Dr. O.I. (Olaf) Perdijk PhD

Universitair docent
Pharmacology
o.i.perdijk@uu.nl

Publicaties

2024

Wetenschappelijke publicaties

Wang, H., Barry, K., Zaini, A., Coakley, G., Moyat, M., Daunt, C. P., Wickramasinghe, L. C., Azzoni, R., Chatzis, R., Yumnam, B., Camberis, M., Le Gros, G., Perdijk, O., Foong, J. P. P., Bornstein, J. C., Marsland, B. J., & Harris, N. L. (2024). Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons. PLoS Pathogens, 20(8), e1011766. https://doi.org/10.1371/journal.ppat.1011766
Azzoni, R., Perdijk, O., Harris, N. L., & Marsland, B. J. (2024). Neuroimmunology of the Lung. Annual Review of Immunology, 42(1), 57-81. https://doi.org/10.1146/annurev-immunol-083122-042512
Perdijk, O., Azzoni, R., & Marsland, B. J. (2024). The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract. Physiological Reviews, 104(2), 835-879. https://doi.org/10.1152/physrev.00020.2023
Perdijk, O., Butler, A., Macowan, M., Chatzis, R., Bulanda, E., Grant, R. D., Harris, N. L., Wypych, T. P., & Marsland, B. J. (2024). Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood. Immunity, 57(8), 1939-1954.e7. https://doi.org/10.1016/j.immuni.2024.06.010

2022

Wetenschappelijke publicaties

Moyat, M., Lebon, L., Perdijk, O., Wickramasinghe, L. C., Zaiss, M. M., Mosconi, I., Volpe, B., Guenat, N., Shah, K., Coakley, G., Bouchery, T., & Harris, N. L. (2022). Microbial regulation of intestinal motility provides resistance against helminth infection. Mucosal Immunology, 15(6), 1283-1295. https://doi.org/10.1038/s41385-022-00498-8
Trompette, A., Pernot, J., Perdijk, O., Alqahtani, R. A. A., Domingo, J. S., Camacho-Muñoz, D., Wong, N. C., Kendall, A. C., Wiederkehr, A., Nicod, L. P., Nicolaou, A., von Garnier, C., Ubags, N. D. J., & Marsland, B. J. (2022). Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation. Mucosal Immunology, 15(5), 908-926. https://doi.org/10.1038/s41385-022-00524-9

2021

Wetenschappelijke publicaties

Wypych, T. P., Pattaroni, C., Perdijk, O., Yap, C., Trompette, A., Anderson, D., Creek, D. J., Harris, N. L., & Marsland, B. J. (2021). Microbial metabolism of l-tyrosine protects against allergic airway inflammation. Nature Immunology, 22(3), 279-286. https://doi.org/10.1038/s41590-020-00856-3

2019

Wetenschappelijke publicaties

van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E., & Joost van Neerven, R. J. (2019). Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women. PLoS One, 14(12), Article e0225825. https://doi.org/10.1371/journal.pone.0225825
Perdijk, O., Baarlen, P. V., Fernandez-Gutierrez, M. M., Brink, E. V., Schuren, F. H. J., Brugman, S., Savelkoul, H. F. J., Kleerebezem, M., & Neerven, R. J. J. V. (2019). Sialyllactose and galactooligosaccharides promote epithelial barrier functioning and distinctly modulate microbiota composition and short chain fatty acid production in vitro. Frontiers in Immunology, 10, Article 94. https://doi.org/10.3389/fimmu.2019.00094
Perdijk, O., & Marsland, B. J. (2019). The microbiome: toward preventing allergies and asthma by nutritional intervention. Current Opinion in Immunology, 60, 10-18. https://doi.org/10.1016/j.coi.2019.04.001

2018

Wetenschappelijke publicaties

Perdijk, O., Joost Van Neerven, R. J., Meijer, B., Savelkoul, H. F. J., & Brugman, S. (2018). Induction of human tolerogenic dendritic cells by 3′-sialyllactose via TLR4 is explained by LPS contamination. Glycobiology, 28(3), 126-130. https://doi.org/10.1093/glycob/cwx106
Perdijk, O., van Splunter, M., Savelkoul, H. F. J., Brugman, S., & van Neerven, R. J. J. (2018). Cow's milk and immune function in the respiratory tract: Potential mechanisms. Frontiers in Immunology, 9, Article 143. https://doi.org/10.3389/fimmu.2018.00143
Perdijk, O., Neerven, R. J. J. V., den Brink, E. V., Savelkoul, H. F. J., & Brugman, S. (2018). Bovine Lactoferrin Modulates Dendritic Cell Differentiation and Function. Nutrients, 10(7), Article 848. https://doi.org/10.3390/nu10070848
Perdijk, O., van Neerven, R. J. J., van den Brink, E., Savelkoul, H. F. J., & Brugman, S. (2018). The oligosaccharides 6’-sialyllactose, 2’-fucosyllactose or galactooligosaccharides do not directly modulate human dendritic cell differentiation or maturation. PLoS One, 13(7), e0200356. https://doi.org/10.1371/journal.pone.0200356
Van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Feitsma, A. L., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., Van Hoffen, E., & Van Neerven, R. J. J. (2018). Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women: Results from a nutritional intervention study with bovine lactoferrin, GOS and Vitamin D. Frontiers in Immunology, 9, Article 2677. https://doi.org/10.3389/fimmu.2018.02677

2017

Wetenschappelijke publicaties

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J. M., Hendriks, R. W., & Savelkoul, H. F. J. (2017). Frontline science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1<sup>-/∆7</sup> mice. Journal of Leukocyte Biology, 101(4), 811-821. https://doi.org/10.1189/jlb.1HI0216-062RR
Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H., & Broersen, K. (2017). Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins. PLoS One, 12(3), e0173778. https://doi.org/10.1371/journal.pone.0173778

2015

Wetenschappelijke publicaties

Brugman, S., Perdijk, O., van Neerven, R. J. J., & Savelkoul, H. F. J. (2015). Mucosal Immune Development in Early Life: Setting the Stage. Archivum Immunologiae et Therapiae Experimentalis, 63, 251-268. https://doi.org/10.1007/s00005-015-0329-y

2013

Wetenschappelijke publicaties

Perdijk, O., Arama, C., Giusti, P., Maiga, B., Troye-Blomberg, M., Dolo, A., Doumbo, O., Persson, J.-O., & Boström, S. (2013). Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali. Malaria Journal, 12, 1-12. https://doi.org/10.1186/1475-2875-12-432