Dr. ir. J.A. (Jan) Mol

Dr. ir. J.A. (Jan) Mol

Inwendige Ziekten

Selected publications:

  • Gracanin A, van Wolferen ME, Sartorius CA, Brenkman AB, Schoonen WG, Mol JA. Canid progesterone receptors lack activation function 3 domain-dependent activity. ENDOCRINOLOGY 153: 6104-6113, 2012.
  • Selvarajah GT, Verheije MH, Kik M, Slob A, Rottier PJ, Mol JA, Kirpensteijn J Expression of epidermal growth factor receptor in canine osteosarcoma: association with clinicopathological parameters and prognosis. VET J 193:412-419, 2012
  • de Jong MK, Schoemaker NJ, Mol JA.  Expression of sfrp1 and activation of the Wnt pathway in the adrenal glands of healthy ferrets and neutered ferrets with hyperadrenocorticism. VET J 2012
  • Buishand FO, van Erp MG, Groenveld HA, Mol JA, Kik M, Robben JH, Kooistra HS, Kirpensteijn J. Expression of insulin-like growth factor-1 by canine insulinomas and their metastases. VET J 191(3): 334-340, 2012
  • Galac S, Kool MM, Naan EC, Daminet S, Mol JA, Kooistra HS. Expression of the ACTH receptor, steroidogenic acute regulatory protein, and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors. DOMEST ANIM ENDOCRINOL 39(4):259-67, 2010
  • Galac S, Kars VJ, Klarenbeek S, Teerds KJ, Mol JA, Kooistra HS. Expression of receptors for luteinizing hormone, gastric-inhibitory polypeptide, and vasopressin in normal adrenal glands and cortisol-secreting adrenocortical tumors in dogs. DOMEST ANIM ENDOCRINOL 39(1):63-75, 2010
  • Selvarajah GT, Kirpensteijn J, van Wolferen ME, Rao NA, Fieten H, Mol JA. Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. MOL CANCER 8:72, 2009.
  • Rao NA, van Wolferen ME, Gracanin A, Bhatti SF, Krol M, Holstege FC, Mol JA. Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors. J PHYSIOL PHARMACOL 60 Suppl 1: 73-84, 2009.
  • Timmermans-Sprang EP, Rao NA, Mol JA: Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells. DOMEST ANIM ENDOCRINOL 34: 403-410, 2008.
  • Rao NA, van Wolferen ME, van den Ham R, van Leenen D, Groot Koerkamp MJ, Holstege FC, Mol JA: cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. ANIM GENET 39: 333-345, 2008
  • Lai CL, van den Ham R, van Leenders G, van der Lugt J, Mol JA, Teske E: Histopathological and immunohistochemical characterization of canine prostate cancer. Prostate 68: 477-488, 2008
  • Galac S, Kars VJ, Voorhout G, Mol JA, Kooistra HS: ACTH-independent hyperadrenocorticism due to food-dependent hypercortisolemia in a dog: a case report. VET J 177: 141-143, 2008
  • Robben JH, van den Brom WE, Mol JA, van Haeften TW, Rijnberk A: Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma. RES VET SCI 80: 25-32, 2006
  • Hanson JM, Kooistra HS, Mol JA, Teske E, Meij BP: Plasma profiles of adrenocorticotropic hormone, cortisol, alpha-melanocyte-stimulating hormone, and growth hormone in dogs with pituitary-dependent hyperadrenocorticism before and after hypophysectomy. J ENDOCRINOL 190: 601-609, 2006
  • Bhatti SF, Duchateau L, Okkens AC, Van Ham LM, Mol JA, Kooistra HS: Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. THERIOGENOLOGY 66: 797-803, 2006
  • Marinelli L, Gabai G, Wolfswinkel J, Mol JA. Mammary steroid metabolizing enzymes in relation to progestin treatment and tumorigenesis in the dog. J STEROID BIOCHEM MOL BIOL 92: 167-173, 2004.
  • Rijnberk A, Kooistra HS, Mol JA. Endocrine diseases in dogs and cats: similarities and differences with endocrine diseases in humans. GROWTH HORM IGF RES. Suppl A:S158-64, 2003
  • Robben JH, Van Garderen E, Mol JA, Wolfswinkel J, Rijnberk A. Locally produced growth hormone in canine insulinomas. MOL CELL ENDOCRINOL. 197(1-2):187-95, 2002.
  • Kirpensteijn J, Timmermans-Sprang EP, van Garderen E, Rutteman GR, Lantinga-van Leeuwen IS, Mol JA. Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. MOL CELL ENDOCRINOL. 197(1-2):179-85, 2002.
  • Lantinga-van Leeuwen IS, Timmermans-Sprang EA, Mol JA. Cloning and characterization of the 5'-flanking region of the canine growth hormone gene. MOL CELL ENDOCRINOL. 197(1-2):133-41, 2002.
  • Schoemaker NJ, Teerds KJ, Mol JA, Lumeij JT, Thijssen JH, Rijnberk A. The role of luteinizing hormone in the pathogenesis of hyperadrenocorticism in neutered ferrets. MOL CELL ENDOCRINOL. 197(1-2):117-25, 2002.
  • Favier RP, Mol JA, Kooistra HS, Rijnberk A Large body size in the dog is associated with transient GH excess at a young age. J ENDOCRINOL 170:479-84, 2001.
  • Kooistra HS, den Hertog E, Okkens AC, Mol JA, Rijnberk A. Pulsatile secretion pattern of growth hormone during the luteal phase and mid-anoestrus beagle bitches. J REPROD FERTIL 119:217-222, 2000.
  • Lantinga-van Leeuwen IS, Van Garderen E, Rutteman GR, Mol JA. Cloning and cellular localization of the canine progesterone receptor. J STEROID BIOCHEM MOL BIOL 75:219-228, 2000.
  • Mahapokai W, Xue Y, Van Garderen E, Van Sluijs FJ, Mol JA, Schalken JA. Cell kinetics and differentiation after hormonal-induced prostatic hyperplasia in the dog. PROSTATE 44:40-48, 2000.
  • Lantinga-van Leeuwen IS, Mol JA, Kooistra HS, Rijnberk A, Breen M, Renier C,van Oost BA. Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.  MAMM GENOME. 11:31-36, 2000.
  • Van Garderen E, van der Poel HJ, Swennenhuis JF, Wissink EH, Rutteman GR,Hellmen E, Mol JA, Schalken JA. Expression and molecular characterization of the growth hormone receptor in canine mammary tissue and mammary tumors.  ENDOCRINOLOGY 140:5907-14, 1999.
  • Lantinga-van Leeuwen IS, Oudshoorn M, Mol JA: Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1.  MOL CELL ENDOCRINOL 150: 121-128, 1999.
  • Oosterlaken-Dijksterhuis MA, Kwant MM, Slob A, Hellmen E, Mol JA: IGF I and Retinoic Acid Regulate the Distribution Pattern of IGFBPs Synthesized by the Canine Mammary Tumor Cell Line CMT U335.  BREAST CANCER RES TREAT 54:11-23, 1999
  • Van de Wetering JK, Elfring RH, Oosterlaken-Dijksterhuis MA, Mol JA, Haagsman HP, Batenburg JJ: Perinatal Expression of IGFBPs in Rat Lung and Its Hormonal Regulation in Fetal Lung Explants.  AMER J PHYSIOL-LUNG CELL M PH 17:L1174-L1181, 1997
  • Van Garderen E, De Wit M, Voorhout WF, Rutteman GR, Mol JA, Nederbragt H, Misdorp W: Expression of Growth Hormone in Canine Mammary Tissue and Mammary Tumors Evidence for a Potential Autocrine/Paracrine Stimulatory Loop.  AMER J PATHOL 150:1037-1047, 1997
  • Mol JA, Van Garderen E, Rutteman GR, Rijnberk A: New Insights in the Molecular Mechanism of Progestin Induced Proliferation of Mammary Epithelium Induction of the Local Biosynthesis of Growth Hormone (GH) in the Mammary Gland of Dogs, Cats and Humans.  J STEROID BIOCHEM MOL BIOL 57:67-71, 1996
  • Mol JA, Van Garderen E, Selman PJ, Wolfswinkel J, Rijnberk A, Rutteman GR: Growth Hormone Messenger RNA in Mammary Gland Tumors of Dogs and Cats.  J CLIN INVEST 95:2028-2034, 1995
  • Mol JA, Henzen-Logmans SC, Hageman P, Misdorp W, Blankenstein MA, Rijnberk A: Expression of the Gene Encoding Growth Hormone in the Human Mammary Gland.  J CLIN ENDOCRINOL METAB 80:3094-3096, 1995
  • Selman PJ, Mol JA, Rutteman GR, Van Garderen E, Rijnberk AD: Progestin Induced Growth Hormone Excess in the Dog Originates in the Mammary Gland.  ENDOCRINOLOGY 134:287-292, 1994
  • Mol JA, Van Wolferen M, Kwant I, Meloen R: Predicted Primary and Antigenic Structure of Canine Corticotropin Releasing Hormone.  NEUROPEPTIDES 27:7-13, 1994
  • Rothuizen J, Reul JM, Van Sluijs FJ, Mol JA, Rijnberk A, De Kloet ER: Increased Neuroendocrine Reactivity and Decreased Brain Mineralocorticoid Receptor Binding Capacity in Aged Dogs.  ENDOCRINOLOGY 132:161-168, 1993
  • Van Wijk PA, Rijnberk A, Croughs RJ, Voorhout G, Sprang EP, Mol  JA. Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism. ENDOCRINOLOGY 131: 2659-2662, 1992.
  • Rijnberk A, van Wees A, Mol JA. Assessment of two tests for the diagnosis of canine hyperadrenocorticism. VET REC 122: 178-180, 1988.
  • Wulffraat NM, Drexhage HA, Wiersinga WM, van der Gaag RD, Jeucken P, Mol JA. Immunoglobulins of patients with Cushing's syndrome due to pigmented adrenocortical micronodular dysplasia stimulate in vitro steroidogenesis. J CLIN ENDOCRINOL METAB 66: 301-307, 1988.
  • Mol JA, Visser TJ. Synthesis and some properties of sulfate esters and sulfamates of iodothyronines. ENDOCRINOLOGY 117: 1-7, 1985.
  • Mol JA, Visser TJ. Rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase. ENDOCRINOLOGY 117: 8-12, 1985.
  • Otten MH, Mol JA, Visser TJ. Sulfation preceding deiodination of iodothyronines in rat hepatocytes. SCIENCE 221: 81- 83, 1983

