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Prof. dr. Gerrit van Meer

Emeritus 
Bètawetenschappen
Bètawetenschappen
Hugo R. Kruytgebouw
Padualaan 8
Kamer O1.01
3584 CH Utrecht

Prof. dr. Gerrit van Meer

Emeritus
Bètawetenschappen
g.vanmeer@uu.nl
Profiel CV Publicaties Prijzen Nevenwerkzaamheden Contact
Profiel CV Publicaties Prijzen Nevenwerkzaamheden Contact

Sleutelpublicaties

van Meer, G., Stelzer, E. H., Wijnaendts van Resandt, R. W., & Simons, K. (1987). Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells. Journal of Cell Biology, 105(4), 1623-1635. https://doi.org/10.1083/jcb.105.4.1623
van Meer, G., Gumbiner, B., & Simons, K. (1986). The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next. Nature, 322(6080), 639-641. https://doi.org/10.1038/322639a0
van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008). Membrane lipids: where they are and how they behave. Nature Reviews Molecular Cell Biology, 9(2), 112-125.
https://dspace.library.uu.nl/bitstream/handle/1874/33200/16.%2520van%2520Meer%25202008%2520pp112-24%2C%252008.pdf?sequence=1
van Meer, G., & Simons, K. (1986). The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells. EMBO Journal, 5(7), 1455-1464.
https://dspace.library.uu.nl/bitstream/handle/1874/294293/emboj00170-0051.pdf?sequence=1
van Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P., & van Meer, G. (1996). MDR1 P-glycoprotein is a lipid translocase of broad specifity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell, 87(3), 507-517. https://doi.org/10.1016/S0092-8674(00)81370-7
Simons, K., & van Meer, G. (1988). Lipid sorting in epithelial cells. Biochemistry, 27(17), 6197-6202. https://doi.org/10.1021/bi00417a001
Fahy, E., Subramaniam, S., Murphy, R. C., Nishijima, M., Raetz, C. R. H., Shimizu, T., Spener, F., van Meer, G., Wakelam, M. J. O., & Dennis, E. A. (2009). Update of the LIPID MAPS comprehensive classification system for lipids. Journal of Lipid Research, 2009(April Suppl.), S9-S14. https://doi.org/10.1194/jlr.R800095-JLR200

Publicaties

2014

Wetenschappelijke publicaties

van der Bijl, P., van Meer, G., & Lopes-Cardozo, M. (2014). Sorting of newly synthesized galactosphingolipids to the two surface domains of epithelial cells. Journal of Cell Biology, 132(5), 813-821. https://doi.org/10.1083/jcb.132.5.813

2013

Wetenschappelijke publicaties

Haberkant, P., Raijmakers, R., Wildwater, M., Sachsenheimer, T., Brügger, B., Maeda, K., Houweling, M., Gavin, A-C., Schultz, C., van Meer, G., Heck, A. J. R., & Holthuis, J. C. M. (2013). Bifunktionalisierte Fettsäuren zur Visualisierung und Identifizierung von Protein-Lipid-Interaktionen in lebenden Zellen. Angewandte Chemie, 125(14), 4125-4130. https://doi.org/10.1002/ange.201210178
Haberkant, P., Raijmakers, R., Wildwater, M., Sachsenheimer, T., Brügger, B., Maeda, K., Houweling, M., Gavin, A-C., Schultz, C., van Meer, G., Heck, A. J. R., & Holthuis, J. C. M. (2013). In vivo profiling and visualization of cellular protein–lipid interactions using bifunctional fatty acids. Angewandte Chemie-International Edition, 52, 4033-4038. https://doi.org/10.1002/anie.201210178

2012

Wetenschappelijke publicaties

van Meer, G., Neumann, S., & Haberkant, P. (2012). Sphingolipid Asymmetry and Transmembrane Translocation in Mammalian Cells. In P. Devaux (Ed.), Transmembrane dynamics of lipids (pp. 65-74). (Wiley series in protein and peptide science). Wiley. https://doi.org/10.1002/9781118120118.ch4

2011

Wetenschappelijke publicaties

van Meer, G. (2011). Dynamic transbilayer lipid asymmetry. Cold Spring Harbor perspectives in biology, 3(5), 1-11. [a004671]. https://doi.org/10.1101/cshperspect.a004671
van der Poel, S., Wolthoorn, J., van den Heuvel, D., Egmond, M. R., Groux-Degroote, S., Neumann, S., Gerritsen, H. C., van Meer, G., & Sprong, H. (2011). Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity. Traffic, 12(11), 1634-1647. https://doi.org/10.1111/j.1600-0854.2011.01263.x

