Dr. I. (Ildiko) van Rhijn

Dr. I. (Ildiko) van Rhijn

Universitair docent
Immunologie
030 253 5740
i.vanrhijn@uu.nl

Find most up to date publication list at:

http://www.ncbi.nlm.nih.gov/pubmed/?term=van+rhijn+i

Key publications in bold:

Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries
N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB. A conserved human T
cell population targets mycobacterial antigens presented by CD1b. Nat Immunol.
2013 Jun 2. doi: 10.1038/ni.2630. [Epub ahead of print] PubMed PMID: 23727893

López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A,
Van Rhijn I, Saghatelian A, Adams EJ. The molecular basis for Mucosal-Associated
Invariant T cell recognition of MR1 proteins. Proc Natl Acad Sci U S A. 2013 May
7;110(19):E1771-8. doi: 10.1073/pnas.1222678110. Epub 2013 Apr 23. PubMed PMID:
23613577; PubMed Central PMCID: PMC3651419.

Van Rhijn I, Ly D, Moody DB. CD1a, CD1b, and CD1c in Immunity Against
Mycobacteria. Adv Exp Med Biol. 2013;783:181-97. doi:
10.1007/978-1-4614-6111-1_10. PubMed PMID: 23468110.

Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I. Lipoproteins are
major targets of the polyclonal human T cell response to Mycobacterium
tuberculosis. J Immunol. 2013 Jan 1;190(1):278-84. doi: 10.4049/jimmunol.1201667.
Epub 2012 Nov 28. PubMed PMID: 23197260; PubMed Central PMCID: PMC3529834.

Wang J, Guillaume J, Pauwels N, Van Calenbergh S, Van Rhijn I, Zajonc DM.
Crystal structures of bovine CD1d reveal altered αGalCer presentation and a
restricted A' pocket unable to bind long-chain glycolipids. PLoS One.
2012;7(10):e47989. doi: 10.1371/journal.pone.0047989. Epub 2012 Oct 23. PubMed
PMID: 23110152; PubMed Central PMCID: PMC3479135.

Looringh van Beeck FA, Leegwater PA, Herrmann T, Broere F, Rutten VP, Willemse
T, Van Rhijn I. Tandem repeats modify the structure of the canine CD1D gene. Anim
Genet. 2013 Jun;44(3):352-5. doi: 10.1111/age.12002. Epub 2012 Sep 19. PubMed
PMID: 22988997.

Nguyen TK, Koets AP, Vordermeier M, Jervis PJ, Cox LR, Graham SP, Santema WJ,
Moody DB, van Calenbergh S, Zajonc DM, Besra GS, Van Rhijn I. The bovine CD1D
gene has an unusual gene structure and is expressed but cannot present
α-galactosylceramide with a C26 fatty acid. Int Immunol. 2013 Feb;25(2):91-8.
doi: 10.1093/intimm/dxs092. Epub 2012 Sep 11. PubMed PMID: 22968995; PubMed
Central PMCID: PMC3619971.

Vrieling M, Santema W, Van Rhijn I, Rutten V, Koets A. γδ T cell homing to
skin and migration to skin-draining lymph nodes is CCR7 independent. J Immunol.
2012 Jan 15;188(2):578-84. doi: 10.4049/jimmunol.1101972. Epub 2011 Dec 12.
PubMed PMID: 22156593.

Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur
RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD,
Moody DB. CD1b tetramers bind αβ T cell receptors to identify a mycobacterial
glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011 Aug
29;208(9):1741-7. doi: 10.1084/jem.20110665. Epub 2011 Aug 1. PubMed PMID:
21807869; PubMed Central PMCID: PMC3171094.

Nguyen TK, Wieland W, Santema W, Hoeboer J, van Eden W, Rutten V, Koets A, Van
Rhijn I. Immune response of cattle immunized with a conjugate of the glycolipid
glucose monomycolate and protein. Vet Immunol Immunopathol. 2011 Aug
15;142(3-4):265-70. doi: 10.1016/j.vetimm.2011.05.016. Epub 2011 May 13. PubMed
PMID: 21640388.

de Jong A, Peña-Cruz V, Cheng TY, Clark RA, Van Rhijn I, Moody DB.
CD1a-autoreactive T cells are a normal component of the human αβ T cell
repertoire. Nat Immunol. 2010 Dec;11(12):1102-9. doi: 10.1038/ni.1956. Epub 2010
Oct 31. PubMed PMID: 21037579; PubMed Central PMCID: PMC3131223.

Girardi E, Wang J, Mac TT, Versluis C, Bhowruth V, Besra G, Heck AJ, Van
Rhijn I, Zajonc DM. Crystal structure of bovine CD1b3 with endogenously bound
ligands. J Immunol. 2010 Jul 1;185(1):376-86. doi: 10.4049/jimmunol.1000042. Epub
2010 Jun 2. PubMed PMID: 20519644; PubMed Central PMCID: PMC3000671.