 

Contributions to books

Mol JA, Lantinga-van LeeuwenIS, Van Garderen E, Rijnberk A. Progestin-induced Mammary Growth Hormone (GH) Production. In: “The Biology of the Mammary Gland”. (J.A. Mol, R. Clegg, eds). Plenum Press, London (2000) pp. 71-76.

 

Mol JA, Meij, BP. Pituitary Function. In: “Clinical Biochemistry of Domestic Animals, 6th edition”. (J.J. Kaneko, J.W. Harvey, M.L. Bruss eds.). Academic Press, Inc.; New York (2008) pp. 561-604.

 

Meij BP, Mol JA. Adrenocortical Function. In: “Clinical Biochemistry of Domestic Animals, 6th edition”. (J.J. Kaneko, J.W. Harvey, M.L. Bruss eds.). Academic Press, Inc.; New York (2008) pp. 605-622. 

Publicaties

2023

Wetenschappelijke publicaties

van der Krift, F., Zijlmans, D. W., Shukla, R., Javed, A., Koukos, P. I., Schwarz, L. LE., Timmermans-Sprang, E. P., Maas, P. E., Gahtory, D., van den Nieuwboer, M., Mol, J. A., Strous, G. J., Bonvin, A. M., van der Stelt, M., Veldhuizen, E. J., Weingarth, M., Vermeulen, M., Klumperman, J., & Maurice, M. M. (2023). A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance. Life Science Alliance, 6(11), [e202302058]. https://doi.org/10.26508/lsa.202302058

2022

Wetenschappelijke publicaties

van der Velden, L. M., Maas, P., van Amersfoort, M., Timmermans-Sprang, E. P. M., Mensinga, A., van der Vaart, E., Malergue, F., Viëtor, H., Derksen, P. W. B., Klumperman, J., van Agthoven, A., Egan, D. A., Mol, J. A., & Strous, G. J. (2022). Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis. Frontiers in Endocrinology, 13, 1-14. [926210]. https://doi.org/10.3389/fendo.2022.926210

2021

Wetenschappelijke publicaties

Beltrán Hernández, I., Grinwis, G. C. M., Di Maggio, A., Van Bergen En Henegouwen, P. M. P., Hennink, W. E., Teske, E., Hesselink, J. W., Van Nimwegen, S. A., Mol, J. A., & Oliveira, S. (2021). Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: A step towards translation to the veterinary clinic. Nanophotonics, 10(12), 3075-3087. https://doi.org/10.1515/nanoph-2021-0195
Oerlemans, A., Figueiredo, D. M., Mol, J. G. J., Nijssen, R., Anzion, R. B. M., van Dael, M. F. P., Duyzer, J., Roeleveld, N., Russel, F. G. M., Vermeulen, R. C. H., & Scheepers, P. T. J. (2021). Personal exposure assessment of pesticides in residents: the association between hand wipes and urinary biomarkers. Environmental Research, 199, 1-9. [111282]. https://doi.org/10.1016/j.envres.2021.111282

2019

Wetenschappelijke publicaties

Oerlemans, A., Verscheijden, L. F. M., Mol, J. G. J., Vermeulen, R. C. H., Westerhout, J., Roeleveld, N., Russel, F. G. M., & Scheepers, P. T. J. (2019). Toxicokinetics of a urinary metabolite of tebuconazole following controlled oral and dermal administration in human volunteers. Archives of Toxicology, 93(9), 2545-2553. https://doi.org/10.1007/s00204-019-02523-5
Abrahão, V., Mol, J., & De Pinna, M. (2019). A new species of Cetopsis from the Guiana Shield (Siluriformes: Cetopsidae: Cetopsinae). Zootaxa, 4664(2), 221-232. https://doi.org/10.11646/zootaxa.4664.2.4
Sanders, K., van Staalduinen, G. J., Uijens, M. C. M., Mol, J. A., Teske, E., Slob, A., Hesselink, J. W., Kooistra, H. S., & Galac, S. (2019). Molecular Markers of Prognosis in Canine Cortisol-Secreting Adrenocortical Tumours. Veterinary and Comparative Oncology, 17(4), 545-552. https://doi.org/10.1111/vco.12521
Timmermans-Sprang, E., Collin, R., Henkes, A., Philipsen, M., & Mol, J. A. (2019). P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines. Oncotarget, 10(31), 2930-2946. https://doi.org/10.18632/oncotarget.26873, https://doi.org/10.18632
Timmermans-Sprang, E. P. M., Mestemaker, H. M., Steenlage, R. R., & Mol, J. A. (2019). Dasatinib inhibition of cSRC prevents the migration and metastasis of canine mammary cancer cells with enhanced Wnt and HER signaling. Veterinary and Comparative Oncology, 17(3), 413-426. https://doi.org/10.1111/vco.12490
Sanders, K., Cirkel, K., Grinwis, G. C. M., Teske, E., van Nimwegen, S. A., Mol, J. A., Hesselink, J. W., Kooistra, H. S., & Galac, S. (2019). The Utrecht Score: A Novel Histopathological Scoring System to Assess the Prognosis of Dogs with Cortisol-Secreting Adrenocortical Tumours. Veterinary and Comparative Oncology, 17(3), 329-337. https://doi.org/10.1111/vco.12474

