Prof. dr. ir. W.E. (Wim) Hennink

Hans Freudenthalgebouw
Budapestlaan 6
3584 CD Utrecht

Prof. dr. ir. W.E. (Wim) Hennink

Emeritus
Pharmaceutics
w.e.hennink@uu.nl

Publicaties

2023

Wetenschappelijke publicaties

Douka, S., Brandenburg, L. E., Casadidio, C., Walther, J., Garcia, B. B. M., Spanholtz, J., Raimo, M., Hennink, W. E., Mastrobattista, E., & Caiazzo, M. (2023). Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells. Journal of controlled release : official journal of the Controlled Release Society, 361, 455-469. https://doi.org/10.1016/j.jconrel.2023.08.014
Ilochonwu, B. C., van der Lugt, S. A., Annala, A., Di Marco, G., Sampon, T., Siepmann, J., Siepmann, F., Hennink, W. E., & Vermonden, T. (2023). Thermo-responsive Diels-Alder stabilized hydrogels for ocular drug delivery of a corticosteroid and an anti-VEGF fab fragment. Journal of controlled release : official journal of the Controlled Release Society, 361, 334-349. https://doi.org/10.1016/j.jconrel.2023.07.052
Liu, M., Lau, C. Y. J., Cabello, I. T., Garssen, J., Willemsen, L. E. M., Hennink, W. E., & van Nostrum, C. F. (2023). Live Cell Imaging by Förster Resonance Energy Transfer Fluorescence to Study Trafficking of PLGA Nanoparticles and the Release of a Loaded Peptide in Dendritic Cells. Pharmaceuticals (Basel, Switzerland), 16(6). https://doi.org/10.3390/ph16060818
Rooimans, T., Damen, M., Markesteijn, C. M. A., Schuurmans, C. C. L., de Zoete, N. H. C., van Hasselt, P. M., Hennink, W. E., van Nostrum, C. F., Hermes, M., Besseling, R., & Vromans, H. (2023). Development of a compounded propofol nanoemulsion using multiple non-invasive process analytical technologies. International Journal of Pharmaceutics, 640, [122960]. https://doi.org/10.1016/j.ijpharm.2023.122960
Casadidio, C., Mayol, L., Biondi, M., Scuri, S., Cortese, M., Hennink, W. E., Vermonden, T., De Rosa, G., Di Martino, P., & Censi, R. (2023). Anionic polysaccharides for stabilization and sustained release of antimicrobial peptides. International Journal of Pharmaceutics, 636, [122798]. https://doi.org/10.1016/j.ijpharm.2023.122798
Yanev, P., van Tilborg, G. A. F., Boere, K. W. M., Stowe, A. M., van der Toorn, A., Viergever, M. A., Hennink, W. E., Vermonden, T., & Dijkhuizen, R. M. (2023). Thermosensitive Biodegradable Hydrogels for Local and Controlled Cerebral Delivery of Proteins: MRI-Based Monitoring of In Vitro and In Vivo Protein Release. ACS Biomaterials Science and Engineering, 9(2), 760-772. https://doi.org/10.1021/acsbiomaterials.2c01224
Liu, M., Thijssen, S., Hennink, W. E., Garssen, J., van Nostrum, C. F., & Willemsen, L. E. M. (2023). Oral pretreatment with β-lactoglobulin derived peptide and CpG co-encapsulated in PLGA nanoparticles prior to sensitizations attenuates cow's milk allergy development in mice. Frontiers in Immunology, 13, [1053107]. https://doi.org/10.3389/fimmu.2022.1053107

Vakpublicaties

Annala, A., Ilochonwu, B. C., Wilbie, D., Sadeghi, A., Hennink, W. E., & Vermonden, T. (2023). Self-Healing Thermosensitive Hydrogel for Sustained Release of Dexamethasone for Ocular Therapy. ACS Polymers Au, 3(1), 118-131. https://doi.org/10.1021/acspolymersau.2c00038

