://doi.org/10.1093/femsyr/foaa029
Pawlik, G., Renne, M. F., Kol, M. A., & de Kroon, A. I. P. M. (2020). The topology of the ER-resident phospholipid methyltransferase Opi3 of Saccharomyces cerevisiae is consistent with in trans catalysis. Journal of Biological Chemistry, 295(8), 2473-2482. https://doi.org/10.1074/jbc.RA119.011102
Li, M., Ingmar van Raath, M., Khakpour, S., Seçilir, A., Sliggers, B. C., Huang, X., Ding, B., Storm, G., van der Hulst, R. R., de Kroon, A. I. P. M., & Heger, M. (2020). In vivo assessment of thermosensitive liposomes for the treatment of port wine stains by antifibrinolytic site-specific pharmaco-laser therapy. Pharmaceutics, 12(6), [591]. https://doi.org/10.3390/pharmaceutics12060591
Patton-Vogt, J., & de Kroon, A. I. P. M. (2020). Phospholipid turnover and acyl chain remodeling in the yeast ER. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865(1), 1-8. [158462]. https://doi.org/10.1016/j.bbalip.2019.05.006

2019

Scholarly publications

Anaokar, S., Kodali, R., Jonik, B., Renne, M. F., Brouwers, J. F. H. M., Lager, I., de Kroon, A. I. P. M., & Patton-Vogt, J. (2019). The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast. Journal of Biological Chemistry, 294(4), 1189-1201. https://doi.org/10.1074/jbc.RA118.005232

2018

Scholarly publications

Henrich, E., Löhr, F., Pawlik, G., Peetz, O., Dötsch, V., Morgner, N., De Kroon, A. I., & Bernhard, F. (2018). Lipid Conversion by Cell-Free Synthesized Phospholipid Methyltransferase Opi3 in Defined Nanodisc Membranes Supports an in Trans Mechanism. Biochemistry, 57(40), 5780-5784. https://doi.org/10.1021/acs.biochem.8b00807
Renne, M. F., & de Kroon, A. I. P. M. (2018). The role of phospholipid molecular species in determining the physical properties of yeast membranes. FEBS Letters, 592(8), 1330-1345. https://doi.org/10.1002/1873-3468.12944

2017

Scholarly publications

de Kroon, A. I. P. M. (2017). Lipidomics in research on yeast membrane lipid homeostasis. Biochimica et Biophysica Acta, 1862(8), 797-799. https://doi.org/10.1016/j.bbalip.2017.02.007

2016

Scholarly publications

Van Raath, M. I., Weijer, R., Nguyen, G. H., Choi, B., De Kroon, A. I., & Heger, M. (2016). Tranexamic acid-encapsulating thermosensitive liposomes for site-specific pharmaco-laser therapy of port wine stains. Journal of Biomedical Nanotechnology, 12(8), 1617-1640. https://doi.org/10.1166/jbn.2016.2277
Renne, M. F., Bao, X., De Smet, C. H., & de Kroon, A. I. P. M. (2016). Lipid Acyl Chain Remodeling in Yeast. Lipid Insights, 8(Suppl 1), 33-40. https://doi.org/10.4137/LPI.S31780

2015

Scholarly publications

Furse, S., & De Kroon, A. I. P. M. (2015). Phosphatidylcholine's functions beyond that of a membrane brick. Molecular Membrane Biology, 32(4), 117-119. https://doi.org/10.3109/09687688.2015.1066894
Furse, S., Wienk, H., Boelens, R., de Kroon, A. I. P. M., & Killian, J. A. (2015). E. coli MG1655 modulates its phospholipid composition through the cell cycle. FEBS Letters, 589(19), 2726-2730. https://doi.org/10.1016/j.febslet.2015.07.043

2014

Scholarly publications

Marques-Gallego, P., & de Kroon, A. I. P. M. (2014). Ligation Strategies for Targeting Liposomal Nanocarriers. BioMed Research International, [129458]. https://doi.org/10.1155/2014/129458