2018

Wetenschappelijke publicaties

Verhoeven, C., Sprang, E. P. M., Liu, JS., Gracanin, A., Coelingh Bennink, H. J. T., & Mol, J. A. (2018). Fetal Estetrol (E4) Inhibits Growth Hormone (GH) Signal Transduction in Breast Cancer Cell Lines. Austin Journal of Obstetrics and Gynecology, 5(7), [1123]. http://austinpublishinggroup.com/obstetrics-gynecology/download.php?file=fulltext/ajog-v5-id1123.pdf
https://dspace.library.uu.nl/bitstream/handle/1874/377591/fulltext_ajog_v5_id1123.pdf?sequence=1
Pijnacker, T., Knies, M., Galac, S., Sanders, K., Mol, J. A., & Kooistra, H. S. (2018). TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism. Veterinary Quarterly, 38(1), 72-78. https://doi.org/10.1080/01652176.2018.1521537
Pijnacker, T., Kooistra, H. S., Vermeulen, C. F., van der Vinne, M., Prins, M., Galac, S., & Mol, J. A. (2018). Use of basal and TRH-stimulated plasma growth hormone concentrations to differentiate between primary hypothyroidism and nonthyroidal illness in dogs. Journal of Veterinary Internal Medicine, 32(4), 1319-1324. https://doi.org/10.1111/jvim.15139
Sanders, K., Mol, J. A., Kooistra, H. S., & Galac, S. (2018). Melanocortin 2 receptor antagonists in canine pituitary-dependent hypercortisolism: in vitro studies. Veterinary Research Communications, 42(4), 283-288. https://doi.org/10.1007/s11259-018-9737-x
Sanders, K., de Wit, W. L., Mol, J. A., Kurlbaum, M., Kendl, S., Kroiss, M., Kooistra, H. S., & Galac, S. (2018). Abiraterone Acetate for Cushing's Syndrome: Study in a Canine Primary Adrenocortical Cell Culture Model. Endocrinology, 159(11), 3689–3698. https://doi.org/10.1210/en.2018-00588
Sanders, K., Mol, J. A., Slob, A., Kooistra, H. S., & Galac, S. (2018). Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: in vitro study. Domestic Animal Endocrinology, 63, 23-30. https://doi.org/10.1016/j.domaniend.2017.11.001
Capodanno, Y., Buishand, F. O., Pang, L. Y., Kirpensteijn, J., Mol, J. A., & Argyle, D. J. (2018). Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells. Endocrine-Related Cancer, 25, 131-144. https://doi.org/10.1530/ERC-17-0415

2017

Wetenschappelijke publicaties

Selvarajah, G. T., Bonestroo, F. A. S., Timmermans Sprang, E. P. M., Kirpensteijn, J., & Mol, J. A. (2017). Reference gene validation for gene expression normalization in canine osteosarcoma: a geNorm algorithm approach. BMC Veterinary Research, 13, [354]. https://doi.org/10.1186/s12917-017-1281-3
Timmermans-Sprang, E. P. M., Gracanin, A., & Mol, J. A. (2017). Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification. Frontiers in Veterinary Science, 4, [53]. https://doi.org/10.3389/fvets.2017.00053

Overige resultaten

Sanders, K., Mol, J. A., Kooistra, H. S., & Galac, S. (2017). Melanocortin 2 Receptor Antagonists in ACTH-Dependent Hypercortisolism: In Vitro Study in Canine Primary Adrenocortical Cell Culture. Poster session presented at endo2017, orland, United States.

2016

Wetenschappelijke publicaties

Sanders, K., Mol, J. A., Kooistra, H. S., Slob, A., & Galac, S. (2016). New Insights in the Functional Zonation of the Canine Adrenal Cortex. Journal of Veterinary Internal Medicine, 30(3), 741-750. https://doi.org/10.1111/jvim.13946
Buishand, F. O., Arkesteijn, G. J. A., Feenstra, L. R., Oorsprong, C. W. D., Mestemaker, M., Starke, A., Speel, E-J. M., Kirpensteijn, J., & Mol, J. A. (2016). Identification of CD90 as Putative Cancer Stem Cell Marker and Therapeutic Target in Insulinomas. Stem Cells and Development, 25(11), 826-835. https://doi.org/10.1089/scd.2016.0032

2015

Wetenschappelijke publicaties

van den Brom, W. E., Oosterlaken-Dijksterhuis, M. A., Tryfonidou, M. A., Mol, J. A., Hazewinkel, H. A. W., & van den Ingh, T. S. G. A. M. (2015). 24-Hydroxylase: potential key regulator in hypervitaminosis D 3 in growing dogs. American Journal of Physiology-Endocrinology and Metabolism, 284(3), E505-E513. https://doi.org/10.1152/ajpendo.00236.2002
Timmermans-Sprang, E. P. M., Gracanin, A., & Mol, J. A. (2015). High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression. BMC Cancer, 15(545). https://doi.org/10.1186/s12885-015-1544-y
Kool, M. M. J., Galac, S., van der Helm, N., Spandauw, C. G., Kooistra, H. S., & Mol, J. A. (2015). Expression of somatostatin, dopamine, progesterone and growth hormone receptor mRNA in canine cortisol-secreting adrenocortical tumours. Veterinary Journal, 108-110. https://doi.org/10.1016/j.tvjl.2015.05.014
https://dspace.library.uu.nl/bitstream/handle/1874/327185/DOPA_and_SST_in_AT.pdf?sequence=1
Kool, M. M. J., Galac, S., van der Helm, N., Corradini, S., Kooistra, H. S., & Mol, J. A. (2015). Insulin-Like Growth Factor-Phosphatidylinositol 3 Kinase Signaling in Canine Cortisol-Secreting Adrenocortical Tumors. Journal of Veterinary Internal Medicine, 29(1), 214-224. https://doi.org/10.1111/jvim.12528
Grünberg, W., Mol, J. A., & Teske, E. (2015). Red blood cell phosphate concentration and osmotic resistance during dietary phosphate depletion in dairy cows. Journal of Veterinary Internal Medicine, 29(1), 395-399. https://doi.org/10.1111/jvim.12497
Mauchle, U., Selvarajah, G. T., Mol, J. A., Kirpensteijn, J., & Verheije, M. H. (Accepted/In press). Identification of anti-proliferative kinase inhibitors as potential therapeutic agents to treat canine osteosarcoma. Veterinary Journal. https://doi.org/10.1016/j.tvjl.2014.08.006
Zandvliet, M., Teske, E., Schrickx, J. A., & Mol, J. A. (2015). A longitudinal study of ABC transporter expression in canine multicentric lymphoma. Veterinary Journal, 205(2), 263-271. https://doi.org/10.1016/j.tvjl.2014.11.002

Overige resultaten

Jaarsma, A. A., Buishand, F. O., Kirpensteijn, J., Mol, J. A., & Schoemaker, N. J. (2015). Characterization and functional analyses of ferret insulinoma cell lines. 367. Abstract from 2nd international conference on avian, herpetological and exotic small mammal medicine (ICARE), Paris, France.

