Key Publications:
1. Van den Eshof, Bart L, Medfai, Lobna, Nolfi, Emanuele, Wawrzyniuk, Magdalena & Sijts, Alice J A M (2021). The function of immunoproteasomes - an immunologists'perspective. Cells 10 (12): 10.3390/cells10123360
2. Platteel, Anouk C M, Liepe, Juliane, van Eden, Willem, Mishto Michele & Sijts, Alice J A M (2017). An unexpected major role for proteasome-catalyzed peptide splicing in generation of T cell epitopes: is there relevance for vaccine design? Front. Immunol. 8:1441
3. Platteel, Anouk C M, Liepe, Juliane, Textoris-Taube, Kathrin, Keller, Christin, Henklein, Petra, Schalkwijk, Hanna H, Cardoso, Rebeca, Kloetzel, Peter M, Mishto, Michele & Sijts, Alice J A M (2017). Multi-level strategy for identifying proteasome-catalyzed spliced epitopes targeted by CD8(+) T cells during bacterial infection. Cell Reports 20 (5): 1242-1253
4. Minutti, C M, Drube, S, Blair, N, Schwartz, C, McCrae, J C, McKenzie, A N, Kamradt, T, Mokry, M, Coffer, P J, Sibilia, M, Sijts, A J, Fallon, P G, Maizels, R M & Zaiss, D M. (2017) Epidermal Growth Factor Receptor expression licenses Type-2 helper T cells to function in a T cell receptor-independent fashion. Immunity 47 (4): 710-722
5. Platteel, Anouk C M, Mishto, Michele, Textoris-Taube, Kathrin, Keller, Christin, Liepe, Juliane, Busch, Dirk H, Kloetzel, Peter M & Sijts, Alice J A M (2016). CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products. Eur. J. Immunol. 46 (5):1109-1118.
6. Zaiss,D.M., van Loosdregt J., Gorlani A., Bekker CJ., Gröne A., Sibilia M., van Bergen en Henegouwen PM., Roovers RC, Coffer PJ, Sijts, A.J. (2013) Unexpected role of the EGF-R in regulatory T-cell mediated immune regulation.Immunity38:275-84
7. Amidi, M., van Helden, M.J., Tabataei, N.R., de Goede, A.L., Schouten, M., de Bot, V., Lanzi, A., Gruters, R.A., Rimmelzwaan, G.F., Sijts, A.J., Mastrobattista E. (2012) Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes. J. Control Release 164:323-30.
8. Sijts, E. J., and Kloetzel P-M. (2011) The role of the proteasome in the generation of MHC class I ligands and immune responses. Cell Mol Life Sci.68:1491.
9. Zaiss, D. M., Bekker, C. P., Gröne, A., Lie, B. A., and Sijts, A. J. (2011) Proteasome Immunosubunits Protect against the Development of CD8 T Cell-Mediated Autoimmune Diseases. J Immunol. 187: 2302.
10. de Graaf, N., van Helden, M .J., Textoris-Taube, K., Chiba, T., Topham, D. J., Kloetzel, P-M., Zaiss, D. M., and Sijts, A. J. (2011) PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. Eur J Immunol. 41:926.
11. Deol, P., Zaiss, D. M., Monaco, J. J., and Sijts, A. J. (2007). Rates of processing determine the immunogenicity of immunoproteasome-generated epitopes. J. Immunol. 178:7557.
12. Seifert U., Liermann, H., Racanelli, V., Halenius, A., Wiese, M., Wedemeyer, H., Ruppert, T., Rispeter, K., Henklein, P., Sijts, A., Hengel, H., Kloetzel, P-M., and Rehermann, B. (2004). Hepatitis C Virus Mutation Affects Proteasomal Epitope Processing in vitro and in vivo. J. Clin. Invest. 114:250.
13. Zaiss, D. M. W., Standera, S., Kloetzel P-M., and Sijts, A. J. A. M. (2002). PI31 is a modulator of proteasome formation and antigen processing. Proc. Natl. Acad. Sci. USA99:14344
14. Sijts, A., Ruppert, T., Rehermann, B., Schmidt, M., Koszinowski, U., and Kloetzel, P.-M. (2000). Efficient generation of a Hepatitis B virus CTL epitope requires the structural features of immunoproteasomes. J. Exp. Med. 191:503
15. Sijts, A. J. A. M., and Pamer, E. G. (1997). Enhanced intracellular dissociation of Major Histocompatibility Complex class I-associated peptides: A mechanism for optimizing the spectrum of cell surface presented cytotoxic T lymphocyte epitopes. J. Exp. Med. 185:1403.
