See google scholar for full publication list https://scholar.google.nl/citations?user=J6Nbq20AAAAJ&hl=en
Publicaties
2024
Wetenschappelijke publicaties
Beausoleil, C., Thébault, A., Andersson, P., Cabaton, N. J., Ermler, S., Fromenty, B., Garoche, C., Griffin, J. L., Hoffmann, S., Kamstra, J. H., Kubickova, B., Lenters, V., Kos, V. M., Poupin, N., Remy, S., Sapounidou, M., Zalko, D., Legler, J., Jacobs, M. N., & Rousselle, C. (2024). Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach. Toxicology and Applied Pharmacology, 489, Article 116995. https://doi.org/10.1016/j.taap.2024.116995
Aardema, H., Vethaak, A. D., Kamstra, J. H., & Legler, J. (2024). Farm animals as a critical link between environmental and human health impacts of micro-and nanoplastics. Microplastics and Nanoplastics, 4(1), Article 5. https://doi.org/10.1186/s43591-024-00082-w
https://dspace.library.uu.nl/bitstream/handle/1874/438156/s43591-024-00082-w.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/438156/s43591-024-00082-w.pdf?sequence=1
2023
Wetenschappelijke publicaties
Yang, J., Kamstra, J., Legler, J., & Aardema, H. (2023). The impact of microplastics on female reproduction and early life. Animal Reproduction, 20(2), 1-14. Article e20230037. https://doi.org/10.1590/1984-3143-ar2023-0037
Cai, A., Portengen, L., Ertaylan, G., Legler, J., Vermeulen, R., Lenters, V., & Remy, S. (2023). Prenatal Exposure to Metabolism-Disrupting Chemicals, Cord Blood Transcriptome Perturbations, and Birth Weight in a Belgian Birth Cohort. International Journal of Molecular Sciences, 24(8), Article 7607. https://doi.org/10.3390/ijms24087607
Bouwmeester, M. C., Tao, Y., Proença, S., van Steenbeek, F. G., Samsom, R.-A., Nijmeijer, S. M., Sinnige, T., van der Laan, L. J. W., Legler, J., Schneeberger, K., Kramer, N. I., & Spee, B. (2023). Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing. Molecules (Basel, Switzerland), 28(2), Article 621. https://doi.org/10.3390/molecules28020621
Cai, A., Portengen, L., Govarts, E., Martin, L. R., Schoeters, G., Legler, J., Vermeulen, R., Lenters, V., & Remy, S. (2023). Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories. Chemosphere, 314, Article 137695. https://doi.org/10.1016/j.chemosphere.2022.137695
Proença, S., van Sabben, N., Legler, J., Kamstra, J. H., & Kramer, N. I. (2023). The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models. Toxicology, 485, Article 153411. https://doi.org/10.1016/j.tox.2022.153411
Dusza, H., van Boxel, J., Duursen, M. B. M. V., Forsberg, M., Legler, J., & Vahakangas, K. (2023). Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics. Science of the Total Environment, 860, Article 160403. https://doi.org/10.1016/j.scitotenv.2022.160403
2022
Wetenschappelijke publicaties
van den Berg, A. E. T., Plantinga, M., Vethaak, D., Adriaans, K. J., Bol-Schoenmakers, M., Legler, J., Smit, J. J., & Pieters, R. H. H. (2022). Environmentally weathered polystyrene particles induce phenotypical and functional maturation of human monocyte-derived dendritic cells. Journal of Immunotoxicology, 19(1), 125-133. https://doi.org/10.1080/1547691X.2022.2143968
Dusza, H. M., Katrukha, E. A., Nijmeijer, S. M., Akhmanova, A., Vethaak, A. D., Walker, D. I., & Legler, J. (2022). Uptake, Transport, and Toxicity of Pristine and Weathered Micro- and Nanoplastics in Human Placenta Cells. Environmental Health Perspectives, 130(9), 1-14. Article 097006. https://doi.org/10.1289/EHP10873
Dusza, H. M., Manz, K. E., Pennell, K. D., Kanda, R., & Legler, J. (2022). Identification of known and novel nonpolar endocrine disruptors in human amniotic fluid. Environment international, 158, 1-15. Article 106904. https://doi.org/10.1016/j.envint.2021.106904
2021
Wetenschappelijke publicaties
Vethaak, A. D., & Legler, J. (2021). Microplastics and human health: Knowledge gaps should be addressed to ascertain the health risks of microplastics. Science (New York, N.Y.), 371(6530), 672-674. https://doi.org/10.1126/science.abe5041
Street, M. E., Audouze, K., Legler, J., Sone, H., & palanza, P. (2021). Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs. International Journal of Molecular Sciences, 22(2), 1-5. Article 933. https://doi.org/10.3390/ijms22020933