Goldfinch N, Reinink P, Connelley T, Koets A, Morrison I, Van Rhijn I.
Conservation of mucosal associated invariant T (MAIT) cells and the MR1
restriction element in ruminants, and abundance of MAIT cells in spleen. Vet Res.
2010 Sep-Oct;41(5):62. doi: 10.1051/vetres/2010034. Epub 2010 May 31. PubMed
PMID: 20507818; PubMed Central PMCID: PMC2896809.

Maas M, Van Rhijn I, Allsopp MT, Rutten VP. Lion (Panthera leo) and cheetah
(Acinonyx jubatus) IFN-gamma sequences. Vet Immunol Immunopathol. 2010 Apr
15;134(3-4):296-8. doi: 10.1016/j.vetimm.2009.10.001. Epub 2009 Oct 12. PubMed
PMID: 19913304.

Van Rhijn I, Nguyen TK, Michel A, Cooper D, Govaerts M, Cheng TY, van Eden W,
Moody DB, Coetzer JA, Rutten V, Koets AP. Low cross-reactivity of T-cell
responses against lipids from Mycobacterium bovis and M. avium paratuberculosis
during natural infection. Eur J Immunol. 2009 Nov;39(11):3031-41. doi:
10.1002/eji.200939619. PubMed PMID: 19688747; PubMed Central PMCID: PMC3136192.

Reinink P, Van Rhijn I. The bovine T cell receptor alpha/delta locus contains
over 400 V genes and encodes V genes without CDR2. Immunogenetics. 2009
Jul;61(7):541-9. doi: 10.1007/s00251-009-0384-9. Epub 2009 Jul 2. PubMed PMID:
19568741; PubMed Central PMCID: PMC2706379.

Kasmar A, Van Rhijn I, Moody DB. The evolved functions of CD1 during
infection. Curr Opin Immunol. 2009 Aug;21(4):397-403. doi:
10.1016/j.coi.2009.05.022. Epub 2009 Jun 21. Review. PubMed PMID: 19541469;
PubMed Central PMCID: PMC2725205.

Nguyen TK, Koets AP, Santema WJ, van Eden W, Rutten VP, Van Rhijn I. The
mycobacterial glycolipid glucose monomycolate induces a memory T cell response
comparable to a model protein antigen and no B cell response upon experimental
vaccination of cattle. Vaccine. 2009 Jul 30;27(35):4818-25. doi:
10.1016/j.vaccine.2009.05.078. Epub 2009 Jun 16. PubMed PMID: 19538998; PubMed
Central PMCID: PMC2719691.

Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC,
León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE,
Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide
antigen with 12 amino acids. J Exp Med. 2009 Jun 8;206(6):1409-22. doi:
10.1084/jem.20082480. Epub 2009 May 25. Erratum in: J Exp Med. 2009 Aug
3;206(8):1831. Barral, Duarte [corrected to Barral, Duarte C]. PubMed PMID:
19468063; PubMed Central PMCID: PMC2715062.

Looringh van Beeck FA, Reinink P, Hermsen R, Zajonc DM, Laven MJ, Fun A,
Troskie M, Schoemaker NJ, Morar D, Lenstra JA, Vervelde L, Rutten VP, van Eden W,
Van Rhijn I. Functional CD1d and/or NKT cell invariant chain transcript in horse,
pig, African elephant and guinea pig, but not in ruminants. Mol Immunol. 2009
Apr;46(7):1424-31. doi: 10.1016/j.molimm.2008.12.009. Epub 2009 Jan 30. PubMed
PMID: 19185921; PubMed Central PMCID: PMC2669151.

Hoek A, Rutten VP, Kool J, Arkesteijn GJ, Bouwstra RJ, Van Rhijn I, Koets AP.
Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high)
Foxp3(+) T cells act as immune regulatory cells ex vivo. Vet Res. 2009
Jan-Feb;40(1):6. doi: 10.1051/vetres:2008044. Epub 2008 Oct 18. PubMed PMID:
18928784; PubMed Central PMCID: PMC2695017.

Van Rhijn I, Godfroid J, Michel A, Rutten V. Bovine tuberculosis as a model
for human tuberculosis: advantages over small animal models. Microbes Infect.
2008 Jun;10(7):711-5. doi: 10.1016/j.micinf.2008.04.005. Epub 2008 Apr 22.
Review. PubMed PMID: 18538612.

Looringh van Beeck FA, Zajonc DM, Moore PF, Schlotter YM, Broere F, Rutten
VP, Willemse T, Van Rhijn I. Two canine CD1a proteins are differentially
expressed in skin. Immunogenetics. 2008 Jun;60(6):315-24. doi:
10.1007/s00251-008-0297-z. Epub 2008 May 17. PubMed PMID: 18488214; PubMed
Central PMCID: PMC2668647.