2022

Wetenschappelijke publicaties

Varela-Moreira, A., van Leur, H., Krijgsman, D., Ecker, V., Braun, M., Buchner, M., Fens, M. H. A. M., Hennink, W. E., & Schiffelers, R. M. (2022). Utilizing in vitro drug release assays to predict in vivo drug retention in micelles. International Journal of Pharmaceutics, 618, 1-10. [121638]. https://doi.org/10.1016/j.ijpharm.2022.121638
Rijcken, C. J. F., De Lorenzi, F., Biancacci, I., Hanssen, R. G. J. M., Thewissen, M., Hu, Q., Atrafi, F., Liskamp, R. M. J., Mathijssen, R. H. J., Miedema, I. H. C., Menke - van der Houven van Oordt, C. W., van Dongen, G. A. M. S., Vugts, D. J., Timmers, M., Hennink, W. E., & Lammers, T. (2022). Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles. Advanced Drug Delivery Reviews, 191, 1-19. [114613]. https://doi.org/10.1016/j.addr.2022.114613
Mesquita, B. S., Fens, M. H. A. M., Di Maggio, A., Bosman, E. D. C., Hennink, W. E., Heger, M., & Oliveira, S. (2022). The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes. International Journal of Molecular Sciences, 23(23), 1-19. https://doi.org/10.3390/ijms232314974
Biancacci, I., De Lorenzi, F., Theek, B., Bai, X., May, J. N., Consolino, L., Baues, M., Moeckel, D., Gremse, F., von Stillfried, S., El Shafei, A., Benderski, K., Azadkhah Shalmani, A., Wang, A., Momoh, J., Peña, Q., Buhl, E. M., Buyel, J., Hennink, W., ... Lammers, T. (2022). Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles. Advanced Science, 9(10), 1-9. [2103745]. https://doi.org/10.1002/advs.202103745
Timmers, M., Weterings, J., Van Geijn, M., Bell, R., Lenting, P. E., Rijcken, C. J. F., Vermonden, T., Hennink, W. E., & Liskamp, R. M. J. (2022). A New Class of Tunable Acid-Sensitive Linkers for Native Drug Release Based on the Trityl Protecting Group. Bioconjugate Chemistry, 33(9), 1707-1715. https://doi.org/10.1021/acs.bioconjchem.2c00310
van Nostrum, C. F., Lammers, T., & Hennink, W. E. (2022). Questionable micelle formation of the double hydrophilic block copolymer PEG-pHPMA. International Journal of Pharmaceutics, 626, 1-3. [122147]. https://doi.org/10.1016/j.ijpharm.2022.122147
https://dspace.library.uu.nl/bitstream/handle/1874/423376/1_s2.0_S0378517322007013_main.pdf?sequence=1
Wang, Y., Fens, M. H., van Kronenburg, N. C. H., Shi, Y., Lammers, T., Heger, M., van Nostrum, C. F., & Hennink, W. E. (2022). Magnetic beads for the evaluation of drug release from biotinylated polymeric micelles in biological media. Journal of controlled release : official journal of the Controlled Release Society, 349, 954-962. https://doi.org/10.1016/j.jconrel.2022.07.044
Bagheri, M., van Nostrum, C. F., Kok, R. J., Storm, G., Hennink, W. E., & Heger, M. (2022). Utility of Intravenous Curcumin Nanodelivery Systems for Improving In Vivo Pharmacokinetics and Anticancer Pharmacodynamics. Molecular Pharmaceutics, 19(9), 3057–3074. https://doi.org/10.1021/acs.molpharmaceut.2c00455
Ilochonwu, B. C., Mihajlovic, M., Maas-Bakker, R. F., Rousou, C., Tang, M., Chen, M., Hennink, W. E., & Vermonden, T. (2022). Hyaluronic Acid-PEG-Based Diels-Alder In Situ Forming Hydrogels for Sustained Intraocular Delivery of Bevacizumab. Biomacromolecules, 23(7), 2914-2929. https://doi.org/10.1021/acs.biomac.2c00383
Lau, C. Y. J., Benne, N., Lou, B., Zharkova, O., Ting, H. J., Ter Braake, D., van Kronenburg, N., Fens, M. H., Broere, F., Hennink, W. E., Wang, J-W., & Mastrobattista, E. (2022). Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction. Journal of controlled release : official journal of the Controlled Release Society, 348, 938-950. https://doi.org/10.1016/j.jconrel.2022.06.025
Lau, C. Y. J., Benne, N., Lou, B., Braake, D. T., Bosman, E., van Kronenburg, N., Fens, M., Broere, F., Hennink, W. E., & Mastrobattista, E. (2022). Tuning surface charges of peptide nanofibers for induction of antigen-specific immune tolerance: an introductory study. Journal of Pharmaceutical Sciences, 111(4), 1004-1011. https://doi.org/10.1016/j.xphs.2022.01.030
Wang, Y., Thies-Weesie, D. M. E., Bosman, E. D. C., van Steenbergen, M. J., van den Dikkenberg, J., Shi, Y., Lammers, T., van Nostrum, C. F., & Hennink, W. E. (2022). Tuning the size of all-HPMA polymeric micelles fabricated by solvent extraction. Journal of controlled release : official journal of the Controlled Release Society, 343, 338-346. https://doi.org/10.1016/j.jconrel.2022.01.042