Publicaties
2025
Wetenschappelijke publicaties
Cormican, J. A., Medfai, L., Wawrzyniuk, M., Pasen, M., Afrache, H., Fourny, C., Khan, S., Gneiße, P., Soh, W. T., Timelli, A., Nolfi, E., Pannekoek, Y., Cope, A., Urlaub, H., Sijts, A. J. A. M., Mishto, M., & Liepe, J. (2025). PEPSeek-mediated identification of novel epitopes from viral and bacterial pathogens and the impact on host cell immunopeptidomes. Molecular and Cellular Proteomics, 100937. Advance online publication. https://doi.org/10.1016/j.mcpro.2025.100937
2024
Wetenschappelijke publicaties
Huynh, D. T., Nolfi, E., Guleed, S., Medfai, L., Wolf, N., Uijen, R. F., de Jonge, M. I., van Ulsen, P., Dietrich, J., Luirink, J., Sijts, A. J. A. M., & Jong, W. S. P. (2024). Intradermal administration of novel particulate Chlamydia trachomatis vaccine candidates drives protective immune responses. Biomedicine and Pharmacotherapy, 180, Article 117563. https://doi.org/10.1016/j.biopha.2024.117563
https://research-portal.uu.nl/ws/files/242960137/1-s2.0-S0753332224014495-main.pdf
https://research-portal.uu.nl/ws/files/242960137/1-s2.0-S0753332224014495-main.pdf
Huynh, D. T., Nolfi, E., Medfai, L., van Ulsen, P., Jong, W. S. P., Sijts, A. J. A. M., & Luirink, J. (2024). Intranasal delivery of Salmonella OMVs decorated with Chlamydia trachomatis antigens induces specific local and systemic immune responses. Human Vaccines and Immunotherapeutics, 20(1), Article 2330768. https://doi.org/10.1080/21645515.2024.2330768
https://dspace.library.uu.nl/bitstream/handle/1874/437921/Intranasal_delivery_of_Salmonella_OMVs_decorated_with_Chlamydia_trachomatis_antigens_induces_specific_local_and_systemic_immune_responses.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/437921/Intranasal_delivery_of_Salmonella_OMVs_decorated_with_Chlamydia_trachomatis_antigens_induces_specific_local_and_systemic_immune_responses.pdf?sequence=1
2023
Wetenschappelijke publicaties
Lyu, Q., Veldhuizen, E. J. A., Ludwig, I. S., Rutten, V. P. M. G., van Eden, W., Sijts, A. J. A. M., & Broere, F. (2023). Characterization of polarization states of canine monocyte derived macrophages. PLoS One, 18(11), Article e0292757. https://doi.org/10.1371/journal.pone.0292757
https://dspace.library.uu.nl/bitstream/handle/1874/434496/journal.pone.0292757.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/434496/journal.pone.0292757.pdf?sequence=1
Vukovic, N., Segués, A., Huang, S., Waterfall, M., Sijts, A. J. A. M., & Zaiss, D. M. (2023). Mouse IgG2a Isotype Therapeutic Antibodies Elicit Superior Tumor Growth Control Compared with mIgG1 or mIgE. Cancer Research Communications, 3(1), 109-118. https://doi.org/10.1158/2767-9764.CRC-22-0356
https://dspace.library.uu.nl/bitstream/handle/1874/427694/crc_22_0356_1_.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/427694/crc_22_0356_1_.pdf?sequence=1
2022
Wetenschappelijke publicaties
Segues Cistero, A., Huang, S., Sijts, A., Berraondo, P., & Zaiss, D. (2022). Opportunities and challenges of bi-specific antibodies. International Review of Cell and Molecular Biology, 369, 45-70. https://doi.org/10.1016/bs.ircmb.2022.05.001
Huang, S., Segués, A., Waterfall, M., Wright, D., Vayssiere, C., van Duijnhoven, S. M. J., van Elsas, A., Sijts, A. J. A. M., & Zaiss, D. M. (2022). Shortened Hinge Design of Fab x sdAb-Fc Bispecific Antibodies Enhances Redirected T-Cell Killing of Tumor Cells. Biomolecules, 12(10), 1-15. Article 1331. https://doi.org/10.3390/biom12101331
https://dspace.library.uu.nl/bitstream/handle/1874/423729/biomolecules_12_01331.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/423729/biomolecules_12_01331.pdf?sequence=1
2021
Wetenschappelijke publicaties
