Ing. M.E. (Monique) van Wolferen
Onderzoeks- en onderwijsmedewerker
Publicaties
2025
Wetenschappelijke publicaties
van den Berg, M. F., Timmermans-Sprang, E. P. M., Viets, F. C., van den Berg, L., Danawar, F., van Wolferen, M. E., Kooistra, H. S., Grinwis, G. C. M., de Jong, W. H. A., van Faassen, M., & Galac, S. (2025). Canine adrenomedullary and pheochromocytoma organoids: a novel in vitro model. Endocrinology, 166(9), Article bqaf114. [DOI] [Portal]
2024
Wetenschappelijke publicaties
van den Berg, M. F., Bechmann, N., Kooistra, H. S., van Wolferen, M. E., Timmermans-Sprang, E. P. M., Peitzsch, M., & Galac, S. (2024). Metabolomic profiling of pheochromocytomas in dogs: Catecholamine phenotype and tricarboxylic acid cycle metabolites. Journal of Veterinary Internal Medicine, 38(5), 2415-2424. [DOI] [Portal]
2023
Wetenschappelijke publicaties
van den Berg, M. F., Kooistra, H. S., Grinwis, G. C. M., Nicoli, S., Golinelli, S., Stammeleer, L., van Wolferen, M. E., Timmermans-Sprang, E. P. M., Zandvliet, M. M. J. M., van Steenbeek, F. G., & Galac, S. (2023). Whole transcriptome analysis of canine pheochromocytoma and paraganglioma. Frontiers in Veterinary Science, 10, Article 1155804. [DOI] [Repository]
van Blokland-Post, K., Weber, M. F., van Wolferen, M. E., Penning, L. C., van Sluijs, F. J., & Kummeling, A. (2023). Prediction of outcome after ligation or thin film banding of extrahepatic shunts, based on plasma albumin concentration and hematologic expression of 8 target genes in 85 dogs. Journal of Veterinary Internal Medicine, 37(2), 537-549. [DOI] [Repository]
2022
Wetenschappelijke publicaties
Krüger, M., Samsom, R.-A., Oosterhoff, L., van Wolferen, M., Kooistra, H., Geijsen, N., Penning, L., Kock, L. M., Sainz-Arnal, P., Baptista, P. M., & Spee, B. (2022). High level of polarized engraftment of porcine intrahepatic cholangiocyte organoids in decellularized liver scaffolds. Journal of Cellular and Molecular Medicine, 26(19), 4949-4958. [DOI] [Repository]
Nguyen, V. V. T., Ye, S., Gkouzioti, V., van Wolferen, M. E., Yengej, F. Y., Melkert, D., Siti, S., de Jong, B., Besseling, P. J., Spee, B., van der Laan, L. J. W., Horland, R., Verhaar, M. C., & van Balkom, B. W. M. (2022). A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles. Journal of Extracellular Vesicles, 11(11), 1-20. Article 12280. [DOI] [Repository]
Bernal, P. N., Bouwmeester, M., Madrid-Wolff, J., Falandt, M., Florczak, S., Rodriguez, N. G., Li, Y., Größbacher, G., Samsom, R.-A., van Wolferen, M., van der Laan, L., Delrot, P., Loterie, D., Malda, J., Moser, C., Spee, B., & Levato, R. (2022). Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories. Advanced Materials, 34(15), 1-16. Article 2110054. [DOI] [Repository]
2021
Wetenschappelijke publicaties
Bouwmeester, M. C., Bernal, P. N., Oosterhoff, L. A., van Wolferen, M., Lehmann, V., Vermaas, M., Buchholz, M.-B., Peiffer, Q., Malda, J., van der Laan, L. J. W., Kramer, N. I., Schneeberger, K., Levato, R., & Spee, B. (2021). Bioprinting of Human Liver-derived Epithelial Organoids for Toxicity Studies. Macromolecular Bioscience, 21(12), 1-10. Article 2100327. [DOI] [Repository]
2020
Wetenschappelijke publicaties
Ye, S., Boeter, J. W. B., Mihajlovic, M., van Steenbeek, F. G., van Wolferen, M. E., Oosterhoff, L. A., Marsee, A., Caiazzo, M., van der Laan, L. J. W., Penning, L. C., Vermonden, T., Spee, B., & Schneeberger, K. (2020). A Chemically Defined Hydrogel for Human Liver Organoid Culture. Advanced Functional Materials, 30(48), Article 2000893. [DOI] [Repository]
Valtolina, C., Robben, J. H., van Wolferen, M. E., Kruitwagen, H. S., Corbee, R. J., Favier, R. P., & Penning, L. C. (2020). Gene expressions of de novo hepatic lipogenesis in feline hepatic lipidosis. Journal of Feline Medicine and Surgery, 22(6), 500-505. [DOI] [Repository]
Kruitwagen, H. S., Oosterhoff, L. A., van Wolferen, M. E., Chen, C., Nantasanti Assawarachan, S., Schneeberger, K., Kummeling, A., van Straten, G., Akkerdaas, I. C., Vinke, C. R., van Steenbeek, F. G., van Bruggen, L. W. L., Wolfswinkel, J., Grinwis, G. C. M., Fuchs, S. A., Gehart, H., Geijsen, N., Vries, R. G., Clevers, H., ... Spee, B. (2020). Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease. Cells, 9(2), 1-16. Article 410. [DOI] [Repository]
