Publicaties
2023
Wetenschappelijke publicaties
Visser, J., Schoemaker, N. J., van Zeeland, Y. R. A., Veraa, S., Kik, M. J. L., Fieten, H., & Kummeling, A. (2023).
Diagnosis and treatment of a congenital portosystemic shunt in a ferret (Mustela putorius furo).
Journal of Small Animal Practice.
https://doi.org/10.1111/jsap.13659 Opmeer, Y., Grinwis, G. C. M., Shelton, G. D., Rosati, M., Alf, V.
, Fieten, H., Leegwater, P. A. J., Matiasek, K.
, & Mandigers, P. J. J. (2023).
An Inflammatory Myopathy in the Dutch Kooiker Dog.
Animals,
13(9), [1508].
https://doi.org/10.3390/ani13091508 Kijan, C.
, Hugen, S., Thomas, R. E., Oberbauer, A. M.
, Leegwater, P. A. J., Fieten, H., German, A. J.
, & Mandigers, P. J. J. (2023).
The Histopathological Characteristic of Gastric Carcinoma in the Belgian Tervueren and Groenendael Dog: A Comparison of Two Classification Methods.
Animals,
13(9), [1532].
https://doi.org/10.3390/ani130915322022
Wetenschappelijke publicaties
Visser, J., Fieten, H., van Velzen, H. W., Zaal, M. D.
, & Kummeling, A. (2022).
Prognostic factors for continence after surgical correction of ectopic ureters of 51 dogs with long-term follow-up.
Acta Veterinaria Scandinavica,
64(1), 1-5. [29].
https://doi.org/10.1186/s13028-022-00648-9 Jong, M. V. D.
, Leegwater, P. A. J., Fieten, H., & Szatmári, V. (2022).
Prevalence of Echocardiographic Evidence of Trace Mitral and Aortic Valve Regurgitation in 50 Clinically Healthy, Young Adult Labrador Retrievers without Heart Murmur.
Animals,
12(18), 1-9. [2442].
https://doi.org/10.3390/ani12182442Gaar-Humphreys, K. R., Spanjersberg, T. C. F., Santarelli, G., Grinwis, G. C. M., Szatmári, V., Roelen, B. A. J., Vink, A., Tintelen, J. P. V., Asselbergs, F. W.
, Fieten, H., Harakalova, M.
, & Steenbeek, F. G. V. (2022).
Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model.
Animals,
12(13), 1-18. [1679].
https://doi.org/10.3390/ani12131679 Gioilli, B. D., Kidane, T. Z.
, Fieten, H., Tellez, M., Dalphin, M., Nguyen, A., Nguyen, K., & Linder, M. C. (2022).
Secretion and Uptake of Copper via a Small Copper Carrier in Blood Fluid.
Metallomics,
14(3), 1-12. [mfac006].
https://doi.org/10.1093/mtomcs/mfac006Vakpublicaties
den Boer, E., Fieten, H., & Vree, L. (2022). Monitoring van 6 criteria voor brachycephale honden in de PETscan database.
den Boer, E., Fieten, H., & Vree, L. (2022). Rapportage diagnoseregistratiesysteem PETscan.
2021
Wetenschappelijke publicaties
Jaffey, J. A., Matheson, J., Shumway, K., Pacholec, C., Ullal, T.
, Van den Bossche, L., Fieten, H., Ringold, R., Lee, K. J., & DeClue, A. E. (2021).
Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele.
PLoS One,
15(12), 1-15. [e0244102].
https://doi.org/10.1371/journal.pone.0244102Jaffey, J. A., Matheson, J., Shumway, K., Pacholec, C., Ullal, T.
, van den Bossche, L., Fieten, H., Ringold, R., Lee, K. J., & DeClue, A. E. (2021).
Correction: Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele.
PLoS One,
16(10), 1-1. [e0258411].
https://doi.org/10.1371/journal.pone.0258411Bogaerts, E.
