Dr. H. (Hille) Fieten

Prof. dr. H. Jakobgebouw
Yalelaan 108110
3584 CM Utrecht

Dr. H. (Hille) Fieten

Universitair hoofddocent
Inwendige Ziekten

Publicaties

2023

Wetenschappelijke publicaties

Visser, J., Schoemaker, N. J., van Zeeland, Y. R. A., Veraa, S., Kik, M. J. L., Fieten, H., & Kummeling, A. (2023). Diagnosis and treatment of a congenital portosystemic shunt in a ferret (Mustela putorius furo). Journal of Small Animal Practice. https://doi.org/10.1111/jsap.13659
Opmeer, Y., Grinwis, G. C. M., Shelton, G. D., Rosati, M., Alf, V., Fieten, H., Leegwater, P. A. J., Matiasek, K., & Mandigers, P. J. J. (2023). An Inflammatory Myopathy in the Dutch Kooiker Dog. Animals, 13(9), [1508]. https://doi.org/10.3390/ani13091508
Kijan, C., Hugen, S., Thomas, R. E., Oberbauer, A. M., Leegwater, P. A. J., Fieten, H., German, A. J., & Mandigers, P. J. J. (2023). The Histopathological Characteristic of Gastric Carcinoma in the Belgian Tervueren and Groenendael Dog: A Comparison of Two Classification Methods. Animals, 13(9), [1532]. https://doi.org/10.3390/ani13091532

2022

Wetenschappelijke publicaties

Visser, J., Fieten, H., van Velzen, H. W., Zaal, M. D., & Kummeling, A. (2022). Prognostic factors for continence after surgical correction of ectopic ureters of 51 dogs with long-term follow-up. Acta Veterinaria Scandinavica, 64(1), 1-5. [29]. https://doi.org/10.1186/s13028-022-00648-9
Jong, M. V. D., Leegwater, P. A. J., Fieten, H., & Szatmári, V. (2022). Prevalence of Echocardiographic Evidence of Trace Mitral and Aortic Valve Regurgitation in 50 Clinically Healthy, Young Adult Labrador Retrievers without Heart Murmur. Animals, 12(18), 1-9. [2442]. https://doi.org/10.3390/ani12182442
Gaar-Humphreys, K. R., Spanjersberg, T. C. F., Santarelli, G., Grinwis, G. C. M., Szatmári, V., Roelen, B. A. J., Vink, A., Tintelen, J. P. V., Asselbergs, F. W., Fieten, H., Harakalova, M., & Steenbeek, F. G. V. (2022). Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model. Animals, 12(13), 1-18. [1679]. https://doi.org/10.3390/ani12131679
Gioilli, B. D., Kidane, T. Z., Fieten, H., Tellez, M., Dalphin, M., Nguyen, A., Nguyen, K., & Linder, M. C. (2022). Secretion and Uptake of Copper via a Small Copper Carrier in Blood Fluid. Metallomics, 14(3), 1-12. [mfac006]. https://doi.org/10.1093/mtomcs/mfac006

Vakpublicaties

den Boer, E., Fieten, H., & Vree, L. (2022). Monitoring van 6 criteria voor brachycephale honden in de PETscan database.
den Boer, E., Fieten, H., & Vree, L. (2022). Rapportage diagnoseregistratiesysteem PETscan.

2021

Wetenschappelijke publicaties

Jaffey, J. A., Matheson, J., Shumway, K., Pacholec, C., Ullal, T., Van den Bossche, L., Fieten, H., Ringold, R., Lee, K. J., & DeClue, A. E. (2021). Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele. PLoS One, 15(12), 1-15. [e0244102]. https://doi.org/10.1371/journal.pone.0244102
Jaffey, J. A., Matheson, J., Shumway, K., Pacholec, C., Ullal, T., van den Bossche, L., Fieten, H., Ringold, R., Lee, K. J., & DeClue, A. E. (2021). Correction: Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele. PLoS One, 16(10), 1-1. [e0258411]. https://doi.org/10.1371/journal.pone.0258411
Bogaerts, E., den Boer, E., Peelman, L., Van Nieuwerburgh, F., Fieten, H., Saunders, J. H., & Broeckx, B. J. G. (2021). Veterinarians' Competence in Applying Basic Genetic Principles and Daily Implementation of Clinical Genetics: A Study in a University Environment. Journal of Veterinary Medical Education, [e20210029]. https://doi.org/10.3138/jvme-2020-0029

