Publicaties

Profiel Publicaties In de media Onderzoek Onderwijs Nevenwerkzaamheden Contact

Expertises

Onderzoeksthema's

Life Sciences (LS)

2025

Wetenschappelijke publicaties

Cook, S. R., Hugen, S., Hayward, J. J., Famula, T. R., Belanger, J. M., McNiel, E., Fieten, H., Oberbauer, A. M., Leegwater, P. A. J., Ostrander, E. A., Mandigers, P. J. J., & Evans, J. M. (2025). Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer. Proceedings of the National Academy of Sciences of the United States of America, 122(22), 1-11. Article e2416723122. https://doi.org/10.1073/pnas.2416723122
https://research-portal.uu.nl/ws/files/265593855/cook-et-al-genomic-analyses-identify-15-risk-loci-and-reveal-hdac2-sox2-ot-and-igf2bp2-in-a-naturally-occurring-canine.pdf

Roelen, Y. S., Spee, B., van Wolferen, M. E., Fieten, H., & den Boer, E. R. (2025). Serum miR-30b is increased in Labrador Retrievers with elevated hepatic copper levels. The Veterinary Journal, 311, Article 106335. https://doi.org/10.1016/j.tvjl.2025.106335
https://research-portal.uu.nl/ws/files/259412216/1-s2.0-S1090023325000395-main.pdf

Hugen, S., Limpens, C., Robben, J. H., Fieten, H., & Mandigers, P. J. J. (2025). Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands. Veterinary Sciences, 12(1), Article 18. https://doi.org/10.3390/vetsci12010018
https://research-portal.uu.nl/ws/files/251564834/vetsci-12-00018.pdf

Opmeer, Y., van Steenbeek, F. G., Rozendom, C., Fieten, H., Diaz Espineira, M. M., Stassen, Q. E. M., van Kooten, P. J., Rutten, V. P. M. G., Hytönen, M. K., Lohi, H., Mandigers, P. J. J., & Leegwater, P. A. (2025). Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus. PLoS Genetics, 21(1), Article e1011538. https://doi.org/10.1371/journal.pgen.1011538
https://research-portal.uu.nl/ws/files/251710749/journal.pgen.1011538.pdf

2024

Wetenschappelijke publicaties

Hugen, S., Limpens, C., Robben, J. H., Fieten, H., & Mandigers, P. J. J. (2024). Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands. Preprints.org. https://doi.org/10.20944/preprints202410.1940.v1
https://research-portal.uu.nl/ws/files/244647879/preprints202410.1940.v1.pdf

Mandigers, P., Opmeer, Y., Alf, V., Diane Shelton, G., van Steenbeek, F., Rozendom, C., van Kooten, P., Rutten, VP., Grinwis, G., Hytönen, M. K., Rosati, M., Fieten, H., Lohi, H., Leegwater, P., & Matiasek, K. (2024). Polymyositis in the Dutch Kooikerdog. Abstract from 36th ESVN-ECVN Congress 2024, Porto, Portugal.

Opmeer, Y., Alf, V., Shelton, G. D., Grinwis, G., Rosati, M., Fieten, H., Leegwater, P., Matiasek, K., & Mandigers, P. (2024). Immune Mediated Polymyositis In The Dutch Kooiker Dog. 108. Abstract from ICCFGG 2024, Helsinki, Finland.
https://research-portal.uu.nl/ws/files/227682311/ICCFGG_2024_Programme_Abstract_Book_Opmeer.pdf

Limpens, C., Mandigers, P., Leegwater, P., & Fieten, H. (2024). Population and health analysis in the worldwide population of the Dutch Kooikerdog. 106. Abstract from ICCFGG 2024, Helsinki, Finland.
https://research-portal.uu.nl/ws/files/227682020/ICCFGG_2024_Programme_Abstract_Book_Limpens.pdf

Leegwater, P., Opmeer, Y., van Steenbeek, F., Rozendom, C., van Kooten, P., Rutten, VP., Fieten, H., Hytönen, M. K., Lohi, H., & Mandigers, P. (2024). Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream the IL21/IL2 genes. 100. Abstract from ICCFGG 2024, Helsinki, Finland.
https://research-portal.uu.nl/ws/files/227681775/ICCFGG_2024_Programme_Abstract_Book_Leegwater.pdf

