Publicaties
2023
Wetenschappelijke publicaties
Kuhns, L., Mies, G., Kroon, E., Willuhn, I.
, Lesscher, H., & Cousijn, J. (2023).
Alcohol cue reactivity in the brain: Age-related differences in the role of social processes in addiction in male drinkers.
Journal of Neuroscience Research,
101(10), 1521-1537.
https://doi.org/10.1002/jnr.25206van Leeuwen, L., Ruiter, A.
, Visser, K., Lesscher, H. M. B., & Jonker, M. (2023).
Acquiring Financial Support for Children's Sports Participation: Co-Creating a Socially Safe Environment for Parents from Low-Income Families.
Children (Basel, Switzerland),
10(5), 1-16. [872].
https://doi.org/10.3390/children10050872Alexandridis, D., Nijhof, S. L.
, van der Rijst, V. G., van der Neut, D. Y., Spijkerman, R.
, Stevens, G. W. J. M., Bakkes, S. C. J., Lesscher, H. M. B., van den Eijnden, R. J. J. M., van der Ent, C. K., van den Berg, G.
, & Peeters, M. (2023).
A cross-sectional study on gaming intensity and social vulnerability in adolescents that have a chronic condition.
Frontiers in Public Health,
11, [1128156].
https://doi.org/10.3389/fpubh.2023.1128156 Cousijn, J., Mies, G., Runia, N., Derksen, M., Willuhn, I.
, & Lesscher, H. (2023).
The impact of age on olfactory alcohol cue-reactivity: A functional magnetic resonance imaging study in adolescent and adult male drinkers.
Alcoholism: Clinical and Experimental Research,
47(4), 668-677.
https://doi.org/10.1111/acer.15037Colyer-Patel, K., Kuhns, L., Weidema, A.
, Lesscher, H., & Cousijn, J. (2023).
Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults.
Neuroscience and Biobehavioral Reviews,
146, 1-29. [105038].
https://doi.org/10.1016/j.neubiorev.2023.105038Vakpublicaties
Lozeman - van t Klooster, J., & Lesscher, H. (2023). Het verfijnen van intraveneuze zelftoediening bij ratten. Biotechniek, 62(2), 9-13.
2022
Wetenschappelijke publicaties
Kuhns, L., Kroon, E.
, Lesscher, H., Mies, G., & Cousijn, J. (2022).
Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.
Translational Psychiatry,
12(1), 1-30. [345].
https://doi.org/10.1038/s41398-022-02100-yHussain, S.
, Lesscher, H. M. D., Day, D. J., & Ellenbroek, B. A. (2022).
Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol.
Psychopharmacology,
239(10), 3145-3159.
https://doi.org/10.1007/s00213-022-06195-5Minnaard, A. M., Luijendijk, M. C. M.
, Baars, A. M., Drost, L., Ramakers, G. M. J., Adan, R. A. H.
, Lesscher, H. M. B., & Vanderschuren, L. J. M. J. (2022).
Increased elasticity of sucrose demand during hyperdopaminergic states in rats.
Psychopharmacology,
239(3), 773-794.
https://doi.org/10.1007/s00213-022-06068-x Smeets, J. A. S., Minnaard, A. M., Ramakers, G. M. J., Adan, R. A. H.
, Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2022).
On the interrelation between alcohol addiction-like behaviors in rats.
Psychopharmacology,
239(4), 1115-1128.
https://doi.org/10.1007/s00213-021-06059-4 2021
Wetenschappelijke publicaties
Pimentel, T., Achterberg, M., Lozeman - van t Klooster, J., Baars, A., Kirchhoff, S., Vanderschuren, L., & Lesscher, H. (2021). Don’t stress play time! On the interaction of social play and glucocorticoids. Poster session presented at Dutch Neuroscience Meeting.
Berkelbach van der Sprenkel, E. E., Nijhof, S. L., Dalmeijer, G. W., Onland-Moret, N. C., de Roos, S. A.
, Lesscher, H. M. B., van de Putte, E. M., van der Ent, C. K.
, Finkenauer, C., & Stevens, G. W. J. M. (2021).
Psychosocial functioning in adolescents growing up with chronic disease: The Dutch HBSC study.
