Sleutelpublicaties
van Meeteren, L. A., Ruurs, P., Christodoulou, E., Goding, J. W., Takakusa, H., Kikuchi, K., Perrakis, A., Nagano, T., & Moolenaar, W. H. (2005). Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. Journal of Biological Chemistry, 280(22), 21155-61. https://doi.org/10.1074/jbc.M413183200
van Meeteren, L. A., Brinkmann, V., Saulnier-Blache, J. S., Lynch, K. R., & Moolenaar, W. H. (2008). Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters, 266(2), 203-8. https://doi.org/10.1016/j.canlet.2008.02.052
Koch, S., van Meeteren, L. A., Morin, E., Testini, C., Weström, S., Björkelund, H., Le Jan, S., Adler, J., Berger, P., & Claesson-Welsh, L. (2014). NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Developmental Cell, 28(6), 633-46. https://doi.org/10.1016/j.devcel.2014.02.010
van Meeteren, L. A., & Moolenaar, W. H. (2007). Regulation and biological activities of the autotaxin-LPA axis. Progress in Lipid Research, 46(2), 145-60. https://doi.org/10.1016/j.plipres.2007.02.001
van Meeteren, L. A., Ruurs, P., Stortelers, C., Bouwman, P., van Rooijen, M. A., Pradère, J. P., Pettit, T. R., Wakelam, M. J. O., Saulnier-Blache, J. S., Mummery, C. L., Moolenaar, W. H., & Jonkers, J. (2006). Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Molecular and Cellular Biology, 26(13), 5015-22. https://doi.org/10.1128/MCB.02419-05
Publicaties
2016
Wetenschappelijke publicaties
Gordon, E. J., Fukuhara, D., Weström, S., Padhan, N., Sjöström, E. O., van Meeteren, L., He, L., Orsenigo, F., Dejana, E., Bentley, K., Spurkland, A., & Claesson-Welsh, L. (2016). The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Science Signaling [E], 9(437). https://doi.org/10.1126/scisignal.aad9256
Maring, J. A., van Meeteren, L. A., Goumans, M. J., & Ten Dijke, P. (2016). Interrogating TGF-β Function and Regulation in Endothelial Cells. Methods in Molecular Biology, 1344, 193-203. https://doi.org/10.1007/978-1-4939-2966-5_11
2014
Wetenschappelijke publicaties
Lebrin, F., Maring, J. A., van den Driesche, S., van der Brink, S., van Dinther, M., Thorikay, M., Martin, S., Kobayashi, K., Hawinkels, L., van Meeteren, L. A., Pardali, E., Korving, J., Letarte, M., Arthur, H. M., Theuer, C., Goumans, M. J., Mummery, C., & ten Dijke, P. (2014). ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis. PLoS One. https://doi.org/10.1371/journal.pone.0086273
Koch, S., van Meeteren, L. A., Morin, E., Testini, C., Weström, S., Björkelund, H., Le Jan, S., Adler, J., Berger, P., & Claesson-Welsh, L. (2014). NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Developmental Cell, 28(6), 633-46. https://doi.org/10.1016/j.devcel.2014.02.010
2013
Wetenschappelijke publicaties
Houben, A. J. S., van Wijk, X. M. R., van Meeteren, L. A., van Zeijl, L., van de Westerlo, E. M. A., Hausmann, J., Fish, A., Perrakis, A., van Kuppevelt, T. H., & Moolenaar, W. H. (2013). The Polybasic Insertion in Autotaxin alpha Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M112.358416
Coma, S., Allard-Ratick, M., Akino, T., van Meeteren, L. A., Mammoto, A., & Klagsbrun, M. (2013). GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis. https://doi.org/10.1007/s10456-013-9370-9
Moolenaar, W. H., Houben, A. J. S., Lee, S-J., & van Meeteren, L. A. (2013). Autotaxin in embryonic development. Biochimica et Biophysica Acta, 1831(1), 13-9. https://doi.org/10.1016/j.bbalip.2012.09.013