Limpens, C., Smits, V., Fieten, H., & Mandigers, P. (2024). The effect of MRI-based screening and selection on the prevalence of syringomyelia in the Dutch and Danish Cavalier King Charles Spaniels. Frontiers in Veterinary Science, 11, 1-9. Article 1326621. https://doi.org/10.3389/fvets.2024.1326621
https://dspace.library.uu.nl/bitstream/handle/1874/435941/fvets-11-1326621.pdf?sequence=1

Visser, J., Schoemaker, N. J., van Zeeland, Y. R. A., Veraa, S., Kik, M. J. L., Fieten, H., & Kummeling, A. (2024). Diagnosis and treatment of a congenital portosystemic shunt in a ferret (Mustela putorius furo). Journal of Small Animal Practice, 65(1), 75-78. https://doi.org/10.1111/jsap.13659
https://dspace.library.uu.nl/bitstream/handle/1874/438020/J_of_Small_Animal_Practice_-_2023_-_Visser_-_Diagnosis_and_treatment_of_a_congenital_portosystemic_shunt_in_a_ferret_.pdf?sequence=1

2023

Wetenschappelijke publicaties

Ullal, T. V., Jaffey, J. A., Kreisler, R., Matheson, J., Pacholec, C., Shumway, K., Van den Bossche, L., Fieten, H., Ringold, R., & DeClue, A. E. (2023). Increasing age and severe intraoperative hypotension associated with nonsurvival in dogs with gallbladder mucocele undergoing cholecystectomy. Journal of the American Veterinary Medical Association, 261(12), 1-9. https://doi.org/10.2460/javma.23.06.0305
https://dspace.library.uu.nl/bitstream/handle/1874/434296/javma-javma.23.06.0305_1_.pdf?sequence=1

Hillman, A., Swafford, B., Delavenne, C., Fieten, H., Boerkamp, K., & Tietje, K. (2023). Descriptive analysis of haemangiosarcoma occurrence in dogs enrolled in the Golden Retriever lifetime study. Veterinary and Comparative Oncology, 21(4), 700-708. https://doi.org/10.1111/vco.12933
https://dspace.library.uu.nl/bitstream/handle/1874/434295/Vet_Comparative_Oncology_-_2023_-_Hillman_-_Descriptive_analysis_of_haemangiosarcoma_occurrence_in_dogs_enrolled_in_the.pdf?sequence=1

Opmeer, Y., Grinwis, G. C. M., Shelton, G. D., Rosati, M., Alf, V., Fieten, H., Leegwater, P. A. J., Matiasek, K., & Mandigers, P. J. J. (2023). An Inflammatory Myopathy in the Dutch Kooiker Dog. Animals, 13(9), Article 1508. https://doi.org/10.3390/ani13091508
https://dspace.library.uu.nl/bitstream/handle/1874/428453/animals_13_01508.pdf?sequence=1

Kijan, C., Hugen, S., Thomas, R. E., Oberbauer, A. M., Leegwater, P. A. J., Fieten, H., German, A. J., & Mandigers, P. J. J. (2023). The Histopathological Characteristic of Gastric Carcinoma in the Belgian Tervueren and Groenendael Dog: A Comparison of Two Classification Methods. Animals, 13(9), Article 1532. https://doi.org/10.3390/ani13091532
https://dspace.library.uu.nl/bitstream/handle/1874/428491/animals_13_01532.pdf?sequence=1

2022

Wetenschappelijke publicaties

Visser, J., Fieten, H., van Velzen, H. W., Zaal, M. D., & Kummeling, A. (2022). Prognostic factors for continence after surgical correction of ectopic ureters of 51 dogs with long-term follow-up. Acta Veterinaria Scandinavica, 64(1), 1-5. Article 29. https://doi.org/10.1186/s13028-022-00648-9
https://dspace.library.uu.nl/bitstream/handle/1874/424347/s13028_022_00648_9.pdf?sequence=1

Jong, M. V. D., Leegwater, P. A. J., Fieten, H., & Szatmári, V. (2022). Prevalence of Echocardiographic Evidence of Trace Mitral and Aortic Valve Regurgitation in 50 Clinically Healthy, Young Adult Labrador Retrievers without Heart Murmur. Animals, 12(18), 1-9. Article 2442. https://doi.org/10.3390/ani12182442
https://dspace.library.uu.nl/bitstream/handle/1874/423096/animals_12_02442.pdf?sequence=1