2020

Wetenschappelijke publicaties

Wu, X., den Boer, E. R., Vos-Loohuis, M., Monroe, G. R., Nijman, I. J., van Steenbeek, F. G., Leegwater, P. A. J., & Fieten, H. (2020). Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers. Life (Basel, Switzerland), 10(11), [266]. https://doi.org/10.3390/life10110266
Li, Y., Qu, C., Spee, B., Zhang, R., Penning, L. C., de Man, R. A., Peppelenbosch, M. P., Fieten, H., & Pan, Q. (2020). Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection. Irish Veterinary Journal, 73(1), [6]. https://doi.org/10.1186/s13620-020-00158-y

2019

Wetenschappelijke publicaties

Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., ... DeClue, A. E. (2019). Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele. Veterinary Journal, 251, [105350]. https://doi.org/10.1016/j.tvjl.2019.105350
Keijser, S. F. A., Vernooij, J. C. M., van Garderen, E., van Rooijen, P., Fieten, H., van Steenbeek, F. G., Hesselink, J. W., & Nielen, M. (2019). Quantification of the health-status of the Dutch Labrador retriever population. Preventive Veterinary Medicine, 171, [104764]. https://doi.org/10.1016/j.prevetmed.2019.104764
Wu, X., Mandigers, P. J. J., Watson, A. L., van den Ingh, T. S. G. A. M., Leegwater, P. A. J., & Fieten, H. (2019). Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs. Journal of Veterinary Internal Medicine, 33(4), 1646-1652. https://doi.org/10.1111/jvim.15536
Sakai, M., Spee, B., Grinwis, G. C. M., Penning, L. C., van Wolferen, M. E., van der Laan, L. J. W., & Fieten, H. (2019). Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 33(1), 151-157. https://doi.org/10.1111/jvim.15366

2018

Wetenschappelijke publicaties

Keijser, S. F. A., Fieten, H., Vos-Loohuis, M., Piek, C. J., Anderson, H., Donner, J., Scholten, I., Nielen, M., Hesselink, J. W., & van Steenbeek, F. G. (2018). DNA panel screening as a potential tool to monitor health and inbreeding in a small, closed dog population. Canine genetics and epidemiology, 5(12), [12]. https://doi.org/10.1186/s40575-018-0068-6
Keijser, S. F. A., Vernooij, J. C. M., Rothuizen, J., Fieten, H., Nielen, M., Hesselink, J. W., & van Steenbeek, F. G. (2018). PETscan: measuring incidence of disease phenotypes to prioritize genetic studies in companion animals. Animal Genetics, 49(5), 492-495. https://doi.org/10.1111/age.12707

2017

Wetenschappelijke publicaties

Wucher, V., Legeai, F., Hedan, B., Rizk, G., Lagoutte, L., Leeb, T., Jagannathan, V., Cadieu, E., David, A., Lohi, H., Cirera, S., Fredholm, M., Botherel, N., Leegwater, P., Le Beguec, C., Fieten, H., Johansson, C., Johnsson, J., Alifoldi, J., ... Derrien, T. (2017). FEELnc: A tool for Long non-coding RNAs annotation and its application to the dog transcriptome. Nucleic Acids Research, 45(8), [e57]. https://doi.org/10.1101/064436, https://doi.org/10.1093/nar/gkw1306
van Straten, G., de Sain - van der Velden, M. G. M., van Geijlswijk, I. M., Favier, R. P., Mesu, S. J., Holwerda-Loof, N. E., van der Ham, M., Fieten, H., Rothuizen, J., Spee, B., & Verhoeven - Duif, N. M. (2017). Saline is as effective as nitrogen scavengers for treatment of hyperammonemia. Scientific Reports, 7(1), [13112]. https://doi.org/10.1038/s41598-017-12686-9
Dirksen, K., Burgener, I. A., Rothuizen, J., van den Ingh, T. S. G. A. M., Penning, L. C., Spee, B., & Fieten, H. (2017). Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 31, 1017–1027. https://doi.org/10.1111/jvim.14716
Dirksen, K., Spee, B., Penning, L. C., van den Ingh, T. S. G. A. M., Burgener, I. A., Watson, A. L., Groot Koerkamp, M., Rothuizen, J., van Steenbeek, F. G., & Fieten, H. (2017). Gene expression patterns in the progression of canine copper-associated chronic hepatitis. PLoS One, 12(5), e0176826. https://doi.org/10.1371/journal.pone.0176826
Keijser, S. F. A., Meijndert, L. E., Fieten, H., Carrière, B. J., van Steenbeek, F. G., Leegwater, P. A. J., Rothuizen, J., & Nielen, M. (2017). Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats. Preventive Veterinary Medicine, 140, 38-44. https://doi.org/10.1016/j.prevetmed.2017.02.016
Dirksen, K., & Fieten, H. (2017). Canine Copper-Associated Hepatitis. Veterinary Clinics of North America - Small Animal Practice. https://doi.org/10.1016/j.cvsm.2016.11.011