Van Rhijn I, Spiering R, Smits M, van Blokland MT, de Weger R, van Eden W,
Rutten VP, Koets AP. Highly diverse TCR delta chain repertoire in bovine tissues
due to the use of up to four D segments per delta chain. Mol Immunol. 2007
May;44(12):3155-61. Epub 2007 Apr 6. PubMed PMID: 17418895.

Van Rhijn I, Rutten VP, Charleston B, Smits M, van Eden W, Koets AP. Massive,
sustained gammadelta T cell migration from the bovine skin in vivo. J Leukoc
Biol. 2007 Apr;81(4):968-73. Epub 2007 Jan 18. PubMed PMID: 17234682.

Cheng TY, Relloso M, Van Rhijn I, Young DC, Besra GS, Briken V, Zajonc DM,
Wilson IA, Porcelli S, Moody DB. Role of lipid trimming and CD1 groove size in
cellular antigen presentation. EMBO J. 2006 Jul 12;25(13):2989-99. Epub 2006 Jun
22. PubMed PMID: 16794581; PubMed Central PMCID: PMC1500985.

Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA,
van Eden W, Rutten VP. The bovine CD1 family contains group 1 CD1 proteins, but
no functional CD1d. J Immunol. 2006 Apr 15;176(8):4888-93. PubMed PMID: 16585584.

Van Rhijn I, Zajonc DM, Wilson IA, Moody DB. T-cell activation by lipopeptide
antigens. Curr Opin Immunol. 2005 Jun;17(3):222-9. Review. PubMed PMID: 15886110.

Van Rhijn I, Young DC, Im JS, Levery SB, Illarionov PA, Besra GS, Porcelli
SA, Gumperz J, Cheng TY, Moody DB. CD1d-restricted T cell activation by
nonlipidic small molecules. Proc Natl Acad Sci U S A. 2004 Sep
14;101(37):13578-83. Epub 2004 Sep 1. PubMed PMID: 15342907; PubMed Central
PMCID: PMC518797.

Van Rhijn I, Logtenberg T, Ang CW, Van den Berg LH. Gammadelta T cell
non-responsiveness in Campylobacter jejuni-associated Guillain-Barré syndrome
patients. Neurology. 2003 Oct 14;61(7):994-6. PubMed PMID: 14557578.

Van Rhijn I, Van den Berg LH, Ang CW, Admiraal J, Logtenberg T. Expansion of
human gammadelta T cells after in vitro stimulation with Campylobacter jejuni.
Int Immunol. 2003 Mar;15(3):373-82. PubMed PMID: 12618481.

Van Rhijn I, Bleumink-Pluym NM, Van Putten JP, Van den Berg LH. Campylobacter
DNA is present in circulating myelomonocytic cells of healthy persons and in
persons with Guillain-Barré syndrome. J Infect Dis. 2002 Jan 15;185(2):262-5.
Epub 2002 Jan 3. PubMed PMID: 11807702.

Van Rhijn I, Van den Berg LH, Bosboom WM, Otten HG, Logtenberg T. Expression
of accessory molecules for T-cell activation in peripheral nerve of patients with
CIDP and vasculitic neuropathy. Brain. 2000 Oct;123 ( Pt 10):2020-9. PubMed PMID:
11004119.

Publicaties

2023

Wetenschappelijke publicaties

Farquhar, R., Van Rhijn, I., Moody, D. B., Rossjohn, J., & Shahine, A. (2023). αβ T cell receptor recognition of self-phosphatidylinositol presented by CD1b. Journal of Biological Chemistry, 299(2), 1-13. [102849]. https://doi.org/10.1016/j.jbc.2022.102849

2022

Wetenschappelijke publicaties

Suliman, S., Kjer-Nielsen, L., Iwany, S. K., Lopez Tamara, K., Loh, L., Grzelak, L., Kedzierska, K., Ocampo, T. A., Corbett, A. J., McCluskey, J., Rossjohn, J., León, S. R., Calderon, R., Lecca-Garcia, L., Murray, M. B., Moody, D. B., & Van Rhijn, I. (2022). Dual TCR-a Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation. Journal of Immunology, 208(6), 1389-1395. https://doi.org/10.4049/jimmunol.2100275