European Journal of Pediatrics.
https://doi.org/10.1007/s00431-021-04268-9Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A-M., Gass, P., Grandjean, J., Havekes, R., ... Genzel, L. (2021).
The continued need for animals to advance brain research.
Neuron,
109(15), 2374-2379.
https://doi.org/10.1016/j.neuron.2021.07.015Lesscher, H. M. B., Achterberg, E. J. M., Siviy, S. M., & Vanderschuren, L. J. M. J. (2021).
Individual differences in social play behaviour predict alcohol intake and control over alcohol seeking in rats.
Psychopharmacology,
238(11), 3119-3130.
https://doi.org/10.1007/s00213-021-05929-1 Minnaard, A. M., Ramakers, G. M. J.
, Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2021).
Baclofen and naltrexone, but not N-acetylcysteine, affect voluntary alcohol drinking in rats regardless of individual levels of alcohol intake.
Behavioural Pharmacology,
32(2&3), 251-257.
https://doi.org/10.1097/FBP.0000000000000615 Populariserende publicaties
Lesscher, H. M. B. (Author). (2021).
Hoe komt het dat de ene persoon wel verslaafd raakt en de andere niet? Interview voor de website Dat Wist Ik Niet, by Ruben Boot.. Web publication/site
https://datwistikniet.com/2021/10/27/heidi-lesscher/ 2020
Wetenschappelijke publicaties
Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M.
, Bontrop, R., Bulthuis, R., Bousema, T.
, Clevers, H., Coenen, T. C. J. J., van Dam, A. M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020).
Correction: How the COVID-19 pandemic highlights the necessity of animal research.
Current Biology,
30(21), 4328.
https://doi.org/10.1016/j.cub.2020.10.033Cousijn, J., Green, K. H., Labots, M.
, Vanderschuren, L., Kenemans, J. L., & Lesscher, H. M. B. (2020).
Motivational and Control Mechanisms Underlying Adolescent versus Adult Alcohol Use.
NeuroSci,
1(1), 44-58.
https://doi.org/10.3390/neurosci1010005Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M.
, Bontrop, R., Bulthuis, R., Bousema, T.
, Clevers, H., Coenen, T. C. J. J., Dam, A-M. V., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020).
How the COVID-19 pandemic highlights the necessity of animal research.
Current Biology,
30(18), R1014-R1018.
https://doi.org/10.1016/j.cub.2020.08.0302018
Wetenschappelijke publicaties
Nijhof, S. L.
, Vinkers, C. H., van Geelen, S. M., Duijff, S. N.
, Achterberg, E. J. M., der Net, J. V.
, Veltkamp, R. C., Grootenhuis, M. A., de Putte, E. M. V., Hillegers, M. H. J., der Brug, A. W. V.
, Wierenga, C. J., Benders, M. J. N. L.
, Engels, R. C. M. E., der Ent, C. K. V.
, Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2018).
Healthy play, better coping: The importance of play for the development of children in health and disease.
Neuroscience and Biobehavioral Reviews,
95, 421-429.
https://doi.org/10.1016/j.neubiorev.2018.09.024Labots, M., Cousijn, J., Jolink, L. A.
, Kenemans, J. L., Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2018).
Age-Related Differences in Alcohol Intake and Control Over Alcohol Seeking in Rats.
Frontiers in Psychiatry,
9, [419].
https://doi.org/10.3389/fpsyt.2018.00419 2017
Wetenschappelijke publicaties
Spoelder, M., Flores Dourojeanni, J. P., de Git, K. C. G.
, Baars, A. M., Lesscher, H. M. B., & Vanderschuren, L. J. M. J. (2017).
Individual differences in voluntary alcohol intake in rats: relationship with impulsivity, decision making and Pavlovian conditioned approach.
Psychopharmacology,
234(14), 2177-2196.
https://doi.org/10.1007/s00213-017-4617-6 Spoelder, M., Pol, S., Janssen, B. S. G.
, Baars, A. M., Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2017).
Loss of control over alcohol seeking in rats depends on individual vulnerability and duration of alcohol consumption experience.
Behavioural Pharmacology,
28(5), 334-344.
https://doi.org/10.1097/FBP.0000000000000304 Lesscher, H. M. B., Bailey, A.