2014

Wetenschappelijke publicaties

Rijnberk, A., Selman, P. J., Mol, J. A., van Garderen, E., & Rutteman, G. R. (2014). Progestin-induced growth hormone excess in the dog originates in the mammary gland. In Endocrinology (pp. 287-292). (Endocrinology; Vol. 134). The Endocrine Society. https://doi.org/10.1210/endo.134.1.7506206
Kool, M. M. J., Galac, S., Kooistra, H. S., & Mol, J. A. (2014). Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, 47(1), 73-82. https://doi.org/10.1016/j.domaniend.2013.11.004
Gracanin, A., Timmermans-Sprang, E. P. M., van Wolferen, M. E., Rao, N. A. S., Grizelj, J., Vince, S., Hellmen, E., & Mol, J. A. (2014). Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. PLoS One, 9(6), [e98698]. https://doi.org/10.1371/journal.pone.0098698
de Jong, M. K., ten Asbroek, E. E. M., Sleiderink, A. J., Conley, A. J., Mol, J. A., & Schoemaker, N. J. (2014). Gonadectomy-related adrenocortical tumors in ferrets demonstrate increased expression of androgen and estrogen synthesizing enzymes together with high inhibin expression. Domestic Animal Endocrinology, 48, 42–47. https://doi.org/10.1016/j.domaniend.2014.02.002
Galac, S., Kool, M. M. J., van den Berg, M. F., Mol, J. A., & Kooistra, H. S. (2014). Expression of steroidogenic factor 1 in canine cortisol-secreting adrenocortical tumors and normal adrenals. Domestic Animal Endocrinology, 49, 1-5. https://doi.org/10.1016/j.domaniend.2014.04.002
Gracanin, A., Voorwald, F. A., van Wolferen, M., Timmermans-Sprang, E., & Mol, J. A. (2014). Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer. Journal of Steroid Biochemistry and Molecular Biology, 144 Pt B, 492-9. https://doi.org/10.1016/j.jsbmb.2014.08.016
Campos, M., Kool, M. M. J., Daminet, S., Ducatelle, R., Rutteman, G., Kooistra, H. S., Galac, S., & Mol, J. A. (2014). Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma. Journal of Veterinary Internal Medicine, 28(6), 1814–1823. https://doi.org/10.1111/jvim.12435
L'Eplattenier, H., Teske, E., Van Sluijs, F., & Mol, J. A. (2014). CAG-repeats in the androgen receptor gene relate with plasma androgen levels in the Bouvier Des Flandres. In Vivo, 28(6), 1051-5.
https://dspace.library.uu.nl/bitstream/handle/1874/314456/2014_L_Eplattenier_In_Vivo.pdf?sequence=1

2013

Wetenschappelijke publicaties

Selvarajah, G., Kirpensteijn, J., Kik, M., Sprang, E. P. M., & Mol, J. (2013). Heat shock protein expression analysis in canine osteosarcoma reveals hsp90 as a potentially relevant therapeutic target. Cell Stress and Chaperones, 18(5), 607-22. [PMC3745254].
Selvarajah, G. T., Bonestroo, F. A. S., Kirpensteijn, J., Kik, M. J. L., van der Zee, R., van Eden, W., Timmermans-Sprang, E. P. M., Slob, A., & Mol, J. A. (2013). Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target. Cell Stress & Chaperones, 18(5), 607-622. https://doi.org/10.1007/s12192-013-0414-2
Buishand, F. O., Kirpensteijn, J., Jaarsma, A. A., Speel, EJ., Kik, M. J. L., & Mol, J. A. (2013). Gene expression profiling of primary canine insulinomas and their metastases. Veterinary Journal, 18(S1090-0233(13)00044-0). https://doi.org/10.1016/j.tvjl.2013.01.021
Kool, M. M. J., Galac, S., Kooistra, H. S., & Mol, J. A. (2013). Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, 10.1111/jvim.12194. https://doi.org/10.1111/jvim.12194
Rutteman, G. R., Erich, S. A., Mol, J. A., Spee, B., Grinwis, G. C. M., Fleckenstein, L., London, C. A., & Efferth, T. (2013). Safety and efficacy field study of artesunate for dogs with non-resectable tumours. Anticancer Research, 33(5), 1819-1827.
Kool, M. M., Galac, S., Spandauw, C. G., Kooistra, H. S., & Mol, J. A. (2013). Activating Mutations of GNAS in Canine Cortisol-Secreting Adrenocortical Tumors. Journal of Veterinary Internal Medicine, 27(6), 1486-1492. https://doi.org/10.1111/jvim.12194
de Jong, M. K., Schoemaker, N. J., & Mol, J. A. (2013). Expression of sfrp1 and activation of the Wnt pathway in the adrenal glands of healthy ferrets and neutered ferrets with hyperadrenocorticism. Veterinary Journal, 196(2013), 176-180. https://doi.org/10.1016/j.tvjl.2012.09.022

2012

Wetenschappelijke publicaties

Gracanin, A., de Gier, J., Zegers, K., Bominaar, M., Rutteman, G. R., Schaefers-Okkens, A. C., Kooistra, H. S., & Mol, J. A. (2012). Progesterone receptor isoforms in the mammary gland of cats and dogs. Reproduction in Domestic Animals, 47(6), 313-317. https://doi.org/10.1111/rda.12045
Gracanin, A., van Wolferen, M. E., Sartorius, C. A., Brenkman, A. B., Schoonen, W. G., & Mol, J. A. (2012). Canid progesterone receptors lack activation function 3 domain-dependent activity. Endocrinology, 153(12), 6104-6113.
Buishand, F. O., van Erp, M. G., Mol, J. A., Groenveld, H. A., Kik, M. J. L., Robben, J. H., Kooistra, H. S., & Kirpensteijn, J. (2012). Expression of insulin-likegrowthfactor-1 by canineinsulinomas and their metastases. Veterinary Journal, 191(3), 334-340. https://doi.org/10.1016/j.tvjl.2011.03.014
Selvarajah, G. T., Verheije, M. H., Kik, M. J. L., Slob, A., Rottier, P. J. M., Mol, J. A., & Kirpensteijn, J. (2012). Expression of epidermal growth factor receptor in canine osteosarcoma: Association with clinicopathological parameters and prognosis. Veterinary Journal, 193(2), 412-419. https://doi.org/10.1016/j.tvjl.2012.02.009

2011

Wetenschappelijke publicaties

Beijerink, N. J., Lee, W. M., Stokhof, A. A., Voorhout, G., Mol, J. A., & Kooistra, H. S. (2011). Evaluation of pulsatile plasma concentrations of growth hormone in healthy dogs and dogs with dilated cardiomyopathy. American Journal of Veterinary Research, 72(1), 59-63. https://doi.org/10.2460/ajvr.72.1.59

2010

Wetenschappelijke publicaties

Meij, B. P., Hanson-Nilsson, J. M., & Mol, J. A. (2010). Predictive value of postoperative plasma ACTH, α-MSH, and cortisol concentrations for recurrence after hypophysectomy in dogs with Cushing's disease. In Proceedings European Neuroendocrine Association (ENEA) (pp. 76-76).
Galac, S., Buijtels, J. J. C. W. M., Mol, J. A., & Kooistra, H. S. (2010). Effects of trilostane treatment on the pituitary-adrenocortical and renin-aldosterone axis in dogs with pituitary-dependent hypercortisolism. Veterinary Journal, 183(1), 75-80. https://doi.org/10.1016/j.tvjl.2008.10.007
Galac, S., Kool, M., Naan, E. C., Daminet, S., Mol, J. A., & Kooistra, H. S. (2010). Expression of ACTH receptor, steroidogenic acute regulatory protein and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology, 39(4), 259-267. https://doi.org/10.1016/j.domaniend.2010.07.001
Galac, S., Kars, V. J., Klarenbeek, S., Teerds, K. J., Mol, J. A., & Kooistra, H. S. (2010). Expression of receptors for gastric-inhibitory polypeptide, luteinizing hormone, and vasopressin in normal adrenals and cortisol-secreting adrenocortical tumors in dogs. Domestic Animal Endocrinology, 39(1), 63-75. https://doi.org/10.1016/j.domaniend.2010.02.003
Hanson, J. M., Mol, J. A., & Meij, B. P. (2010). Expression of leukemia inhibitory factor and leukemia inhibitory factor receptor in the canine pituitary gland and corticotrope adenomas. Domestic Animal Endocrinology, 38(4), 260-271.