2021

Wetenschappelijke publicaties

Reijneveld, J. F., Marino, L., Cao, T-P., Cheng, T-Y., Dam, D., Shahine, A., Witte, M. D., Filippov, D. V., Suliman, S., van der Marel, G. A., Moody, D. B., Minnaard, A. J., Rossjohn, J., Codee, J., & Van Rhijn, I. (2021). Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. Journal of Biological Chemistry, 297(4), 1-13. [101197]. https://doi.org/10.1016/j.jbc.2021.101197
Almeida, C. F., Smith, D. G. M., Cheng, T-Y., Harpur, C. M., Batleska, E., Nguyen-Robertson, C. V., Nguyen, T., Thelemann, T., Reddiex, S. J. J., Li, S., Eckle, S. B. G., Van Rhijn, I., Rossjohn, J., Uldrich, A. P., Moody, D. B., Williams, S. J., Pellicci, D. G., & Godfrey, D. I. (2021). Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d. Proceedings of the National Academy of Sciences of the United States of America, 118(34), 1-12. [e2104420118]. https://doi.org/10.1073/pnas.2104420118
Nathan, A., Beynor, J. I., Baglaenko, Y., Suliman, S., Ishigaki, K., Asgari, S., Huang, C-C., Luo, Y., Zhang, Z., Lopez, K., Lindestam Arlehamn, C. S., Ernst, J. D., Jimenez, J., Calderón, R. I., Lecca, L., Van Rhijn, I., Moody, D. B., Murray, M. B., & Raychaudhuri, S. (2021). Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease. Nature Immunology, 22(6), 781-793. https://doi.org/10.1038/s41590-021-00933-1
Cotton, R. N., Wegrecki, M., Cheng, T-Y., Chen, Y-L., Veerapen, N., Le Nours, J., Orgill, D. P., Pomahac, B., Talbot, S. G., Willis, R., Altman, J. D., de Jong, A., Van Rhijn, I., Clark, R. A., Besra, G. S., Ogg, G., Rossjohn, J., & Moody, D. B. (2021). CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal of Experimental Medicine, 218(7), [e20202699]. https://doi.org/10.1084/jem.20202699
Van Rhijn, I., & Le Nours, J. (2021). CD1 and MR1 recognition by human γδ T cells. Molecular Immunology, 133, 95-100. https://doi.org/10.1016/j.molimm.2020.12.008
Cotton, R. N., Cheng, T-Y., Wegrecki, M., Le Nours, J., Orgill, D. P., Pomahac, B., Talbot, S. G., Willis, R. A., Altman, J. D., de Jong, A., Ogg, G., Van Rhijn, I., Rossjohn, J., Clark, R. A., & Moody, D. B. (2021). Human skin is colonized by T cells that recognize CD1a independently of lipid. Journal of Clinical Investigation, 131(1), 1-15. [e140706]. https://doi.org/10.1172/jci140706
Reijneveld, J. F., Holzheimer, M., Young, D. C., Lopez, K., Suliman, S., Jimenez, J., Calderon, R., Lecca, L., Murray, M. B., Ishikawa, E., Yamasaki, S., Minnaard, A. J., Moody, D. B., & Van Rhijn, I. (2021). Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle. Scientific Reports, 11(1), 1-10. [2010]. https://doi.org/10.1038/s41598-021-81474-3

2020

Wetenschappelijke publicaties

Nathan, A., Beynor, J., Baglaenko, Y., Suliman, S., Ishigaki, K., Asgari, S., Huang, C-C., Luo, Y., Zhang, Z., Lopez Tamara, K., Jimenez, J., Calderón, R. I., Lecca, L., van Rhijn, I., Moody, D. B., Murray, M. B., & Raychaudhuri, S. (Accepted/In press). Multimodal Profiling of 500,000 Memory T Cells from a Tuberculosis Cohort Identifies Cell State Associations with Demographics, Environment, and Disease. SSRN. https://doi.org/10.2139/ssrn.3652337
Reijneveld, J. F., Ocampo, T. A., Shahine, A., Gully, B. S., Vantourout, P., Hayday, A. C., Rossjohn, J., Moody, D. B., & Van Rhijn, I. (2020). Human γδ T cells recognize CD1b by two distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944-22952. https://doi.org/10.1073/pnas.2010545117
Adolescent Cohort Study team (2020). RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response. Scientific Reports, 10(1), [8629]. https://doi.org/10.1038/s41598-020-65043-8
South African Tuberculosis Vaccine Initiative (SATVI) Clinical Immunology Team (2020). Peripheral blood mucosal-associated invariant T (MAIT) cells in tuberculosis patients and healthy Mycobacterium tuberculosis-exposed controls. Journal of Infectious Diseases, [jiaa173]. https://doi.org/10.1093/infdis/jiaa173
Holzheimer, M., Reijneveld, J. F., Ramnarine, A., Misiakos, G., Young, D. C., Ishikawa, E., Cheng, T-Y., Yamasaki, S., Moody, D. B., Van Rhijn, I., & Minnaard, A. J. (2020). Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity. ACS Chemical Biology. https://doi.org/10.1021/acschembio.0c00030
Nathan, A., Beynor, J. I., Baglaenko, Y., Suliman, S., Ishigaki, K., Asgari, S., Huang, C-C., Luo, Y., Zhang, Z., Tamara, K. L., Jimenez, J., Calderon, R. I., Lecca, L., Rhijn, I. V., Moody, B., Murray, M. B., & Raychaudhuri, S. (2020). Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression. bioRxiv. https://doi.org/10.1101/2020.04.23.057828
Lopez, K., Iwany, S. K., Suliman, S., Reijneveld, J. F., Ocampo, T. A., Jimenez, J., Calderon, R., Lecca, L., Murray, M. B., Moody, D. B., & Van Rhijn, I. (2020). CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.00199
Tahiri, N., Fodran, P., Jayaraman, D., Buter, J., Witte, M. D., Ocampo, T. A., Moody, D. B., Van Rhijn, I., & Minnaard, A. J. (2020). Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis. Angewandte Chemie-International Edition. https://doi.org/10.1002/anie.202000523
Nicolai, S., Wegrecki, M., Cheng, T-Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., Monnot, G. C., Le Nours, J., Van Rhijn, I., Rossjohn, J., Moody, D. B., & de Jong, A. (2020). Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products. Science immunology, 5(43), [eaax5430]. https://doi.org/10.1126/sciimmunol.aax5430