2010

Wetenschappelijke publicaties

van Meer, G. (2010). Membranes in motion. EMBO Reports, 11(5), 331-333. https://doi.org/10.1038/embor.2010.60
Kälin, N. V. M., & van Meer, G. (2010). Tight junctions and cell surface lipid polarity. In M. Cereijido, & J. M. Anderson (Eds.), Tight junctions (pp. 305-332). CRC Press. https://doi.org/10.1201/9781420038538.ch14
van Meer, G., & Hoetzl, S. (2010). Sphingolipid topology and the dynamic organization and function of membrane proteins. FEBS Letters, 584(9), 1800-1805. https://doi.org/10.1016/j.febslet.2009.10.020
Holthuis, J. C. M., Pomorski, T., Raggers, R. J., Sprong, H., & van Meer, G. (2010). The organizing potential of sphingolipids in intracellular membrane transport. Physiological Reviews, 81(4), 1689-1723. https://doi.org/10.1152/physrev.2001.81.4.1689
Bader, A. N., Hoetzl, S., Hofman, E. G., Voortman, J., van Bergen en Henegouwen, P. M. P., van Meer, G., & Gerritsen, H. C. (2010). Homo-FRET Imaging as a tool to quantify protein and lipid clustering. ChemPhysChem, 12(3), 475-483. https://doi.org/10.1002/cphc.201000801
van Meer, G., & de Kroon, A. I. P. M. (2010). Lipid map of the mammalian cell. Journal of Cell Science, 124, 5-8. https://doi.org/10.1242/jcs.071233
Maxfield, F. R., & van Meer, G. (2010). Cholesterol, the central lipid of mammalian cells. Current Opinion in Cell Biology, 22(4), 422-429. https://doi.org/10.1016/j.ceb.2010.05.004

2009

Wetenschappelijke publicaties

Haberkant, P., & van Meer, G. (2009). Protein-lipid interactions: paparazzi hunting for snap-shots. Biological Chemistry, 390(8), 795-803. https://doi.org/10.1515/BC.2009.074
Verhage, M., & van Meer, G. (2009). Synaptobrevin, sphingolipids, and secretion: lube 'n' go at the synapse. Neuron, 62, 603-605.
Fahy, E., Subramaniam, S., Murphy, R. C., Nishijima, M., Raetz, C. R. H., Shimizu, T., Spener, F., van Meer, G., Wakelam, M. J. O., & Dennis, E. A. (2009). Update of the LIPID MAPS comprehensive classification system for lipids. Journal of Lipid Research, 2009(April Suppl.), S9-S14. https://doi.org/10.1194/jlr.R800095-JLR200

Overige resultaten

van Meer, G., Wolthoorn, J., Groux-Degroote, S., van den Heuvel, D., Gerritsen, H. C., Halter, D., Neumann, S., van der Poel, S., & Sprong, H. (2009). Unexpected role of glycosphingo-lipids in cell physiology. 371-371. Abstract from Unknown event, Asilomar, USA.

2008

Wetenschappelijke publicaties

van Meer, G., Spener, F., Leeflang, B. R., Beisiegel, U., Bougnoux, P., Goñi, F. M., Griffiths, W., Hartmann, T., Helms, J. B., Hoekstra, D., Julià-Sapé, M., Larijani, B., Moschetta, A., Mouritsen, O. G., Danilo Norata, G., Payrastre, B., Record, M., Schmitz, G., Simons, K., ... Wanders, R. J. A. (2008). Structure Medicine II: The Importance of Lipidomics for Health and Disease. In European Science Foundation Policy Breefing European Science Foundation Policy Briefing. http://www.esf.org/fileadmin/Public_documents/Publications/SPB31_StructuralMedicineII.pdf
van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008). Membrane lipids: where they are and how they behave. Nature Reviews Molecular Cell Biology, 9(2), 112-125.
https://dspace.library.uu.nl/bitstream/handle/1874/33200/16.%2520van%2520Meer%25202008%2520pp112-24%2C%252008.pdf?sequence=1
Neumann, S., & van Meer, G. (2008). Sphingolipid management by an orchestra of lipid transfer proteins. Biological Chemistry, 389(11), 1349-1360.
https://dspace.library.uu.nl/bitstream/handle/1874/33217/10.%2520Neumann%25202008%2520pp%25201349-60.pdf?sequence=1
Marsh, M., & van Meer, G. (2008). No ESCRTs for exosomes. Science, 319(5867), 1191-1192.
https://dspace.library.uu.nl/bitstream/handle/1874/33218/8.%2520Marsh%25202008%2520pp%25201191-1192.pdf?sequence=1

2007

Wetenschappelijke publicaties

van Meer, G., Leeflang, B. R., Liebisch, G., Schmitz, G., & Goñi, F. M. (2007). The European Lipidomics Initiative: enabling technologies. Methods in Enzymology, 213-232. https://doi.org/10.1016/S0076-6879(07)32009-0
Futerman, A. H., & van Meer, G. (2007). An appreciation of Dr Steven Pfeiffer, 1940–2007. Journal of Neurochemistry, 103 Sup 1, 1.
https://dspace.library.uu.nl/bitstream/handle/1874/26969/Futerman%25202007%2520pp%25201.pdf?sequence=1
Hötzl, S., Sprong, H., & van Meer, G. (2007). The way we view cellular (glyco)sphingolipids. Journal of Neurochemistry, 103 Supl 1, 3-13.
https://dspace.library.uu.nl/bitstream/handle/1874/26973/H_246_tzl%25202007%2520pp%25203-13.pdf?sequence=1
van Meer, G., van der Poel, S., Halter, D., & Sprong, H. (2007). Novel function of glycosphingolipids in cellular physiology. In Glycoscience 2003-2007. In commemoration of the 15th anniversary of the Mizutani Foundation for Glycoscience (pp. 118-119). Mizutani Foundation for Glycoscience.