Jakobsson, L., & van Meeteren, L. A. (2013). Transforming growth factor β family members in regulation of vascular function: in the light of vascular conditional knockouts. Experimental Cell Research, 319(9), 1264-70. https://doi.org/10.1016/j.yexcr.2013.02.015
2012
Wetenschappelijke publicaties
van Meeteren, L. A., & ten Dijke, P. (2012). Regulation of endothelial cell plasticity by TGF-beta. Cell and Tissue Research. https://doi.org/10.1007/s00441-011-1222-6
van Meeteren, L. A., Thorikay, M., Bergqvist, S., Pardali, E., Stampino, C. G., Hu-Lowe, D., Goumans, M-J., & ten Dijke, P. (2012). Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. Journal of Biological Chemistry, 287(22), 18551-61. https://doi.org/10.1074/jbc.M111.338103
2011
Wetenschappelijke publicaties
Dusaulcy, R., Gres, S., Wanecq, E., Rancoule, C., Colom, A., Guigne, C., van Meeteren, L. A., Moolenaar, W. H., Valet, P., & Saulnier-Blache, J. S. (2011). The invalidation of the autotaxin adipocyte exacerbates obesity and nutrition reduces plasma lysophosphatidic acid. Diabetes & Metabolism. https://doi.org/10.1016/S1262-3636(11)70614-0
Albers, H., Dong, A. P., van Meeteren, L. A., Egan, D. A., Sunkara, M., van Tilburg, E. W., Schuurman, K., van Tellingen, O., Morris, A. J., Smyth, S. S., Moolenaar, W. H., & Ovaa, H. (2011). Discovery, development and biological validation of boronic acid-based inhibitors of autotaxin. Abstracts of Papers of the American Chemical Society.
Hausmann, J., Kamtekar, S., Christodoulou, E., Day, J. E., Wu, T., Fulkerson, Z., Albers, H., van Meeteren, L. A., Houben, A. J. S., van Zeijl, L., Jansen, S., Andries, M., Hall, T., Pegg, L. E., Benson, T. E., Kasiem, M., Harlos, K., Kooi, C. W. V., Smyth, S. S., ... Perrakis, A. (2011). Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural and Molecular Biology, 18, 198–204. https://doi.org/10.1038/nsmb.1980
Dusaulcy, R., Rancoule, C., Gres, S., Wanecq, E., Colom, A., Guigne, C., van Meeteren, L. A., Moolenaar, W. H., Valet, P., & Saulnier-Blache, J. S. (2011). Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. Journal of Lipid Research. https://doi.org/10.1194/jlr.M014985
2010
Wetenschappelijke publicaties
Hausmann, J., Christodoulou, E., Kasiem, M., De Marco, V., van Meeteren, L. A., Moolenaar, W. H., Axford, D., Owen, R. L., Evans, G., & Perrakis, A. (2010). Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. https://doi.org/10.1107/s1744309110032938
Albers, H., van Meeteren, L. A., Egan, D. A., van Tilburg, E. W., Moolenaar, W. H., & Ovaa, H. (2010). Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm1005012
Albers, H., Dong, A. P., van Meeteren, L. A., Egan, D. A., Sunkara, M., van Tilburg, E. W., Schuurman, K., van Tellingen, O., Morris, A. J., Smyth, S. S., Moolenaar, W. H., & Ovaa, H. (2010). Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1001529107
Geretti, E., van Meeteren, L. A., Shimizu, A., Dudley, A. C., Claesson-Welsh, L., & Klagsbrun, M. (2010). A Mutated Soluble Neuropilin-2 B Domain Antagonizes Vascular Endothelial Growth Factor Bioactivity and Inhibits Tumor Progression. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.mcr-10-0157
Hagberg, C. E., Falkevall, A., Larsson, E., Huusko, J., Nilsson, I., van Meeteren, L. A., Samen, E., Lu, L., Vanwildemeersch, M., Klar, J., Genove, G., Pietras, K., Stone-Elander, S., Claesson-Welsh, L., Ylä-Herttuala, S., Lindahl, P., & Eriksson, U. (2010). Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature, 464(7290), 917-21. https://doi.org/10.1038/nature08945