, & Vanderschuren, L. J. M. J. (2017).
Genetic variability in adenosine deaminase-like contributes to variation in alcohol preference in mice.
Alcoholism: Clinical and Experimental Research,
41(7), 1271-1279.
https://doi.org/10.1111/acer.13409 Vanderschuren, L. J. M. J., Minnaard, A. M., Smeets, J. A. S., & Lesscher, H. M. B. (2017).
Punishment models of addictive behavior.
Current Opinion in Behavioral Sciences,
13, 77-84.
https://doi.org/10.1016/j.cobeha.2016.10.007 Spoelder, M., Hesseling, P., Styles, M.
, Baars, A. M., Lozeman-van 't Klooster, J. G.
, Lesscher, H. M. B., & Vanderschuren, L. J. M. J. (2017).
Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol Reinforcement.
European Journal of Neuroscience,
45(1), 147-158.
https://doi.org/10.1111/ejn.13358 2016
Wetenschappelijke publicaties
Spoelder, M., Baars, A. M., Rotte, M. D.
, Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2016).
Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats.
Psychopharmacology,
233(14), 2715–2725.
https://doi.org/10.1007/s00213-016-4330-x 2015
Wetenschappelijke publicaties
Spoelder, M., Hesseling, P., Baars, A. M., Lozeman - van t Klooster, J., Rotte, M. D.
, Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2015).
Individual Variation in Alcohol Intake Predicts Reinforcement, Motivation, and Compulsive Alcohol Use in Rats.
Alcoholism: Clinical and Experimental Research,
39(12), 2427-37.
https://doi.org/10.1111/acer.12891 Lesscher, H. M. B., Spoelder, M., Rotte, M. D., Janssen, M. J.
, Hesseling, P., Lozeman-Van't Klooster, J. G.
, Baars, A. M., & Vanderschuren, L. J. M. J. (2015).
Early social isolation augments alcohol consumption in rats.
Behavioural Pharmacology,
26(7 Spec No), 673-80.
https://doi.org/10.1097/FBP.0000000000000165 Spoelder, M., Lesscher, H. M. B., Hesseling, P., Baars, A. M., Lozeman-van T Klooster, J. G., Mijnsbergen, R.
, & Vanderschuren, L. J. M. J. (2015).
Altered performance in a rat gambling task after acute and repeated alcohol exposure.
Psychopharmacology,
232, 3649-3662.
https://doi.org/10.1007/s00213-015-4020-0 Spoelder, M., Tsutsui, K. T.
, Lesscher, H. M. B., Vanderschuren, L. J. M. J., & Clark, J. J. (2015).
Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues through Potentiation of Phasic Dopamine Signaling.
Neuropsychopharmacology,
40(13), 2873-2885.
https://doi.org/10.1038/npp.2015.139 2014
Wetenschappelijke publicaties
Boleij, H., Willems, J., Leijten, M.
, Lozeman - van t Klooster, J., Lesscher, H. M. B., Kirchhoff, S., Lavrijsen, M., Arndt, S. S., & Ohl, F. (2014).
Chronic social stress does not affect behavioural habituation in male CD1 mice.
Behavioural Brain Research,
273, 34-44.
https://doi.org/10.1016/j.bbr.2014.07.015 2013
Populariserende publicaties
2012
Wetenschappelijke publicaties
Lesscher, H. M. B., Houthuijzen, J. M., Groot Koerkamp, M., Holstege, F. C. P.
, & Vanderschuren, L. J. M. J. (2012).
Amygdala 14-3-3 zeta as a novel modulator of escalating alcohol intake in mice. PLoS One,
7(5), e37999.
https://doi.org/10.1371/journal.pone.0037999 2010
Wetenschappelijke publicaties
Lesscher, H. M. B., van Kerkhof, L. W. M.
, & Vanderschuren, L. J. M. J. (2010).
Inflexible and indifferent alcohol drinking in male mice.
Alcoholism: Clinical and Experimental Research,
34(7), 1219-25.
https://doi.org/10.1111/j.1530-0277.2010.01199.x 2009
Wetenschappelijke publicaties
Lesscher, H. M. B., Wallace, M. J., Zeng, L., Wang, V., Deitchman, J. K., McMahon, T., Messing, R. O., & Newton, P. M. (2009).