2013

Scholarly publications

Broekgaarden, M., de Kroon, A. I. P. M., van Gulik, T. M., & Heger, M. (2013). Development and In Vitro Proof-of-Concept of Interstitially Targeted Zinc- Phthalocyanine Liposomes for Photodynamic Therapy. Current Medicinal Chemistry, 21(3), 377-391. https://doi.org/10.2174/09298673113209990211
Tavassoli, S., Chao, J. T., Young, B. P., Cox, R. C., Prinz, W. A., de Kroon, A. I. P. M., & Loewen, C. I. R. (2013). Plasma membrane—endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis. EMBO Reports, 14, 434-440. https://doi.org/10.1038/embor.2013.36
de Kroon, A. I. P. M., Rijken, P. J., & De Smet, C. H. (2013). Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective. Progress in Lipid Research, 52(4), 374-394. https://doi.org/10.1016/j.plipres.2013.04.006
De Smet, C. H., Cox, R., Brouwers, J. F. H. M., & de Kroon, A. I. P. M. (2013). Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1831(6), 1167-1176. https://doi.org/10.1016/j.bbalip.2013.03.002

2012

Scholarly publications

Broekgaarden, M., Van Vught, R., De Kroon, A. I. P. M., Breukink, E., Van Gulik, T. M., & Heger, M. (2012). Assessment of in vitro efficiency of multi-targeting liposomes containing zinc-phthalocyanine for photodynamic therapy. Lasers in Surgery and Medicine, 44, 38-39. https://doi.org/10.1002/lsm.22023
De Smet, C. H., Vittone, E., Scherer, M., Houweling, M., Liebisch, G., Brouwers, J. F. H. M., & de Kroon, T. (2012). The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p. Molecular Biology of the Cell, Apr; 23((7)), 1146-1156. https://doi.org/10.1091/mbc.E11-07-0624

2011

Scholarly publications

Bilgin, M., Markgraf, D. F., Duchoslav, E., Knudsen, J., Jensen, O. N., de Kroon, A. I. P. M., & Ejsing, C. S. (2011). Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: a tool for monitoring PE metabolism. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1811(12), 1091-1089. https://doi.org/10.1016/j.bbalip.2011.09.018

2010

Scholarly publications

Gubbens, J., & de Kroon, A. I. P. M. (2010). Proteome-wide detection of phospholipid-protein interactions in mitochondria by photocrosslinking and click chemistry. Molecular BioSystems, 6(10), 1751-1759. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956516299&partnerID=40&md5=9a525e73a7c3b399b2efc8f19b0aac0a
van Gestel, R. A., Rijken, P. J., Surinova, S., O'Flaherty, M., Heck, A. J. R., Killian, J. A., de Kroon, A. I. P. M., & Slijper, M. (2010). The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; An unexpected effect of cardiolipin in α-ketoglutarate dehydrogenase and prohibitin complexes. Journal of Proteomics, 73(4), 806-814. http://www.scopus.com/inward/record.url?eid=2-s2.0-74849123638&partnerID=40&md5=8d25891dcf14b62fd2c86c96c3373efa
van Meer, G., & de Kroon, A. I. P. M. (2010). Lipid map of the mammalian cell. Journal of Cell Science, 124, 5-8.
https://dspace.library.uu.nl/bitstream/handle/1874/202651/Lipidmaoofthemammaliancell.pdf?sequence=1