2009

Wetenschappelijke publicaties

Krol, M., Skierski, J., Rao, N. A., Hellmen, E., Mol, J. A., & Motyl, T. (2009). Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential. Journal of Physiology and Pharmacology, 60(Suppl. 1), 95-106.
https://dspace.library.uu.nl/bitstream/handle/1874/39278/Transcriptomic%2520profile.pdf?sequence=1
Lai, C-L., van den Ham, R., Mol, J. A., & Teske, E. (2009). Immunostaining of the androgen receptor and sequence analysis of its DNA-binding domain in canine prostate cancer. Veterinary Journal, 181, 256-260.
Rao, N. A., van Wolferen, M. E., Gracanin, A., Bhatti, S. F., Krol, M., Holstege, F. C. P., & Mol, J. A. (2009). Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors. Journal of Physiology and Pharmacology, 60(suppl. 1), 73-84. http://www.ncbi.nlm.nih.gov/pubmed/19609016?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8
Diaz-Espineira, M. M., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2009). Adenohypophyseal function in dogs with primary hypothyroidism and non-thyroidal illness. Journal of Veterinary Internal Medicine, 23, 100-107.
Selvarajah, G. T., Kirpensteijn, J., van Wolferen, M. E., Rao, N. A., Fieten, H., & Mol, J. A. (2009). Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Molecular Cancer, 8, 72. https://doi.org/10.1186/1476-4598-8-72
Pawlowski, K. M., Krol, M., Majewska, A., Badowska-Kozakiewicz, A., Mol, J. A., Malicka, E., & Motyl, T. (2009). Comparison of cellular and tissue transcriptional profiles in canine mammary tumor. Journal of Physiology and Pharmacology, 60(Suppl. 1), 85-94.
https://dspace.library.uu.nl/bitstream/handle/1874/39324/Comparison%2520of%2520cellular%2520and%2520tissue.pdf?sequence=1

2008

Wetenschappelijke publicaties

Diaz Espineira, M. M., Galac, S., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2008). Thyrotropin releasing hormone-induced growth hormone secretion in dogs with primary hypothyroidism. Domestic Animal Endocrinology, 34, 176-181.
Diaz Espineira, M. M., Mol, J. A., van den Ingh, T. S. G. A. M., van der Vlugt-Meijer, R. H., Rijnberk, A., & Kooistra, H. S. (2008). Functional and morphological changes in the adenohypophysis of dogs with induced primary hypothyroidism; loss of TSH hypersecretion, hypersomatotropism, hypoprolactinemia, and pituitary enlargement with transdifferentiation. Domestic Animal Endocrinology, 35, 98-111.
Lai, C-L., van den Ham, H. J., Verseijden, F., Jagtenberg, A., Mol, J. A., & Teske, E. (2008). Androgen receptor CAG repeat polymorphisms in canine prostate cancer. Journal of Veterinary Internal Medicine, 22(6), 1380-1384. https://doi.org/10.1111/j.1939-1676.2008.0181.x
Galac, S., Kars, V. J., Voorhout, G., Mol, J. A., & Kooistra, H. S. (2008). ACTH-independent hyperadrenocorticism due to meal induced hypercortisolaemia in a dog. Veterinary Journal, 177, 141-143.
Meij, B. P., & Mol, J. A. (2008). Adrenocortical Function. In JJ. Kaneko, JW. Harvey, & ML. Bruss (Eds.), Clinical Biochemistry of Domestic Animals (6th edition). Academic Press Inc..
Timmermans-Sprang, E. P. M., Rao, N. A., & Mol, J. A. (2008). Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells. Domestic Animal Endocrinology, 34(4), 403-410.
Rao, N. A., van Wolferen, M. E., van den Ham, R., van Leenen, D., Groot Koerkamp, M. J. A., Holstege, F. C. P., & Mol, J. A. (2008). cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. Animal Genetics, 39(4), 333-345.
Mol, J. A., & Meij, B. P. (2008). Pituitary function. In JJ. Kaneko, JW. Harvey, & ML. Bruss (Eds.), Clinical Biochemistry of Domestic Animals (pp. 561-604). (6th edition). Academic Press Inc..
Schoemaker, N. J., van Deijk, R., Muijlaert, B., Kik, M. J. L., Kuijten, A., de Jong, F. H., Trigg, T. E., Kruitwagen, C. L. J. J., & Mol, J. A. (2008). Use of a gonadotropin releasing hormone agonist implant as an alternative for surgical castration in male ferrets (Mustela putorius furo). Theriogenology, 70, 161-167.
Hanson, J. M., Mol, J. A., Leegwater, P. A. J., Bilodeau, S., Drouin, J., & Meij, B. P. (2008). Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas. Domestic Animal Endocrinology, 34, 454-460.
Lai, C-L., van den Ham, R., van Leenders, G., van der Lugt, J. J., Mol, J. A., & Teske, E. (2008). Histopathological and immunohistochemical characterization of canine prostate cancer. Prostate, 68, 477-488.
https://dspace.library.uu.nl/bitstream/handle/1874/31962/Chen-Li%2520Lai%2520et%2520al%25202008.pdf?sequence=1

2007

Wetenschappelijke publicaties

L'Eplattenier, H. F., Lai, C. L., van den Ham, R., Mol, J., van Sluijs, F., & Teske, E. (2007). Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation. Journal of Veterinary Internal Medicine, 21(4), 776-82.
Klarenbeek, M., Schaefers-Okkens, A. C., Kooistra, H. S., Mol, J. A., Bevers, M. M., & Taverne, M. A. M. (2007). Plasma oxytocin concentrations during late pregnancy and parturition in the dog. Theriogenology, 68(8), 1169-1176.
Cerundolo, R., Lloyd, D. H., Vaessen, M. M. A. R., Mol, J. A., Kooistra, H. S., & Rijnberk, A. (2007). Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback. Veterinary Record, 160(12), 393-397.
Beijerink, N. J., Bhatti, S. F., Schaefers-Okkens, A. C., Dieleman, S. J., Mol, J. A., Duchateau, L., van Ham, L. M., & Kooistra, H. S. (2007). Adenohypophyseal function in bitches treated with medroxyprogesterone acetate. Domestic Animal Endocrinology, 32, 63-78.
https://dspace.library.uu.nl/bitstream/handle/1874/19768/Beijrink%2C%2520Bhatti%2C%2520Okkens%2C%2520Dieleman%2C%2520Mol%2C%2520Duchateau%2C%2520van%2520Ham%2C%2520Kooistra%2520-%2520Adenohypophyseal%2520function%2520in%2520bitches%2520treated%2520with%2520medroxyprogesterone%2520acetate.pdf?sequence=1
Bhatti, S. F., Rao, N. S. R., Schaefers-Okkens, A. C., Mol, J. A., Duchateau, L., Ducatelle, R., van den Ingh, T. S. G. A. M., Tshamala, M., van Ham, L. M. L., Coryn, M., Rijnberk, A., & Kooistra, H. S. (2007). Role progestin-induced mammary-derived growth hormone in the pathogenesis of cystic endometrial hyperplasia in the bitch. Domestic Animal Endocrinology, 33, 294-312.
Diaz Espineira, M. M., Mol, J. A., Peeters, M. E., Pollak, Y. W., Iversen, L., van Dijk, J. E., Rijnberk, A., & Kooistra, H. S. (2007). Assessment of thyroid function in dogs with low plasma thyroxine concentration. Journal of Veterinary Internal Medicine, 21, 25-32.