Krüger, M., Oosterhoff, L. A., van Wolferen, M. E., Schiele, S. A., Walther, A., Geijsen, N., De Laporte, L., van der Laan, L. J. W., Kock, L. M., & Spee, B. (2020). Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids. Advanced healthcare materials, 9(6), Article 1901658. [DOI] [Repository]
Haaker, M. W., Kruitwagen, H. S., Vaandrager, A. B., Houweling, M., Penning, L. C., Molenaar, M. R., van Wolferen, M. E., Oosterhoff, L. A., Spee, B., & Helms, J. B. (2020). Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system. Journal of Veterinary Internal Medicine, 34(1), 132-138. [DOI] [Repository]
Schneeberger, K., Sánchez-Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., Colemonts-Vroninks, H., Schene, I., Hoekstra, R., Verstegen, M. M. A., van der Laan, L. J. W., Penning, L. C., Fuchs, S. A., Clevers, H., De Kock, J., ... Spee, B. (2020). Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells. Hepatology, 72(1), 257-270. [DOI] [Repository]
2019
Wetenschappelijke publicaties
Oosterhoff, L. A., Kruitwagen, H. S., van Wolferen, M. E., van Balkom, B. W. M., Mokry, M., Lansu, N., van den Dungen, N. A. M., Penning, L. C., Spanjersberg, T. C. F., de Graaf, J. W., Veenendaal, T., Zomerdijk, F., Fledderus, J. O., Spee, B., & van Steenbeek, F. G. (2019). Characterization of Endothelial and Smooth Muscle Cells From Different Canine Vessels. Frontiers in Physiology, 10, Article 101. [DOI] [Repository]
Sakai, M., Spee, B., Grinwis, G. C. M., Penning, L. C., van Wolferen, M. E., van der Laan, L. J. W., & Fieten, H. (2019). Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 33(1), 151-157. [DOI] [Repository]
2018
Wetenschappelijke publicaties
Kruitwagen, H. S., Westendorp, B., Viebahn, C. S., Post, K., van Wolferen, M. E., Oosterhoff, L. A., Egan, D. A., Delabar, J.-M., Toussaint, M. J., Schotanus, B. A., de Bruin, A., Rothuizen, J., Penning, L. C., & Spee, B. (2018). DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells. Stem Cells and Development, 27(2), 133-146. [DOI] [Repository]
Chen, C., Pla-Palacín, I., Baptista, P. M., Shang, P., Oosterhoff, L. A., van Wolferen, M. E., Penning, L. C., Geijsen, N., & Spee, B. (2018). Hepatocyte-like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers. Biotechnology and Bioengineering, 115(11), 2807-2816. [DOI] [Repository]
Otte, C. M., Valtolina, C., Vreman, S., Hubers, S., van Wolferen, M. E., Favier, R. P., Rothuizen, J., & Penning, L. C. (2018). Immunohistochemical evaluation of the activation of hepatic progenitor cells and their niche in feline lymphocytic cholangitis. Journal of Feline Medicine and Surgery, 20(1), 30-37. [DOI] [Repository]
2017
Wetenschappelijke publicaties
Kruitwagen, H. S., Oosterhoff, L. A., Vernooij, I. G. W. H., Schrall, I. M., van Wolferen, M. E., Bannink, F., Roesch, C., van Uden, L., Molenaar, M. R., Helms, J. B., Grinwis, G. C. M., Verstegen, M. M. A., van der Laan, L. J. W., Huch, M., Geijsen, N., Vries, R. R. G., Clevers, H., Rothuizen, J., Schotanus, B. A., ... Spee, B. (2017). Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis. Stem Cell Reports, 8(4), 822-830. [DOI] [Repository]
van Sprundel, R. G. H. M., van den Ingh, T. S., Schotanus, B. A., van Wolferen, M. E., Penning, L. C., Rothuizen, J., & Spee, B. (2017). Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour. AERA Open, 4(1), Article e000212. [DOI] [Repository]
Van den Bossche, L., Schoonenberg, V. A. C., Burgener, I. A., Penning, L. C., Schrall, I. M., Kruitwagen, H. S., van Wolferen, M. E., Grinwis, G. C. M., Kummeling, A., Rothuizen, J., van Velzen, J. F., Stathonikos, N., Molenaar, M. R., Helms, B. J., Brouwers, J. F. H. M., Spee, B., & van Steenbeek, F. G. (2017). Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts. PLoS One, 12(10), Article e0186491. [DOI] [Repository]
2016
Wetenschappelijke publicaties
Dirksen, K., Roelen, Y. S., van Wolferen, M. E., Kruitwagen, H. S., Penning, L. C., Burgener, I. A., Spee, B., & Fieten, H. (2016). Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers. Veterinary Journal, 218, 1-6. [DOI] [Repository]