2021

Wetenschappelijke publicaties

Lou, B., Lau, C. Y. J., Hennink, W. E., & Mastrobattista, E. (2021). Preparation of mRNA Polyplexes with Post-conjugated Endosome-Disruptive Peptides. In W. M. Hussein, R. J. Stephenson, & I. Toth (Eds.), Peptide Conjugation: Methods and Protocols (1 ed., pp. 275-286). (Methods in Molecular Biology; Vol. 2355). Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1617-8_21
Levey, R. E., Coulter, F. B., Scheiner, K. C., Deotti, S., Robinson, S. T., McDonough, L., Nguyen, T. T., Steendam, R., Canney, M., Wylie, R., Burke, L. P., Dolan, E. B., Dockery, P., Kelly, H. M., Ghersi, G., Hennink, W. E., Kok, R. J., O'Cearbhaill, E., & Duffy, G. P. (2021). Assessing the Effects of VEGF Releasing Microspheres on the Angiogenic and Foreign Body Response to a 3D Printed Silicone-Based Macroencapsulation Device. Pharmaceutics, 13(12), 1-16. [2077]. https://doi.org/10.3390/pharmaceutics13122077
Su, X., Ramírez-Escudero, M., Sun, F., van den Dikkenberg, J. B., van Steenbergen, M. J., Pieters, R. J., Janssen, B. J. C., van Hasselt, P. M., Hennink, W. E., & van Nostrum, C. F. (2021). Internalization and transport of PEGylated lipid-based mixed micelles across Caco-2 cells mediated by scavenger receptor B1. Pharmaceutics, 13(12), 1-22. [2022]. https://doi.org/10.3390/pharmaceutics13122022
Schuurmans, C. C. L., Brouwer, A. J., Jong, J. A. W., Boons, G-J. P. H., Hennink, W. E., & Vermonden, T. (2021). Hydrolytic (In)stability of Methacrylate Esters in Covalently Cross-Linked Hydrogels Based on Chondroitin Sulfate and Hyaluronic Acid Methacrylate. ACS Omega, 6(40), 26302-26310. https://doi.org/10.1021/acsomega.1c03395
Lipophilic Drug Delivery Despite Cholestasis Study Group (2021). Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions. Gastroenterology, 161(3), 1056-1059.e5. https://doi.org/10.1053/j.gastro.2021.05.056
Driest, P. J., Jong, J. A. W., Smakman, R., Moret, M-E., Verhaar, M. C., Hennink, W. E., Gerritsen, K. G. F., & van Nostrum, C. F. (2021). Correction to "Reactivity of (Vicinal) Carbonyl Compounds with Urea". ACS Omega, 6(31), 20719-20721. https://doi.org/10.1021/acsomega.1c03307
Geremia, I., A.W. Jong, J., van Nostrum, C. F., Hennink, W. E., G.F. Gerritsen, K., & Stamatialis, D. (2021). New mixed matrix membrane for the removal of urea from dialysate solution. Separation and Purification Technology, 277, 1-6. [119408]. https://doi.org/10.1016/j.seppur.2021.119408
Beltrán Hernández, I., Grinwis, G. C. M., Di Maggio, A., Van Bergen En Henegouwen, P. M. P., Hennink, W. E., Teske, E., Hesselink, J. W., Van Nimwegen, S. A., Mol, J. A., & Oliveira, S. (2021). Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: A step towards translation to the veterinary clinic. Nanophotonics, 10(12), 3075-3087. https://doi.org/10.1515/nanoph-2021-0195
Liu, M., Thijssen, S., van Nostrum, C. F., Hennink, W. E., Garssen, J., & Willemsen, L. E. M. (Accepted/In press). Inhibition of cow’s milk allergy development in mice by oral delivery of β-lactoglobulin-derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing. Clinical and Experimental Allergy. https://doi.org/10.1111/cea.13967
Najafi, M., Habibi, M., Fokkink, R., Hennink, W. E., & Vermonden, T. (2021). LCST polymers with UCST behavior. Soft Matter, 17(8), 2132-2141. https://doi.org/10.1039/d0sm01505a
Ojha, T., Hu, Q., Colombo, C., Wit, J., van Geijn, M., van Steenbergen, M. J., Bagheri, M., Königs-Werner, H., Buhl, E. M., Bansal, R., Shi, Y., Hennink, W. E., Storm, G., Rijcken, C. J. F., & Lammers, T. (2021). Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges. Biotechnology Journal, 16(6), [2000212]. https://doi.org/10.1002/biot.202000212
Grainger, D. W., Hennink, W., Schiffelers, R., & Bae, Y. H. (2021). Preface (special issue, sung wan Kim memorial, Journal of Controlled Release). Journal of controlled release : official journal of the Controlled Release Society, 332, 592-593. https://doi.org/10.1016/j.jconrel.2021.02.023
Beltrán Hernández, I., Kromhout, J. Z., Teske, E., Hennink, W. E., van Nimwegen, S. A., & Oliveira, S. (2021). Molecular targets for anticancer therapies in companion animals and humans: what can we learn from each other? Theranostics, 11(8), 3882-3897. https://doi.org/10.7150/THNO.55760

