The Exposome Project for Health and Occupational Research (EPHOR) will lay the groundwork for evidence-based and cost-effective prevention for improving health at work, by developing a working life exposome toolbox. This toolbox can be used by scientists, occupational health practitioners, and policy makers. The consortium consists of 19 exposure, health, and data scientists and technology partners from 12 different countries. Together we will advance occupational health science in a unique way to reduce the burden of disease.