, den Boer, E., Peelman, L., Van Nieuwerburgh, F.
, Fieten, H., Saunders, J. H., & Broeckx, B. J. G. (2021).
Veterinarians' Competence in Applying Basic Genetic Principles and Daily Implementation of Clinical Genetics: A Study in a University Environment.
Journal of Veterinary Medical Education, [e20210029].
https://doi.org/10.3138/jvme-2020-00292020
Wetenschappelijke publicaties
Wu, X.
, den Boer, E. R., Vos-Loohuis, M., Monroe, G. R., Nijman, I. J.
, van Steenbeek, F. G., Leegwater, P. A. J., & Fieten, H. (2020).
Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers.
Life (Basel, Switzerland),
10(11), [266].
https://doi.org/10.3390/life10110266Li, Y., Qu, C.
, Spee, B., Zhang, R.
, Penning, L. C., de Man, R. A., Peppelenbosch, M. P.
, Fieten, H., & Pan, Q. (2020).
Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection.
Irish Veterinary Journal,
73(1), [6].
https://doi.org/10.1186/s13620-020-00158-y2019
Wetenschappelijke publicaties
Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., ... DeClue, A. E. (2019).
Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele.
Veterinary Journal,
251, [105350].
https://doi.org/10.1016/j.tvjl.2019.105350Keijser, S. F. A., Vernooij, J. C. M., van Garderen, E., van Rooijen, P.
, Fieten, H., van Steenbeek, F. G., Hesselink, J. W., & Nielen, M. (2019).
Quantification of the health-status of the Dutch Labrador retriever population.
Preventive Veterinary Medicine,
171, [104764].
https://doi.org/10.1016/j.prevetmed.2019.104764 Wu, X.
, Mandigers, P. J. J., Watson, A. L., van den Ingh, T. S. G. A. M.
, Leegwater, P. A. J., & Fieten, H. (2019).
Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs.
Journal of Veterinary Internal Medicine,
33(4), 1646-1652.
https://doi.org/10.1111/jvim.15536Sakai, M.
, Spee, B., Grinwis, G. C. M., Penning, L. C., van Wolferen, M. E., van der Laan, L. J. W.
, & Fieten, H. (2019).
Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers.
Journal of Veterinary Internal Medicine,
33(1), 151-157.
https://doi.org/10.1111/jvim.153662018
Wetenschappelijke publicaties
Keijser, S. F. A., Fieten, H., Vos-Loohuis, M., Piek, C. J., Anderson, H., Donner, J., Scholten, I.
, Nielen, M., Hesselink, J. W., & van Steenbeek, F. G. (2018).
DNA panel screening as a potential tool to monitor health and inbreeding in a small, closed dog population.
Canine genetics and epidemiology,
5(12), [12].
https://doi.org/10.1186/s40575-018-0068-6 Keijser, S. F. A., Vernooij, J. C. M., Rothuizen, J., Fieten, H., Nielen, M., Hesselink, J. W., & van Steenbeek, F. G. (2018).
PETscan: measuring incidence of disease phenotypes to prioritize genetic studies in companion animals.
Animal Genetics,
49(5), 492-495.
https://doi.org/10.1111/age.12707 2017
Wetenschappelijke publicaties
Wucher, V., Legeai, F., Hedan, B., Rizk, G., Lagoutte, L., Leeb, T., Jagannathan, V., Cadieu, E., David, A., Lohi, H., Cirera, S., Fredholm, M., Botherel, N.
, Leegwater, P., Le Beguec, C.
, Fieten, H., Johansson, C., Johnsson, J., Alifoldi, J., ... Derrien, T. (2017).
FEELnc: A tool for Long non-coding RNAs annotation and its application to the dog transcriptome.
Nucleic Acids Research,
45(8), [e57].
https://doi.org/10.1101/064436,
https://doi.org/10.1093/nar/gkw1306van Straten, G., de Sain - van der Velden, M. G. M.
