prof. dr. R.J. (Roland) Pieters
R.J.Pieters@uu.nl
Gegenereerd op 2017-11-18 18:44:11


Leeropdracht
Chemische biologie van multivalente systemen
Profiel

Wij maken nieuwe verbindingen d.m.v. organische synthese die ziekte veroorzakende processen kunnen blokkeren of detecteren, met hoge affiniteit en selectiviteit. In veel gevallen gaat het om eiwit–koolhydraat interacties. Multivalentie is een belangrijk thema en wordt gebruikt om de werkingskracht van veelal zwak bindende koolhydraten te versterken.

Boomachtige structuren (dendrimeren) worden gebruikt om systemen multivalent te maken, maar ook nanodeeltjes en ‘array’ oppervlakken worden onderzocht.

Gegenereerd op 2017-11-18 18:44:11
Alle publicaties
  2017 - Wetenschappelijke publicaties
Sharif, Suhela, Shi, Jie, Mostafa, Bourakba, Ruijtenbeek, Rob & Pieters, Roland J (2017). Measuring O-GlcNAc cleavage by OGA and cell lysates on a peptide microarray. Analytical Biochemistry Copyright © 2017. Published by Elsevier Inc..
Sevsek, Alen, Šrot, Luka, Rihter, Jakob, Čelan, Maša, van Ufford, Linda Quarles, Moret, Ed E, Martin, Nathaniel I & Pieters, Roland J (2017). N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase. ChemMedChem, 12 (7), (pp. 483–486). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim..
  2016 - Wetenschappelijke publicaties
Shi, Jie, Sharif, Suhela, Ruijtenbeek, Rob & Pieters, Roland J (2016). Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. PLoS One, 11 (3).
Sevšek, Alen, Čelan, Maša, Erjavec, Bibi, Quarles van Ufford, Linda, Sastre Toraño, Javier, Moret, Ed E, Pieters, Roland J & Martin, Nathaniel I (2016). Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic and Biomolecular Chemistry, 14 (37), (pp. 8670-3) (4 p.).
Zomer-Van Ommen, Domenique D., Pukin, Aliaksei V., Fu, Ou, Quarles Van Ufford, Linda H C, Janssens, Hettie M., Beekman, Jeffrey M. & Pieters, Roland J. (2016). Functional characterization of cholera toxin inhibitors using human intestinal organoids. Journal of Medicinal Chemistry, 59 (14), (pp. 6968-6972) (5 p.).
Delaine, Tamara, Collins, Patrick, Mackinnon, Alison, Sharma, G., Stegmayr, John, Rajput, Vishal K., Mandal, Santanu, Cumpstey, Ian, Larumbe, Amaia, Salameh, Bader A., Kahl-Knutsson, Barbro, van Hattum, Hilde, van Scherpenzeel, Monique, Pieters, Roland J., Sethi, Tariq, Schambye, Hans, Oredsson, Stina, Leffler, Hakon, Blanchard, Helen & Nilsson, Ulf J. (2016). Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. ChemBioChem
Broekgaarden, M., Van Vught, R., Oliveira, Sabrina, Roovers, R. C., Van Bergen En Henegouwen, P. M P, Pieters, R. J., Van Gulik, T. M., Breukink, E. & Heger, M. (28-03-2016). Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale, 8 (12), (pp. 6490-6494) (5 p.).
  2015 - Wetenschappelijke publicaties
Fu, Ou, Pukin, Aliaksei V., Quarlesvanufford, H. C., Kemmink, Johan, DeMol, Nico J. & Pieters, Roland J. (01-08-2015). Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin. ChemistryOpen, 4 (4), (pp. 463-470) (8 p.).
Visini, Ricardo, Jin, Xian, Bergmann, Myriam, Michaud, Gaelle, Pertici, Francesca, Fu, Ou, Pukin, Aliaksei, Branson, Thomas R., Thies-Weesie, Dominique M E, Kemmink, Johan, Gillon, Emilie, Imberty, Anne, Stocker, Achim, Darbre, Tamis, Pieters, Roland J. & Reymond, Jean Louis (20-11-2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA. ACS Chemical Biology, 10 (11), (pp. 2455-2462) (8 p.).