2006

Wetenschappelijke publicaties

van Meer, G., Egmond, M. R., & Halter, D. (2006). Sphingolipids and multidrug resistance of cancer cells. In Y. Hirabayashi, Y. Igarashi, & A. H. Merrill jr. (Eds.), Sphingolipid Biology (pp. 263-270). Springer.
Helms, J. B., & van Meer, G. (2006). Lipidome and disease. FEBS Letters, 580, 5429.
https://dspace.library.uu.nl/bitstream/handle/1874/20260/6.Helms%25202006%2520pp%25205429.pdf?sequence=1
Tivodar, S., Paladino, S., Pillich, R., Prinetti, A., Chigorno, V., van Meer, G., Sonnino, S., & Zurzolo, C. (2006). Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells. FEBS Letters, 580, 5705-5712.
https://dspace.library.uu.nl/bitstream/handle/1874/19994/12.Tivodar%25202006%2520pp5705-12.pdf?sequence=1
van Meer, G., Halter, D., Sprong, H., Somerharju, P., & Egmond, M. R. (2006). ABC lipid transporters: extruders, flippases, or flopless activators? FEBS Letters, 580, 1171-1177.
https://dspace.library.uu.nl/bitstream/handle/1874/19996/15.%2520van%2520Meer%25202006%2520pp1171-77.pdf?sequence=1
van Meer, G. (2006). How do sphingolipids and lipid rafts relate to pathology? European Journal of Lipid Science and Technology, 108(10), 799-801. https://doi.org/10.1002/ejlt.200600184
Odintsova, E., Butters, T. D., Monti, E., Sprong, H., van Meer, G., & Berditschevski, F. (2006). Gangliosides play an important role in the organization of CD82-enriched microdomains. Biochemical Journal, 400, 315-325.
https://dspace.library.uu.nl/bitstream/handle/1874/19993/7.Odintsova%25202006%2520pp315-25.pdf?sequence=1
Flügge, U. I., & van Meer, G. (2006). ABC transporters. FEBS Letters, 580, 997. https://doi.org/10.1016/j.febslet.2006.01.015

2005

Wetenschappelijke publicaties

van Meer, G., & Liskamp, R. M. J. (2005). Brilliant lipids. Nature Methods, 2(1), 14-15. https://doi.org/10.1038/nmeth0105-14
van Meer, G., & Vaz, W. L. C. (2005). Membrane curvature sorts lipids : stabilized lipid rafts in membrane transport. EMBO Reports, 6(5), 418-419. https://doi.org/10.1038/sj.embor.7400410
Fahy, E., Subramaniam, S., Brown, H. A., Glass, C. K., Merrill, A. H., Murphy, R. C., Raetz, C. R. H., Russell, D. W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M. S., White, S. H., Witztum, J., & Dennis, E. A. (2005). A comprehensive classification system for lipids. Journal of Lipid Research, 46, 839-861. https://doi.org/10.1194/jlr.E400004-JLR200
Fahy, E., Subramaniam, S., Brown, H. A., Glass, C. K., Merrill, A. H., Murphy, R. C., Raetz, C. R. H., Russell, D. W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M. S., White, S. H., Witztum, J., & Dennis, E. A. (2005). A comprehensive classification system for lipids. European Journal of Lipid Science and Technology, 107(5), 337-364. https://doi.org/10.1002/ejlt.200405001

Vakpublicaties

van Meer, G. (2005). Cellular lipidomics. EMBO Journal, 24(18), 3159-3165. https://doi.org/10.1038/sj.emboj.7600798

2004

Wetenschappelijke publicaties

van Meer, G. (2004). Invisible rafts at work. Traffic, 5, 211-212. https://doi.org/10.1111/j.1600-0854.2004.00176.x
Degroote, S., Wolthoorn, J., & van Meer, G. (2004). The cell biology of glycosphingolipids. Seminars in cell & developmental biology, 15, 375-387. https://doi.org/10.1016/j.semcdb.2004.03.007
Pomorski, T., Holthuis, J. C. M., Herrmann, A., & van Meer, G. (2004). Tracking down lipid flippases and their biological functions. Journal of Cell Science, 117(6), 805-813.
https://dspace.library.uu.nl/bitstream/handle/1874/14467/10.Pomorski2004%2520pp805-13.pdf?sequence=1
Futerman, A. H., & van Meer, G. (2004). The cell biology of lysosomal storage disorders. Nature Reviews Molecular Cell Biology, 5, 554-565. https://doi.org/10.1038/nrm1423
Riezman, H., & van Meer, G. (2004). Lipid pickup and delivery. Nature Cell Biology, 6(1), 15-16.
https://dspace.library.uu.nl/bitstream/handle/1874/14466/11.Riezman2004%2520pp15-16.pdf?sequence=1
Kalin, N. E., Fernandes, J., Hrafnsdottir, S., & van Meer, G. (2004). Natural phosphatidylcholine is actively translocated across the plasma membrane to the surface of mammalian cells. Journal of Biological Chemistry, 279(32), 33228-33236.
https://dspace.library.uu.nl/bitstream/handle/1874/14469/6.K_228_lin2004%2520pp33228-36.pdf?sequence=1
van Meer, G., & Sprong, H. (2004). Membrane lipids and vesicular traffic. Current Opinion in Cell Biology, 16, 373-378.
https://dspace.library.uu.nl/bitstream/handle/1874/14465/15.vanMeer2004%2520pp373-78.pdf?sequence=1

Vakpublicaties

Futerman, A. H., & van Meer, G. (2004). When cells stash their trash. Nature Cell Biology, 6, 1019-1019.
https://dspace.library.uu.nl/bitstream/handle/1874/14543/3.Futerman2004%2520pp1019.pdf?sequence=1