, van Geijlswijk, I. M., Favier, R. P., Mesu, S. J., Holwerda-Loof, N. E.
, van der Ham, M., Fieten, H., Rothuizen, J., Spee, B., & Verhoeven - Duif, N. M. (2017).
Saline is as effective as nitrogen scavengers for treatment of hyperammonemia.
Scientific Reports,
7(1), [13112].
https://doi.org/10.1038/s41598-017-12686-9 Dirksen, K., Burgener, I. A., Rothuizen, J., van den Ingh, T. S. G. A. M.
, Penning, L. C., Spee, B., & Fieten, H. (2017).
Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers.
Journal of Veterinary Internal Medicine,
31, 1017–1027.
https://doi.org/10.1111/jvim.14716 Dirksen, K., Spee, B., Penning, L. C., van den Ingh, T. S. G. A. M.
, Burgener, I. A., Watson, A. L., Groot Koerkamp, M.
, Rothuizen, J., van Steenbeek, F. G., & Fieten, H. (2017).
Gene expression patterns in the progression of canine copper-associated chronic hepatitis.
PLoS One,
12(5), e0176826.
https://doi.org/10.1371/journal.pone.0176826 Keijser, S. F. A.
, Meijndert, L. E., Fieten, H., Carrière, B. J.
, van Steenbeek, F. G., Leegwater, P. A. J., Rothuizen, J., & Nielen, M. (2017).
Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats.
Preventive Veterinary Medicine,
140, 38-44.
https://doi.org/10.1016/j.prevetmed.2017.02.0162016
Wetenschappelijke publicaties
Dirksen, K., Roelen, Y. S.
, van Wolferen, M. E., Kruitwagen, H. S., Penning, L. C., Burgener, I. A., Spee, B., & Fieten, H. (2016).
Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers.
Veterinary Journal,
218, 1-6.
https://doi.org/10.1016/j.tvjl.2016.10.007 Dirksen, K., Verzijl, T.
, Grinwis, G. C., Favier, R. P., Penning, L. C., Burgener, I. A., van der Laan, L. J., Fieten, H., & Spee, B. (2016).
Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs.
Journal of Veterinary Internal Medicine,
30(6), 1816-1823.
https://doi.org/10.1111/jvim.14602 Dirksen, K., Verzijl, T., van den Ingh, T. S. G. A. M.
, Vernooij, J. C. M., van der Laan, L. J. W., Burgener, I. A., Spee, B., & Fieten, H. (2016).
Hepatocyte-derived microRNAs as sensitive serum biomarkers of hepatocellular injury in Labrador retrievers.
Veterinary Journal,
211, 75-81.
https://doi.org/10.1016/j.tvjl.2016.01.010 Bartuzi, P., Billadeau, D. D.
, Favier, R., Rong, S., Dekker, D., Fedoseienko, A.
, Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., van der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., ... van de Sluis, B. (2016).
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Nature Communications [E],
7, [10961].
https://doi.org/10.1038/ncomms10961Wu, X.
, Leegwater, P. A. J., & Fieten, H. (2016).
Canine Models for Copper Homeostasis Disorders.
International Journal of Molecular Sciences,
17(2), [196].
https://doi.org/10.3390/ijms17020196Fieten, H., Gill, Y., Martin, A. J., Concilli, M.
, Dirksen, K., van Steenbeek, F. G., Spee, B., van den Ingh, T. S. G. A. M.
, Martens, E. C. C. P., Festa, P., Chesi, G., van de Sluis, B., Houwen, R. H. J. H., Watson, A. L., Aulchenko, Y. S., Hodgkinson, V. L., Zhu, S., Petris, M. J., Polishchuk, R. S.
, ... Rothuizen, J. (2016).
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.
Disease Models & Mechanisms,
9, 25-38.
https://doi.org/10.1242/dmm.020263 2015
Wetenschappelijke publicaties
Fieten, H., Biourge, V. C., Watson, A. L.
