Publications
2021
Scholarly publications
Renne, M. F., Bao, X., Hokken, M. W., Bierhuizen, A. S., Hermansson, M., Sprenger, R. R., Ewing, T. A., Ma, X.
, Cox, R. C., Brouwers, J. F., De Smet, C. H., Ejsing, C. S.
, & de Kroon, A. I. (2021).
Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids.
EMBO Journal,
41(2), 1-16. [e106837].
https://doi.org/10.15252/embj.2020106837 Bao, X., Koorengevel, M. C., Groot Koerkamp, M. J. A.
, Homavar, A., Weijn, A., Crielaard, S.
, Renne, M. F., Lorent, J. H., Geerts, W. J. C., Surma, M. A., Mari, M., Holstege, F. C. P., Klose, C.
, & de Kroon, A. I. P. M. (2021).
Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast.
EMBO Journal,
40(20), 1-26. [e107966].
https://doi.org/10.15252/embj.2021107966 2020
Scholarly publications
Renne, M. F., Bao, X., & de Kroon, A. I. P. M. (2020).
Water soluble lipid precursor contaminants in yeast culture medium ingredients.
FEMS Yeast Research,
20(5), [foaa029].
https://doi.org/10.1093/femsyr/foaa029 Pawlik, G., Renne, M. F., Kol, M. A., & de Kroon, A. I. P. M. (2020).
The topology of the ER-resident phospholipid methyltransferase Opi3 of Saccharomyces cerevisiae is consistent with in trans catalysis.
Journal of Biological Chemistry,
295(8), 2473-2482.
https://doi.org/10.1074/jbc.RA119.011102 Li, M., Ingmar van Raath, M., Khakpour, S., Seçilir, A., Sliggers, B. C., Huang, X., Ding, B.
, Storm, G., van der Hulst, R. R.
, de Kroon, A. I. P. M., & Heger, M. (2020).
In vivo assessment of thermosensitive liposomes for the treatment of port wine stains by antifibrinolytic site-specific pharmaco-laser therapy.
Pharmaceutics,
12(6), [591].
https://doi.org/10.3390/pharmaceutics12060591Patton-Vogt, J.
, & de Kroon, A. I. P. M. (2020).
Phospholipid turnover and acyl chain remodeling in the yeast ER.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids,
1865(1), 1-8. [158462].
https://doi.org/10.1016/j.bbalip.2019.05.0062019
Scholarly publications
Anaokar, S., Kodali, R., Jonik, B.
, Renne, M. F., Brouwers, J. F. H. M., Lager, I.
, de Kroon, A. I. P. M., & Patton-Vogt, J. (2019).
The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast.
Journal of Biological Chemistry,
294(4), 1189-1201.
https://doi.org/10.1074/jbc.RA118.0052322018
Scholarly publications
Henrich, E., Löhr, F.
, Pawlik, G., Peetz, O., Dötsch, V., Morgner, N.
, De Kroon, A. I., & Bernhard, F. (2018).
Lipid Conversion by Cell-Free Synthesized Phospholipid Methyltransferase Opi3 in Defined Nanodisc Membranes Supports an in Trans Mechanism.
Biochemistry,
57(40), 5780-5784.
https://doi.org/10.1021/acs.biochem.8b00807Renne, M. F., & de Kroon, A. I. P. M. (2018).
The role of phospholipid molecular species in determining the physical properties of yeast membranes.
FEBS Letters,
592(8), 1330-1345.
https://doi.org/10.1002/1873-3468.12944 2017
Scholarly publications
2016
Scholarly publications
Van Raath, M. I.
, Weijer, R., Nguyen, G. H., Choi, B.
, De Kroon, A. I., & Heger, M. (2016).
Tranexamic acid-encapsulating thermosensitive liposomes for site-specific pharmaco-laser therapy of port wine stains.
Journal of Biomedical Nanotechnology,
12(8), 1617-1640.
https://doi.org/10.1166/jbn.2016.2277Renne, M. F., Bao, X., De Smet, C. H., & de Kroon, A. I. P. M. (2016).
Lipid Acyl Chain Remodeling in Yeast.
