dr. ing. J. (Jitske) Jansen
j.jansen3@uu.nl
Gegenereerd op 2017-09-26 07:34:28


Profiel

 

 As a junior postdoctoral researcher I focus on the development of therapeutic entities to treat kidney failure. During my PhD research I successfully developed functional kidney tubules as the operative core of an extracorporeal bioartificial kidney (BAK). In my current project I aim to develop three-dimensional bioprinted implantable kidney tubules consisting of stem cell-derived kidney cells and advanced biomaterials, as a novel treatment modality to replace renal function.

 

Strategische thema's / focusgebieden
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Curriculum vitae

Jitske Jansen started her PhD career after a 7 year position as a technician at the Canisius Wilhelmina Hospital and RadboudUMC, Nijmegen. She performed her PhD research at the department of Pharmacology & Toxicoloy, in collaboration with the dept. of Physiology and Pediatrics, RadboudUMC, Nijmegen  (2012-2015). In this project she focused on the development of an extracorporeal bioartificial kidney (BAK) as a promising avenue to improve current renal replacement therapies. She successfully developed fully-functional bioengineered renal tubules as the operative core of an extracorporeal BAK device. She was awarded the best publication prize for PhD students for her paper on these results published in Nature Scientific Reports in 2015, by the Federation of European Pharmacology Societies (EPHAR) and the European Association for Clinical Pharmacology and Therapeutics (EACPT) in June 2016. 

In her current position as a junior postdoctoral researcher she aims to develop three-dimensional bioprinted implantable kidney tubules consisting of stem cell-derived kidney cells and advanced biomaterials. To get acquainted with induced pluripotent stem cell (iPSC) biology and kidney organoids culture, she initiated a collaboration with Prof. M.H. Little (Royal Children’s Hospital, MCRI, Melbourne, Australia) and performed a fellowship in her lab in 2017. To support this research, she received a Dutch Kidney Foundation Kolff Postdoc Fellowship abroad grant and an EMBO Short-Term Fellowship. Recently, a Dutch Kidney Foundation PhD student grant entitled 'Three-dimensional bioprinting of vascularized kidney tubules' was awarded which will support the development of novel treatment modalities to replace kidney function.  

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Alle publicaties
  2017 - Wetenschappelijke publicaties
Caetano-Pinto, Pedro, Jamalpoor, Amer, Ham, Janneke, Goumenou, Anastasia, Mommersteeg, Monique, Pijnenburg, Dirk, Ruijtenbeek, Rob, Sánchez-Romero, Natalia, van Zelst, Bertrand, Heil, Sandra, Jansen, Jitske, Wilmer, Martijn J, van Herpen, Carla M L & Masereeuw, Rosalinde (05-06-2017). Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Molecular Pharmaceutics, 14 (6), (pp. 2147-2157) (11 p.).
Jansen, Jitske, Jankowski, Joachim, Gajjala, Prathibha R, Wetzels, Jack F M & Masereeuw, Rosalinde (15-07-2017). Disposition and clinical implications of protein-bound uremic toxins. Clinical Science, 131 (14), (pp. 1631-1647) (17 p.). © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society..
  2016 - Wetenschappelijke publicaties
Jansen, J, Fedecostante, M, Wilmer, M J, Peters, J G, Kreuser, U M, van den Broek, P H, Mensink, R A, Boltje, T J, Stamatialis, D, Wetzels, J F, van den Heuvel, L P, Hoenderop, J G & Masereeuw, R (2016). Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports, 6.
Chevtchik, Natalia Vladimirovna, Fedecostante, Michele, Jansen, Jitske, Mihajlovic, Milos, Wilmer, Martijn, Rüth, Marieke, Masereeuw, Rosalinde & Stamatialis, Dimitrios (06-07-2016). Upscaling of a living membrane for bioartificial kidney device. European Journal of Pharmacology Copyright © 2016. Published by Elsevier B.V..
  2015 - Wetenschappelijke publicaties
Jansen, Jitske, De Napoli, I E, Fedecostante, M, Schophuizen, C M S, Chevtchik, N V, Wilmer, M J, van Asbeck, A H, Croes, H J, Pertijs, J C, Wetzels, J F M, Hilbrands, L B, van den Heuvel, L P, Hoenderop, J G, Stamatialis, D & Masereeuw, R (17-11-2015). Human proximal tubule epithelial cells cultured on hollow fibers - living membranes that actively transport organic cations. Scientific Reports, 5 (12 p.).