2009

Scholarly publications

Hamelers, I. H. L., & de Kroon, A. I. P. M. (2009). Nanocapsules of platinum-based anticancer drugs. In A. Bonetti (Ed.), Platinum and other heavy metal compounds in cancer chemotherapy (pp. 27-32). (Cancer drug discovery and development). Humana Press.
Rijken, P. J., Houtkooper, R. H., Akbari, H., Brouwers, J. F. H. M., Koorengevel, M. C., de Kruijff, B., Frentzen, M., Vaz, F. M., & de Kroon, A. I. P. M. (2009). Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: New insights into acyl chain remodeling of cardiolipin. Journal of Biological Chemistry, 284(40), 27609-27619.
Bryde, S., & de Kroon, A. I. P. M. (2009). Nanocapsules of platinum anticancer drugs: development towards therapeutic use. Future medicinal chemistry, 8(1), 1467-1480.
Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma cells depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15(4), 1259-1268.
Heger, M., Salles, I. I., de Kroon, A. I. P. M., & Deckmyn, H. (2009). Platelets and PEGylated lecithin liposomes: When stealth is allegedly picked up on the radar (and eaten). Microvascular Research, 78(1), 1-3.
Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma celles depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15, 1259-1268.
Gubbens, J., Ruijter, E., Fays, L. E. V., Damen, J. M. A., de Kruijff, B., Slijper, M., Rijkers, D. T. S., Liskamp, R. M. J., & de Kroon, A. I. P. M. (2009). Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface. Chemistry & Biology, 16, 3-14.

2008

Scholarly publications

Gubbens, J., Slijper, M., de Kruijff, B., & de Kroon, A. I. P. M. (2008). Protein complexes in bacterial and yeast mitochondrial membranes differ in their sensitivity towards dissociation by SDS. Biochimica et Biophysica Acta, 1784(12), 2012-2018.
https://dspace.library.uu.nl/bitstream/handle/1874/32608/5Gubbens-Protein%2520complexes.pdf?sequence=1
Staffhorst, R. W. H. M., van der Born, K., Erkelens, C. A. M., Hamelers, I. H. L., Peters, G. J., Boven, E., & de Kroon, A. I. P. M. (2008). Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts. Anti-Cancer Drugs, 19(7), 721-727.
https://dspace.library.uu.nl/bitstream/handle/1874/33267/13Staffhorst-Antitumor%2520activity.pdf?sequence=1

2007

Scholarly publications

Hamelers, I. H. L., & de Kroon, A. I. P. M. (2007). Nanocapsules: a novel lipid formulation platform for platinum-based anti-cancer drugs. Journal of Liposome Research, 17, 183-189.
Hamelers, I. H. L., & de Kroon, A. I. P. M. (2007). Nanocapsules: a novel formulation technology for platinum-based anticancer drugs. Future Lipidology, 2, 445-453.
https://dspace.library.uu.nl/bitstream/handle/1874/26626/Hamelers-Nanocapsules%2520review%2520FL.pdf?sequence=1
Gubbens, J., Vader, P., Damen, J. M. A., O'Flaherty, M. C., Slijper, M., de Kruijff, B., & de Kroon, A. I. P. M. (2007). Probing the membrane interface-interacting proteome using photactivatable lipid cross-linkers. Journal of Proteome Research, 6, 1951-1962.
https://dspace.library.uu.nl/bitstream/handle/1874/26331/13_probing_gubbens.pdf?sequence=1
Rijken, P. J., de Kruijff, B., & de Kroon, A. I. P. M. (2007). Phosphatidylcholine is essential for efficient functioning of the mitochondrial glycerol-3-phosphate dehydrogenase Gut2 in Saccharomyces cerevisiae. Molecular Membrane Biology, 24, 269-281.
https://dspace.library.uu.nl/bitstream/handle/1874/26607/Rijken-Phosphatidylcholinepdf.pdf?sequence=1
de Kroon, A. I. P. M. (2007). Metabolism of phosphatidylcholine and its implications for lipid acyl chain composition in Saccharomyces cerevisiae. Biochimica et Biophysica Acta, 1771, 343-352.
https://dspace.library.uu.nl/bitstream/handle/1874/26600/DeKroon-metabolism.pdf?sequence=1