Amygdala protein kinase C epsilon controls alcohol consumption.
Genes, Brain, and Behavior,
8(5), 493-9.
https://doi.org/10.1111/j.1601-183X.2009.00485.x Lesscher, H. M. B., Kas, M. J. H., van der Elst, S., van Lith, H. A., & Vanderschuren, L. J. M. J. (2009). A grandparent-influenced locus for alcohol preference on mouse chromosome 2. Pharmacogenetics and Genomics, 19, 719-729.
2008
Wetenschappelijke publicaties
Lesscher, H. M. B., McMahon, T., Lasek, A. W., Chou, W-H., Connolly, J., Kharazia, V., & Messing, R. O. (2008).
Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior.
Genes, Brain, and Behavior,
7(3), 323-33.
https://doi.org/10.1111/j.1601-183X.2007.00356.x Choi, D-S., Wei, W., Deitchman, J. K., Kharazia, V. N.
, Lesscher, H. M. B., McMahon, T., Wang, D., Qi, Z-H., Sieghart, W., Zhang, C., Shokat, K. M., Mody, I., & Messing, R. O. (2008).
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.
Journal of Neuroscience,
28(46), 11890-9.
https://doi.org/10.1523/JNEUROSCI.3156-08.20082005
Wetenschappelijke publicaties
Lesscher, H. M. B., Hordijk, M., Bondar, N. P., Alekseyenko, O. V., Burbach, J. P. H.
, van Ree, J. M., & Gerrits, M. A. F. M. (2005).
Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice.
Neuropsychopharmacology,
30(2), 278-85.
https://doi.org/10.1038/sj.npp.1300529 Mathon, D., Lesscher, H. M. B., Gerrits, M. A. F. M., Kamal, A., Pintar, J. E., Schuller, A. G., Spruijt, B. M., Burbach, J. P. H., Smidt, M. P., & Ramakers, G. M. J. (2005). Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice. Neuroscience, 130(2), 359-367.
Lesscher, H. M. B., Hoogveld, E., Burbach, J. P. H., van Ree, J. M., & Gerrits, M. A. F. M. (2005). Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization. European Neuropsychopharmacology, 15(1), 31-7.
2004
Wetenschappelijke publicaties
Bailey, A., Davis, L., Lesscher, H. M. B., Kelly, M. D. W., Ledent, C., Hourani, S. M. O., & Kitchen, I. (2004). Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice. Journal of Neurochemistry, 88(4), 827-34.
Kas, M. J. H., van den Bos, R.
, Baars, A. M., Lubbers, M.
, Lesscher, H. M. B., Hillebrand, J. J. G., Schuller, A. G., Pintar, J. E.
, & Spruijt, B. M. (2004).
Mu-opioid receptor knockout mice show diminished food-anticipatory activity.
European Journal of Neuroscience,
20(6), 1624-1632.
https://doi.org/10.1111/j.1460-9568.2004.03581.x2003
Wetenschappelijke publicaties
Lesscher, H. M. B., Burbach, J. P. H., van Ree, J. M., & Gerrits, M. A. F. M. (2003). ERK1/2 activation in rat ventral tegmental area by the mu-opioid agonist fentanyl: an in vitro study. Neuroscience, 116(1), 139-44.
Lesscher, H. M. B., Bailey, A., Burbach, J. P. H., Van Ree, J. M., Kitchen, I., & Gerrits, M. A. F. M. (2003). Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice. European Journal of Neuroscience, 17(5), 1006-12.
Gerrits, M. A. F. M., Lesscher, H. B. M., & van Ree, J. M. (2003). Drug dependence and the endogenous opioid system. European Neuropsychopharmacology, 13(6), 424-34.
2001
Wetenschappelijke publicaties
Workel, J. O., Oitzl, M. S., Fluttert, M., Lesscher, H., Karssen, A., & de Kloet, E. R. (2001). Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence. Journal of Neuroendocrinology, 13(7), 569-80.
Schaaf, M. J., Workel, J. O., Lesscher, H. M., Vreugdenhil, E., Oitzl, M. S., & de Kloet, E. R. (2001). Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats. Brain Research, 915(2), 227-33.