2003

Wetenschappelijke publicaties

Sprong, H., Degroote, S., Nilsson, T., Kawakita, M., Ishida, N., van der Sluijs, P., & van Meer, G. (2003). Association of the golgi UDP-galactose transporter with UDP-galactose: ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. Molecular Biology of the Cell, 14(8), 3482-3493.
https://dspace.library.uu.nl/bitstream/handle/1874/14342/8.Sprong2003%2520pp3482-93.pdf?sequence=1
Holthuis, J. C. M., van Meer, G., & Huitema, K. R. (2003). Lipid microdomains, lipid translocation and the organization of intracellular membrane transport. Molecular Membrane Biology, 20, 231-241.
https://dspace.library.uu.nl/bitstream/handle/1874/14380/3.Holthuis2003%2520pp231-41.pdf?sequence=1
Borst, P., van Meer, G., & Oude Elferink, R. P. J. (2003). Lipid transport by ABC-transporters. In I. B. Holland (Ed.), ABC proteins : from bacteria to man (pp. 461-478). Academic Press Inc.. http://www.elsevierdirect.com
van Meer, G., Wolthoorn, J., & Degroote, S. (2003). The fate and function of glycosphingolipid glucosylceramide. Philosophical transactions / Royal Society of London. Biological sciences, 358, 869-873. https://doi.org/10.1098/rstb.2003.1266
Harder, T., & van Meer, G. (2003). Lipid-based membrane domains: physics meets immunology. Traffic, 4, 812-820. https://doi.org/10.1034/j.1600-0854.2003.00131.x
Sprong, H., Degroote, S., Nilsson, T., Kawakita, M., Ishida, N., van der Sluijs, P., & van Meer, G. (2003). Erratum: Association of the Golgi UDP-galactose transporter with UDP-galactose: Ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum (Molecular Biology of the Cell (2003) 14 (3482-3493)). Molecular Biology of the Cell, 14(9), i.
Spilsberg, B., van Meer, G., & Sandvig, K. (2003). Role of lipids in the retrograde pathway of ricin intoxication. Traffic, 4, 544-552.
https://dspace.library.uu.nl/bitstream/handle/1874/14488/7.Spilsberg2003%2520pp544-52.pdf?sequence=1

Vakpublicaties

Zurzolo, C., van Meer, G., & Mayor, S. (2003). The order of rafts. EMBO Reports, 4(12), 1117-1121.
https://dspace.library.uu.nl/bitstream/handle/1874/14560/13Zurzolo2003%2520pp1117-21.pdf?sequence=1
Pomorski, T., Lombardi, R., Riezman, H., Devaux, P. F., van Meer, G., & Holthuis, J. C. M. (2003). Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a rol in endocytosis. Molecular Biology of the Cell, 14, 1240-1254.
https://dspace.library.uu.nl/bitstream/handle/1874/14286/6.Pomorski2003%2520pp1240-54.pdf?sequence=1
van Meer, G., Raggers, R. J., Sprong, H., van der Sluijs, P., van Helvoort, A., Kojima, K., Vogels, I., & Borst, P. (2003). Glycosphingolipid translocation by multidrug resistance P-glycoproteins? In Commemorative booklet Mizutani Foundation for Glycoscience

2002

Wetenschappelijke publicaties

van Meer, G. (2002). Glycosphingolipids and protein sorting: rafts and more. Directions in Science, 1, 86-88.
https://dspace.library.uu.nl/bitstream/handle/1874/14266/15.Van%2520Meer2002%2520pp86-88.pdf?sequence=1
van Meer, G., & Lisman, C. Q. (2002). Sphingolipid transport: rafts and translocators. Journal of Biological Chemistry, 277(29), 25855-25858.
https://dspace.library.uu.nl/bitstream/handle/1874/14264/17.Van%2520Meer2002%2520pp25855-58.pdf?sequence=1
Raggers, R. J., Vogels, I., & van Meer, G. (2002). Upregulation of the expression of endogenous Mdr1 P-glycoprotein enhances lipid translocation in MDCK cells transfected with human MRP2. Histochemistry and Cell Biology, 117, 181-185.
https://dspace.library.uu.nl/bitstream/handle/1874/14263/14.Raggers%25202002%2520pp%2520181-5.pdf?sequence=1
van Meer, G. (2002). The different hues of lipid rafts. Science, 296, 855-857. https://doi.org/10.1126/science.1071491

2001

Wetenschappelijke publicaties

Sprong, H., van der Sluijs, P., & van Meer, G. (2001). How proteins move lipids and lipids move proteins. Nature Reviews Molecular Cell Biology, 2, 504-513. https://doi.org/10.1038/35080071
van Meer, G. (2001). Caveolin, cholesterol, and lipid droplets? Journal of Cell Biology, 152(5), F29-F34. http://www.jcb.org
Raggers, R. J., Vogels, I., & van Meer, G. (2001). Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. Biochemical Journal, 357, 859-865. https://doi.org/10.1042/0264-6021:3570859
van Meer, G. (2001). What sugar next? Dimerization of sphingolipid glycosyltransferases. Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1321-1323. http://www.nasonline.org
Sprong, H., Degroote, S., Claessens, T., van Drunen, J., Oorschot, V. M. J., Westerink, B. H., Hirabayashi, Y., Klumperman, J., van der Sluijs, P., & van Meer, G. (2001). Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. Journal of Cell Biology, 155(3), 369-380. https://doi.org/10.1083/jcb.200106104
Killian, J. A., & van Meer, G. (2001). The 'double lives' of membrane lipids. EMBO Reports, 2(2), 91-95. https://doi.org/10.1093/embo-reports/kve029
Pomorski, T., Hrafnsdóttir, S., Devaux, P. F., & van Meer, G. (2001). Lipid distribution and transport across cellular membranes. Seminars in cell & developmental biology, 12(2), 139-148.