Gaar-Humphreys, K. R., Spanjersberg, T. C. F., Santarelli, G., Grinwis, G. C. M., Szatmári, V., Roelen, B. A. J., Vink, A., Tintelen, J. P. V., Asselbergs, F. W., Fieten, H., Harakalova, M., & Steenbeek, F. G. V. (2022). Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model. Animals, 12(13), 1-18. Article 1679. https://doi.org/10.3390/ani12131679
https://dspace.library.uu.nl/bitstream/handle/1874/421403/animals_12_01679_v2.pdf?sequence=1

Gioilli, B. D., Kidane, T. Z., Fieten, H., Tellez, M., Dalphin, M., Nguyen, A., Nguyen, K., & Linder, M. C. (2022). Secretion and Uptake of Copper via a Small Copper Carrier in Blood Fluid. Metallomics, 14(3), 1-12. Article mfac006. https://doi.org/10.1093/mtomcs/mfac006
https://dspace.library.uu.nl/bitstream/handle/1874/419750/mfac006.pdf?sequence=1

Bogaerts, E., den Boer, E., Peelman, L., Van Nieuwerburgh, F., Fieten, H., Saunders, J. H., & Broeckx, B. J. G. (2022). Veterinarians' Competence in Applying Basic Genetic Principles and Daily Implementation of Clinical Genetics: A Study in a University Environment. Journal of Veterinary Medical Education, 49(6), 799-806. Article e20210029. https://doi.org/10.3138/jvme-2020-0029
https://dspace.library.uu.nl/bitstream/handle/1874/431359/jvme-2021-0029.pdf?sequence=1

Vakpublicaties

den Boer, E., Fieten, H., & Vree, L. (2022). Monitoring van 6 criteria voor brachycephale honden in de PETscan database.

den Boer, E., Fieten, H., & Vree, L. (2022). Rapportage diagnoseregistratiesysteem PETscan.

2021

Wetenschappelijke publicaties

Jaffey, J. A., Matheson, J., Shumway, K., Pacholec, C., Ullal, T., Van den Bossche, L., Fieten, H., Ringold, R., Lee, K. J., & DeClue, A. E. (2021). Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele. PLoS One, 15(12), 1-15. Article e0244102. https://doi.org/10.1371/journal.pone.0244102
https://dspace.library.uu.nl/bitstream/handle/1874/416270/journal.pone.0244102_2_.pdf?sequence=1

Jaffey, J. A., Matheson, J., Shumway, K., Pacholec, C., Ullal, T., van den Bossche, L., Fieten, H., Ringold, R., Lee, K. J., & DeClue, A. E. (2021). Correction: Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele. PLoS One, 16(10), 1-1. Article e0258411. https://doi.org/10.1371/journal.pone.0258411
https://dspace.library.uu.nl/bitstream/handle/1874/419071/journal.pone.0258411.pdf?sequence=1

2020

Wetenschappelijke publicaties

Wu, X., den Boer, E. R., Vos-Loohuis, M., Monroe, G. R., Nijman, I. J., van Steenbeek, F. G., Leegwater, P. A. J., & Fieten, H. (2020). Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers. Life (Basel, Switzerland), 10(11), Article 266. https://doi.org/10.3390/life10110266
https://dspace.library.uu.nl/bitstream/handle/1874/409747/life_10_00266.pdf?sequence=1

Li, Y., Qu, C., Spee, B., Zhang, R., Penning, L. C., de Man, R. A., Peppelenbosch, M. P., Fieten, H., & Pan, Q. (2020). Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection. Irish Veterinary Journal, 73(1), Article 6. https://doi.org/10.1186/s13620-020-00158-y
https://dspace.library.uu.nl/bitstream/handle/1874/408081/s13620_020_00158_y.pdf?sequence=1

2019

Wetenschappelijke publicaties

Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., ... DeClue, A. E. (2019). Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele. Veterinary Journal, 251, Article 105350. https://doi.org/10.1016/j.tvjl.2019.105350
https://dspace.library.uu.nl/bitstream/handle/1874/396720/1_s2.0_S1090023319300838_main.pdf?sequence=1

Keijser, S. F. A., Vernooij, J. C. M., van Garderen, E., van Rooijen, P., Fieten, H., van Steenbeek, F. G., Hesselink, J. W., & Nielen, M. (2019). Quantification of the health-status of the Dutch Labrador retriever population. Preventive Veterinary Medicine, 171, Article 104764. https://doi.org/10.1016/j.prevetmed.2019.104764
https://dspace.library.uu.nl/bitstream/handle/1874/384847/Quantification.pdf?sequence=1