2019

Wetenschappelijke publicaties

Penn-Nicholson, A., Mbandi, S. K., Thompson, E., Mendelsohn, S., Suliman, S., Chegou, N. N., Malherbe, S. T., Darboe, F., Erasmus, M., Hanekom, W. A., Bilek, N., Fisher, M., Kaufmann, S. HE., Winter, J., Murphy, M., Wood, R., Morrow, C., Rhijn, I. V., Moody, D. B., ... Scriba, T. (2019). RISK6, a universal 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response. medRxiv. https://doi.org/10.1101/19006197
Reinink, P., Shahine, A., Gras, S., Cheng, T-Y., Farquhar, R., Lopez, K., Suliman, S. A., Reijneveld, J. F., Le Nours, J., Tan, L. L., León, S. R., Jimenez, J., Calderon, R., Lecca, L., Murray, M. B., Rossjohn, J., Moody, D. B., & Van Rhijn, I. (2019). A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins. Journal of Immunology, 203(12), 3395-3406. https://doi.org/10.4049/jimmunol.1900872
Mishra, V. K., Buter, J., Blevins, M. S., Witte, M. D., Van Rhijn, I., Moody, D. B., Brodbelt, J. S., & Minnaard, A. J. (2019). Total Synthesis of an Immunogenic Trehalose Phospholipid from Salmonella Typhi and Elucidation of Its sn-Regiochemistry by Mass Spectrometry. Organic Letters, 21(13), 5126-5131. https://doi.org/10.1021/acs.orglett.9b01725
Reinink, P., Buter, J., Mishra, V. K., Ishikawa, E., Cheng, T-Y., Willemsen, P. T. J., Porwollik, S., Brennan, P. J., Heinz, E., Mayfield, J. A., Dougan, G., van Els, C. A., Cerundolo, V., Napolitani, G., Yamasaki, S., Minnaard, A. J., McClelland, M., Moody, D. B., & Van Rhijn, I. (2019). Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria. Journal of Experimental Medicine, 216 ( 4 ), 757–771. https://doi.org/10.1084/jem.20181812
Reinink, P., Souter, M. N. T., Cheng, T-Y., van Gorkom, T., Lenz, S., Kubler-Kielb, J., Strle, K., Kremer, K., Thijsen, S. F. T., Steere, A. C., Godfrey, D. I., Pellicci, D. G., Moody, D. B., & Van Rhijn, I. (2019). CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells. European Journal of Immunology, 49(5), 737-746. https://doi.org/10.1002/eji.201847949
Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T-Y., Minnaard, A. J., Altman, J. D., Lenz, S., Prandi, J., Kubler-Kielb, J., Moody, D. B., Rossjohn, J., & Van Rhijn, I. (2019). A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nature Communications, 10(1), [56]. https://doi.org/10.1038/s41467-018-07898-0

2018

Wetenschappelijke publicaties

Wun, K. S., Reijneveld, J. F., Cheng, T-Y., Ladell, K., Uldrich, A. P., Le Nours, J., Miners, K. L., McLaren, J. E., Grant, E. J., Haigh, O. L., Watkins, T. S., Suliman, S., Iwany, S., Jimenez, J., Calderon, R., Tamara, K. L., Leon, S. R., Murray, M. B., Mayfield, J. A., ... Rossjohn, J. (2018). T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology, 19(4), 397–406. https://doi.org/10.1038/s41590-018-0065-7
James, C. A., Yu, K. K. Q., Gilleron, M., Prandi, J., Yedulla, V. R., Moleda, Z. Z., Diamanti, E., Khan, M., Aggarwal, V. K., Reijneveld, J. F., Reinink, P., Lenz, S., Emerson, R. O., Scriba, T. J., Souter, M. N. T., Godfrey, D. I., Pellicci, D. G., Moody, D. B., Minnaard, A. J., ... Van Rhijn, I. (2018). CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2018.01.006
Gras, S., Van Rhijn, I., Shahine, A., & Le Nours, J. (2018). Molecular recognition of microbial lipid-based antigens by T cells. Cellular and Molecular Life Sciences, 75(9), 1623-1639. https://doi.org/10.1007/s00018-018-2749-4