, Leegwater, P. A. J., van den Ingh, T. S. G. A. M.
, & Rothuizen, J. (2015).
Dietary management of labrador retrievers with subclinical hepatic copper accumulation.
Journal of Veterinary Internal Medicine,
29(3), 822-7.
https://doi.org/10.1111/jvim.12574 Nantasanti, S.
, Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N.
, Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G.
, Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015).
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
Stem Cell Reports [E],
5(5), 895-907.
https://doi.org/10.1016/j.stemcr.2015.09.002Fieten, H. (2015).
Copper-associated hepatitis in the Labrador retriever: diagnosis, treatment and genetics. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University.
https://dspace.library.uu.nl/handle/1874/312769 Favier, R. P., Spee, B., Fieten, H., van den Ingh, T. S. G. A. M.
, Schotanus, B. A., Brinkhof, B., Rothuizen, J., & Penning, L. C. (2015).
Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.
Journal of Trace Elements in Medicine and Biology,
29, 347-53.
https://doi.org/10.1016/j.jtemb.2014.06.007 2014
Wetenschappelijke publicaties
van der Laan, L. J. W., de Ruiter, P. E.
, van Gils, I. M., Fieten, H., Spee, B., Pan, Q.
, Rothuizen, J., & Penning, L. C. (2014).
Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort.
Journal of Viral Hepatitis,
21(12), 894-896.
https://doi.org/10.1111/jvh.12268Fieten, H., Biourge, V., Watson, AL.
, Leegwater, P., van den Ingh, T. S. G. A. M.
, & Rothuizen, J. (2014).
Nutritional managment of inherited copper-associated hepatitis in the Labrador retriever. Veterinary Journal,
199(3), 429-433.
https://doi.org/10.1016/j.tvjl.2013.12.017 Fieten, H., & Rothuizen, J. (2014). Copper-associated hepatitis. In J. D. Bonagura, & D. C. Twedt (Eds.), Kirk’s Current veterinary therapy XV (pp. e231-e236). Elsevier Saunders.
van Straten, G., van Steenbeek, F. G., Grinwis, G. C. M., Favier, R. P., Kummeling, A., Gils, I. H.
, Fieten, H., Groot Koerkamp, M. J. A., Holstege, F. C. P.
, Rothuizen, J., & Spee, B. (2014).
Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts.
PLoS One,
9(6), [e100077].
https://doi.org/10.1371/journal.pone.0100077 Fieten, H., Penning, L. C., Leegwater, P. A. J., & Rothuizen, J. (2014).
New canine models of copper toxicosis: diagnosis, treatment, and genetics.
Annals of the New York Academy of Sciences,
1314, 42-48.
https://doi.org/10.1111/nyas.12442 Overige resultaten
Schotanus, B. A., Nantasanti, S., Huch, M.
, Oosterhoff, L., Fieten, H., Kruitwagen, H. S., van Wolferen, M., Grinwis, G. C. M., Wubbolts, R., Favier, R. P., Penning, L. C., Vries, R. G. J., Clevers, H., Rothuizen, J., & Spee, B. (2014).
Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS: Journal of Hepatology.
Journal of Hepatology,
60(1, Suppl), S272. [P610].
https://doi.org/10.1016/S0168-8278(14)60772-8 2013
Wetenschappelijke publicaties
Fieten, H., Hugen, S., van den Ingh, T. S. G. A. M.
, Hendriks, W. H., Vernooij, H., Bode, P., Watson, A. L.
, Leegwater, P. A. J., & Rothuizen, J. (2013).
Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs.
Veterinary Journal,
197(2), 468-473.
https://doi.org/10.1016/j.tvjl.2013.03.003 Fieten, H., Dirksen, K., van den Ingh, T. S. G. A. M., Winter, E. A., Watson, A. L.
, Leegwater, P. A. J., & Rothuizen, J. (2013).
D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.