Crespo, D., Assis, L. H. C., Zhang, Y. T., Safian, D., Furmanek, T., Skaftnesmo, K. O., Norberg, B., Ge, W., Choi, Y.-C., den Broeder, M. J., Legler, J., Bogerd, J., & Schulz, R. W. (2021). Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells. Communications Biology, 4(1), Article 204. https://doi.org/10.1038/s42003-021-01708-y
2020
Wetenschappelijke publicaties
Legler, J., Zalko, D., Jourdan, F., Jacobs, M., Fromenty, B., Balaguer, P., Bourguet, W., Munic Kos, V., Nadal, A., Beausoleil, C., Cristobal, S., Remy, S., Ermler, S., Margiotta-Casaluci, L., Griffin, J. L., Blumberg, B., Chesné, C., Hoffmann, S., Andersson, P. L., & Kamstra, J. H. (2020). The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds. International Journal of Molecular Sciences, 21(10), Article 3480. https://doi.org/10.3390/ijms21103480
Tukker, A. M., Bouwman, L. M. S., van Kleef, R. G. D. M., Hendriks, H. S., Legler, J., & Westerink, R. H. S. (2020). Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro. Scientific Reports, 10(1), Article 5311. https://doi.org/10.1038/s41598-020-62152-2
den Broeder, M. J., Ballangby, J., Kamminga, L. M., Aleström, P., Legler, J., Lindeman, L. C., & Kamstra, J. H. (2020). Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenetics and Chromatin, 13(1), 1-16. Article 5. https://doi.org/10.1186/s13072-020-0329-y
2019
Wetenschappelijke publicaties
Dusza, H. M., Janssen, E., Kanda, R., & Legler, J. (2019). Method Development for Effect-Directed Analysis of Endocrine Disrupting Compounds in Human Amniotic Fluid. Environmental Science & Technology, 53(24), 14649-14659. https://doi.org/10.1021/acs.est.9b04255
Zwartsen, A., Litjens, C. H. C., Hondebrink, L., van den Heuvel, J. J. M. W., Greupink, R., Russel, F. G. M., de Lange, D. W., Legler, J., Koenderink, J. B., & Westerink, R. H. S. (2019). Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT). Toxicology, 422, 69-75. https://doi.org/10.1016/j.tox.2019.04.012
2018
Wetenschappelijke publicaties
Kamstra, J. H., Hurem, S., Martin, L. M., Lindeman, L. C., Legler, J., Oughton, D., Salbu, B., Brede, D. A., Lyche, J. L., & Aleström, P. (2018). Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Scientific Reports, 8(1), Article 15373. https://doi.org/10.1038/s41598-018-33817-w
Bastos Sales, L., van Esterik, J. C. J., Hodemaekers, H. M., Lamoree, M. H., Hamers, T., van der Ven, L. T. M., & Legler, J. (2018). Analysis of Lipid Metabolism, Immune Function, and Neurobehavior in Adult C57BL/6JxFVB Mice After Developmental Exposure to di (2-ethylhexyl) Phthalate. Frontiers in Endocrinology, 9, Article 684. https://doi.org/10.3389/fendo.2018.00684
van Straalen, N. M., & Legler, J. (2018). Decision-making in a storm of discontent. Science, 360(6392), 958-960. https://doi.org/10.1126/science.aat0567
Govarts, E., Iszatt, N., Trnovec, T., de Cock, M., Eggesbø, M., Palkovicova Murinova, L., van de Bor, M., Guxens, M., Chevrier, C., Koppen, G., Lamoree, M., Hertz-Picciotto, I., Lopez-Espinosa, M. J., Lertxundi, A., Grimalt, J. O., Torrent, M., Goñi-Irigoyen, F., Vermeulen, R., Legler, J., & Schoeters, G. (2018). Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts. Environment international, 115, 267-278. https://doi.org/10.1016/j.envint.2018.03.017
2017
Wetenschappelijke publicaties
Kamstra, J. H., Sales, L. B., Aleström, P., & Legler, J. (2017). Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono(2-ethylhexyl) phthalate and 5-azacytidine in zebrafish. Epigenetics and Chromatin, 10(1). https://doi.org/10.1186/s13072-017-0126-4
den Broeder, M. J., Moester, M. J. B., Kamstra, J. H., Cenijn, P. H., Davidoiu, V., Kamminga, L. M., Ariese, F., De Boer, J. F., & Legler, J. (2017). Altered adipogenesis in zebrafish larvae following high fat diet and chemical exposure is visualised by stimulated raman scattering microscopy. International Journal of Molecular Sciences, 18(4), Article 894. https://doi.org/10.3390/ijms18040894
2016
Wetenschappelijke publicaties
Bouwmeester, M. C., Ruiter, S., Lommelaars, T., Sippel, J., Hodemaekers, H. M., van den Brandhof, E.-J., Pennings, J. L. A., Kamstra, J. H., Jelinek, J., Issa, J.-P. J., Legler, J., & van der Ven, L. T. M. (2016). Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicology and Applied Pharmacology, 291, 84-96. https://doi.org/10.1016/j.taap.2015.12.012