2016

Wetenschappelijke publicaties

Dirksen, K., Roelen, Y. S., van Wolferen, M. E., Kruitwagen, H. S., Penning, L. C., Burgener, I. A., Spee, B., & Fieten, H. (2016). Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers. Veterinary Journal, 218, 1-6. https://doi.org/10.1016/j.tvjl.2016.10.007
Dirksen, K., Verzijl, T., Grinwis, G. C., Favier, R. P., Penning, L. C., Burgener, I. A., van der Laan, L. J., Fieten, H., & Spee, B. (2016). Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs. Journal of Veterinary Internal Medicine, 30(6), 1816-1823. https://doi.org/10.1111/jvim.14602
Dirksen, K., Verzijl, T., van den Ingh, T. S. G. A. M., Vernooij, J. C. M., van der Laan, L. J. W., Burgener, I. A., Spee, B., & Fieten, H. (2016). Hepatocyte-derived microRNAs as sensitive serum biomarkers of hepatocellular injury in Labrador retrievers. Veterinary Journal, 211, 75-81. https://doi.org/10.1016/j.tvjl.2016.01.010
Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., van der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., ... van de Sluis, B. (2016). CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nature Communications [E], 7, [10961]. https://doi.org/10.1038/ncomms10961
Wu, X., Leegwater, P. A. J., & Fieten, H. (2016). Canine Models for Copper Homeostasis Disorders. International Journal of Molecular Sciences, 17(2), [196]. https://doi.org/10.3390/ijms17020196
Fieten, H., Gill, Y., Martin, A. J., Concilli, M., Dirksen, K., van Steenbeek, F. G., Spee, B., van den Ingh, T. S. G. A. M., Martens, E. C. C. P., Festa, P., Chesi, G., van de Sluis, B., Houwen, R. H. J. H., Watson, A. L., Aulchenko, Y. S., Hodgkinson, V. L., Zhu, S., Petris, M. J., Polishchuk, R. S., ... Rothuizen, J. (2016). The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders. Disease Models & Mechanisms, 9, 25-38. https://doi.org/10.1242/dmm.020263

2015

Wetenschappelijke publicaties

Fieten, H., Biourge, V. C., Watson, A. L., Leegwater, P. A. J., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2015). Dietary management of labrador retrievers with subclinical hepatic copper accumulation. Journal of Veterinary Internal Medicine, 29(3), 822-7. https://doi.org/10.1111/jvim.12574
Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports [E], 5(5), 895-907. https://doi.org/10.1016/j.stemcr.2015.09.002
Fieten, H. (2015). Copper-associated hepatitis in the Labrador retriever: diagnosis, treatment and genetics. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University. https://dspace.library.uu.nl/handle/1874/312769
Favier, R. P., Spee, B., Fieten, H., van den Ingh, T. S. G. A. M., Schotanus, B. A., Brinkhof, B., Rothuizen, J., & Penning, L. C. (2015). Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs. Journal of Trace Elements in Medicine and Biology, 29, 347-53. https://doi.org/10.1016/j.jtemb.2014.06.007

2014

Wetenschappelijke publicaties

van der Laan, L. J. W., de Ruiter, P. E., van Gils, I. M., Fieten, H., Spee, B., Pan, Q., Rothuizen, J., & Penning, L. C. (2014). Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort. Journal of Viral Hepatitis, 21(12), 894-896. https://doi.org/10.1111/jvh.12268
Fieten, H., Biourge, V., Watson, AL., Leegwater, P., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2014). Nutritional managment of inherited copper-associated hepatitis in the Labrador retriever. Veterinary Journal, 199(3), 429-433. https://doi.org/10.1016/j.tvjl.2013.12.017
Fieten, H., & Rothuizen, J. (2014). Copper-associated hepatitis. In J. D. Bonagura, & D. C. Twedt (Eds.), Kirk’s Current veterinary therapy XV (pp. e231-e236). Elsevier Saunders.
van Straten, G., van Steenbeek, F. G., Grinwis, G. C. M., Favier, R. P., Kummeling, A., Gils, I. H., Fieten, H., Groot Koerkamp, M. J. A., Holstege, F. C. P., Rothuizen, J., & Spee, B. (2014). Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. PLoS One, 9(6), [e100077]. https://doi.org/10.1371/journal.pone.0100077
Fieten, H., Penning, L. C., Leegwater, P. A. J., & Rothuizen, J. (2014). New canine models of copper toxicosis: diagnosis, treatment, and genetics. Annals of the New York Academy of Sciences, 1314, 42-48. https://doi.org/10.1111/nyas.12442