van den Eshof, B., Medfai, L., Nolfi, E., Wawrzyniuk, M., & Sijts, A. (2021). The Function of Immunoproteasomes—An Immunologists’ Perspective. Cells, 10(12), 1-16. Article 3360. https://doi.org/10.3390/cells10123360
https://dspace.library.uu.nl/bitstream/handle/1874/413965/cells_10_03360_v2.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/413965/cells_10_03360_v2.pdf?sequence=1
Segués, A., van Duijnhoven, S. M. J., Parade, M., Driessen, L., Vukovic, N., Zaiss, D., Sijts, A. J. A. M., Berraondo, P., & van Elsas, A. (2021). Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies. Journal of Immunological Methods, 499, 1-9. Article 113173. https://doi.org/10.1016/j.jim.2021.113173
https://dspace.library.uu.nl/bitstream/handle/1874/413576/1_s2.0_S0022175921002180_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/413576/1_s2.0_S0022175921002180_main.pdf?sequence=1
Zonneveld, M. I., van Herwijnen, M. J. C., Fernandez-Gutierrez, M. M., Giovanazzi, A., de Groot, A. M., Kleinjan, M., van Capel, T. M. M., Sijts, A. J. A. M., Taams, L. S., Garssen, J., de Jong, E. C., Kleerebezem, M., Nolte-'t Hoen, E. N. M., Redegeld, F. A., & Wauben, M. H. M. (2021). Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses. Journal of Extracellular Vesicles, 10(5), 1-17. Article e12071. https://doi.org/10.1002/jev2.12071
https://dspace.library.uu.nl/bitstream/handle/1874/411733/jev2.12071.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/411733/jev2.12071.pdf?sequence=1
2020
Wetenschappelijke publicaties
Zonneveld, M. I., van Herwijnen, M. J. C., Fernandez-Gutierrez, M., Giovanazzi, A., de Groot, A. M., Kleinjan, M., van Capel, T. M., Sijts, E. J. A. M., Taams, L. S., Garssen, J., de Jong, E., Kleerebezem, M., t Hoen, E. N. M., Redegeld, F. A. M., & Wauben, M. H. M. (2020). Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses. (bioRxiv). https://doi.org/10.1101/2020.04.29.068841
https://dspace.library.uu.nl/bitstream/handle/1874/411404/2020.04.29.068841.full.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/411404/2020.04.29.068841.full.pdf?sequence=1
Huang, S., van Duijnhoven, S. M. J., Sijts, A. J. A. M., & van Elsas, A. (2020). Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy. Journal of Cancer Research and Clinical Oncology, 146(12), 3111-3122. https://doi.org/10.1007/s00432-020-03404-6
https://dspace.library.uu.nl/bitstream/handle/1874/412307/Huang2020_Article_BispecificAntibodiesTargetingD.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/412307/Huang2020_Article_BispecificAntibodiesTargetingD.pdf?sequence=1
Lyu, Q., Wawrzyniuk, M., Rutten, V. P. M. G., van Eden, W., Sijts, A. J. A. M., & Broere, F. (2020). Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line. International Journal of Molecular Sciences, 21(18), Article 6464. https://doi.org/10.3390/ijms21186464
https://dspace.library.uu.nl/bitstream/handle/1874/409107/ijms_21_06464.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/409107/ijms_21_06464.pdf?sequence=1
Huang, S., Segués, A., Hulsik, D. L., Zaiss, D. M., Sijts, A. J. A. M., van Duijnhoven, S. M. J., & van Elsas, A. (2020). A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing. Journal of Immunological Methods, 483, Article 112811. https://doi.org/10.1016/j.jim.2020.112811
https://dspace.library.uu.nl/bitstream/handle/1874/408411/1_s2.0_S0022175920300958_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/408411/1_s2.0_S0022175920300958_main.pdf?sequence=1
Lyu, Q., Ludwig, I. S., Kooten, P. J. S., Sijts, A. J. A. M., Rutten, V. P. M. G., van Eden, W., & Broere, F. (2020). Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells. Cell Stress & Chaperones, 25, 235-243. https://doi.org/10.1007/s12192-019-01066-z