Lipid Insights,
8(Suppl 1), 33-40.
https://doi.org/10.4137/LPI.S31780 2015
Scholarly publications
Furse, S., Wienk, H., Boelens, R., de Kroon, A. I. P. M., & Killian, J. A. (2015).
E. coli MG1655 modulates its phospholipid composition through the cell cycle.
FEBS Letters,
589(19), 2726-2730.
https://doi.org/10.1016/j.febslet.2015.07.043 2014
Scholarly publications
Marques-Gallego, P., & de Kroon, A. I. P. M. (2014).
Ligation Strategies for Targeting Liposomal Nanocarriers.
BioMed Research International, [129458].
https://doi.org/10.1155/2014/129458 2013
Scholarly publications
Broekgaarden, M., de Kroon, A. I. P. M., van Gulik, T. M.
, & Heger, M. (2013).
Development and In Vitro Proof-of-Concept of Interstitially Targeted Zinc- Phthalocyanine Liposomes for Photodynamic Therapy.
Current Medicinal Chemistry,
21(3), 377-391.
https://doi.org/10.2174/09298673113209990211 Tavassoli, S., Chao, J. T., Young, B. P.
, Cox, R. C., Prinz, W. A.
, de Kroon, A. I. P. M., & Loewen, C. I. R. (2013).
Plasma membrane—endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis.
EMBO Reports,
14, 434-440.
https://doi.org/10.1038/embor.2013.36de Kroon, A. I. P. M., Rijken, P. J., & De Smet, C. H. (2013).
Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective.
Progress in Lipid Research,
52(4), 374-394.
https://doi.org/10.1016/j.plipres.2013.04.006 De Smet, C. H., Cox, R.
, Brouwers, J. F. H. M., & de Kroon, A. I. P. M. (2013).
Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids,
1831(6), 1167-1176.
https://doi.org/10.1016/j.bbalip.2013.03.002 2012
Scholarly publications
Broekgaarden, M., Van Vught, R., De Kroon, A. I. P. M., Breukink, E., Van Gulik, T. M.
, & Heger, M. (2012).
Assessment of in vitro efficiency of multi-targeting liposomes containing zinc-phthalocyanine for photodynamic therapy.
Lasers in Surgery and Medicine,
44, 38-39.
https://doi.org/10.1002/lsm.22023 De Smet, C. H., Vittone, E., Scherer, M.
, Houweling, M., Liebisch, G.
, Brouwers, J. F. H. M., & de Kroon, T. (2012).
The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p. Molecular Biology of the Cell,
Apr; 23((7)), 1146-1156.
https://doi.org/10.1091/mbc.E11-07-0624 2011
Scholarly publications
Bilgin, M., Markgraf, D. F., Duchoslav, E., Knudsen, J., Jensen, O. N.
, de Kroon, A. I. P. M., & Ejsing, C. S. (2011).
Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: a tool for monitoring PE metabolism.
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids,
1811(12), 1091-1089.
https://doi.org/10.1016/j.bbalip.2011.09.018 2010
Scholarly publications
van Gestel, R. A., Rijken, P. J., Surinova, S., O'Flaherty, M.
, Heck, A. J. R., Killian, J. A., de Kroon, A. I. P. M., & Slijper, M. (2010).
The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; An unexpected effect of cardiolipin in α-ketoglutarate dehydrogenase and prohibitin complexes.
Journal of Proteomics,
73(4), 806-814.
http://www.scopus.com/inward/record.url?eid=2-s2.0-74849123638&partnerID=40&md5=8d25891dcf14b62fd2c86c96c3373efa 2009
Scholarly publications
Hamelers, I. H. L., & de Kroon, A. I. P. M. (2009). Nanocapsules of platinum-based anticancer drugs. In A. Bonetti (Ed.), Platinum and other heavy metal compounds in cancer chemotherapy (pp. 27-32). (Cancer drug discovery and development). Humana Press.
Rijken, P. J., Houtkooper, R. H., Akbari, H., Brouwers, J. F. H. M., Koorengevel, M. C., de Kruijff, B., Frentzen, M., Vaz, F. M., & de Kroon, A. I. P. M. (2009). Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: New insights into acyl chain remodeling of cardiolipin. Journal of Biological Chemistry, 284(40), 27609-27619.