Wu, X., Mandigers, P. J. J., Watson, A. L., van den Ingh, T. S. G. A. M., Leegwater, P. A. J., & Fieten, H. (2019). Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs. Journal of Veterinary Internal Medicine, 33(4), 1646-1652. https://doi.org/10.1111/jvim.15536
https://dspace.library.uu.nl/bitstream/handle/1874/389119/Wu_et_al_2019_Journal_of_Veterinary_Internal_Medicine.pdf?sequence=1

Sakai, M., Spee, B., Grinwis, G. C. M., Penning, L. C., van Wolferen, M. E., van der Laan, L. J. W., & Fieten, H. (2019). Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 33(1), 151-157. https://doi.org/10.1111/jvim.15366
https://dspace.library.uu.nl/bitstream/handle/1874/375998/Association.pdf?sequence=1

2018

Wetenschappelijke publicaties

Keijser, S. F. A., Fieten, H., Vos-Loohuis, M., Piek, C. J., Anderson, H., Donner, J., Scholten, I., Nielen, M., Hesselink, J. W., & van Steenbeek, F. G. (2018). DNA panel screening as a potential tool to monitor health and inbreeding in a small, closed dog population. Canine genetics and epidemiology, 5(12), Article 12. https://doi.org/10.1186/s40575-018-0068-6
https://dspace.library.uu.nl/bitstream/handle/1874/376610/s40575_018_0068_6.pdf?sequence=1

Keijser, S. F. A., Vernooij, J. C. M., Rothuizen, J., Fieten, H., Nielen, M., Hesselink, J. W., & van Steenbeek, F. G. (2018). PETscan: measuring incidence of disease phenotypes to prioritize genetic studies in companion animals. Animal Genetics, 49(5), 492-495. https://doi.org/10.1111/age.12707
https://dspace.library.uu.nl/bitstream/handle/1874/370788/PETscan.pdf?sequence=1

2017

Wetenschappelijke publicaties

Wucher, V., Legeai, F., Hedan, B., Rizk, G., Lagoutte, L., Leeb, T., Jagannathan, V., Cadieu, E., David, A., Lohi, H., Cirera, S., Fredholm, M., Botherel, N., Leegwater, P., Le Beguec, C., Fieten, H., Johansson, C., Johnsson, J., Alifoldi, J., ... Derrien, T. (2017). FEELnc: A tool for Long non-coding RNAs annotation and its application to the dog transcriptome. Nucleic Acids Research, 45(8), Article e57. https://doi.org/10.1101/064436, https://doi.org/10.1093/nar/gkw1306
https://dspace.library.uu.nl/bitstream/handle/1874/346312/feelnc.pdf?sequence=3

van Straten, G., de Sain - van der Velden, M. G. M., van Geijlswijk, I. M., Favier, R. P., Mesu, S. J., Holwerda-Loof, N. E., van der Ham, M., Fieten, H., Rothuizen, J., Spee, B., & Verhoeven - Duif, N. M. (2017). Saline is as effective as nitrogen scavengers for treatment of hyperammonemia. Scientific Reports, 7(1), Article 13112. https://doi.org/10.1038/s41598-017-12686-9
https://dspace.library.uu.nl/bitstream/handle/1874/360435/s41598_017_12686_9.pdf?sequence=1

Dirksen, K., Burgener, I. A., Rothuizen, J., van den Ingh, T. S. G. A. M., Penning, L. C., Spee, B., & Fieten, H. (2017). Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 31, 1017–1027. https://doi.org/10.1111/jvim.14716
https://dspace.library.uu.nl/bitstream/handle/1874/360419/Dirksen_et_al_2017_Journal_of_Veterinary_Internal_Medicine.pdf?sequence=1

Dirksen, K., Spee, B., Penning, L. C., van den Ingh, T. S. G. A. M., Burgener, I. A., Watson, A. L., Groot Koerkamp, M., Rothuizen, J., van Steenbeek, F. G., & Fieten, H. (2017). Gene expression patterns in the progression of canine copper-associated chronic hepatitis. PLoS One, 12(5), e0176826. https://doi.org/10.1371/journal.pone.0176826
https://dspace.library.uu.nl/bitstream/handle/1874/360409/heaptitis.pdf.crdownload?sequence=1