2006

Wetenschappelijke publicaties

Hanson, J. M., Kooistra, H. S., Mol, J. A., Teske, E., & Meij, B. P. (2006). Plasma profiles of adrenocorticotropic hormone, cortisol, α-melanocyte-stimulating hormone, and growth hormone in dogs with pituitary-dependent hyperadrenocorticism before and after hypophysectomy. Journal of Endocrinology, 190(3), 601-609. https://doi.org/10.1677/joe.1.06782
Bhatti, S. F., Duchateau, L., Schaefers-Okkens, A. C., van Ham, L. M., Mol, J. A., & Kooistra, H. S. (2006). Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. Theriogenology, 66, 797-803.
https://dspace.library.uu.nl/bitstream/handle/1874/20202/Bhatti%2C%2520Duchateau%2C%2520Okkens%2C%2520van%2520Ham%2C%2520Mol%2C%2520Kooistra-Treatment%2520of%2520growth%2520hormone%2520excess%2520in%2520dogs%2520with%2520the%2520progesterone%2520receptor%2520antagonist.pdf?sequence=1
Robben, J. H., van den Brom, W. E., Mol, J. A., van Haeften, T. W., & Rijnberk, A. (2006). Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma. Research in Veterinary Science, 80(1), 25-32.
Bhatti, S. F., Duchateau, L., van Ham, L. M. L., de Vlieger, S. P., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2006). Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs. Veterinary Journal, 72(3), 515-525.
https://dspace.library.uu.nl/bitstream/handle/1874/20251/Bhatti%2C%2520Duchateau%2C%2520van%2520Ham%2C%2520de%2520Vlieger%2C%2520Mol%2C%2520Rijberk%2C%2520Kooistra-%2520Effects%2520of%2520growth%2520hormone%2520secretagogues%2520on%2520the%2520release%2520of%2520adenohypophyseal%2520hormones%2520in%2520young%2520and%2520old%2520healthy%2520dogs.pdf?sequence=1
Lee, M. H., Kooistra, H. S., Mol, J. A., Dieleman, S. J., & Schaefers-Okkens, A. C. (2006). Ovariectomy during the luteal phase influences secretion of prolactin, growth hormone, and insulin-like growth factor-I in the bitch. Theriogenology, 66, 484-490.
https://dspace.library.uu.nl/bitstream/handle/1874/20223/Lee%2C%2520Kooistra%2C%2520Mol%2C%2520Dieleman%2C%2520Schaefers-Okkens%2520-Ovariectomy%2520during%2520the%2520luteal%2520phase%2520influences%2520secretion%2520of%2520prolactin%2C%2520growth%2520hormone%2C%2520and%2520insulin-like%2520growth%2520factor-I%2520in%2520the%2520bitch.pdf?sequence=1
Bhatti, S. F., Hofland, L. J., van Koetsveld, P. M., van Ham, L. M., Duchateau, L., Mol, J. A., van der Lely, A. J., & Kooistra, H. S. (2006). Effects of food intake and food withholding on plasma ghrelin concentrations in healthy dogs. American Journal of Veterinary Research, 67(9), 1557-1563.
Hanson-Nilsson, J. M., Mol, J. A., Leegwater, P. A. J., Kooistra, H. S., & Meij, B. P. (2006). The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs. Research in Veterinary Science, 81(3), 316-320.
Bhatti, S. F., de Vliegher, S. P., Mol, J. A., van Ham, L. M., & Kooistra, H. S. (2006). Ghrelin-stimulation test in the diagnosis of canine pituitary dwarfism. Research in Veterinary Science, 81, 24-30.
https://dspace.library.uu.nl/bitstream/handle/1874/20200/Bhatti%2C%2520De%2520Vliegher%2C%2520Mol%2C%2520van%2520Ham%2C%2520Kooistra%2520-%2520Ghrelin-stimulation%2520test%2520in%2520the%2520diagnosis%2520of%2520canine%2520pituitary%2520dwarfism.pdf?sequence=1
Theyse, L. F. H., Mol, J. A., Voorhout, G., Terlou, M., & Hazewinkel, H. A. W. (2006). The efficacy of the bone markers osteocalcin and the carboxyterminal cross-linked telopeptide of type-I collagen in evaluating osteogenesis in a canine crural lengthening model. Veterinary Journal, 171, 525-531.
Hanson-Nilsson, J. M., Kooistra, H. S., Mol, J. A., Teske, E., & Meij, B. P. (2006). Plasma profiles of adrenocorticotropic hormone, cortisol, alpha-melanocyte-stimulating hormone, and growth hormone in dogs with pituitary-dependent hyperadrenocorticism before and after hypophysectomy. Journal of Endocrinology, 190(3), 601-609.
Bhatti, S. F., van Ham, L. M., Mol, J. A., & Kooistra, H. S. (2006). Ghrelin, an endogenous growth hormone secretagogue with diverse endocrine and nonendocrine effects. American Journal of Veterinary Research, 67(1), 180-188.
https://dspace.library.uu.nl/bitstream/handle/1874/20203/Bhatti%2C%2520van%2520Ham%2C%2520Mol%2C%2520Kooistra%2520-%2520Ghrelin%2C%2520an%2520endogenous%2520growth%2520hormone%2520secretagogue%2520with%2520diverse%2520endocrine%2520and%2520nonendocrine%2520effects.pdf?sequence=1
Theyse, L. F. H., Oosterlaken-Dijksterhuis, M. A., van Doorn, J., Terlou, M., Mol, J. A., Voorhout, G., & Hazewinkel, H. A. W. (2006). Expression of osteotropic growth factors and growth hormone receptor in a canine distraction osteogenesis model. Journal of Bone and Mineral Research, 24(4), 266-273.

2005

Wetenschappelijke publicaties

Galac, S., Kooistra, H. S., Voorhout, G., van den Ingh, T. S. G. A. M., Mol, J. A., van den Berg, L., & Meij, B. P. (2005). Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone. Domestic Animal Endocrinology, 28, 338-348.