Malagola, E., Teunissen, M., van der Laan, L. J. W., Verstegen, M., Schotanus, B. A., van Steenbeek, F. G., Penning, L. C., van Wolferen, M. E., Tryfonidou, M. A., & Spee, B. (2016). Characterization and comparison of canine multipotent stromal cells derived from liver and bone marrow. Stem Cells and Development, 35(2). [DOI] [Repository]
2015
Wetenschappelijke publicaties
Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports [E], 5(5), 895-907. [DOI] [Repository]
2014
Wetenschappelijke publicaties
Gracanin, A., Timmermans-Sprang, E. P. M., van Wolferen, M. E., Rao, N. A. S., Grizelj, J., Vince, S., Hellmen, E., & Mol, J. A. (2014). Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. PLoS One, 9(6), Article e98698. [DOI] [Repository]
Gracanin, A., Voorwald, F. A., van Wolferen, M., Timmermans-Sprang, E., & Mol, J. A. (2014). Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer. Journal of Steroid Biochemistry and Molecular Biology, 144 Pt B, 492-9. [DOI]
van Sprundel, R. G. H. M., van den Ingh, T. S. G. A. M., Guscetti, F., Kershaw, O., van Wolferen, M. E., Rothuizen, J., & Spee, B. (2014). Classification of primary hepatic tumours in the cat. Veterinary Journal, 202(2), 255-66. [DOI]
Schotanus, B. A., Kruitwagen, H. S., van den Ingh, T., van Wolferen, M. E., Rothuizen, J., Penning, L. C., & Spee, B. (2014). Enhanced Wnt/ß-catenin and Notch signalling in the activated canine hepatic progenitor cell niche. BMC Veterinary Research, 10, Article 10:309 . [DOI] [Repository]
Overige resultaten
Schotanus, B. A., Nantasanti, S., Huch, M., Oosterhoff, L., Fieten, H., Kruitwagen, H. S., van Wolferen, M., Grinwis, G. C. M., Wubbolts, R., Favier, R. P., Penning, L. C., Vries, R. G. J., Clevers, H., Rothuizen, J., & Spee, B. (2014). Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS: Journal of Hepatology. Journal of Hepatology, 60(1, Suppl), S272. Article P610. [DOI]
2013
Wetenschappelijke publicaties
Boerkamp, K. M., van der Kooij, M. A., van Steenbeek, F. G., van Wolferen, M. E., Groot Koerkamp, M. J. A., van Leenen, D., Grinwis, G. C. M., Penning, L. C., Wiemer, E. A., & Rutteman, G. R. (2013). Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog. PLoS One, 8, e71094. [DOI]
2012
Wetenschappelijke publicaties
Gracanin, A., van Wolferen, M. E., Sartorius, C. A., Brenkman, A. B., Schoonen, W. G., & Mol, J. A. (2012). Canid progesterone receptors lack activation function 3 domain-dependent activity. Endocrinology, 153(12), 6104-6113.
2009
Wetenschappelijke publicaties
Rao, N. A., van Wolferen, M. E., Gracanin, A., Bhatti, S. F., Krol, M., Holstege, F. C. P., & Mol, J. A. (2009). Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors. Journal of Physiology and Pharmacology, 60(suppl. 1), 73-84. http://www.ncbi.nlm.nih.gov/pubmed/19609016?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8
Selvarajah, G. T., Kirpensteijn, J., van Wolferen, M. E., Rao, N. A., Fieten, H., & Mol, J. A. (2009). Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Molecular Cancer, 8, 72. [DOI] [Repository]
2008
Wetenschappelijke publicaties
Rao, N. A., van Wolferen, M. E., van den Ham, R., van Leenen, D., Groot Koerkamp, M. J. A., Holstege, F. C. P., & Mol, J. A. (2008). cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. Animal Genetics, 39(4), 333-345.
2007
Wetenschappelijke publicaties
Paris, M. C. J., & Schlatt, S. (2007). Ovarian and testicular tissue xenografting: its potential for germline preservation of companion animals, non-domestic and endangered species. Reproduction Fertility and Development, 19(6), 771-782.
Paris, M. C. J., Mastromonaco, G., Paris, D. B. B. P., & Krisher, R. (2007). A perspective on the role of emerging technologies for the propagation of CANDES. Reproduction Fertility and Development, 19, iii-vii.
2003
Wetenschappelijke publicaties
Peters, M. A. J., Mol, J. A., van Wolferen, M. E., Oosterlaken-Dijksterhuis, M. A., Teerds, K. J., & van Sluijs, F. J. (2003). Expression of the insulin-like growth factor (IGF) system and steroidogeneic enzymes in canine testis tumors. Biology of Reproduction, 1:22, 1-8.
2002
Wetenschappelijke publicaties
Everts, R. E., van Wolferen, M. E., Versteeg, S. A., Zijlstra, C., Engelen, J. J. M., Bosma, A. A., & van Oost, B. A. (2002). A radiation hybrid map of the X-chromosome of the dog (Canis familiaris). Cytogenetics and Cell Genetics, 98, 86-92.