Keijser, S. F. A., Meijndert, L. E., Fieten, H., Carrière, B. J., van Steenbeek, F. G., Leegwater, P. A. J., Rothuizen, J., & Nielen, M. (2017). Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats. Preventive Veterinary Medicine, 140, 38-44. https://doi.org/10.1016/j.prevetmed.2017.02.016
https://dspace.library.uu.nl/bitstream/handle/1874/360829/1_s2.0_S0167587717301708_main.pdf?sequence=1

Dirksen, K., & Fieten, H. (2017). Canine Copper-Associated Hepatitis. Veterinary Clinics of North America - Small Animal Practice. https://doi.org/10.1016/j.cvsm.2016.11.011
https://dspace.library.uu.nl/bitstream/handle/1874/359706/hepatitis.pdf?sequence=1

2016

Wetenschappelijke publicaties

Dirksen, K., Roelen, Y. S., van Wolferen, M. E., Kruitwagen, H. S., Penning, L. C., Burgener, I. A., Spee, B., & Fieten, H. (2016). Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers. Veterinary Journal, 218, 1-6. https://doi.org/10.1016/j.tvjl.2016.10.007
https://dspace.library.uu.nl/bitstream/handle/1874/345556/Erythrocyte.pdf?sequence=1

Dirksen, K., Verzijl, T., Grinwis, G. C., Favier, R. P., Penning, L. C., Burgener, I. A., van der Laan, L. J., Fieten, H., & Spee, B. (2016). Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs. Journal of Veterinary Internal Medicine, 30(6), 1816-1823. https://doi.org/10.1111/jvim.14602
https://dspace.library.uu.nl/bitstream/handle/1874/345529/serum.pdf?sequence=1

Dirksen, K., Verzijl, T., van den Ingh, T. S. G. A. M., Vernooij, J. C. M., van der Laan, L. J. W., Burgener, I. A., Spee, B., & Fieten, H. (2016). Hepatocyte-derived microRNAs as sensitive serum biomarkers of hepatocellular injury in Labrador retrievers. Veterinary Journal, 211, 75-81. https://doi.org/10.1016/j.tvjl.2016.01.010
https://dspace.library.uu.nl/bitstream/handle/1874/345446/hepatocyte.pdf?sequence=1

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., van der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., ... van de Sluis, B. (2016). CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nature Communications [E], 7, Article 10961. https://doi.org/10.1038/ncomms10961
https://dspace.library.uu.nl/bitstream/handle/1874/346710/endosomal.pdf?sequence=1

Wu, X., Leegwater, P. A. J., & Fieten, H. (2016). Canine Models for Copper Homeostasis Disorders. International Journal of Molecular Sciences, 17(2), Article 196. https://doi.org/10.3390/ijms17020196
https://dspace.library.uu.nl/bitstream/handle/1874/345911/ijms_17_00196.pdf?sequence=1

Fieten, H., Gill, Y., Martin, A. J., Concilli, M., Dirksen, K., van Steenbeek, F. G., Spee, B., van den Ingh, T. S. G. A. M., Martens, E. C. C. P., Festa, P., Chesi, G., van de Sluis, B., Houwen, R. H. J. H., Watson, A. L., Aulchenko, Y. S., Hodgkinson, V. L., Zhu, S., Petris, M. J., Polishchuk, R. S., ... Rothuizen, J. (2016). The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders. Disease Models & Mechanisms, 9, 25-38. https://doi.org/10.1242/dmm.020263
https://dspace.library.uu.nl/bitstream/handle/1874/345422/Menkes.full.pdf?sequence=1

2015

Wetenschappelijke publicaties

Fieten, H., Biourge, V. C., Watson, A. L., Leegwater, P. A. J., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2015). Dietary management of labrador retrievers with subclinical hepatic copper accumulation. Journal of Veterinary Internal Medicine, 29(3), 822-827. https://doi.org/10.1111/jvim.12574
https://research-portal.uu.nl/ws/files/259859301/Veterinary_Internal_Medicne_-_2015_-_Fieten_-_Dietary_Management_of_Labrador_Retrievers_with_Subclinical_Hepatic_Copper.pdf

Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports [E], 5(5), 895-907. https://doi.org/10.1016/j.stemcr.2015.09.002
https://dspace.library.uu.nl/bitstream/handle/1874/327197/213671115002647.pdf?sequence=1

