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Dr. P. (Paula) Perez Pardo

Universitair docent 
Bètawetenschappen
Farmaceutische wetenschappen
Pharmacology
Pharmacology
David de Wiedgebouw
Universiteitsweg 99
Kamer OPEN WERKP
3584 CG Utrecht

Dr. P. (Paula) Perez Pardo

Universitair docent
Pharmacology
030 253 7353
p.perezpardo@uu.nl
Profiel CV Publicaties Onderwijs Contact
Profiel CV Publicaties Onderwijs Contact
Onderzoeksthema's

Full list of publications Google scholar

Publicaties

2025

Wetenschappelijke publicaties

On behalf of the GEMMA Consortium, Prince, N., Peralta Marzal, L. N., Roussin, L., Monnoye, M., Philippe, C., Maximin, E., Ahmed, S., Salenius, K., Lin, J., Autio, R., Adolfs, Y., Pasterkamp, R. J., Garssen, J., Naudon, L., Rabot, S., Kraneveld, A. D., & Perez-Pardo, P. (2025). Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism. Gut Microbes, 17(1), Article 2447822. Advance online publication. https://doi.org/10.1080/19490976.2024.2447822
https://research-portal.uu.nl/ws/files/251792765/Mouse_strain-specific_responses_along_the_gut-brain_axis_upon_fecal_microbiota_transplantation_from_children_with_autism.pdf

2024

Wetenschappelijke publicaties

Elford, J. D., Becht, N., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2024). Buty and the beast: the complex role of butyrate in Parkinson’s disease. Frontiers in Pharmacology, 15, Article 1388401. https://doi.org/10.3389/fphar.2024.1388401
https://dspace.library.uu.nl/bitstream/handle/1874/438460/fphar-15-1388401.pdf?sequence=1
Prince, N., Peralta Marzal, L. N., Markidi, A., Ahmed, S., Adolfs, Y., Pasterkamp, R. J., Kumar, H., Roeselers, G., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2024). Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder. Acta Pharmacologica Sinica, 45(8), 1591-1603. https://doi.org/10.1038/s41401-024-01268-x
https://research-portal.uu.nl/ws/files/233817000/s41401-024-01268-x.pdf
Markidi, A., Elford, J. D., Berkers, C., Kraneveld, A. D., & Perez-Pardo, P. (2024). Gut Microbes in Parkinson's Disease. In The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (2 ed., pp. 217-240) https://doi.org/10.1016/b978-0-323-99971-7.00002-3
Peralta-Marzal, L. N., Rojas-Velazquez, D., Rigters, D., Prince, N., Garssen, J., Kraneveld, A. D., Perez-Pardo, P., & Lopez-Rincon, A. (2024). A robust microbiome signature for autism spectrum disorder across different studies using machine learning. Scientific Reports, 14(1), Article 814. https://doi.org/10.1038/s41598-023-50601-7
https://dspace.library.uu.nl/bitstream/handle/1874/435328/s41598-023-50601-7.pdf?sequence=1

2023

Wetenschappelijke publicaties

Zheng, Y., Prince, N., Hattem, C. V., Garssen, J., Pardo, P. P., & Kraneveld, A. D. (2023). The interaction between intestinal bacterial metabolites and phosphatase and tensin homolog in autism spectrum disorder. Molecular and Cellular Neuroscience, 124(March 2023), Article 103805. https://doi.org/10.1016/j.mcn.2022.103805
https://dspace.library.uu.nl/bitstream/handle/1874/435527/1-s2.0-S1044743122001117-main.pdf?sequence=1
Kidwai, S., Barbiero, P., Meijerman, I., Tonda, A., Perez-Pardo, P., Lio, P., van der Maitland-Zee, A. H., Oberski, D. L., Kraneveld, A. D., & Lopez-Rincon, A. (2023). A robust mRNA signature obtained via recursive ensemble feature selection predicts the responsiveness of omalizumab in moderate-to-severe asthma. Clinical and Translational Allergy, 13(11), 1-11. Article e12306. https://doi.org/10.1002/clt2.12306
https://dspace.library.uu.nl/bitstream/handle/1874/434887/Clinical_Translational_All_-_2023_-_Kidwai_-_A_robust_mRNA_signature_obtained_via_recursive_ensemble_feature_selection.pdf?sequence=1
Cui, H., Elford, J. D., Alitalo, O., Perez-Pardo, P., Tampio, J., Huttunen, K. M., Kraneveld, A., Forsberg, M. M., Myöhänen, T. T., & Jalkanen, A. J. (2023). Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon. Neurobiology of Aging, 129, 62-71. https://doi.org/10.1016/j.neurobiolaging.2023.05.007
https://dspace.library.uu.nl/bitstream/handle/1874/432871/1-s2.0-S0197458023000982-main.pdf?sequence=1