Fu, Ou, Pukin, Aliaksei V., Quarles Van Ufford, Linda, Branson, Thomas R., Thies-Weesie, Dominique M E, Turnbull, W. Bruce, Visser, Gerben M. & Pieters, Roland J. (01-08-2015). Tetra- versus Pentavalent Inhibitors of Cholera Toxin. ChemistryOpen, 4 (4), (pp. 471-477) (7 p.).
Pukin, Aliaksei V, Brouwer, Arwin J, Koomen, Leonie, Quarles van Ufford, H C, Kemmink, Johan, de Mol, Nico J & Pieters, Roland J (03-11-2015). Thiourea-based spacers in potent divalent inhibitors of Pseudomonas aeruginosa virulence lectin LecA. Organic and Biomolecular Chemistry, 13 (44), (pp. 10923-10928) (6 p.).
  2014 - Wetenschappelijke publicaties
González-Ortiz, Gemma, Bronsoms, Sílvia, Quarles Van Ufford, H C, Halkes, S Bart A, Virkola, Ritva, Liskamp, Rob M J, Beukelman, Cees J, Pieters, Roland J, Pérez, José Francisco & Martín-Orúe, Susana María (2014). A proteinaceous fraction of wheat bran may interfere in the attachment of enterotoxigenic E. coli K88 (F4+) to porcine epithelial cells. PLoS One, 9 (8), (pp. e104258).
Van Der Wal, Steffen, Fu, Ou, Rontogianni, Stamatia, Pieters, Roland J. & Liskamp, Rob M J (2014). Convenient stereoselective synthesis of substituted ureido glycosides using stable 4-chlorophenylcarbamates without the requirement of Lewis acids. Synlett, 25 (2), (pp. 205-208) (4 p.).
Wang, Linlin, Cummings, Richard D, Smith, David F, Huflejt, Margaret, Campbell, Christopher T, Gildersleeve, Jeffrey C, Gerlach, Jared Q, Kilcoyne, Michelle, Joshi, Lokesh, Serna, Sonia, Reichardt, Niels-Christian, Parera Pera, Núria, Pieters, Roland J, Eng, William & Mahal, Lara K (2014). Cross-platform comparison of glycan microarray formats. Glycobiology, 24 (6), (pp. 507-17) (11 p.).
González-Ortiz, Gemma, Quarles Van Ufford, H C, Halkes, S Bart A, Cerdà-Cuéllar, Marta, Beukelman, Cees J, Pieters, Roland J, Liskamp, Rob M J, Pérez, José F & Martín-Orue, Susana M (2014). New properties of wheat bran - anti-biofilm activity and interference with bacteria quorum-sensing systems. Environmental Microbiology, 16 (5), (pp. 1346-1353) (8 p.). © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd..
Van Vught, Remko, Pieters, Roland J. & Breukink, Eefjan (01-01-2014). Site-specific functionalization of proteins and their applications to therapeutic antibodies. Computational and Structural Biotechnology Journal, 9 (14).
  2013 - Wetenschappelijke publicaties
Kouki, A., Pieters, R.J., Nilsson, U.J., Loimaranta, V., Finne, J. & Haataja, S. (2013). Bacterial adhesion of Streptococcus suis to host cells and its inhibition by carbohydrate ligands. Biology, 19, (pp. 918-935) (18 p.).
Wittmann, V. & Pieters, R.J. (2013). Bridging lecting binding sites by my multivalent carbohydrates. Chemical Society Reviews, 42, (pp. 4492-4503) (12 p.).
van Hattum, H., Martin, N.I., Ruijtenbeek, R. & Pieters, R.J. (2013). Development of a microarray detection method for galectin cancer proteins based on ligand binding. Analytical Biochemistry, (pp. 99-104) (6 p.).
Pertici, F., Varga, N., van Duijn, A., Rey Carrizo, M., Bernardi, A. & Pieters, R.J. (2013). Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors. Beilstein Journal of Organic Chemistry, 9, (pp. 215-222) (8 p.).
Kooij, R., Branderhorst, H.M., Bonte, S., Wieclawska, S., Martin, N.I. & Pieters, R.J. (2013). Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives. MedChemComm, 4, (pp. 387-393) (7 p.).
Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K.-J., Lahmann, M., Lindhorst, T.K., Marradi, M., Messner, P., Molinaro, A., Murphy, P.V., Nativi, C., Oscarson, S., Penades, S., Peri, F., Pieters, R.J., Renaudet, O., Reymond, J.-L., Richichi, B., Rojo, J., Sansone, F., Schaffer, C., Turnbull, W.B., Velasco-Torrijos, T., Vidal, S., Vincent, S., Wennekes, T., Zuilhof, H. & Imberty, A. (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society Reviews, 42, (pp. 4709-4727) (19 p.).
Pertici, F., de Mol, N.J., Kemmink, J. & Pieters, R.J. (2013). Optimizing bivalent inhibitors of Pseudomonas aeruginosa lectin LecA using a rigid spacer. Chemistry-A European Journal, 19, (pp. 16923-16927) (5 p.).
van Hattum, H., Branderhorst, H.M., Moret, E.E., Nilsson, U.J., Leffler, H. & Pieters, R.J. (2013). Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. Journal of Medicinal Chemistry, 56 (3), (pp. 1350-1354) (5 p.).
Thomsen, L.B., Linemann, T., Pondman, K.M., Lichota, J., Kim, K.S., Pieters, R.J., Visser, G.M. & Moos, T. (2013). Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells. ACS Chemical Biology, 19, (pp. 16923-16927) (5 p.).
Pieters, R.J., Slotved, H.-C., Moller Mortensen, H., Arler, L., Finne, J., Haataja, S., Joosten, J.A.F., Branderhorst, H.M. & Krogfelt, K.A. (2013). Use of tetravalent galabiose for inhibition of Streptococcus suis serotype 2 infection in a mouse model. Biology, 2, (pp. 702-718) (17 p.).
  2012 - Wetenschappelijke publicaties
Arnusch, Christopher J, Pieters, Roland J & Breukink, Eefjan (2012). Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides. PLoS One, 7 (6), (pp. e39768).
Arnusch, C.J., Pieters, R.J. & Breukink, E.J. (2012). Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides. PLoS One, 7, (pp. e39768) (1 p.).
Chamorro Perez, M.C., Boerman, M.A., Arnusch, C.J., Breukink, E.J. & Pieters, R.J. (2012). Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes, 1818, (pp. 2171-2174) (4 p.).
van Hattum, H., van der Zwaluw, K., Visser, G.M., van Putten, J., Ruijtenbeek, R. & Pieters, R.J. (2012). Functional assay for Shiga-like toxin via detection by antibody capture and multivalent galabiose binding. Bioorganic and Medicinal Chemistry Letters, 22, (pp. 7448-7450) (3 p.).
Van Esch, B., Van Bilsen, J., Jeurink, P., Garssen, J., Verhoeckx, K., Smit, J., Pieters, R. & Knippels, L. (01-11-2012). Multicentre validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulae. Allergy: European Journal of Allergy and Clinical Immunology, 67, (pp. 118) (1 p.).
Pertici, F. & Pieters, R.J. (2012). Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA. Chemical Communications, 48, (pp. 4008-4010) (3 p.).
van der Kaaden, M., Breukink, E.J. & Pieters, R.J. (2012). Synthesis and antifungal properties of papulacandin derivatives. Beilstein Journal of Organic Chemistry, 8, (pp. 732-737) (6 p.).
  2011 - Wetenschappelijke publicaties
Pieters, R.J. (2011). Carbohydrate mediated bacterial adhesion. Advances in Experimental Medicine and Biology, 715, (pp. 227-240) (14 p.).
Pieters, R.J. (2011). Enhanced inhibition of protein carbohydrate interactions by dendritic multivalent glycoligands. In X. Huang & J.J. Barchi (Eds.), Petite and Sweet: Glyco-nanotechnology as a bridge to new medicines (pp. 91-103) (13 p.). Washington, DC: American Chemical Society, ACS Symposium Series 109.
van de Briel, R., Cransveld, C.C., Crommelin, D.J.A., Diamant, Z., Glazenburg, B., Joos, G., Kuper, F., Natsch, A., Nijkamp, F.P., Noteborn, H., Pieters, R.J., Roberts, D., Roggen, E., Rorije, E., van den Heuvel, R., Engelen, J., Verstaelen, S. & van Loveren, H. (2011). Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation. Toxicology in Vitro, 25 (7), (pp. 1251-1258) (8 p.).