Fieten, H. (2015). Copper-associated hepatitis in the Labrador retriever: diagnosis, treatment and genetics. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University. https://dspace.library.uu.nl/handle/1874/312769
https://research-portal.uu.nl/ws/files/12275894/Copper_associated_hepatitis_in_the_Labrador_retriever_diagnosis_treatment_and_genetics_Hille_Fieten_NW_V2_.pdf

Favier, R. P., Spee, B., Fieten, H., van den Ingh, T. S. G. A. M., Schotanus, B. A., Brinkhof, B., Rothuizen, J., & Penning, L. C. (2015). Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs. Journal of Trace Elements in Medicine and Biology, 29, 347-353. https://doi.org/10.1016/j.jtemb.2014.06.007
https://research-portal.uu.nl/ws/files/258467981/1-s2.0-S0946672X14001126-main.pdf

2014

Wetenschappelijke publicaties

van der Laan, L. J. W., de Ruiter, P. E., van Gils, I. M., Fieten, H., Spee, B., Pan, Q., Rothuizen, J., & Penning, L. C. (2014). Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort. Journal of Viral Hepatitis, 21(12), 894-896. https://doi.org/10.1111/jvh.12268

Fieten, H., Biourge, V., Watson, AL., Leegwater, P., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2014). Nutritional managment of inherited copper-associated hepatitis in the Labrador retriever. Veterinary Journal, 199(3), 429-433. https://doi.org/10.1016/j.tvjl.2013.12.017

Fieten, H., & Rothuizen, J. (2014). Copper-associated hepatitis. In J. D. Bonagura, & D. C. Twedt (Eds.), Kirk’s Current veterinary therapy XV (pp. e231-e236). Elsevier Saunders.

van Straten, G., van Steenbeek, F. G., Grinwis, G. C. M., Favier, R. P., Kummeling, A., Gils, I. H., Fieten, H., Groot Koerkamp, M. J. A., Holstege, F. C. P., Rothuizen, J., & Spee, B. (2014). Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. PLoS One, 9(6), Article e100077. https://doi.org/10.1371/journal.pone.0100077
https://dspace.library.uu.nl/bitstream/handle/1874/308995/7.pdf?sequence=1

Fieten, H., Penning, L. C., Leegwater, P. A. J., & Rothuizen, J. (2014). New canine models of copper toxicosis: diagnosis, treatment, and genetics. Annals of the New York Academy of Sciences, 1314, 42-48. https://doi.org/10.1111/nyas.12442

Overige resultaten

Schotanus, B. A., Nantasanti, S., Huch, M., Oosterhoff, L., Fieten, H., Kruitwagen, H. S., van Wolferen, M., Grinwis, G. C. M., Wubbolts, R., Favier, R. P., Penning, L. C., Vries, R. G. J., Clevers, H., Rothuizen, J., & Spee, B. (2014). Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS: Journal of Hepatology. Journal of Hepatology, 60(1, Suppl), S272. Article P610. https://doi.org/10.1016/S0168-8278(14)60772-8

2013

Wetenschappelijke publicaties

Fieten, H., Hugen, S., van den Ingh, T. S. G. A. M., Hendriks, W. H., Vernooij, H., Bode, P., Watson, A. L., Leegwater, P. A. J., & Rothuizen, J. (2013). Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs. Veterinary Journal, 197(2), 468-473. https://doi.org/10.1016/j.tvjl.2013.03.003

Fieten, H., Dirksen, K., van den Ingh, T. S. G. A. M., Winter, E. A., Watson, A. L., Leegwater, P. A. J., & Rothuizen, J. (2013). D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers. Veterinary Journal, 196, 522-527. https://doi.org/10.1016/j.tvjl.2012.12.013

Overige resultaten

Roelen, Y. S., Dirksen, K., Fieten, H., & Spee, B. (2013). A Biomarker for Copper associated Hepatitis in Labrador Retrievers. Abstract from Voorjaarsdagen, Amsterdam & Utrecht.