2000

Wetenschappelijke publicaties

Sillence, D. J., Raggers, R. J., Neville, D. C. A., Harvey, D. J., & van Meer, G. (2000). Assay for the transbilayer distribution of glycolipids: Selective oxidation of glucosylceramide to glucuronylceramide by TEMPO nitroxyl radicals. Journal of Lipid Research, 41(8), 1252-1260.
https://dspace.library.uu.nl/bitstream/handle/1874/293949/J.%2520Lipid%2520Res.-2000-Sillence-1252-60.pdf?sequence=1
Sillence, D. J., Raggers, R. J., & van Meer, G. (2000). Assays for transmembrane movement of sphingolipids. Methods in Enzymology, 312, 562-579. https://doi.org/10.1016/S0076-6879(00)12939-8
Raggers, R. J., Pomorski, T., Holthuis, J. C. M., Kälin, N., & van Meer, G. (2000). Lipid traffic: the ABC of transbilayer movement. Traffic, 1(3), 226-234. https://doi.org/10.1034/j.1600-0854.2000.010305.x
van Meer, G. (2000). Cellular organelles: How lipids get there, and back. Trends in Cell Biology, 10(12), 550-552. https://doi.org/10.1016/S0962-8924(00)01851-1
van Meer, G., & Holthuis, J. C. M. (2000). Sphingolipid transport in eukaryotic cells. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1486(1), 145-170. https://doi.org/10.1016/S1388-1981(00)00054-8
Smith, A. J., van Helvoort, A., van Meer, G., Szabó, K., Welker, E., Szakács, G., Váradi, A., Sarkadi, B., & Borst, P. (2000). MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drags as judged by interference with nucleotide trapping. Journal of Biological Chemistry, 275(31), 23530-23539. https://doi.org/10.1074/jbc.M909002199

1999

Wetenschappelijke publicaties

Pomorski, T., Herrmann, A., Müller, P., van Meer, G. F. B. P., & Burger, K. N. J. (1999). Protein-mediated inward translocation of phospholipids occurs in both the apical and basolateral plasma membrane domains of epithelial cells. Biochemistry, 38(1), 142-150. https://doi.org/10.1021/bi981244n
Raggers, R. J., van Helvoort, A., Evers, R., & van Meer, G. (1999). The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane. Journal of Cell Science, 112(3), 415-422.
https://dspace.library.uu.nl/bitstream/handle/1874/293821/J%2520Cell%2520Sci-1999-Raggers-415-22.pdf?sequence=1
Sprong, H., van Meer, G., & van der Sluijs, P. (1999). Analysis of galactolipids and UDP-galactose: Ceramide galactosyltransferase. Methods in Enzymology, 311, 59-73. https://doi.org/10.1016/S0076-6879
Matlin, K. S., & van Meer, G. (1999). Nobelprijs Fysiologie of Geneeskunde 1999 voor de ontdekking dat eiwitten intrinsieke signalen hebben voor transport en lokalisatie binnen de cel. Nederlands Tijdschrift voor Geneeskunde, 143(52), 2604-2607.
van Meer, G., Sillence, D. J., Sprong, H., Kälin, N., & Raggers, R. J. (1999). Transport of (glyco)sphingolipids in and between cellular membranes; multidrug transporters and lateral domains. Bioscience Reports, 19(4), 327-333.
https://dspace.library.uu.nl/bitstream/handle/1874/294291/0190327.pdf?sequence=1

1998

Wetenschappelijke publicaties

Futerman, A. H., Ghidoni, R., & van Meer, G. (1998). A kibbutz full of lipids. Lipids: Regulatory Functions in Membrane Traffic and Cell Development, Kfar Blum Kibbutz Guest House, Galilee, Israel, May 10-15, 1998. EMBO Journal, 17(23), 6772-6775. https://doi.org/10.1093/emboj/17.23.6772
van Meer, G. (1998). Lipids of the Golgi membrane. Trends in Cell Biology, 8(1), 29-33. https://doi.org/10.1016/S0962-8924
Sprong, H., Kruithof, B., Leijendekker, R. L., Slot, J. W., van Meer, G., & van der Sluijs, P. (1998). UDP-galactose: ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. Journal of Biological Chemistry, 273(40), 25880-25888.

1997

Wetenschappelijke publicaties

Riezman, H., Woodman, P. G., van Meer, G., & Marsh, M. (1997). Molecular Mechanisms of Endocytosis. Cell, 91(6), 731-738. https://doi.org/10.1016/S0092-8674(00)80461-4
van Helvoort, A., Giudici, M. L., Thielemans, M., & van Meer, G. (1997). Transport of sphingomyelin to the cell surface is inhibited by brefeldin A and in mitosis, where C6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity. Journal of Cell Science, 110(1), 75-83.
https://dspace.library.uu.nl/bitstream/handle/1874/292653/75.full.pdf?sequence=1
van Helvoort, A., Stoorvogel, W., van Meer, G., & Burger, K. N. J. (1997). Sphingomyelin synthase is absent from endosomes. Journal of Cell Science, 110, 781-788.
https://dspace.library.uu.nl/bitstream/handle/1874/292664/781.full.pdf?sequence=1