Mulder, M.P.C., Kruijtzer, J.A.W., Breukink, E.J., Kemmink, J., Pieters, R.J. & Liskamp, R.M.J. (2011). Synthesis and evaluation of novel macrocyclic antifungal peptides. Bioorganic and Medicinal Chemistry, 19, (pp. 6505-6517) (13 p.).
Pieters, R.J. (2011). The role of carbohydrates in bacterial infections. In B. Wang & G.-J. Boons (Eds.), Carbohydrate Recognition (pp. 93-106) (14 p.). Singapore: Wiley.
  2011 - Overige resultaten
Pieters, R.J. (12-09-2011). Het feest van de suikers en andere gasten. (17 p.). Utrecht: Universiteit Utrecht, Leerstoel: Chemische biologie van multivalente systemen.
  2010 - Wetenschappelijke publicaties
Parera Pera, N., Kouki, A., Haataja, S., Branderhorst, H.M., Liskamp, R.M.J., Visser, G.M., Finne, J. & Pieters, R.J. (2010). Detection of pathogenic streptococcus suis bacteria using magnetic glycoparticles. Organic and Biomolecular Chemistry, 8, (pp. 2425-2429) (5 p.).
Arnusch, C.J., Ippel, J.H., Kooijman, H., Spek, A.L., Liskamp, R.M.J., Kemmink, J. & Pieters, R.J. (2010). Direct structural comparison of a rigid cyclic peptidic scaffold using crystallography and NMR in strained PH polymer gels. Annalen der Pharmacie, (pp. 4501-4507) (7 p.).
van Scherpenzeel, M., van den Berg, R.J.B.H.N., Donker-Koopman, W.E., Liskamp, R.M.J., Aerts, J.M.F.G., Overkleeft, H.S. & Pieters, R.J. (2010). Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorganic and Medicinal Chemistry, 18, (pp. 267-273) (7 p.).
Parera Pera, N., Branderhorst, H.M., Kooij, R., Maierhofer, C., van der Kaaden, M., Liskamp, R.M.J., Wittmann, V., Ruijtenbeek, R. & Pieters, R.J. (2010). Rapid screening of lectins of multivalency effects with a glycodendrimer microarray. ChemBioChem, 11, (pp. 1896-1904) (9 p.).
Pieters, R.J. (2010). Towards multivalent carbohydrate drugs. Drug Discovery Today: Technologies, 6, (pp. e27-e31) (5 p.).
  2009 - Wetenschappelijke publicaties
Kuil, J., Branderhorst, H.M., Pieters, R.J., de Mol, N.J. & Liskamp, R.M.J. (2009). ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain. Organic and Biomolecular Chemistry, 7, (pp. 4088-4094) (7 p.).
Pieters, R.J. (2009). Maximising multivalency effects in protein-carbohydrate interactions. Organic and Biomolecular Chemistry, 7, (pp. 2013-2025) (13 p.).
Pieters, R.J., Arnusch, C.J. & Breukink, E.J. (2009). Membrane permeabilization by multivalent anti-microbial peptides. Protein and Peptide Letters, 16, (pp. 736-742) (7 p.).
Pieters, R.J. (2009). Multivalency effects and the inhibition of carbohydrate-based adhesion of bacteria and bacterial toxins. Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides (pp. 549-562) (14 p.). Kerala: Transworld Research Network.
Albada, H.B., Arnusch, C.J., Branderhorst, H.M., Verel, A.M., Janssen, W.T.M., Breukink, E.J., de Kruijff, B., Pieters, R.J. & Liskamp, R.M.J. (2009). Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic and Medicinal Chemistry Letters, 19, (pp. 3721-3724) (4 p.).
van Scherpenzeel, M., Moret, E.E., Ballell, L., Liskamp, R.M.J., Nilsson, U.J., Leffler, H. & Pieters, R.J. (2009). Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. ChemBioChem, 10, (pp. 1724-1733) (10 p.).