2022

Wetenschappelijke publicaties

Zheng, Y., Prince, N. Z., Peralta Marzal, L. N., Ahmed, S., Garssen, J., Perez Pardo, P., & Kraneveld, A. D. (2022). The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10. International Journal of Molecular Sciences, 23(19), Article 11013. https://doi.org/10.3390/ijms231911013
https://dspace.library.uu.nl/bitstream/handle/1874/424679/ijms_23_11013_v2.pdf?sequence=1

2021

Wetenschappelijke publicaties

Zheng, Y., Bek, M. K., Prince, N. Z., Peralta Marzal, L. N., Garssen, J., Perez Pardo, P., & Kraneveld, A. D. (2021). The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience, 15, 1-17. Article 738220. https://doi.org/10.3389/fnins.2021.738220
https://dspace.library.uu.nl/bitstream/handle/1874/413537/fnins_15_738220.pdf?sequence=1
Peralta-Marzal, L. N., Prince, N., Bajic, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2021). The impact of gut microbiota-derived metabolites in autism spectrum disorders. International Journal of Molecular Sciences, 22(18), 1-25. Article 10052. https://doi.org/10.3390/ijms221810052
https://dspace.library.uu.nl/bitstream/handle/1874/413059/ijms_22_10052.pdf?sequence=1
Zheng, Y., Verhoeff, T. A., Pardo, P. P., Garssen, J., & Kraneveld, A. D. (2021). The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17. International Journal of Molecular Sciences, 22(1), 1-27. Article 118. https://doi.org/10.3390/ijms22010118
https://dspace.library.uu.nl/bitstream/handle/1874/411876/ijms_22_00118_v2.pdf?sequence=1
Perez-Pardo, P., Grobben, Y., Willemsen-Seegers, N., Hartog, M., Tutone, M., Muller, M., Adolfs, Y., Pasterkamp, R. J., Vu-Pham, D., van Doornmalen, A. M., van Cauter, F., de Wit, J., Gerard Sterrenburg, J., Uitdehaag, J. C. M., de Man, J., Buijsman, R. C., Zaman, G. J. R., & Kraneveld, A. D. (2021). Pharmacological validation of TDO as a target for Parkinson’s disease. FEBS Journal, 288(14), 4311-4331. https://doi.org/10.1111/febs.15721
https://dspace.library.uu.nl/bitstream/handle/1874/418770/The_FEBS_Journal_2021_Perez_Pardo_Pharmacological_validation_of_TDO_as_a_target_for_Parkinson_s_disease.pdf?sequence=1

2020

Wetenschappelijke publicaties

Troisi, J., Autio, R., Beopoulos, T., Bravaccio, C., Carraturo, F., Corrivetti, G., Cunningham, S., Devane, S., Fallin, D., Fetissov, S., Gea, M., Giorgi, A., Iris, F., Joshi, L., Kadzielski, S., Kraneveld, A., Kumar, H., Ladd-Acosta, C., Leader, G., ... Fasano, A. (2020). Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) Study Design: Biomarkers Identification for Precision Treatment and Primary Prevention of Autism Spectrum Disorders by an Integrated Multi-Omics Systems Biology Approach. Brain Sciences, 10(10), Article 743. https://doi.org/10.3390/brainsci10100743
https://dspace.library.uu.nl/bitstream/handle/1874/409292/brainsci_10_00743_v2.pdf?sequence=1
Roussin, L., Prince, N., Perez-Pardo, P., Kraneveld, A. D., Rabot, S., & Naudon, L. (2020). Role of the gut microbiota in the pathophysiology of autism spectrum disorder: Clinical and preclinical evidence. Microorganisms, 8(9), Article 1369. https://doi.org/10.3390/microorganisms8091369
https://dspace.library.uu.nl/bitstream/handle/1874/408898/microorganisms_08_01369.pdf?sequence=1