 Additional full papers:

  1. Mihajlovic M, van den Heuvel LP, Hoenderop JG, Jansen J, Wilmer MJ, Westheim AJF, Allebes WA, Stamatialis D, Hilbrands LB, Masereeuw R. Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application. Nature Scientific Reports. 2017; 7:7103. Impact factor 5.5.
  2. Jansen J, Schirris TJJ, Mihajlovic M, van den Heuvel LP, Masereeuw R, Russel FGM. Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model. Nature Scientific Reports. In Press. 2017. Impact factor 5.5.
  3. Jansen K, Schuurmans CCL, Jansen J, Masereeuw R, Vermonden T. Hydrogel-based cell therapies for kidney regeneration: current trends in biofabrication and in vivo repair. Current Pharmaceutical Design. In Press, 2017. Impact factor 3.1.
  4. Caetano-Pinto P, Jansen J, Assaraf YG, Masereeuw R. The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance. Drug Resistance Updates. 2017; 30:15-27. Impact factor 10.5
  5. Schophuizen CM, De Napoli IE, Jansen J, Teixeira S, Wilmer MJ, Hoenderop JG, Van den Heuvel LP, Masereeuw R, Stamatialis D. Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane. Acta Biomaterialia. 2015;14:22-32. Impact factor 6.4.
  6. Poesen R, Mutsaers HA, Windey K, van den Broek PH, Verweij V, Augustijns P, Kuypers D, Jansen J, Evenepoel P, Verbeke K, Meijers B, Masereeuw R. The influence of dietary protein intake on mammalian tryptophan and phenolic metabolites. PloS One. 2015;10(10):e0140820. Impact factor 3.5.
  7. Jansen J, Schophuizen CM, Wilmer MJ, Lahham SH, Mutsaers HA, Wetzels JF, Bank RA, van den Heuvel LP, Hoenderop JG, Masereeuw R. A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue. Experimental Cell Research. 2014;323(1):87-99. Impact factor 3.4.
  8. Jansen J, Fedecostante M, Wilmer MJ, van den Heuvel LP, Hoenderop JG, Masereeuw R. Biotechnological challenges of bioartificial kidney engineering. Biotechnology Advances. 2014;32(7):1317-27. Impact factor 11.8.
  9. Schophuizen CM, Wilmer MJ, Jansen J, Gustavsson L, Hilgendorf C, Hoenderop JG, van den Heuvel LP, Masereeuw R. Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter. Pflugers Archiv.: European Journal of Physiology. 2013;465(12):1701-14. Impact factor 4.1.
  10. Mutsaers HA, Wilmer MJ, Reijnders D, Jansen J, van den Broek PH, Forkink M, Schepers E, Glorieux G, Vanholder R, van den Heuvel LP, Hoenderop JG, Masereeuw R. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochimica et Biophysica Acta. 2013;1832(1):142-50. Impact factor 4.8.
  11. Jonckheere AI, Huigsloot M, Lammens M, Jansen J, van den Heuvel LP, Spiekerkoetter U, von Kleist-Retzow JC, Forkink M, Koopman WJ, Szklarczyk R, Huynen MA, Fransen JA, Smeitink JA, Rodenburg RJ. Restoration of complex V deficiency caused by a novel deletion in the human TMEM70 gene normalizes mitochondrial morphology. Mitochondrion. 2011;11(6):954-63. Impact factor 3.7.
  12. Westra D, Volokhina E, van der Heijden E, Vos A, Huigen M, Jansen Jvan Kaauwen E, van der Velden T, van de Kar N, van den Heuvel LP.Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS). Nephrology, Dialysis, Transplantation. 2010;25(7):2195-202. Impact factor 4.1.
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Gegenereerd op 2017-09-26 07:34:28

 

 

 

 

 

Research management

Supervisor of PhD candidates:

Katja Jansen, MSc. (2016-2020). NWO-funded graduate programme Future Drugs, ‘3D printed kidney tubes for renal function replacement’.