2017

Wetenschappelijke publicaties

Van Rhijn, I., Iwany, S. K., Fodran, P., Cheng, T-Y., Gapin, L., Minnaard, A. J., & Moody, D. B. (2017). CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails. European Journal of Immunology, 47(9), 1525-1534. https://doi.org/10.1002/eji.201747062
Shahine, A., Van Rhijn, I., Cheng, T-Y., Iwany, S., Gras, S., Moody, D. B., & Rossjohn, J. (2017). A molecular basis of human T cell receptor autoreactivity toward self-phospholipids. Science immunology, 2(16), [eaao1384]. https://doi.org/10.1126/sciimmunol.aao1384
Bagchi, S., He, Y., Cao, L., Van Rhijn, I., Moody, D. B., Gudjonsson, J. E., & Wang, C-R. (2017). CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice. Journal of Clinical Investigation, 127(6), 2339-2352. https://doi.org/10.1172/JCI92217

2016

Wetenschappelijke publicaties

Cheng, J., Liu, L., Pellicci, D., Reddiex, S. J., Cotton, R., Cheng, T-Y., Young, D., Van Rhijn, I., Moody, B., Rossjohn, J., Fairlie, D., Godfrey, D., & Williams, S. J. (2016). Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: Diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognition. Chemistry-A European Journal, 23, 1694-1701. https://doi.org/10.1002/chem.201605287
Gras, S., Van Rhijn, I., Shahine, A., Cheng, T-Y., Bhati, M., Tan, L. L., Halim, H., Tuttle, K. D., Gapin, L., Le Nours, J., Moody, D. B., & Rossjohn, J. (2016). T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nature Communications [E], 7, [13257]. https://doi.org/10.1038/ncomms13257
Reinink, P., & Van Rhijn, I. (2016). Mammalian CD1 and MR1 genes. Immunogenetics, 68(8), 515–523. https://doi.org/10.1007/s00251-016-0926-x

2015

Wetenschappelijke publicaties

Van Rhijn, I., van Berlo, T., Hilmenyuk, T., Cheng, T-Y., Wolf, B. J., Tatituri, R. V. V., Uldrich, A. P., Napolitani, G., Cerundolo, V., Altman, J. D., Willemsen, P., Huang, S., Rossjohn, J., Besra, G. S., Brenner, M. B., Godfrey, D. I., & Moody, D. B. (2015). Human autoreactive T cells recognize CD1b and phospholipids. Proceedings of the National Academy of Sciences of the United States of America, 113(2), 380-385. https://doi.org/10.1073/pnas.1520947112
Van Rhijn, I., Godfrey, D. I., Rossjohn, J., & Moody, D. B. (2015). Lipid and small-molecule display by CD1 and MR1. Nature Reviews. Immunology, 15, 643-654. https://doi.org/10.1038/nri3889
Van Rhijn, I., & Moody, D. B. (2015). Donor Unrestricted T Cells: A Shared Human T Cell Response. Journal of Immunology, 195(5), 1927-1932. https://doi.org/10.4049/jimmunol.1500943
Nguyen, T. K. A., Reinink, P., Messlaki, C. E., Im, J. S., Ercan, A., Porcelli, S. A., & Rhijn, I. V. (2015). Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies. PLoS One, 10(3), [e0121923]. https://doi.org/10.1371/journal.pone.0121923
Van Rhijn, I., & Moody, D. B. (2015). CD1 and mycobacterial lipids activate human T cells. Immunological Reviews, 264(1), 138-53. https://doi.org/10.1111/imr.12253

2014

Wetenschappelijke publicaties

Kawasaki, N., Rillahan, C. D., Cheng, T-Y., Van Rhijn, I., Macauley, M. S., Moody, D. B., & Paulson, J. C. (2014). Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. Journal of Immunology, 193(4), 1560-6. https://doi.org/10.4049/jimmunol.1303278
van Schaik, B., Klarenbeek, P., Doorenspleet, M., van Kampen, A., Moody, B., de Vries, N., & Van Rhijn, I. (2014). Discovery of Invariant T Cells by Next-Generation Sequencing of the Human TCR α-Chain Repertoire. Journal of Immunology, 193(10), 5338-44. https://doi.org/10.4049/jimmunol.1401380
de Jong, A., Cheng, T. Y., Huang, S., Gras, S., Birkinshaw, R. W., Kasmar, A., van Rhijn, I., Pena-Cruz, V., Ruan, D. T., Altman, J. D., Rossjohn, J., & Moody, D. B. (2014). CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. Nature Immunology, 15, 177-185. https://doi.org/10.1038/ni.2790