2019

Wetenschappelijke publicaties

Bullich, C., Keshavarzian, A., Garssen, J., Kraneveld, A., & Perez-Pardo, P. (2019). Gut Vibes in Parkinson's Disease: The Microbiota-Gut-Brain Axis. Movement Disorders Clinical Practice, 6(8), 639-651. https://doi.org/10.1002/mdc3.12840
https://dspace.library.uu.nl/bitstream/handle/1874/388285/Bullich_et_al_2019_Movement_Disorders_Clinical_Practice_11_.pdf?sequence=1
van Sadelhoff, J. H. J., Perez Pardo, P., Wu, J., Garssen, J., van Bergenhenegouwen, J., Hogenkamp, A., Hartog, A., & Kraneveld, A. D. (2019). The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids. Frontiers in Endocrinology, 10, 247. https://doi.org/10.3389/fendo.2019.00247
https://dspace.library.uu.nl/bitstream/handle/1874/381087/fendo_10_00247.pdf?sequence=1
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., Shannon, K. M., Garssen, J., Kraneveld, A. D., & Keshavarzian, A. (2019). Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice. Gut, 68, 829-843. https://doi.org/10.1136/gutjnl-2018-316844
https://dspace.library.uu.nl/bitstream/handle/1874/391752/829.full.pdf?sequence=1

2018

Wetenschappelijke publicaties

Perez-Pardo, P., Broersen, L. M., Kliest, T., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2018). Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Frontiers in Aging Neuroscience, 10, Article 237. https://doi.org/10.3389/fnagi.2018.00237
https://dspace.library.uu.nl/bitstream/handle/1874/375401/fnagi_10_00237_1_.pdf?sequence=1
Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Naqib, A., Forsyth, C. B., Green, S. J., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018). Gut bacterial composition in a mouse model of Parkinson's disease. Beneficial microbes, 9(5), 799-814. https://doi.org/10.3920/BM2017.0202
https://dspace.library.uu.nl/bitstream/handle/1874/375394/bm2017.0202.pdf?sequence=1
Perez-Pardo, P., Dodiya, H. B., Broersen, L. M., Douna, H., van Wijk, N., Lopes da Silva, S., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018). Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. Nutritional Neuroscience, 21(6), 391-402. https://doi.org/10.1080/1028415X.2017.1294555
https://dspace.library.uu.nl/bitstream/handle/1874/358515/Gut_brain_and_brain_gut_axis_in_Parkinson_s_disease_models_Effects_of_a_uridine_and_fish_oil_diet.pdf?sequence=1

2017

Wetenschappelijke publicaties

Perez-Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017). Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson's Disease. Current Topics in Behavioral Neurosciences, 4(4), 361-368. https://doi.org/10.1007/s40473-017-0129-2
https://dspace.library.uu.nl/bitstream/handle/1874/359123/10.1007_2Fs40473_017_0129_2.pdf?sequence=1
Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017). Exploring Braak's Hypothesis of Parkinson's Disease. Frontiers in Neurology, 8, Article 37. https://doi.org/10.3389/fneur.2017.00037
https://dspace.library.uu.nl/bitstream/handle/1874/359030/fneur_08_00037.pdf?sequence=1
Perez-Pardo, P., de Jong, E. M., Broersen, L. M., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2017). Promising effects of neurorestorative diets on motor, cognitive, and gastrointestinal dysfunction after symptom development in a mouse model of Parkinson's disease. Frontiers in Aging Neuroscience, 9, Article 57. https://doi.org/10.3389/fnagi.2017.00057
https://dspace.library.uu.nl/bitstream/handle/1874/407435/diets.pdf?sequence=1
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017). The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies. European Journal of Pharmacology, 817, 86-95. https://doi.org/10.1016/j.ejphar.2017.05.042
https://dspace.library.uu.nl/bitstream/handle/1874/359028/parkinson.pdf?sequence=1
Perez Pardo, P. (2017). Targeting the Gut-Brain axis in Parkinson's disease. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/354242/Perez_Pardo.pdf?sequence=1

2015

Wetenschappelijke publicaties

Perez Pardo, P., De Jong, E. M., Broersen, L. M., Attali, A., Van Wijk, N., Garssen, J., Olivier, B., & Kraneveld, A. D. (2015). Dietary interventions with strong preventive and therapeutic effects on both motor and non-motor symptoms in a mouse model of parkinson's disease. Neuro-degenerative Diseases, 15, 1319. https://doi.org/10.1159/000381736

2014

Wetenschappelijke publicaties

Perez-Pardo, P., Douna, H., Wijnands, T., Da Silva, S. L., Forsyth, C. B., Dodiya, H. B., Garssen, J., Olivier, B., Keshavarzian, A., & Kraneveld, A. D. (2014). The role of toll-like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Gastroenterology, 146(5), 59. https://doi.org/10.1016/S0016-5085(14)60206-7
Perez Pardo, P., Wijnands, T., Lopes Da Silva, S., Forsyth, C., Dodiya, H., Garssen, J., Keshavarzian, A., & Kraneveld, A. (2014). The role of toll like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Basic & Clinical Pharmacology & Toxicology, 115, 156-157.
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