Overige resultaten

Schotanus, B. A., Nantasanti, S., Huch, M., Oosterhoff, L., Fieten, H., Kruitwagen, H. S., van Wolferen, M., Grinwis, G. C. M., Wubbolts, R., Favier, R. P., Penning, L. C., Vries, R. G. J., Clevers, H., Rothuizen, J., & Spee, B. (2014). Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS: Journal of Hepatology. Journal of Hepatology, 60(1, Suppl), S272. [P610]. https://doi.org/10.1016/S0168-8278(14)60772-8

2013

Wetenschappelijke publicaties

Fieten, H., Hugen, S., van den Ingh, T. S. G. A. M., Hendriks, W. H., Vernooij, H., Bode, P., Watson, A. L., Leegwater, P. A. J., & Rothuizen, J. (2013). Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs. Veterinary Journal, 197(2), 468-473. https://doi.org/10.1016/j.tvjl.2013.03.003
Fieten, H., Dirksen, K., van den Ingh, T. S. G. A. M., Winter, E. A., Watson, A. L., Leegwater, P. A. J., & Rothuizen, J. (2013). D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers. Veterinary Journal, 196, 522-527. https://doi.org/10.1016/j.tvjl.2012.12.013

Overige resultaten

Roelen, Y. S., Dirksen, K., Fieten, H., & Spee, B. (2013). A Biomarker for Copper associated Hepatitis in Labrador Retrievers. Abstract from Voorjaarsdagen, Amsterdam & Utrecht.

2012

Wetenschappelijke publicaties

Fieten, H., Leegwater, P. A. J., Watson, A. L., & Rothuizen, J. (2012). Canine models of copper toxicosis for understanding mammalian copper metabolism. Mammalian Genome, 23(1-2), 62-75. https://doi.org/10.1007/s00335-011-9378-7
Fieten, H., Hooijer-Nouwens, B. D., Biourge, V., Leegwater, P. A. J., Watson, A. L., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2012). Association of dietary copper and zinc levels with hepatic copper and zinc concentration in Labrador Retrievers. Journal of Veterinary Internal Medicine, 2012(26), 1274-1280. https://doi.org/10.1111/j.1939-1676.2012.01001.x
Favier, R. P., Spee, B., Schotanus, B. A., van den Ingh, T. S. G. A. M., Fieten, H., Brinkhof, B., Viebahn, C. S., Penning, L. C., & Rothuizen, J. (2012). COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis. PLoS One, 7(8), e42158. https://doi.org/10.1371/journal.pone.0042158

Overige resultaten

Fieten, H., Leegwater, P. A. J., Martin, A., Watson, A. L., & Rothuizen, J. (2012). New canine model for copper toxicosis: a genome wide association study in the Labrador retriever. 56-56. Poster session presented at 8th International Copper meeting Copper in Biology, Alghero, Sardinia, Italy.
Fieten, H., Leegwater, P. A. J., & Rothuizen, J. (2012). Copper associated liver diseases in the dog. 73-73. Abstract from 58th Jahreskongress der Deutschen Gesellschaft fur Kleintiermedizin, Dusseldorf.
Fieten, H., van Steenbeek, F. G., Leegwater, P. A. J., Favier, R. P., & Rothuizen, J. (2012). Portosystemic vascular anomalies in dogs: genetics, diagnosis and therapeutic options. 65-65. Abstract from 58th Jahreskongress der Deutschen Gesellschaft fur Kleintiermedizin, Dusseldorf.
Fieten, H., Nouwens, B., Biourge, V., Leegwater, P. A. J., Watson, A. L., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2012). Hepatic copper concentration and blood parameters in subclinical Labrador retrievers and association with diet. 262. Poster session presented at ECVIM Congres, Maastricht.

2011

Wetenschappelijke publicaties

Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C. T., Karlsson, E. K., Bannasch, D. L., Vilà, C., Lohi, H., Galibert, F., Fredholm, M., Häggström, O., Hedhammar, A., André, C., ... Webster, M. T. (2011). Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping. PLoS Genetics, 7(10), [e1002316]. https://doi.org/10.1371/journal.pgen.1002316
https://dspace.library.uu.nl/bitstream/handle/1874/234168/vaysse%2520et%2520al%2520Plos%2520Genetics%2520TR2.pdf?sequence=2

2009

Wetenschappelijke publicaties

Fieten, H., Spee, B., Ijzer, J., Kik, M. J., Penning, L. C., & Kirpensteijn, J. (2009). Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Veterinary Pathology, 46(5), 869-877. https://doi.org/10.1354/vp.08-VP-0155-F-FL
Selvarajah, G. T., Kirpensteijn, J., van Wolferen, M. E., Rao, N. A., Fieten, H., & Mol, J. A. (2009). Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Molecular Cancer, 8, 72. https://doi.org/10.1186/1476-4598-8-72