2009
Wetenschappelijke publicaties
Pamuklar, Z., Federico, L., Liu, S. Y., Umezu-Goto, M., Dong, A. P., Panchatcharam, M., Fulerson, Z., Berdyshev, E., Natarajan, V., Fang, X. J., Van Meeteren, L. A., Moolenaar, W. H., Mills, G. B., Morris, A. J., & Smyth, S. S. (2009). Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M807820200
2008
Wetenschappelijke publicaties
Kortlever, R. M., Brummelkamp, T. R., van Meeteren, L. A., Moolenaar, W. H., & Bernards, R. (2008). Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.mcr-08-0066
Kawamura, H., Li, X. J., Goishi, K., van Meeteren, L. A., Jakobsson, L., Cebe-Suarez, S., Shimizu, A., Edholm, D., Ballmer-Hofer, K., Kjellen, L., Klagsbrun, M., & Claesson-Welsh, L. (2008). Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood. https://doi.org/10.1182/blood-2007-12-125856
van Meeteren, L. A., Brinkmann, V., Saulnier-Blache, J. S., Lynch, K. R., & Moolenaar, W. H. (2008). Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters, 266(2), 203-8. https://doi.org/10.1016/j.canlet.2008.02.052
2007
Wetenschappelijke publicaties
Savaskan, N. E., Rocha, L., Kotter, M. R., Baer, A., Lubec, G., van Meeteren, L. A., Kishi, Y., Aoki, J., Moolenaar, W. H., Nitsch, R., & Brauer, A. U. (2007). Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-006-6412-0
van Meeteren, L. A., & Moolenaar, W. H. (2007). Regulation and biological activities of the autotaxin-LPA axis. Progress in Lipid Research, 46(2), 145-60. https://doi.org/10.1016/j.plipres.2007.02.001
2006
Wetenschappelijke publicaties
Ferguson, C. G., Bigman, C. S., Richardson, R. D., van Meeteren, L. A., Moolenaar, W. H., & Prestwich, G. D. (2006). Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity. Organic Letters. https://doi.org/10.1021/ol060414i
van Meeteren, L. A., Ruurs, P., Stortelers, C., Bouwman, P., van Rooijen, M. A., Pradère, J. P., Pettit, T. R., Wakelam, M. J. O., Saulnier-Blache, J. S., Mummery, C. L., Moolenaar, W. H., & Jonkers, J. (2006). Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Molecular and Cellular Biology, 26(13), 5015-22. https://doi.org/10.1128/MCB.02419-05
2005
Wetenschappelijke publicaties
Durgam, G. G., Virag, T., Walker, M. D., Tsukahara, R., Yasuda, S., Liliom, K., van Meeteren, L. A., Moolenaar, W. H., Wilke, N., Siess, W., Tigyi, G., & Miller, D. D. (2005). Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPAR gamma, and inhibitors of autotaxin. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm049609r
van Meeteren, L. A., Ruurs, P., Christodoulou, E., Goding, J. W., Takakusa, H., Kikuchi, K., Perrakis, A., Nagano, T., & Moolenaar, W. H. (2005). Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. Journal of Biological Chemistry, 280(22), 21155-61. https://doi.org/10.1074/jbc.M413183200
2004
Wetenschappelijke publicaties
Moolenaar, W. H., van Meeteren, L. A., & Giepmans, B. N. G. (2004). The ins and outs of lysophosphatidic acid signaling. BioEssays, 26(8), 870-81. https://doi.org/10.1002/bies.20081
van Meeteren, L. A., Frederiks, F., Giepmans, B. N. G., Pedrosa, M. F. F., Billington, S. J., Jost, B. H., Tambourgi, D. V., & Moolenaar, W. H. (2004). Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine. Journal of Biological Chemistry, 279(12), 10833-6. https://doi.org/10.1074/jbc.C300563200