Bryde, S., & de Kroon, A. I. P. M. (2009). Nanocapsules of platinum anticancer drugs: development towards therapeutic use. Future medicinal chemistry, 8(1), 1467-1480.
Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma cells depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15(4), 1259-1268.
Heger, M., Salles, I. I., de Kroon, A. I. P. M., & Deckmyn, H. (2009). Platelets and PEGylated lecithin liposomes: When stealth is allegedly picked up on the radar (and eaten). Microvascular Research, 78(1), 1-3.
Hamelers, I. H. L., Staffhorst, R. W. H. M., Voortman, J., de Kruijff, B., Reedijk, J., van Bergen en Henegouwen, P. M. P., & de Kroon, A. I. P. M. (2009). High cytotoxicity of cisplatin nanocapsules in ovarian carcinoma celles depends on uptake by caveolae-mediated endocytosis. Clinical Cancer Research, 15, 1259-1268.
Gubbens, J., Ruijter, E., Fays, L. E. V., Damen, J. M. A., de Kruijff, B., Slijper, M., Rijkers, D. T. S., Liskamp, R. M. J., & de Kroon, A. I. P. M. (2009). Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface. Chemistry & Biology, 16, 3-14.
2008
Scholarly publications
Staffhorst, R. W. H. M., van der Born, K., Erkelens, C. A. M.
, Hamelers, I. H. L., Peters, G. J., Boven, E.
, & de Kroon, A. I. P. M. (2008).
Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts.
Anti-Cancer Drugs,
19(7), 721-727.
https://dspace.library.uu.nl/bitstream/handle/1874/33267/13Staffhorst-Antitumor%2520activity.pdf?sequence=12007
Scholarly publications
Hamelers, I. H. L., & de Kroon, A. I. P. M. (2007). Nanocapsules: a novel lipid formulation platform for platinum-based anti-cancer drugs. Journal of Liposome Research, 17, 183-189.
Gubbens, J., Vader, P., Damen, J. M. A., O'Flaherty, M. C.
, Slijper, M., de Kruijff, B., & de Kroon, A. I. P. M. (2007).
Probing the membrane interface-interacting proteome using photactivatable lipid cross-linkers.
Journal of Proteome Research,
6, 1951-1962.
https://dspace.library.uu.nl/bitstream/handle/1874/26331/13_probing_gubbens.pdf?sequence=1 2006
Scholarly publications
Helleman, J.
, Burger, K. N. J., Hamelers, I. H. L., Boersma, A. W. M.
, de Kroon, A. I. P. M., Stoter, G., & Nooter, K. (2006).
Impaired cisplatin influx in an A2780 mutant cell line.
Cancer Biology & Therapy,
5(8), 943-949.
https://dspace.library.uu.nl/bitstream/handle/1874/19482/9%2520Helleman-Impaired%2520cisplatin.pdf?sequence=1Boumann, H. A.
, Gubbens, J., Koorengevel, M. C., Oh, C-S., Martin, C. E.
, Heck, A. J. R., Patton-Vogt, J., Henry, S. A.
, de Kruijff, B., & de Kroon, A. I. P. M. (2006).
Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote.
Molecular Biology of the Cell,
17, 1006-1017.
https://dspace.library.uu.nl/bitstream/handle/1874/19761/Boumann-Depletion%2520of%2520phosphatidylcholine.pdf?sequence=1Hamelers, I. H. L., van Loenen, E., Staffhorst, R. W. H. M.
, de Kruijff, B., & de Kroon, A. I. P. M. (2006).
Carboplatin nanocapsules: a highly cytotoxic, phospholipid-based formulation of carboplatin.
Molecular Cancer Therapeutics,
2006, 2007-2012.
https://dspace.library.uu.nl/bitstream/handle/1874/25787/7%2520Hamelers-Carboplatin%2520nanocapsules.pdf?sequence=1 2005
Scholarly publications
2004
Scholarly publications
Boumann, H. A.
, Chin, P. T. K., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2004).