1996

Wetenschappelijke publicaties

van Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P., & van Meer, G. (1996). MDR1 P-glycoprotein is a lipid translocase of broad specifity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell, 87(3), 507-517. https://doi.org/10.1016/S0092-8674(00)81370-7
Zinkl, G. M., Zuk, A., van der Bijl, P., van Meer, G., & Matlin, K. S. (1996). An antiglycolipid antibody inhibits Madin-Darby canine kidney cell adhesion to laminin and interferes with basolateral polarization and tight junction formation. Journal of Cell Biology, 133(3), 695-708. https://doi.org/10.1083/jcb.133.3.695
Burger, K. N. J., Bijl, P., & van Meer, G. (1996). Topology of sphingolipid galactosyltransferases in ER and Golgi: Transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis. Journal of Cell Biology, 133(1), 15-28. https://doi.org/10.1083/jcb.133.1.15
van Greevenbroek, M. M. J., van Meer, G., Erkelens, D. W., & de Bruin, T. W. A. (1996). Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. Atherosclerosis, 121(1), 139-150. https://doi.org/10.1016/0021-9150(95)05712-9
Sandvig, K., Garred, Ø., van Helvoort, A., van Meer, G., & van Deurs, B. (1996). Importance of glycolipid synthesis for butyric acid-induced sensitization to Shiga toxin and intracellular sorting of toxin in A431 cells. Molecular Biology of the Cell, 7(9), 1391-1404. https://doi.org/10.1091/mbc.7.9.1391
van der Bijl, P., Strous, G. J. A. M., Lopes-Cardozo, M., Thomas-Oates, J. E., & van Meer, G. (1996). Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. Biochemical Journal, 317(2), 589-597.
https://dspace.library.uu.nl/bitstream/handle/1874/293994/3170589.pdf?sequence=1

1995

Wetenschappelijke publicaties

van Helvoort, A., & van Meer, G. (1995). Intracellular lipid heterogeneity caused by topology of synthesis and specificity in transport. Example: Sphingolipids. FEBS Letters, 369(1), 18-21. https://doi.org/10.1016/0014-5793(95)00616-H
Mays, R. W., Siemers, K. A., Fritz, B. A., Lowe, A. W., van Meer, G., & Nelson, W. J. (1995). Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells. Journal of Cell Biology, 130(5), 1105-1115. https://doi.org/10.1083/jcb.130.5.1105
van Genderen, I. L., Godeke, G. J., Rottier, P. J. M., & van Meer, G. (1995). The phospholipid composition of enveloped viruses depends on the intracellular membrane through which they bud. Biochemical Society Transactions, 23(3), 523-526. https://doi.org/10.1042/bst0230523
van Genderen, I. L., & van Meer, G. (1995). Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells. Journal of Cell Biology, 131(3), 645-654. https://doi.org/10.1083/jcb.131.3.645
van Greevenbroek, M. M. J., Voorhout, W. F., Erkelens, D. W., van Meer, G., & de Bruin, T. W. A. (1995). Palmitic acid and linoleic acid metabolism in Caco-2 cells: Different triglyceride synthesis and lipoprotein secretion. Journal of Lipid Research, 36, 13-24. [1].
https://dspace.library.uu.nl/bitstream/handle/1874/293993/J.%2520Lipid%2520Res.-1995-van%2520Greevenbroek-13-24.pdf?sequence=1

1994

Wetenschappelijke publicaties

van Genderen, I. L., Brandimarti, R., Torrisi, M. R., Campadelli, G., & van Meer, G. (1994). The phospholipid composition of extracellular herpes simplex virions differs from that of host cell nuclei. Virology, 200(2), 831-836. https://doi.org/10.1006/viro.1994.1252
Desjardins, M., Celis, J. E., van Meer, G., Dieplinger, H., Jahraus, A., Griffiths, G., & Huber, L. A. (1994). Molecular characterization of phagosomes. Journal of Biological Chemistry, 269(51), 32194-32200.
van 't Hof, W. J., & van Meer, G. (1994). Lipid polarity and sorting in epithelial cells. Current Topics in Membranes, 40(C), 539-563. https://doi.org/10.1016/S0070-2161(08)60995-8
van Meer, G., & van Genderen, I. L. (1994). Intracellular lipid distribution, transport, and sorting. A cell biologist's need for physicochemical information. Subcellular biochemistry. https://doi.org/10.1007/978-1-4615-1863-1_1
Zurzolo, C., van 't Hof, W. J., van Meer, G., & Rodriguez-Boulan, E. (1994). VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells. EMBO Journal, 13(1).
https://dspace.library.uu.nl/bitstream/handle/1874/294302/emboj00049-0050.pdf?sequence=1
Zurzolo, C., van 't Hof, W. J., van Meer, G., & Rodriguez-Boulan, E. (1994). Glycosphingolipid clusters and the sorting of GPI-anchored proteins in epithelial cells. Brazilian Journal of Medical and Biological Research, 27(2), 317-322.
van Helvoort, A., van 't Hof, W. J., Ritsema, T., Sandra, A., & van Meer, G. (1994). Conversion of diacylglycerol to phosphatidylcholine on the basolateral surface of epithelial (Madin-Darby canine kidney) cells. Evidence for the reverse action of a sphingomyelin synthase. Journal of Biological Chemistry, 269(3), 1763-1769.
Schweizer, A., Clausen, H., van Meer, G., & Hauri, H. P. (1994). Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment. Journal of Biological Chemistry, 269(6), 4035-4041.
https://dspace.library.uu.nl/bitstream/handle/1874/293948/J.%2520Biol.%2520Chem.-1994-Schweizer-4035-41.pdf?sequence=1