Veterinary Journal,
196, 522-527.
https://doi.org/10.1016/j.tvjl.2012.12.013 Overige resultaten
Roelen, Y. S., Dirksen, K., Fieten, H., & Spee, B. (2013). A Biomarker for Copper associated Hepatitis in Labrador Retrievers. Abstract from Voorjaarsdagen, Amsterdam & Utrecht.
2012
Wetenschappelijke publicaties
Fieten, H., Leegwater, P. A. J., Watson, A. L.
, & Rothuizen, J. (2012).
Canine models of copper toxicosis for understanding mammalian copper metabolism.
Mammalian Genome,
23(1-2), 62-75.
https://doi.org/10.1007/s00335-011-9378-7 Fieten, H., Hooijer-Nouwens, B. D., Biourge, V.
, Leegwater, P. A. J., Watson, A. L., van den Ingh, T. S. G. A. M.
, & Rothuizen, J. (2012).
Association of dietary copper and zinc levels with hepatic copper and zinc concentration in Labrador Retrievers.
Journal of Veterinary Internal Medicine,
2012(26), 1274-1280.
https://doi.org/10.1111/j.1939-1676.2012.01001.x Favier, R. P., Spee, B., Schotanus, B. A., van den Ingh, T. S. G. A. M.
, Fieten, H., Brinkhof, B., Viebahn, C. S., Penning, L. C., & Rothuizen, J. (2012).
COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis.
PLoS One,
7(8), e42158.
https://doi.org/10.1371/journal.pone.0042158 Overige resultaten
Fieten, H., Leegwater, P. A. J., Martin, A., Watson, A. L., & Rothuizen, J. (2012). New canine model for copper toxicosis: a genome wide association study in the Labrador retriever. 56-56. Poster session presented at 8th International Copper meeting Copper in Biology, Alghero, Sardinia, Italy.
Fieten, H., Leegwater, P. A. J., & Rothuizen, J. (2012). Copper associated liver diseases in the dog. 73-73. Abstract from 58th Jahreskongress der Deutschen Gesellschaft fur Kleintiermedizin, Dusseldorf.
Fieten, H., van Steenbeek, F. G., Leegwater, P. A. J., Favier, R. P., & Rothuizen, J. (2012). Portosystemic vascular anomalies in dogs: genetics, diagnosis and therapeutic options. 65-65. Abstract from 58th Jahreskongress der Deutschen Gesellschaft fur Kleintiermedizin, Dusseldorf.
Fieten, H., Nouwens, B., Biourge, V., Leegwater, P. A. J., Watson, A. L., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2012). Hepatic copper concentration and blood parameters in subclinical Labrador retrievers and association with diet. 262. Poster session presented at ECVIM Congres, Maastricht.
2011
Wetenschappelijke publicaties
Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C. T., Karlsson, E. K., Bannasch, D. L., Vilà, C., Lohi, H., Galibert, F., Fredholm, M., Häggström, O., Hedhammar, A., André, C., ... Webster, M. T. (2011).
Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping.
PLoS Genetics,
7(10), [e1002316].
https://doi.org/10.1371/journal.pgen.1002316https://dspace.library.uu.nl/bitstream/handle/1874/234168/vaysse%2520et%2520al%2520Plos%2520Genetics%2520TR2.pdf?sequence=22009
Wetenschappelijke publicaties
Fieten, H., Spee, B., Ijzer, J., Kik, M. J., Penning, L. C., & Kirpensteijn, J. (2009).
Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma.
Veterinary Pathology,
46(5), 869-877.
https://doi.org/10.1354/vp.08-VP-0155-F-FL Selvarajah, G. T., Kirpensteijn, J., van Wolferen, M. E., Rao, N. A.
, Fieten, H., & Mol, J. A. (2009).
Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times.
Molecular Cancer,
8, 72.
https://doi.org/10.1186/1476-4598-8-72
Prof. dr. H. Jakobgebouw