2013

Wetenschappelijke publicaties

Nguyen, T. K. A., Koets, A. P., Vordermeier, M., Jervis, P. J., Cox, L. R., Graham, S. P., Santema, W. J., Moody, D. B., van Calenbergh, S., Zajonc, D. M., Besra, G. S., & van Rhijn, I. (2013). The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid. International Immunology, 25(2), 91-98. https://doi.org/10.1093/intimm/dxs092
Sheshadri, C., Turner, M. T., Lewinsohn, D. M., Branch Moody, D., & van Rhijn, I. (2013). Lipoproteins Are Major Targets of the Polyclonal Human T Cell Response to Mycobacterium tuberculosis. Journal of Immunology, 190(1), 278-284. https://doi.org/10.4049/jimmunol.1201667
van Rhijn, I., Ly, D., & Branch Moody, D. (2013). CD1a, CD1b, and CD1c in Immunity Against Mycobacteria. Advances in Experimental Medicine and Biology, 783, 181-197. https://doi.org/10.1007/978-1-4614-6111-1_10
López-Sagasta, J., Dulberger, C. L., Crooks, J. E., Parks, C. D., Luoma, A. M., McFedries, A., van Rhijn, I., Saghatelian, A., & Adams, E. J. (2013). The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proceedings of the National Academy of Sciences of the United States of America, 110(19), 1771-1778. https://doi.org/10.1073/pnas.1222678110
van Rhijn, I., Kasmar, A., de Jong, A., Gras, S., Bhati, M., Doorenspleet, M. E., Godfrey, D. I., Altman, J. D., de Jager, W., Rossjohn, J., & Branch Moody, D. (2013). A conserved human T cell population targets mycobacterial antigens presented by CD1b. Nature Immunology, 14(7), 706-713. https://doi.org/10.1038/ni.2630
Looringh van Beeck, F. A., Leegwater, P. A. J., Herrmann, T., Broere, F., Rutten, V. P. M. G., Willemse, T., & van Rhijn, I. (2013). Tandem repeats modify the structure of the canine CD1D gene. Animal Genetics, 44, 352-355. https://doi.org/10.1111/age.12002

2012

Wetenschappelijke publicaties

Vrieling, M., Santema, W. J., van Rhijn, I., Rutten, V. P. M. G., & Koets, A. P. (2012). γδ T Cell Homing to Skin and Migration to Skin-Draining Lymph Nodes Is CCR7 Independent. Journal of Immunology, 188(2), 578-584. https://doi.org/10.4049/jimmunol.1101972

2011

Wetenschappelijke publicaties

Nguyen, T. K. A., Wieland, W. H., Santema, W. J., Hoeboer, J., van Eden, W., Rutten, V. P. M. G., Koets, A. P., & van Rhijn, I. (2011). Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein. Veterinary Immunology and Immunopathology, 142, 265-270. https://doi.org/10.1016/j.vetimm.2011.05.016
Kasmar, A., van Rhijn, I., Cheng, T. Y., Turner, M., Seshadri, C., Schiefner, A., Kalathur, R. C., Annand, J. W., de Jong, A., Shires, J., Leon, L., Brenner, M., Wilson, I. A., Altman, J. D., & Moody, D. B. (2011). CD1b tetramers bind αß T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. Journal of Experimental Medicine, 208(9), 1741-1747. https://doi.org/10.1084/jem.20110665
https://dspace.library.uu.nl/bitstream/handle/1874/235398/Kasmar%2520ea%2520CD1b.pdf?sequence=1

2010

Wetenschappelijke publicaties

Maas, M., van Rhijn, I., Allsopp, M. T., & Rutten, V. P. M. G. (2010). Lion (Panthera leo) and cheetah (Acinonyx jubatus) IFN-y sequences. Veterinary Immunology and Immunopathology, 134(3-4), 296-298. https://doi.org/10.1016/j.vetimm.2009.10.001
Goldfinch, N., Reinink, P., Connelly, T., Koets, A. P., Morrison, I., & van Rhijn, I. (2010). Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen. Veterinary Research, 41(5), 41-62. https://doi.org/10.1051/vetres/2010034
Girardi, E., Wang, J., Mac, T. T., Versluis, C., Bhowruth, V., Besra, G., Heck, A. J. R., van Rhijn, I., & Zajonc, D. M. (2010). Crystal structure of bovine CD1b3 with endogenously bound ligands. Journal of Immunology, 185, 376-386. https://doi.org/10.4049/jimmunol.1000042