Sisu, C., Baron, A.J., Branderhorst, H.M., Connel, S.D., Weijers, C.A.G.M., de Vries, R., Hayes, E.D., Pukin, A.V., Gilbert, M., Pieters, R.J., Zuilhof, H., Visser, G.M. & Turnball, W.B. (2009). The influence of ligand valency on aggregation mechanisms for inhibiting bacterial toxins. ChemBioChem, 10, (pp. 329-337) (9 p.).
  2008 - Wetenschappelijke publicaties
Branderhorst, H.M., Ruijtenbeek, R., Liskamp, R.M.J. & Pieters, R.J. (2008). Multivalent carbohydrate recognition on a glycodendrimer-functionalized flow-through chip. ChemBioChem, 9, (pp. 1836-1844) (9 p.).
Pieters, R.J. & Liskamp, R.M.J. (2008). Multivalent presentation strategies in novel inhibitors of bacterial (toxin) adhesion and synthetic vaccines. Anti-Infective Agents in Medicinal Chemistry, 7, (pp. 193-200) (8 p.).
Branderhorst, H.M., Kooij, R., Salminen, A., Jongeneel, L.H., Arnusch, C.J., Liskamp, R.M.J., Finne, J. & Pieters, R.J. (2008). Synthesis of multivalent streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and "click" conjugation. Organic and Biomolecular Chemistry, 6, (pp. 1425-1434) (10 p.).
Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J., de Kruijff, B., Pieters, R.J. & Breukink, E.J. (2008). The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47 (48), (pp. 12661-12663) (3 p.).
  2007 - Wetenschappelijke publicaties
Pieters, R.J., Rijkers, D.T.S. & Liskamp, R.M.J. (2007). Application of the 1,3-dipolar cycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers. QSAR and Combinatorial Science, 26, (pp. 1181-1190) (10 p.).
van Scherpenzeel, M., van der Pot, M., Arnusch, C.J., Liskamp, R.M.J. & Pieters, R.J. (2007). Detection of galectin-3 by novel peptidic photoprobes. Bioorganic and Medicinal Chemistry Letters, 17, (pp. 376-378) (3 p.).
Arnusch, C.J., Branderhorst, H.M., de Kruijff, B., Liskamp, R.M.J., Breukink, E.J. & Pieters, R.J. (2007). Enhanced membrane pore information by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46, (pp. 13437-13442) (6 p.).
Salminen, A., Loimaranta, V., Joosten, J.A.F., Khan, A.S., Hacker, J., Pieters, R.J. & Finne, J. (2007). Inhibition of P-fimbriated Escherichia coli adhesion by multivalent galabiose derivatives studied by a live-bacteria application of surface plasmon resonance. Journal of Antimicrobial Chemotherapy, 60, (pp. 495-501) (7 p.).
Pieters, R.J. (2007). Intervention with bacterial adhesion by multivalent carbohydrates. Medicinal Research Reviews, 27, (pp. 796-816) (21 p.).
Branderhorst, H.M., Liskamp, R.M.J. & Pieters, R.J. (2007). Solid phase carbohydrate synthesis via on-bead protecting group chemistry. Tetrahedron Letters, 63, (pp. 4290-4296) (7 p.).
Branderhorst, H.M., Liskamp, R.M.J., Visser, G.M. & Pieters, R.J. (2007). Strong inhibition of cholera toxin binding by galactose dendrimers. Chemical Communications, (pp. 5043-5045) (3 p.).
Pukin, A.V., Branderhorst, H.M., Sisu, C., Weijers, C.A.G.M., Gilbert, M., Liskamp, R.M.J., Visser, G.M., Zuilhof, H. & Pieters, R.J. (2007). Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8, (pp. 1500-1503) (4 p.).
van Zoelen, D.J., Egmond, M.R., Pieters, R.J. & Liskamp, R.M.J. (2007). Synthesis and evaluation of TAC-based inhibitors of papain as mimics of cystatin B. ChemBioChem, 8, (pp. 1950-1956) (7 p.).