2004

Wetenschappelijke publicaties

Vaessen, M. M. A. R., Kooistra, H. S., Mol, J. A., & Rijnberk, A. (2004). Urinary corticoid:creatinine ratios in healthy pet dogs after oral low-dose dexamethasone suppression tests. Veterinary Record, 155, 18-21.
Coert, A., Verheijen, F. M., Horspool, L. J., & Mol, J. A. (2004). Aspects of pharmacodynamics and biotransformation of the glucocorticoid resocortol butyrate. Journal of Veterinary Pharmacology and Therapeutics, 27, 309-315.
Schoemaker, N. J., Mol, J. A., Lumeij, J. T., Thijssen, J. H. H., & Rijnberk, A. (2004). Effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets. Veterinary Record, 152(19), 591-595.
Duijsings, D. M. J. M., Houweling, M., Vaandrager, A. B., Mol, J. A., & Teerds, K. J. (2004). Hexadecylphosphocholine causes rapid cell death in canine mammary tumour cells. European Journal of Pharmacology, 502, 185-193.
Marinelli, L., Gabai, G., Wolfswinkel, J., & Mol, J. A. (2004). Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorgenesis in the dog. Journal of Steroid Biochemistry and Molecular Biology, 92(3), 167-173. https://doi.org/10.1016/j.jsbmb.2004.08.001
Javadi, S., Slingerland, L. I., van de Beek, M. G., Boer, P., Boer, W. H., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2004). Plasma renin activity and plasma concentrations of aldosterone, cortisol, adrenocorticotropic hormone, and alpha-melanocyte-stimulating hormone in healthy cats. Journal of Veterinary Internal Medicine, 18, 625-631.
Schoemaker, N. J., Wolfswinkel, J., Mol, J. A., Voorhout, G., Lumeij, J. T., Rijnberk, A., & Kik, M. J. L. (2004). Urinary glucocorticoid excretion in the diagnosis of hyperadrenocorticism in ferrets. Domestic Animal Endocrinology, 27, 13-24.
Geerars-van Vonderen, I. K., Wolfswinkel, J., van den Ingh, T. S. G. A. M., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2004). Urinary aquaporin-2 excretion in dogs: a marker for collecting duct responsiveness to vasopressin. Domestic Animal Endocrinology, 27, 141-153.

2003

Wetenschappelijke publicaties

Javadi, S., Kooistra, H. S., Mol, J. A., Boer, P., Boer, W. H., & Rijnberk, A. (2003). Plasma aldosterone concentrations and plasma renin activity in healthy dogs and dogs with hyperadrenocorticism. Veterinary Record, 153, 521-525.
Rijnberk, A., Kooistra, H. S., Bhatti, S. F., Lee, W. M., Mol, J. A., & Meij, B. P. (2003). Pulsatile secretion pattern of growth hormone in dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology, 44, 59-68.
Tryfonidou, M. A., Oosterlaken-Dijksterhuis, M. A., Mol, J. A., van den Ingh, T. S. G. A. M., van den Brom, W. E., & Hazewinkel, H. A. W. (2003). 24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs. American Journal of Physiology-Endocrinology and Metabolism, 284, 505-513.
Peters, M. A. J., Mol, J. A., van Wolferen, M. E., Oosterlaken-Dijksterhuis, M. A., Teerds, K. J., & van Sluijs, F. J. (2003). Expression of the insulin-like growth factor (IGF) system and steroidogeneic enzymes in canine testis tumors. Biology of Reproduction, 1:22, 1-8.

2002

Wetenschappelijke publicaties

Peeters, M., Sprang, E. P. M., & Mol, J. (2002). Feline thyroid adenomas are in part associated with mutations in the G (s alpha)gene and not with polymorphisms found in the thyrotropin receptor. Thyroid, 12(7), 571-5. [pmid12193300].
Peeters, M. E., Timmermans-Sprang, E. P. M., & Mol, J. A. (2002). Feline thyroid adenomas are in part associated with mutations in the Gsalpha gene and not with polymorphisms found in the thyrotropin receptor. Thyroid, 12, 571-575.
Kirpensteijn, J., Timmermans-Sprang, E. P. M., van Garderen, E., Rutteman, G. R., Lantinga-van Leeuwen, I. S., & Mol, J. A. (2002). Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. Molecular and Cellular Endocrinology, 197, 179-185. https://doi.org/10.1016/s0303-7207(02)00269-1
Schoemaker, N. J., Mol, J. A., Lumeij, J. T., & Rijnberk, A. (2002). Plasma concentrations of adrenocorticotrophic hormone and alpha-melanocyte-stimulating hormone in ferrets (Mustela putorius furo) with hyperadrenocorticism. American Journal of Veterinary Research, 63, 1395-1399.
Lantinga-van Leeuwen, I. S., Timmermans-Sprang, E. A. P., & Mol, J. A. (2002). Cloning and characterization of the 5'-flanking region of the canine growth hormone gene. Molecular and Cellular Endocrinology, 197(1-2), 133-41. https://doi.org/10.1016/s0303-7207(02)00257-5
Schoemaker, N. J., Teerds, K. J., Mol, J. A., Lumeij, J. T., Thijssen, J. H. H., & Rijnberk, A. (2002). The role of luteinizing hormone in the pathogenesis of hyperadrenocorticism in neutered ferrets. Molecular and Cellular Endocrinology, 197, 117-125.
Robben, J. H., Mol, J. A., van Garderen, E., Wolfswinkel, J., & Rijnberk, A. (2002). Growth hormone mRNA and growth hormone protein in canine insulinomas. Molecular and Cellular Endocrinology, 197, 187-197.
Tryfonidou, M. A., Stevenhagen, J. J., van den Bemd, G. J. C. M., Oosterlaken-Dijksterhuis, M. A., DeLuca, H. F., Mol, J. A., van den Brom, W. E., van Leeuwen, J. P. T. M., & Hazewinkel, H. A. W. (2002). Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs. Journal of Nutrition, 132, 2644-2650.
Robben, J. H., van Garderen, E., Mol, J. A., Wolfswinkel, J., & Rijnberk, A. (2002). Locally produced growth hormone in canine insulinomas. Molecular and Cellular Endocrinology, 197, 187-195.
Bosje, J. T., Rijnberk, A., Mol, J. A., Voorhout, G., & Kooistra, H. S. (2002). Plasma concentrations of ACTH precursors correlate with pituitary size and resistance to dexamethasone in dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology, 22, 201-210.

Vakpublicaties

Tryfonidou, M. A., Oosterlaken-Dijksterhuis, M. A., Mol, J. A., & Hazewinkel, H. A. W. (2002). Verhoogde productie en verhoogde metabole klaring van 1,25(OH)2D3 bij langdurige vitamine-D3-suppletie. Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, 6, 95-96.

2001

Wetenschappelijke publicaties

Zijlstra, C., De Haan, N. A., Lantinga-Van Leeuwen, I. S., Mol, J. A., & Bosma, A. A. (2001). Assignment of progesterone receptor (PGR) to canine chromosome band 21q1.2 by in situ hybridization. Cytogenetics and Cell Genetics, 95(3-4), 236-7. https://doi.org/59352
Favier, R. P., Mol, J. A., Kooistra, H. S., & Rijnberk, A. (2001). Plasma concentrations of growth hormone and insulin-like growth factors-I and -II during the prepubertal phase of the life of small and giant dog breeds. In Proceedings of the 11th ESVIM Annual Congress, Dublin Ireland. (pp. 186-187)
Lee, W. M., Diaz-Espineira, M. M., Mol, J. A., Rijnberk, A., & Kooistra, H. S. (2001). Primary hypothyroidism in dogs is associated with elevated GH release. Journal of Endocrinology, 168, 59-66.
van Loo, P. L. P., Mol, J. A., Koolhaas, J. M., van Zutphen, L. F. M., & Baumans, V. (2001). Modulation of aggression in male mice: influence of group size and cage size. Physiology & behavior, 72, 675-683.
Mol, J. A. (2001). Introduction to RT-PCR and RIA/IRMA. In International Symposium "Comparative Clinical and Molecular Endocrinology" - Utrecht The Netherlands. (pp. 39-41)
van der Veek, Y., Dorrestein, G. M., Mol, J. A., & McLean, P. (2001). The effect of administration of potassium iodide on goitre and serum T4 levels in lesser spotted dogfish (Scylliorhinus caniculus). In Proceedings of the 40th International Symposion on Diseases of Zooanimals and Wildlife. (pp. 35-40)
Favier, R. P., Mol, J. A., Kooistra, H. S., & Rijnberk, A. (2001). Large body size in the dog is associated with transient GH excess at a young age. Journal of Endocrinology, 170, 479-484.
Kooistra, H. S., Schaefers-Okkens, A. C., Dieleman, S. J., Mol, J. A., & Rijnberk, A. (2001). Pulsatile secretion patterns of adenohypophyseal hormones in relation to ovarian activity in the dog. In Proceedings of the 11th ESVIM Annual Congress. (pp. 87-88)
Rijnberk, A., Kooistra, H. S., Geerars-van Vonderen, I. K., Mol, J. A., Voorhout, G., van Sluijs, F. J., IJzer, J., van den Ingh, T. S. G. A. M., Boer, P., & Boer, W. H. (2001). Aldosteronoma in a dog with polyuria as the leading symptom. Domestic Animal Endocrinology, 20, 227-240.