2006

Scholarly publications

Helleman, J., Burger, K. N. J., Hamelers, I. H. L., Boersma, A. W. M., de Kroon, A. I. P. M., Stoter, G., & Nooter, K. (2006). Impaired cisplatin influx in an A2780 mutant cell line. Cancer Biology & Therapy, 5(8), 943-949.
https://dspace.library.uu.nl/bitstream/handle/1874/19482/9%2520Helleman-Impaired%2520cisplatin.pdf?sequence=1
Boumann, H. A., Gubbens, J., Koorengevel, M. C., Oh, C-S., Martin, C. E., Heck, A. J. R., Patton-Vogt, J., Henry, S. A., de Kruijff, B., & de Kroon, A. I. P. M. (2006). Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote. Molecular Biology of the Cell, 17, 1006-1017.
https://dspace.library.uu.nl/bitstream/handle/1874/19761/Boumann-Depletion%2520of%2520phosphatidylcholine.pdf?sequence=1
de Kroon, A. I. P. M., Stafhorst, R. W. H. M., de Kruijff, B., & Burger, K. N. J. (2006). Nanocapsules: a new vehicle for intracellular delivery of drugs. In R. Harris (Ed.), Cell Biology Protocols (pp. 250-254). Wiley.
https://dspace.library.uu.nl/bitstream/handle/1874/19472/12%2520DeKroon-Nanocapsules.pdf?sequence=1
Hamelers, I. H. L., van Loenen, E., Staffhorst, R. W. H. M., de Kruijff, B., & de Kroon, A. I. P. M. (2006). Carboplatin nanocapsules: a highly cytotoxic, phospholipid-based formulation of carboplatin. Molecular Cancer Therapeutics, 2006, 2007-2012.
https://dspace.library.uu.nl/bitstream/handle/1874/25787/7%2520Hamelers-Carboplatin%2520nanocapsules.pdf?sequence=1

2005

Scholarly publications

de Kroon, A. I. P. M., Staffhorst, R. W. H. M., de Kruijff, B., & Burger, K. N. J. (2005). Cisplatin nanocapsules. Methods in Enzymology, 391, 118-125.
https://dspace.library.uu.nl/bitstream/handle/1874/7923/DeKroon-Cisplatin%2520nanocapsules.pdf?sequence=2
Boumann, H. A., & de Kroon, A. I. P. M. (2005). The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast. Biochemical Society Transactions, 33, 1146-1149.
https://dspace.library.uu.nl/bitstream/handle/1874/14737/Boumann-The%2520contributions.pdf?sequence=1

2004

Scholarly publications

Boumann, H. A., de Kruijff, B., Heck, A. J. R., & de Kroon, A. I. P. M. (2004). The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. FEBS Letters, 569, 173-177.
https://dspace.library.uu.nl/bitstream/handle/1874/14460/Boumann-The%2520selective%2520utilization.pdf?sequence=1
Kol, M. A., de Kroon, A. I. P. M., Killian, J. A., & de Kruijff, B. (2004). Transbilayer movement of phospholipids in biogenic membranes. Biochemistry, 43, 2673-2681.
https://dspace.library.uu.nl/bitstream/handle/1874/14618/Kol-Transbilayer%2520movement.pdf?sequence=1
Boumann, H. A., Chin, P. T. K., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2004). The yeast phospholipid N-methyltransferases catalyzing the synthesis of phosphatidylcholine preferentially convert di-C16:1 substrates both in vivo and in vitro. Journal of Biological Chemistry, 279, 40314-40319.
https://dspace.library.uu.nl/bitstream/handle/1874/14609/Boumann-The%2520yeast%2520phospholipid.pdf?sequence=1
Velinova, M. J., Staffhorst, R. W. H. M., Mulder, W. J. M., Dries, A. S., Jansen, B. A. J., de Kruijff, B., & de Kroon, A. I. P. M. (2004). Preparation and stability of lipid-coated nanocapsules of cisplatin: anionic phospholipid specificity. Biochimica et Biophysica Acta-Biomembranes, 1663, 135-142.
https://dspace.library.uu.nl/bitstream/handle/1874/14625/Velinova-Preparation%2520and%2520stability.pdf?sequence=1
Kol, M. A., Kuster, D. W. D., Boumann, H. A., de Cock, J. J. P. A., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2004). Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli. Biochimica et Biophysica Acta, 1636, 205-212.
https://dspace.library.uu.nl/bitstream/handle/1874/14638/Kol-Uptake%2520and%2520remodeling.pdf?sequence=1
Chupin, V. V., de Kroon, A. I. P. M., & de Kruijff, B. (2004). Molecular architecture of nanocapsules, bilayer enclosed solid particles of cisplatin. Journal of the American Chemical Society, 126, 13816-13821.
https://dspace.library.uu.nl/bitstream/handle/1874/14612/Chupin-Molecular%2520supp%2520inf.pdf?sequence=1