The yeast phospholipid N-methyltransferases catalyzing the synthesis of phosphatidylcholine preferentially convert di-C16:1 substrates both in vivo and in vitro.
Journal of Biological Chemistry,
279, 40314-40319.
https://dspace.library.uu.nl/bitstream/handle/1874/14609/Boumann-The%2520yeast%2520phospholipid.pdf?sequence=1Velinova, M. J., Staffhorst, R. W. H. M.
, Mulder, W. J. M., Dries, A. S., Jansen, B. A. J.
, de Kruijff, B., & de Kroon, A. I. P. M. (2004).
Preparation and stability of lipid-coated nanocapsules of cisplatin: anionic phospholipid specificity.
Biochimica et Biophysica Acta-Biomembranes,
1663, 135-142.
https://dspace.library.uu.nl/bitstream/handle/1874/14625/Velinova-Preparation%2520and%2520stability.pdf?sequence=1Kol, M. A., Kuster, D. W. D., Boumann, H. A.
, de Cock, J. J. P. A., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2004).
Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli.
Biochimica et Biophysica Acta,
1636, 205-212.
https://dspace.library.uu.nl/bitstream/handle/1874/14638/Kol-Uptake%2520and%2520remodeling.pdf?sequence=1 2003
Scholarly publications
Boumann, H. A.
, Damen, J. M. A., Versluis, C., Heck, A. J. R., de Kruijff, B., & de Kroon, A. I. P. M. (2003).
The two biosynthetic routes leading to posphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling.
Biochemistry,
42, 3054-3059.
https://dspace.library.uu.nl/bitstream/handle/1874/14364/Boumann-The%2520two%2520biosynthetic.pdf?sequence=1Kol, M. A., van Dalen, A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Translocation of phospholipids is facilitated by a subset of membrane-spanning proteins of the bacterial cytoplasmic membrane. Journal of Biological Chemistry, 278, 24586-24593.
de Kroon, A. I. P. M., Koorengevel, M. C., Vromans, T. A. M.
, & de Kruijff, B. (2003).
Continuous Equilibration of Phosphatidylcholine and Its Precursors between Endoplasmic Reticulum and Mitochondria in Yeast.
Molecular Biology of the Cell,
14(5), 2142-2150.
https://doi.org/10.1091/mbc.e02-08-0460 Kol, M. A., van Laak, A. N. C., Rijkers, D. T. S., Killian, J. A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. Biochemistry, 42, 231-237.
2002
Scholarly publications
Janssen, M. J. F. W., van Voorst, F., Ploeger, G. E. J., Mose Larsen, P., Larsen, M. R.
, de Kroon, A. I. P. M., & de Kruijff, B. (2002).
Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase (Gut2p) in yeast mitochondria.
Biochemistry,
41, 5702-5711.
https://www.researchgate.net/publication/11389915_Photolabeling_Identifies_an_Interaction_between_Phosphatidylcholine_and_Glycerol-3-phosphate_Dehydrogenase_Gut2p_in_Yeast_MitochondriaOther output
Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2002). The transmembrane domains of membrane-spanning proteins induce phospholipid flop. 147a. Abstract from Unknown event, Asilomar, USA.
2001
Scholarly publications
de Kroon, A. I. P. M., Ahting, U., Niggemeyer, B., Neupert, W., de Kruijff, B., Lill, R., & Diekert, K. (2001). Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. EMBO Journal, 20, 5626-5635.
Diekert, K., de Kroon, A. I. P. M., Kispal, G., & Lill, R. (2001). Isolation and subfractionation of mitochondria from the yeast saccharomyces cerevisiae. Methods in Cell Biology, 20, 5626-5635.
Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2001). Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli. Biochemistry, 40, 10500-10506.
1992
Scholarly publications
Kruijff, B. D., Breukink, E., Demel, R. A., T Hof, R. V., Jongh, H. H. J. D., Jordi, W., Keller, R. C. A.
, Killian, J. A., Kroon, A. I. P. M. D., Kusters, R., & Pilon, M. (1992).
Lipid involvement in protein translocation.
New Comprehensive Biochemistry,
22(C), 85-101.
https://doi.org/10.1016/S0167-7306(08)60085-X