Vakpublicaties

Hazewinkel, H. A. W., Tryfonidou, M. A., Mol, J. A., How, K. L., Schoenmakers, I., & Nap, R. C. (2001). De invloed van UV-licht en calcium in de voeding op de plasmaconcentratie van vitamine D3-metabolieten bij de hond. Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, 70-70.

2000

Wetenschappelijke publicaties

Suriyasathaporn-Mahapokai, W., Xue, Y., van Garderen, E., van Sluijs, F. J., & Mol, J. A. (2000). Cell kinetics and differentiation after hormonal-induced prostatic hyperplasia in the dog. Prostate, 44, 40-48.
Lantinga-van Leeuwen, I. S., Kooistra, H. S., Mol, J. A., Renier, C., Breen, M., & van Oost, B. A. (2000). Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1); exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. Cytogenetics and Cell Genetics, 88, 140-144.
Lantinga-van Leeuwen, I. S., Mol, J. A., Kooistra, H. S., Rijnberk, A., Breen, M., Renier, C., & van Oost, B. A. (2000). Cloning of canine gene encoding transcription factor pit-1 and its exclusion as canditate gene in a canine model of pituitary dwarfism. Mammalian Genome, 11, 31-36.
Mol, J. A., & Clegg, R. A. (2000). Biology of the mammary gland. Advances in Experimental Medicine and Biology, 480, 1-311.
Kooistra, H. S., den Hertog, E. J., Okkens, A. C., Mol, J. A., & Rijnberk, A. (2000). Pulsatile secretion pattern of growth hormone during the luteal phase and mid-anoestrus in beagle bitches. Journal of Reproduction and Fertility, 119, 217-222.
Mol, J. A. (2000). Hormone and insuline-like growth factors: modulators of proliferation and immune function. In Proceedings of the Xth ESVIM Annual Congress (pp. 108-109).
Kooistra, H. S., Voorhout, G., Mol, J. A., & Rijnberk, A. (2000). Combined pituitary hormone deficiency in German shepherd dogs with dwarfism. Domestic Animal Endocrinology, 19, 177-190.
Mol, J. A., Lantinga-van Leeuwen, I. S., van Garderen, E., & Rijnberk, A. (2000). Progestin-induced mammary growth hormone (GH) production. Advances in Experimental Medicine and Biology, 480, 71-76.
Beerda, B., Schilder, M. B. H., van Hooff, J. A. R. A. M., de Vries, H., & Mol, J. A. (2000). Behavioral and hormonal indicators of enduring environmental stress in dogs. Animal Welfare, 9, 49-62.
Lantinga-van Leeuwen, I. S., Teske, E., van Garderen, E., & Mol, J. A. (2000). Growth hormone gene expression in normal lymph nodes and lymphomas of the dog. Anticancer Research, 20, 2371-2376.
Kooistra, H. S., Diaz-Espineira, M. M., Mol, J. A., van den Brom, W. E., & Rijnberk, A. (2000). Secretion pattern of thyroid-stimulating hormone in dogs during euthyroidism and hypothyroidism. Domestic Animal Endocrinology, 18, 19-29.

1999

Wetenschappelijke publicaties

Schoenmakers, I., Nap, R. C., Mol, J. A., & Hazewinkel, H. A. W. (1999). Calcium metabolism: an overview of its hormonal regulation and interrelation with skeletal integrity. Veterinary Quarterly, 21(4), 147-153.
https://dspace.library.uu.nl/bitstream/handle/1874/37333/hpPDFJuly-17-2009.pdf?sequence=1
Beerda, B., Schilder, M. B. H., Bernadina, W., van Hooff, J. A. R. A. M., de Vries, H. W., & Mol, J. A. (1999). Chronic stress in dogs subjected to social and spatial restriction II. Hormonal and immunological responses. Physiology & behavior, 66(2), 243-254.

Vakpublicaties

Beerda, B., Schilder, M. B. H., van Hooff, J. A. R. A. M., de Vries, H. W., & Mol, J. A. (1999). Chronic stress in dogs subjected to social and spatial restriction I. Behavioral Responses. Physiology & behavior, 66(2), 233-242.

1997

Wetenschappelijke publicaties

Mol, J. A., Selman, P. J., Sprang, E. P., van Neck, J. W., & Oosterlaken-Dijksterhuis, M. A. (1997). The role of progestins, insulin-like growth factor (IGF) and IGF-binding proteins in the normal and neoplastic mammary gland of the bitch: a review. Journal of reproduction and fertility. Supplement, 51, 339-44.
van Wijk, P. A., Rijnberk, A., Croughs, R. J. M., Meij, B. P., van Leeuwen, I. S., Sprang, E. P. M., & Mol, J. A. (1997). Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-depen dent hyperadrenocorticism. Journal of Endocrinological Investigation, 20, 1-7.
Schilder, M. B. H., Beerda, B., Janssen, N. S. C. R. M., & Mol, J. A. (1997). The use of Saliva cortisol, urinary cortisol, and catecholamine measurements for a noninvasive assessment of stress responses in dogs. Hormones and Behavior, 30, 272-279.

1995

Wetenschappelijke publicaties

Mol, J. A., Henzen-Lomans, S. C., Hageman, P., Misdorp, W., Blankenstein, M. A., & Rijnberk, A. (1995). Expression of the gene encoding growth hormone in the human mammary gland. Journal of Clinical Endocrinology and Metabolism, 44, 577-582.

1992

Wetenschappelijke publicaties

Van Wijk, P. A., Rijnberk, A., Croughs, R. J., Voorhout, G., Mol, J. A., & Sprang, E. P. M. (1992). Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism. Endocrinology, 131(6), 2659-62. https://doi.org/10.1210/endo.131.6.1332844

1989

Wetenschappelijke publicaties

OVERDUIN, L. M., VAN GOGH, H., MOL, J. A., & VAN NES, J. J. (1989). Pharmacokinetics of three formulations of diphenylhydantoin in the dog. Research in Veterinary Science, 46(2), 271-273. https://doi.org/10.1016/s0034-5288(18)31157-3

1986

Wetenschappelijke publicaties

Teske, E., Rothuizen, J., de Bruijne, J. J., & Mol, J. A. (1986). Separation and heat stability of the corticosteroid-induced and hepatic alkaline phosphatase isoenzymes in canine plasma. Journal of Chromatography, 369(2), 349-56.