  2006 - Wetenschappelijke publicaties
Ballell Pages, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J. & Pieters, R.J. (2006). A new chemical probe for the detection of the cancer-linked galectin-3. Organic and Biomolecular Chemistry, 4, (pp. 4387-4394) (8 p.).
Pieters, R.J. (2006). Inhibition and detection of galectins. ChemBioChem, 7, (pp. 721-728) (8 p.).
Kasyanov, V., Isenburg, J., Draughn, R.A., Hazard, S., Hodde, J., Ozolanta, I., Murovska, M., Halkes, S.B.A., Vrasidas, I., Liskamp, R.M.J., Pieters, R.J., Simionescu, D., Markwald, R.R. & Mironov, V. (2006). Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials, 27, (pp. 745-751) (7 p.).
  2005 - Wetenschappelijke publicaties
Autar, R., Liskamp, R.M.J. & Pieters, R.J. (2005). A facile synthesis of the GalNAc beta 1 -> 4Gal target sequence of respiratory pathogens. Carbohydrate Research, 340, (pp. 2436-2442) (7 p.).
Ballell Pages, L., Alink, K.J., Slijper, M., Versluis, C., Liskamp, R.M.J. & Pieters, R.J. (2005). A new chemical probe for proteomics of carbohydrate-binding proteins. ChemBioChem, 6, (pp. 291-295) (5 p.).
Rijkers, D.T.S., van Esse, G.W., Merkx, N.S.M., Brouwer, A.J., Jacobs, J.J.F., Pieters, R.J. & Liskamp, R.M.J. (2005). Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry. Chemical Communications, (pp. 4581-4583) (3 p.).
Joosten, J.A.F., Tholen, N.T.H., ait el Maate, F., Brouwer, A.J., van Esse, G.W., Rijkers, D.T.S., Liskamp, R.M.J. & Pieters, R.J. (2005). High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers via copper-catalyzed [3+2] cycloaddition. Annalen der Pharmacie, (pp. 3182-3185) (4 p.).
Benedek, O, Khan, A.S., Schneider, G., Nagy, G., Autar, R., Pieters, R.J. & Emödy, L. (2005). Identification of laminin-binding motifs of Yersinia pestis plasminogen activator by phage display. International Journal of Medical Microbiology, 295, (pp. 87-98) (12 p.).
André, S., Arnusch, C.J., Kuwabara, I., Russwurm, R., Kaltner, H., Gabius, H.-J. & Pieters, R.J. (2005). Identification of peptide ligands for malignancy and growth-regulation galectins using random phage-display and designed combinatorial peptide libraries. Bioorganic and Medicinal Chemistry, 13, (pp. 563-573) (11 p.).
Appeldoorn, C.C.M., Joosten, J.A.F., ait el Maate, F., Dobrindt, U., Hacker, J., Liskamp, R.M.J., Khan, A.S. & Pieters, R.J. (2005). Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli. Tetrahedron Asymmetry, 16, (pp. 361-372) (12 p.).
  2005 - Populariserende publicaties
Pieters, R.J. (01-06-2005). Synthetic probes for the selective capture of galectins. NPC Highlights, (pp. 12-15) (3 p.).
  2004 - Wetenschappelijke publicaties
Joosten, J.A.F., Loimaranta, V., Appeldoorn, C.C.M., Haataja, S., ait el Maate, F., Liskamp, R.M.J., Finne, J. & Pieters, R.J. (2004). Inhibition of Streptococcus Suis adhesion by dendritic galabiose compounds at low nanomolar concentration. Journal of Medicinal Chemistry, 47, (pp. 6499-6508) (10 p.).
Arnusch, C.J., Andre, S., Valentini, P., Lensch, M., Russworm, R., Siebert, H.-C., Fischer, M.J.E., Gabius, H.-J. & Pieters, R.J. (2004). Interference of the galactose-dependant binding of lectins by novel pentapeptide ligands. Bioorganic and Medicinal Chemistry Letters, 14, (pp. 1437-1440) (4 p.).
Pieters, R.J. (2004). Interference with lectin binding and bacterial adhesion by multivalent carbohydrates and peptidic carbohydrate mimics. Trends in Glycoscience and Glycotechnology, 16, (pp. 243-254) (12 p.).