2009

Wetenschappelijke publicaties

Looringh van Beeck, F. A., Reinink, P., Hermsen, R., Zajonc, D. M., Laven, M. J., Fun, A., Troskie, M., Schoemaker, N. J., Morar, D., Lenstra, J. A., Vervelde, L., Rutten, V. P. M. G., van Eden, W., & Van Rhijn, I. (2009). Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants. Molecular Immunology, 46(7), 1424-1431. https://doi.org/10.1016/j.molimm.2008.12.009
Reinink, P., & van Rhijn, I. (2009). The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2. Immunogenetics, 61(7), 541-549. https://doi.org/10.1007/s00251-009-0384-9
van Rhijn, I., Nguyen, T. K. A., Michel, A. L., Cooper, D., Govaerts, M., Cheng, T. Y., van Eden, W., Moody, D. B., Coetzer, J. A. W., Rutten, V. P. M. G., & Koets, A. P. (2009). Low cross-reactivity of T cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection. European Journal of Immunology, 39(11), 3031-3041.
van Rhijn, I., Young, D. C., de Jong, A., Vazquez, J., Cheng, T. Y., Talekar, R., Barral, D., Leon, L., Brenner, M. B., Katz, J. T., Riese, R., Ruprecht, R. M., O'Connor, P. B., Costello, C. E., Porcelli, S. A., Briken, V., & Moody, D. B. (2009). CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. Journal of Experimental Medicine, 206(6), 1409-1422.
https://dspace.library.uu.nl/bitstream/handle/1874/39415/Rhijn%2520ea%2520CD1c%2520bypasses.pdf?sequence=1
Hoek, A., Rutten, V. P. M. G., Kool, J., Bouwstra, R. J., Arkesteijn, G. J., van Rhijn, I., & Koets, A. P. (2009). Subpopulations of bovine WC1+ gammadelta T cells rather than CD4+CD25highFoxp3+ T cells act as immune regulatory cells ex vivo. Veterinary Research, 40(1), 6.

2008

Wetenschappelijke publicaties

Hoek, A., Rutten, V. P. M. G., Kool, M. M. J., Arkesteijn, G., Bouwstra, R. J., van Rhijn, I., & Koets, A. P. (2008). Subpopulations of bovine WC1+ T cells rather than CD4+CD25highFoxp3+ T cells act as immune regulatory cells ex vivo. Onbekend GW. https://doi.org/10.1051/vetres:2008044
Looringh van Beeck, F. A., Zajonc, D. M., Moore, P. F., Schlotter, Y. M., Broere, F., Rutten, V. P. M. G., Willemse, A., & van Rhijn, I. (2008). Two canine CD1a proteins are differentially expressed in skin. Immunogenetics, 60(6), 315-234.
https://dspace.library.uu.nl/bitstream/handle/1874/32007/Looringh%2520ea%2520Two%2520canine.pdf?sequence=1

2007

Wetenschappelijke publicaties

van Rhijn, I., Spiering, R., Smits, M., van Blokland, M. T., de Weger, R. A., van Eden, W., Rutten, V. P. M. G., & Koets, A. P. (2007). Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain. Molecular Immunology, 44(12), 3155-3161.
https://dspace.library.uu.nl/bitstream/handle/1874/26049/Rhijn%2520ea%2520Highly%2520diverse.pdf?sequence=1
van Rhijn, I., Rutten, V. P. M. G., Charleston, B., Smits, M., van Eden, W., & Koets, A. P. (2007). Massive, sustained gammadelta T cell migration from the bovine skin in vivo. Journal of Leukocyte Biology, 81(4), 968-973.
https://dspace.library.uu.nl/bitstream/handle/1874/26208/Rhijn%2520ea%2520Massive%2520sustained.pdf?sequence=1

2006

Wetenschappelijke publicaties

Cheng, T. Y., Relloso, M., van Rhijn, I., Young, D. C., Besra, G. S., Briken, V., Zajonc, D. M., Wilson, I. A., Porcelli, S. A., & Moody, D. B. (2006). Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO Journal, 25(13), 2989-2999.
https://dspace.library.uu.nl/bitstream/handle/1874/20241/cheng%2520ea%2520role%2520of%2520lipid%2520trimming.pdf?sequence=1
van Rhijn, I., Koets, A. P., Im, J. S., Piebes, D., Reddington, F., Besra, G. S., Porcelli, S. A., van Eden, W., & Rutten, V. P. M. G. (2006). The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d. Journal of Immunology, 176(8), 4888-4893.
https://dspace.library.uu.nl/bitstream/handle/1874/20232/Rhijn%2520Bovine%2520CD1%2520family.pdf?sequence=1

2005

Wetenschappelijke publicaties

van Rhijn, I., Zajonc, D. M., Wilson, I. A., & Moody, D. B. (2005). T-cell activation by lipopeptide antigens. Current Opinion in Immunology, 17, 222-229.

2004

Wetenschappelijke publicaties

van Rhijn, I., Young, D. C., Im, J. S., Levery, S. B., Illarionov, P. A., Besra, G. S., Porcelli, S. A., Gumperz, J., Cheng, T. Y., & Moody, D. B. (2004). CD1d-restricted T cell activation by nonlipidic small molecules. Proceedings of the National Academy of Sciences of the United States of America, 101, 13578-13583.

Overige resultaten

van Rhijn, I., Young, D. C., & Moody, D. B. (2004). Methods and compositions for immune modulation. (Patent No. 10/966.874).

2000

Wetenschappelijke publicaties

Van Rhijn, I., Van den Berg, L. H., Bosboom, W. M., Otten, H. G., & Logtenberg, T. (2000). Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy. Brain, 123 ( Pt 10), 2020-9.