https://dspace.library.uu.nl/bitstream/handle/1874/394537/Lyu2020_Article_LeucinostatinActsAsACo_inducer.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/394537/Lyu2020_Article_LeucinostatinActsAsACo_inducer.pdf?sequence=1
2018
Wetenschappelijke publicaties
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, H., Nielsen, H. M., Broere, F., Gay, N. J., Foged, C., & Sijts, A. J. A. M. (2018). Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design. Molecular Therapy - Nucleic Acids, 11, 159-169. https://doi.org/10.1016/j.omtn.2018.02.003
https://dspace.library.uu.nl/bitstream/handle/1874/373037/Immunogenicity.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/373037/Immunogenicity.pdf?sequence=1
de Groot, A. M., Du, G., Mönkäre, J., Platteel, A. C. M., Broere, F., Bouwstra, J. A., & Sijts, A. J. A. M. (2018). Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium. Journal of Controlled Release, 266, 27-35. https://doi.org/10.1016/j.jconrel.2017.09.017
https://dspace.library.uu.nl/bitstream/handle/1874/361614/groot.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/361614/groot.pdf?sequence=1
2017
Wetenschappelijke publicaties
de Groot, A. M., Platteel, A. C. M., Kuijt, N., van Kooten, P. J. S., Vos, P. J., Sijts, A. J. A. M., & van der Maaden, K. (2017). Nanoporous Microneedle Arrays Effectively Induce Antibody Responses against Diphtheria and Tetanus Toxoid. Frontiers in Immunology, 8, Article 1789. https://doi.org/10.3389/fimmu.2017.01789
https://dspace.library.uu.nl/bitstream/handle/1874/361711/Nanoporous_Microneedle_Arrays.PDF?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/361711/Nanoporous_Microneedle_Arrays.PDF?sequence=1
Platteel, A. C. M., Nieuwenhuizen, N. E., Domaszewska, T., Schürer, S., Zedler, U., Brinkmann, V., Sijts, A., & Kaufmann, S. H. E. (2017). Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model. Frontiers in Immunology, 8, 1-15. Article 1744. https://doi.org/10.3389/fimmu.2017.01744
https://dspace.library.uu.nl/bitstream/handle/1874/360515/h56cdna.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/360515/h56cdna.pdf?sequence=1
Betancourt, A. B., Lyu, Q., Broere, F., Sijts, A., Rutten, V. P. M. G., & Eden, W. V. (2017). T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins. Frontiers in Immunology, 8(October), 1-10. https://doi.org/10.3389/fimmu.2017.01408
https://dspace.library.uu.nl/bitstream/handle/1874/361627/fimmu_08_01408.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/361627/fimmu_08_01408.pdf?sequence=1
Platteel, A. C. M., Liepe, J., van Eden, W., Mishto, M., & Sijts, A. J. A. M. (2017). An unexpected major role for proteasome-catalyzed peptide splicing in generation of T cell epitopes: Is there relevance for vaccine development? Frontiers in Immunology, 8, Article 1441. https://doi.org/10.3389/fimmu.2017.01441
https://dspace.library.uu.nl/bitstream/handle/1874/361625/fimmu_08_01441.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/361625/fimmu_08_01441.pdf?sequence=1
Platteel, A. C. M., Henri, S., Zaiss, D. M., & Sijts, A. J. A. M. (2017). Dissecting antigen processing and presentation routes in dermal vaccination strategies. Vaccine, 35(50), 7057-7063. https://doi.org/10.1016/j.vaccine.2017.10.044
https://dspace.library.uu.nl/bitstream/handle/1874/360434/platteel.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/360434/platteel.pdf?sequence=1
Minutti, C. M., Drube, S., Blair, N., Schwartz, C., McCrae, J. C., McKenzie, A. N., Kamradt, T., Mokry, M., Coffer, P. J., Sibilia, M., Sijts, A. J., Fallon, P. G., Maizels, R. M., & Zaiss, D. M. (2017). Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity, 47(4), 710-722.e6. https://doi.org/10.1016/j.immuni.2017.09.013
https://dspace.library.uu.nl/bitstream/handle/1874/361618/PIIS1074761317304247.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/361618/PIIS1074761317304247.pdf?sequence=1