2012

Wetenschappelijke publicaties

Fieten, H., Leegwater, P. A. J., Watson, A. L., & Rothuizen, J. (2012). Canine models of copper toxicosis for understanding mammalian copper metabolism. Mammalian Genome, 23(1-2), 62-75. https://doi.org/10.1007/s00335-011-9378-7
https://dspace.library.uu.nl/bitstream/handle/1874/272912/Canine%2520models%2520of%2520copper%2520toxicosis%2520for%2520understanding.pdf?sequence=1

Fieten, H., Hooijer-Nouwens, B. D., Biourge, V., Leegwater, P. A. J., Watson, A. L., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2012). Association of dietary copper and zinc levels with hepatic copper and zinc concentration in Labrador Retrievers. Journal of Veterinary Internal Medicine, 2012(26), 1274-1280. https://doi.org/10.1111/j.1939-1676.2012.01001.x

Favier, R. P., Spee, B., Schotanus, B. A., van den Ingh, T. S. G. A. M., Fieten, H., Brinkhof, B., Viebahn, C. S., Penning, L. C., & Rothuizen, J. (2012). COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis. PLoS One, 7(8), e42158. https://doi.org/10.1371/journal.pone.0042158
https://dspace.library.uu.nl/bitstream/handle/1874/365500/COMMD1-Deficient%2520Dogs%2520Accumulate%2520Copper....pdf?sequence=1

Overige resultaten

Fieten, H., Leegwater, P. A. J., Martin, A., Watson, A. L., & Rothuizen, J. (2012). New canine model for copper toxicosis: a genome wide association study in the Labrador retriever. 56-56. Poster session presented at 8th International Copper meeting Copper in Biology, Alghero, Sardinia, Italy.

Fieten, H., Leegwater, P. A. J., & Rothuizen, J. (2012). Copper associated liver diseases in the dog. 73-73. Abstract from 58th Jahreskongress der Deutschen Gesellschaft fur Kleintiermedizin, Dusseldorf.

Fieten, H., van Steenbeek, F. G., Leegwater, P. A. J., Favier, R. P., & Rothuizen, J. (2012). Portosystemic vascular anomalies in dogs: genetics, diagnosis and therapeutic options. 65-65. Abstract from 58th Jahreskongress der Deutschen Gesellschaft fur Kleintiermedizin, Dusseldorf.

Fieten, H., Nouwens, B., Biourge, V., Leegwater, P. A. J., Watson, A. L., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2012). Hepatic copper concentration and blood parameters in subclinical Labrador retrievers and association with diet. 262. Poster session presented at ECVIM Congres, Maastricht.

2011

Wetenschappelijke publicaties

Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C. T., Karlsson, E. K., Bannasch, D. L., Vilà, C., Lohi, H., Galibert, F., Fredholm, M., Häggström, O., Hedhammar, A., André, C., ... Webster, M. T. (2011). Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping. PLoS Genetics, 7(10), Article e1002316. https://doi.org/10.1371/journal.pgen.1002316
https://dspace.library.uu.nl/bitstream/handle/1874/234168/vaysse%2520et%2520al%2520Plos%2520Genetics%2520TR2.pdf?sequence=2

2009

Wetenschappelijke publicaties

Fieten, H., Spee, B., Ijzer, J., Kik, M. J., Penning, L. C., & Kirpensteijn, J. (2009). Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Veterinary Pathology, 46(5), 869-877. https://doi.org/10.1354/vp.08-VP-0155-F-FL
https://dspace.library.uu.nl/bitstream/handle/1874/308733/Expression1.pdf?sequence=1

Selvarajah, G. T., Kirpensteijn, J., van Wolferen, M. E., Rao, N. A., Fieten, H., & Mol, J. A. (2009). Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Molecular Cancer, 8, 72. https://doi.org/10.1186/1476-4598-8-72
https://dspace.library.uu.nl/bitstream/handle/1874/37483/1476-4598-8-72.pdf?sequence=1

Bekijk publicaties op de UU Research Portal

Dr. H. (Hille) Fieten

Dr. H. (Hille) Fieten

Publicaties

2025

Wetenschappelijke publicaties

2024

Wetenschappelijke publicaties

2023

Wetenschappelijke publicaties

2022

Wetenschappelijke publicaties

Vakpublicaties

2021

Wetenschappelijke publicaties

2020

Wetenschappelijke publicaties

2019

Wetenschappelijke publicaties

2018

Wetenschappelijke publicaties

2017

Wetenschappelijke publicaties

2016

Wetenschappelijke publicaties

2015

Wetenschappelijke publicaties

2014

Wetenschappelijke publicaties

Overige resultaten

2013

Wetenschappelijke publicaties

Overige resultaten

2012

Wetenschappelijke publicaties

Overige resultaten

2011

Wetenschappelijke publicaties

2009

Wetenschappelijke publicaties

Footer menu (NL)

Direct naar

Diensten

Over de UU