1993

Wetenschappelijke publicaties

van Genderen, I. L., & van Meer, G. (1993). Lipid sorting - Measurement and interpretation. Biochemical Society Transactions, 21(2), 235-239.
Sodeik, B., Doms, R. W., Ericsson, M., Hiller, G., Machamer, C. E., van 't Hof, W. J., van Meer, G., Moss, B., & Griffiths, G. (1993). Assembly of vaccinia virus: Role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacks. Journal of Cell Biology, 121(3), 521-542. https://doi.org/10.1083/jcb.121.3.521
van Meer, G., & van 't Hof, W. J. (1993). Epithelial sphingolipid sorting is insensitive to reorganization of the Golgi by nocodazole, but is abolished by monensin in MDCK cells and by brefeldin A in Caco-2 cells. Journal of Cell Science, 104(3), 833-842.
https://dspace.library.uu.nl/bitstream/handle/1874/294298/J%2520Cell%2520Sci-1993-van%2520Meer-833-42.pdf?sequence=1
van Meer, G. (1993). Transport and sorting of membrane lipids. Current Opinion in Cell Biology, 5(4), 661-673. https://doi.org/10.1016/0955-0674(93)90137-F
Strous, G. J. A. M., van Kerkhof, P. J. M., van Meer, G., Rijnboutt, S., & Stoorvogel, W. (1993). Differential effects of brefeldin A on transport of secretory and lysosomal proteins. Journal of Biological Chemistry, 268(4), 2341-2347.
https://dspace.library.uu.nl/bitstream/handle/1874/293955/J.%2520Biol.%2520Chem.-1993-Strous-2341-7.pdf?sequence=1

1992

Wetenschappelijke publicaties

Jeckel, D., Karrenbauer, A., Burger, K. N. J., van Meer, G., & Wieland, F. (1992). Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. Journal of Cell Biology, 117(2), 259-267. https://doi.org/10.1083/jcb.117.2.259
van 't Hof, W. J., Silvius, J. R., Wieland, F. T., & van Meer, G. (1992). Epithelial sphingolipid sorting allows for extensive variation of the fatty acyl chain and the sphingosine backbone. Biochemical Journal, 283(3), 913-917.
https://dspace.library.uu.nl/bitstream/handle/1874/294299/2830913.pdf?sequence=1
van Meer, G., & Burger, K. N. J. (1992). Sphingolipid trafficking - Sorted out? Trends in Cell Biology, 2(11), 332-337. https://doi.org/10.1016/0962-8924(92)90182-M

1991

Wetenschappelijke publicaties

Voorhout, W. F., van Genderen, I. L., van Meer, G., & Geuze, H. J. (1991). Preservation and immunogold localization of lipids by freeze-substitution and low temperature embedding. Scanning Microscopy, 5(4), S17-S25.
van Genderen, I. L., van Meer, G., Slot, J. W., Geuze, H. J., & Voorhout, W. F. (1991). Subcellular localization of forssman glycolipid in epithelial MDCK cells by immuno-electronmicroscopy after freeze-substitution. Journal of Cell Biology, 115(4), 1009-1019. https://doi.org/10.1083/jcb.115.4.1009

1990

Wetenschappelijke publicaties

van 't Hof, W. J., & van Meer, G. (1990). Generation of lipid polarity in intestinal epithelial (Caco-2) cells: Sphingolipid synthesis in the Golgi complex and sorting before vesicular traffic to the plasma membrane. Journal of Cell Biology, 111(3), 977-986. https://doi.org/10.1083/jcb.111.3.977

1989

Wetenschappelijke publicaties

van Meer, G. (1989). Lipid traffic in animal cells. Annual Review of Cell Biology, 5, 247-275. https://doi.org/10.1146/annurev.cb.05.110189.001335
Ho, W. C., Allan, V. J., van Meer, G., Berger, E. G., & Kreis, T. E. (1989). Reclustering of scattered Golgi elements occurs along microtubules. European Journal of Cell Biology, 48(2), 250-263.

1988

Wetenschappelijke publicaties

van Meer, G. (1988). Atherosclerosis, endothelium and plasma membrane lipid polarity. Agents and actions. Supplements, 26, 15-25.
van Meer, G., & Simons, K. (1988). Lipid polarity and sorting in epithelial cells. Journal of Cellular Biochemistry, 36(1), 51-58. https://doi.org/10.1002/jcb.240360106
Knoll, G., Burger, K. N. J., Bron, R., van Meer, G., & Verkleij, A. J. (1988). Fusion of liposomes with the plasma membrane of epithelial cells: Fate of incorporated lipids as followed by freeze fracture and autoradiography of plastic sections. Journal of Cell Biology, 107(6 II), 2511-2521.
https://dspace.library.uu.nl/bitstream/handle/1874/293029/2511.full.pdf?sequence=1
van Meer, G. (1988). How epithelia grease their microvilli. Trends in Biochemical Sciences, 13(7), 242-243.
https://dspace.library.uu.nl/bitstream/handle/1874/294285/1-s2.0-0968000488901569-main.pdf?sequence=1
Simons, K., & van Meer, G. (1988). Lipid sorting in epithelial cells. Biochemistry, 27(17), 6197-6202. https://doi.org/10.1021/bi00417a001