Ballell Pages, L., Joosten, J.A.F., ait el Maate, F., Liskamp, R.M.J. & Pieters, R.J. (2004). Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides. Tetrahedron Letters, 45, (pp. 6685-6687) (3 p.).
Arnusch, C.J. & Pieters, R.J. (2004). Synthesis of a novel 14-membered highly constrained cyclic peptidic scaffold. Tetrahedron Letters, 45, (pp. 4153-4156) (4 p.).
  2003 - Wetenschappelijke publicaties
Autar, R., Khan, A.S., Schad, M., Hacker, J., Liskamp, R.M.J. & Pieters, R.J. (2003). Adhesion inhibition of F1C-fimbriated Escherichia coli and Pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands. ChemBioChem, 4, (pp. 1317-1325) (9 p.).
Kopitz, J., André, S., Von Reitzenstein, C., Versluis, C., Kaltner, H., Pieters, R.J., Wasano, K., Kuwabara, I., Liu, F-T., Cantz, M., Heck, A.J.R. & Gabius, H.-J. (2003). Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Oncogene, 22, (pp. 6277-6288) (12 p.).
Vrasidas, I., Andre, S., Valentini, P., Bock, C., Lensch, M., Kaltner, H., Liskamp, R.M.J., Gabius, H.-J. & Pieters, R.J. (2003). Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors. Organic and Biomolecular Chemistry, 1, (pp. 803-810) (8 p.).
Arnusch, C.J. & Pieters, R.J. (2003). Solid phase synthesis of Vancomycine mimics. Annalen der Pharmacie, (pp. 3131-3138) (8 p.).
  2002 - Wetenschappelijke publicaties
Branderhorst, H.M., Kemmink, J., Liskamp, R.M.J. & Pieters, R.J. (2002). Catalytic conversions of diazosugars. Tetrahedron Letters, 43, (pp. 9601-9603) (3 p.).
Halkes, S.B.A., Vrasidas, I., Rooijer, G.R., van den Berg, A.J.J., Liskamp, R.M.J. & Pieters, R.J. (2002). Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. Bioorganic and Medicinal Chemistry Letters, 12, (pp. 1567-1570) (4 p.).
Vrasidas, I., Kemmink, J., Liskamp, R.M.J. & Pieters, R.J. (2002). Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic Letters, 4, (pp. 1807-1808) (2 p.).
  2001 - Wetenschappelijke publicaties
Vrasidas, I., de Mol, N.J., Liskamp, R.M.J. & Pieters, R.J. (2001). Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit. Annalen der Pharmacie, (pp. 4685-4692) (8 p.).
Pieters, R.J., Lutje Spelberg, J.H., Kellogg, R.M. & Janssen, D.B. (2001). The enantioselectivity of haloalkane dehalogenases. Tetrahedron Letters, 42, (pp. 469-471) (3 p.).
André, S., Pieters, R.J., Vrasidas, I., Kaltner, H., Kuwabara, I., Liu, F-T., Liskamp, R.M.J. & Gabius, H.-J. (2001). Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates. ChemBioChem, 2, (pp. 822-830) (9 p.).
  2000 - Wetenschappelijke publicaties
Pieters, R.J. (2000). Synthesis and binding studies of carboxylate binding pocket analogs of Vancomycin. Tetrahedron Letters, 41, (pp. 7541) (1 p.).
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Gegenereerd op 2017-11-18 18:44:11
Nevenfuncties
  • Coördinator EU project POLYCARB (2002-2006). 
  • Bestuurslid KNCV sectie Organische Chemie (1998-2005). 
  • Deelnemer + meeting organisator COST D34 (2005-2010). 
  • Commissielid NWO-CW TOP-ECHO subsidies (2006-2008).
Gegenereerd op 2017-11-18 18:44:11
Volledige naam
prof. dr. R.J. Pieters Contactgegevens
David de Wiedgebouw

Universiteitsweg 99
Kamer 5.70
3584 CG  UTRECHT

Telefoonnummer direct 06 20 293 387
Telefoonnummer afdeling 030 253 7307
Gegenereerd op 2017-11-18 18:44:11
Laatst bijgewerkt op 22-02-2013