2015
Wetenschappelijke publicaties
Kamstra, J. H., Aleström, P., Kooter, J. M., & Legler, J. (2015). Zebrafish as a model to study the role of DNA methylation in environmental toxicology. Environmental science and pollution research international, 22(21), 16262-16276. https://doi.org/10.1007/s11356-014-3466-7
van Esterik, J. C. J., Verharen, H. W., Hodemaekers, H. M., Gremmer, E. R., Nagarajah, B., Kamstra, J. H., Dolle, M. E. T., Legler, J., & van der Ven, L. T. M. (2015). Compound- and sex-specific effects on programming of energy and immune homeostasis in adult C57BL/6JxWB mice after perinatal TCDD and PCB 153. Toxicology and Applied Pharmacology, 289(2), 262-275. https://doi.org/10.1016/j.taap.2015.09.017
Kamstra, J. H., Løken, M., Aleström, P., & Legler, J. (2015). Dynamics of DNA hydroxymethylation in zebrafish. Zebrafish, 12(3), 230-237. https://doi.org/10.1089/zeb.2014.1033
van Esterik, J. C. J., Vitins, A. P., Hodemaekers, H. M., Kamstra, J. H., Legler, J., Pennings, J. L. A., Steegenga, W. T., Lute, C., Jelinek, J., Issa, J. P. J., Dollé, M. E. T., & Van der Ven, L. T. M. (2015). Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A. Toxicology Letters, 232(1), 293-300. https://doi.org/10.1016/j.toxlet.2014.10.021
2014
Wetenschappelijke publicaties
Kamstra, J. H., Hruba, E., Blumberg, B., Janesick, A., Mandrup, S., Hamers, T., & Legler, J. (2014). Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant bde-47. Environmental Science and Technology, 48(7), 4110-4119. https://doi.org/10.1021/es405524b
2013
Wetenschappelijke publicaties
Bastos Sales, L., Kamstra, J. H., Cenijn, P. H., van Rijt, L. S., Hamers, T., & Legler, J. (2013). Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation. Toxicology in Vitro, 27(6), 1634-1643. https://doi.org/10.1016/j.tiv.2013.04.005
2012
Wetenschappelijke publicaties
Hawliczek, A., Nota, B., Cenijn, P., Kamstra, J., Pieterse, B., Winter, R., Winkens, K., Hollert, H., Segner, H., & Legler, J. (2012). Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo[b]fluorene and retene in the zebrafish Danio rerio. Reproductive Toxicology, 33(2), 213-223. https://doi.org/10.1016/j.reprotox.2011.11.001
2010
Wetenschappelijke publicaties
Van Esterik, J. C. J., Dollé, M. E. T., Imholz, S., Kamstra, J. H., Van Boxtel, A. L., Hamers, T., Legler, J., De Boever, P., Hollanders, K., Wens, B., & Van Der Ven, L. T. M. (2010). Experimental studies to analyze prenatal programming of obesity later in life by environmental endocrine disruptors. Obesity Reviews, 11(11), 820-821. https://doi.org/10.1111/j.1467-789X.2010.00822.x
van Boxtel, A. L., Kamstra, J. H., Fluitsma, D. M., & Legler, J. (2010). Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity. Toxicology and Applied Pharmacology, 244(2), 156-161. https://doi.org/10.1016/j.taap.2009.12.028
van boxtel, A. L., Pieterse, B., Cenijn, P., Kamstra, J. H., Brouwer, A., van wieringen, W., de Boer, J., & Legler, J. (2010). Dithiocarbamates induce craniofacial abnormalities and downregulate sox9a during zebrafish development. Toxicological Sciences, 117(1), 209-217. https://doi.org/10.1093/toxsci/kfq169
2008
Wetenschappelijke publicaties
Van Boxtel, A. L., Kamstra, J. H., Cenijn, P. H., Pieterse, B., Wagner, M. J., Antink, M., Krab, K., Van Der Burg, B., Marsh, G., Brouwer, A., & Legler, J. (2008). Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish. Environmental Science and Technology, 42(5), 1773-1779. https://doi.org/10.1021/es0720863
2006
Wetenschappelijke publicaties
Hamers, T., Kamstra, J. H., Sonneveld, E., Murk, A. J., Kester, M. H. A., Andersson, P. L., Legler, J., & Brouwer, A. (2006). In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicological Sciences, 92(1), 157-173. https://doi.org/10.1093/toxsci/kfj187
2000
Wetenschappelijke publicaties
Drenth, H. J., Letcher, R. J., Legler, J., Oehme, M., Brouwer, B., & van den Berg, M. (2000). (Anti)estrogenic effect of four toxaphene congeners and the technical mixture in stably transfected human T47D.LUC breast cancer cells. Organohalogen Compounds, 49, 367-370.