2003

Scholarly publications

Boumann, H. A., Damen, J. M. A., Versluis, C., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2003). The two biosynthetic routes leading to posphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling. Biochemistry, 42, 3054-3059.
https://dspace.library.uu.nl/bitstream/handle/1874/14364/Boumann-The%2520two%2520biosynthetic.pdf?sequence=1
Kol, M. A., van Dalen, A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Translocation of phospholipids is facilitated by a subset of membrane-spanning proteins of the bacterial cytoplasmic membrane. Journal of Biological Chemistry, 278, 24586-24593.
de Kroon, A. I. P. M., Koorengevel, M. C., Vromans, T. A. M., & de Kruijff, B. (2003). Continuous Equilibration of Phosphatidylcholine and Its Precursors between Endoplasmic Reticulum and Mitochondria in Yeast. Molecular Biology of the Cell, 14(5), 2142-2150. https://doi.org/10.1091/mbc.e02-08-0460
Kol, M. A., van Laak, A. N. C., Rijkers, D. T. S., Killian, J. A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. Biochemistry, 42, 231-237.

2002

Scholarly publications

Janssen, M. J. F. W., de Jong, H. M., de Kruijff, B., & de Kroon, A. I. P. M. (2002). Cooperative activity of phospholipid-N-methyltransferases localized in different membranes. FEBS Letters, 513, 197-202.
https://dspace.library.uu.nl/bitstream/handle/1874/14360/Janssen-Cooperative%2520activity.pdf?sequence=1
Kol, M. A., de Kruijff, B., & de Kroon, A. I. P. M. (2002). Phospholipid flip-flop in biogenic membranes: what is needed to connect opposite sides. Seminars in cell & developmental biology, 13, 163-170. https://www.sciencedirect.com/science/article/pii/S1084952102000447
Janssen, M. J. F. W., van Voorst, F., Ploeger, G. E. J., Mose Larsen, P., Larsen, M. R., de Kroon, A. I. P. M., & de Kruijff, B. (2002). Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria. Biochemistry, 41, 5702-5711. https://www.researchgate.net/publication/11389915_Photolabeling_Identifies_an_Interaction_between_Phosphatidylcholine_and_Glycerol-3-phosphate_Dehydrogenase_Gut2p_in_Yeast_Mitochondria
Janssen, M. J. F. W., de Kruijff, B., & de Kroon, A. I. P. M. (2002). Phosphate is required to maintain the outer membrane integrity and membrane potential of respiring yeast mitochondria. Analytical Biochemistry, 300, 27-33. https://www.sciencedirect.com/science/article/pii/S0003269701954387

Other output

Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2002). The transmembrane domains of membrane-spanning proteins induce phospholipid flop. 147a. Abstract from Unknown event, Asilomar, USA.

2001

Scholarly publications

de Kroon, A. I. P. M., Ahting, U., Niggemeyer, B., Neupert, W., de Kruijff, B., Lill, R., & Diekert, K. (2001). Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. EMBO Journal, 20, 5626-5635.
Diekert, K., de Kroon, A. I. P. M., Kispal, G., & Lill, R. (2001). Isolation and subfractionation of mitochondria from the yeast saccharomyces cerevisiae. Methods in Cell Biology, 20, 5626-5635.
Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2001). Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli. Biochemistry, 40, 10500-10506.

1992

Scholarly publications

Kruijff, B. D., Breukink, E., Demel, R. A., T Hof, R. V., Jongh, H. H. J. D., Jordi, W., Keller, R. C. A., Killian, J. A., Kroon, A. I. P. M. D., Kusters, R., & Pilon, M. (1992). Lipid involvement in protein translocation. New Comprehensive Biochemistry, 22(C), 85-101. https://doi.org/10.1016/S0167-7306(08)60085-X