Mission statement:

Regulation in cells and organisms is achieved by the interplay of proteins acting in concert to achieve a control over time and space. In many cases, the proteins involved are multi-domain proteins that function in large complexes. This enables a collective set of proteins to form a protein machinery that carries out elementary regulatory functions such as initiation, amplification, localization and inhibition. Our goal is to reveal the mechanisms of tertiary and quaternary-induced activation in multi-domain proteins and multi-protein complexes that underlie these recognition and regulation processes.

In addition, we remain to have a keen interest in methodology with respect to improving structural representations.

Primary techniques used in the lab:

• protein chemistry
• molecular biology
• crystallography and
• cryo-EM

Fields of interest:

• complement imune defence
• infection and immunity
• bio-medical important molecular recognition and regulation processes
• plasma-proteins, cell-surface receptors and membrane proteins