1987

Wetenschappelijke publicaties

van Meer, G., Stelzer, E. H., Wijnaendts van Resandt, R. W., & Simons, K. (1987). Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells. Journal of Cell Biology, 105(4), 1623-1635. https://doi.org/10.1083/jcb.105.4.1623
van Meer, G. (1987). Plasma membrane cholesterol pools. Trends in Biochemical Sciences, 12(C), 375-376.
https://dspace.library.uu.nl/bitstream/handle/1874/294286/1-s2.0-0968000487901733-main.pdf?sequence=1

1986

Wetenschappelijke publicaties

Metsikkö, K., van Meer, G., & Simons, K. (1986). Reconstitution of the fusogenic activity of vesicular stomatitis virus. EMBO Journal, 5(13), 3429-3435.
van Meer, G., Gumbiner, B., & Simons, K. (1986). The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next. Nature, 322(6080), 639-641. https://doi.org/10.1038/322639a0
Hansson, G. C., Simons, K., & van Meer, G. (1986). Two strains of the Madin-Darby canine kidney (MDCK) cell line have distinct glycosphingolipid compositions. EMBO Journal, 5(3), 483-589.
van Meer, G., & Simons, K. (1986). The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells. EMBO Journal, 5(7), 1455-1464.
https://dspace.library.uu.nl/bitstream/handle/1874/294293/emboj00170-0051.pdf?sequence=1
van Meer, G. (1986). Reply from Van Meer. Trends in Biochemical Sciences, 11(10), 401. https://doi.org/10.1016/0968-0004

1983

Wetenschappelijke publicaties

van Meer, G., & Simons, K. (1983). An efficient method for introducing defined lipids into the plasma membrane of mammalian cells. Journal of Cell Biology, 97(5 I), 1365-1374.
https://dspace.library.uu.nl/bitstream/handle/1874/294294/J%2520Cell%2520Biol-1983-van%2520Meer-1365-74.pdf?sequence=1

1982

Wetenschappelijke publicaties

van Meer, G., & Simons, K. (1982). Viruses budding from either the apical or the basolateral plasma membrane domain of MDCK cells have unique phospholipid compositions. EMBO Journal, 1(7), 847-852.
https://dspace.library.uu.nl/bitstream/handle/1874/294296/emboj00299-0073.pdf?sequence=1
van Meer, G., & op den Kamp, J. A. F. (1982). Transbilayer movement of various phosphatidylcholine species in intact human erythrocytes. Journal of Cellular Biochemistry, 19(2), 193-204. https://doi.org/10.1002/jcb.240190209

1981

Wetenschappelijke publicaties

van Meer, G. (1981). Trans-bilayer distribution and mobility of phospholipid in mammalian plasmamembranes. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
van Meer, G., Gahmberg, C. G., op den Kamp, J. A. F., & van Deenen, L. L. M. (1981). Phospholipid distribution in human En(a-) red cell membranes which lack the major sialoglycoprotein, glycophorin A. FEBS Letters, 135(1), 53-55. https://doi.org/10.1016/0014-5793
van Meer, G., Simons, K., op den Kamp, J. A. F., & van Deenen, L. L. M. (1981). Phospholipid asymmetry in Semliki Forest virus grown on baby hamster kidney (BHK-21) cells. Biochemistry, 20(7). https://doi.org/10.1021/bi00510a037

Overige resultaten

Roelofsen, B., van Meer, G., & op den Kamp, J. A. F. (1981). The lipids of red cell membranes. Compositional, structural and functional aspects.

1980

Wetenschappelijke publicaties

van Meer, G. (1980). Protein-stimulated exchange of phosphatidylcholine between intact erythrocytes and various membrane systems. Biochimica et Biophysica Acta-Biomembranes, 598(1), 173-177. https://doi.org/10.1016/0005-2736(80)90275-8
Lange, L. G., van Meer, G., op den Kamp, J. A. F., & van Deenen, L. L. M. (1980). Hemolysis of rat erythrocytes by replacement of the natural phosphatidylcholine by various phosphatidylcholines. European Journal of Biochemistry, 110(1), 115-121. https://doi.org/10.1111/j.1432-1033.1980.tb04846.x
van Meer, G., de Kruijff, B., op den Kamp, J. A. F., & van Deenen, L. L. M. (1980). Preservation of bilayer structure in human erythrocytes and erythrocyte ghosts after phospholipase treatment. A 31P-NMR study. Biochimica et Biophysica Acta-Biomembranes, 596(1), 1-9.
van Meer, G., Poorthuis, B. J. H. M., Wirtz, K. W. A., op den Kamp, J. A. F., & van Deenen, L. L. M. (1980). Transbilayer distribution and mobility of phosphatidylcholine in intact erythrocyte membranes. A study with phosphatidylcholine exchange protein. European Journal of Biochemistry, 103(2), 283-288. https://doi.org/10.1111/j.1432-1033.1980.tb04313.x

1979

Wetenschappelijke publicaties

Bishop, D. G., Bevers, E. M., van Meer, G., op den Kamp, J. A. F., & van Deenen, L. L. M. (1979). A monolayer study of the reaction of trinitrobenzene sulphonic acid with amino phospholipids. Biochimica et Biophysica Acta-Biomembranes, 551(1), 122-128. https://doi.org/10.1016/0005-2736(79)90358-4

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