Anne Metje van Genderen, MSc. (2017-2021). Dutch Kidney Foundation PhD student grant 'Three-dimensional bioprinting of vascularized kidney tubules for uremic toxin removal'. Co-applicant.

 

Supervision internships MSc thesis 2013 – present:

  • Y. van Deursen, Pharmacy, Utrecht University
  • U.M. Kreuser, Molecular Mechanisms of Disease, Radboud University
  • K. Redert, Molecular Life Sciences, Radboud University
  • A. Othman, Drug Innovation, Utrecht University

Supervision internships BSc thesis 2013 – present:

  • J. Stoop, Biomedical Sciences, Radboud University
  • I. Donderwinkel, Molecular Life Sciences, Radboud University
  • N. Ali Khan, University College Utrecht

 

 

International presentations

Oral

Apr 2017          MCRI KDDR meeting. Bioartificial kidney engineering; first steps towards iPS-derived kidney tubules. Melbourne, Australia.Selected lecture.

Jun 2016          EPHAR/EACPT conference. Bioengineered kidney tubules efficiently secrete uremic toxins. Istanbul, Turkey. Invited lecture.

Apr 2016          EUTox conference. ‘Renal tubular excretion of protein bound uremic toxins and their regulation of renal drug transporters’. Hamburg, Germany. Selected lecture.

Mar 2015          EUTox conference. ‘Transport and regulation of anionic uremic toxins in human proximal tubule epithelial cells’. Marseille, France. Selected lecture.

Mar 2015          EUTox conference. ‘Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations’. Marseille, France. Selected lecture.

Nov 2014          ASN meeting. ‘Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations’. Philadelphia, USA. Selected lecture.

 

Poster

Jun 2017          TERMIS conference, Davos, Switzerland.

Sept 2015         Nephrotools conference. Liverpool, UK.

Nov 2014          ASN conference. Philadelphia, USA. 

 

Acquired Research Grants

Amount

Year

Dutch Kidney Foundation PhD student grant, co-applicant

€ 260,000

2017

NVF travel grant

€   500

2017

EMBO Short-Term Fellowship

€ 6,072

2017

DKF Kolff Postdoc Fellowship abroad

€ 3,750

2017

Young Investigator Award of the Federation of European Pharmacology Societies (EPHAR) and the European Association for Clinical Pharmacology and Therapeutics (EACPT), Istanbul, Turkey.

€ 1,000

2016

Radboud University Internationalisation Fund - travel grant to visit ASN conference in Philadelphia, US.

€ 750

2014

Van Noordwijk Stipendium prize (Battle of the Universities), Eindhoven, The Netherlands.

€ 1,000

2014

Best poster award New Frontiers in regenerative medicine, Nijmegen, The Netherlands.

€ 100

2014

 

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  • Course director PhD program Regenerative Medicine Utrecht: Enabling Technologies, May 2016 - present.
  • Radboud University Medical Center, Capita Selecta programme for Bachelor and Master Medicine students 2014-2015: Bioartificial kidney engineering.
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Nevenfuncties
  • Co-organizer (National) World Kidney Day event 2015-2017.
  • Renal board member of the Renal Theme research Nijmegen, 2015.
  • One year full ERA-EDTA membership following presentations during the EUtox meeting, France, 2015.
  • Membership Dutch federation of Nephrology, 2012 – present; Dutch Pharmacological Society, 2015-present
Gegenereerd op 2017-09-26 07:34:28
Volledige naam
dr. ing. J. Jansen Contactgegevens
David de Wiedgebouw

Universiteitsweg 99
Kamer -
3584 CG  UTRECHT

Telefoonnummer direct 062 025 1035
Gegenereerd op 2017-09-26 07:34:28
Laatst bijgewerkt op 17-08-2017