2020

Wetenschappelijke publicaties

Varela-Moreira, A., van Straten, D., van Leur, H. F., Ruiter, R. W. J., Deshantri, A. K., Hennink, W. E., Fens, M. H. A. M., Groen, R. W. J., & Schiffelers, R. M. (2020). Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model. International Journal of Pharmaceutics: X, 2, [100049]. https://doi.org/10.1016/j.ijpx.2020.100049

1995

Wetenschappelijke publicaties

van Dijk-Wotthuis, W. N. E., Franssen, O., Talsma, H., van Steenbergen, M. J., Kettenes-van den Bosch, J. J., & Hennink, W. E. (1995). Synthesis, Characterization, and Polymerization of Glycidyl Methacrylate Derivatized Dextran. Macromolecules, 28(18), 6317-6322. https://doi.org/10.1021/ma00122a044

1994

Wetenschappelijke publicaties

Borchert, J. C. H., Van Soest, M. J., & Hennink, W. E. (1994). Controlled release of proteins from hydrogels. Proceedings of the Controlled Release Society, (21), 306-307.
Borchert, J. C. H., & Hennink, W. E. (1994). SC5 controlled release of proteins from dextran hydrogels. European Journal of Pharmaceutical Sciences, 2(1-2), 92. https://doi.org/10.1016/0928-0987(94)90087-6

1990

Wetenschappelijke publicaties

Deurloo, M. J. M., Bohlken, S., Kop, W., Lerk, C. F., Hennink, W., Bartelink, H., & Begg, A. C. (1990). Intratumoural administration of cisplatin in slow-release devices - I. Tumour response and toxicity. Cancer Chemotherapy and Pharmacology, 27(2), 135-140. https://doi.org/10.1007/BF00689098

1987

Wetenschappelijke publicaties

Engbers, G. H. M., Dost, L., Hennink, W. E., Aarts, P. A. M. M., Sixma, J. J., & Feijen, J. (1987). An in vitro study of the adhesion of blood platelets onto vascular catheters. Part I. Journal of Biomedical Materials Research, 21(5), 613-627. https://doi.org/10.1002/jbm.820210507
Hennink, W. E., van den Berg, J. W. A., & Feijen, J. (1987). Standardization of heparins by means of high performance liquid chromatography equipped with a low angle laser light scattering detector. Thrombosis Research, 45(5), 463-475. https://doi.org/10.1016/0049-3848(87)90309-4

1986

Wetenschappelijke publicaties

Engbers, G. H. M., Dost, L., & Hennink, W. E. (1986). Platelet adhesion studies onto albumin-heparin conjugate coated catheters. Life Support Systems, 4(SUPPL. 2), 416-418.
Hennink, W. E., Knipmeijer, A. J. K., Engbers, G. H. M., Dost, L., & Feijen, J. (1986). IS THE USE OF LOW MOLECULAR WEIGHT HEPARIN IN BLOOD COMPATIBLE SURFACE COATINGS ADVANTAGEOUS OVER THAT OF NONFRACTIONATED HEPARIN?. 7. 1-7. 11.

1985

Wetenschappelijke publicaties

Hennink, W. E., Kim, S. W., & Feijen, J. (1985). Inhibition of surface induced coagulation by preadsorption of albumin‐heparin conjugates. Journal of Biomedical Materials Research, 19(4), 467. https://doi.org/10.1002/jbm.820190411

1984

Wetenschappelijke publicaties

Hennink, W. E., Ebert, C. D., Kim, S. W., Breemhaar, W., Bantjes, A., & Feijen, J. (1984). Interaction of antithrombin III with preadsorbed albumin-heparin conjugates. Biomaterials, 5(5), 264-268. https://doi.org/10.1016/0142-9612(84)90070-X

1983

Wetenschappelijke publicaties

Hennink, W. E., Dost, L., Feijen, J., & Kim, S. W. (1983). Interaction of albumin-heparin conjugate preadsorbed surfaces with blood. Transactions - American Society for Artificial Internal Organs, 29(1), 200-205.