Platteel, A. C. M., Liepe, J., Textoris-Taube, K., Keller, C., Henklein, P., Schalkwijk, H. H., Cardoso, R., Kloetzel, P. M., Mishto, M., & Sijts, A. J. A. M. (2017). Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8(+) T Cells during Bacterial Infection. Cell Reports, 20(5), 1242-1253. https://doi.org/10.1016/j.celrep.2017.07.026
https://dspace.library.uu.nl/bitstream/handle/1874/361615/PIIS2211124717309920.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/361615/PIIS2211124717309920.pdf?sequence=1
2016
Wetenschappelijke publicaties
Zonneveld, M. I., Van Herwijnen, M. J. C., Kleinjan, M., De Groot, M., Fernandez-Gutierrez, M., Sijts, A., Kleerebezem, M., Taams, L. S., Garssen, J., T'-Hoen, E. N. M., Redegeld, F. A., & Wauben, M. H. M. (2016). Breast milk-derived extracellular vesicles influence the development of the epithelial and immunological gastrointestinal barrier. Journal of Extracellular Vesicles, 5, 139. https://doi.org/10.3402/jev.v5.31552
Platteel, A. C. M., Marit de Groot, A., Andersen, P., Ovaa, H., Kloetzel, P. M., Mishto, M., & Sijts, A. J. A. M. (2016). Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing. Vaccine, 34(42), 1532-1540. https://doi.org/10.1016/j.vaccine.2016.08.039
https://dspace.library.uu.nl/bitstream/handle/1874/345976/strategies.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/345976/strategies.pdf?sequence=1
Platteel, A. C. M., Mishto, M., Textoris-Taube, K., Keller, C., Liepe, J., Busch, D. H., Kloetzel, P. M., & Sijts, A. J. A. M. (2016). CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products. European Journal of Immunology, 46(5), 1109–1118. https://doi.org/10.1002/eji.201545989
https://dspace.library.uu.nl/bitstream/handle/1874/345916/Platteel.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/345916/Platteel.pdf?sequence=1
2015
Wetenschappelijke publicaties
Zeng, X., de Groot, A. M., Sijts, A. J. A. M., Broere, F., Oude Blenke, E., Colombo, S., van Eden, W., Franzyk, H., Nielsen, H. M., & Foged, C. (2015). Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro. Nanoscale, 7(46), 19687-19698. https://doi.org/10.1039/c5nr04807a
https://research-portal.uu.nl/ws/files/259860238/c5nr04807a.pdf
https://research-portal.uu.nl/ws/files/259860238/c5nr04807a.pdf
Kristensen, M., de Groot, A. M., Berthelsen, J., Franzyk, H., Sijts, A., & Nielsen, H. M. (2015). Conjugation of Cell-Penetrating Peptides to Parathyroid Hormone Affects Its Structure, Potency, and Transepithelial Permeation. Bioconjugate Chemistry, 26(3), 477–488. https://doi.org/10.1021/bc5005763
https://research-portal.uu.nl/ws/files/258921997/berthelsen-et-al-2015-conjugation-of-cell-penetrating-peptides-to-parathyroid-hormone-affects-its-structure-potency-and.pdf
https://research-portal.uu.nl/ws/files/258921997/berthelsen-et-al-2015-conjugation-of-cell-penetrating-peptides-to-parathyroid-hormone-affects-its-structure-potency-and.pdf
Meulenbroeks, C., van Weelden, H., Schwartz, C., Voehringer, D., Redegeld, F. A. M., Rutten, V. P. M. G., Willemse, T., Sijts, A. J. A. M., & Zaiss, D. M. W. (2015). Basophil-Derived Amphiregulin Is Essential for UVB Irradiation-Induced Immune Suppression. Journal of Investigative Dermatology, 135(1), 222-228. https://doi.org/10.1038/jid.2014.329
https://dspace.library.uu.nl/bitstream/handle/1874/325163/75_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/325163/75_main.pdf?sequence=1
2014
Wetenschappelijke publicaties
Rashid, O., Meulenbroeks, C., Gröne, A., Zaiss, D. M. W., & Sijts, E. J. A. M. (2014). Enhanced Inflammatory Potential of CD4+ T-Cells That Lack Proteasome Immunosubunit Expression, in a T-Cell Transfer-Based Colitis Model. PLoS One, 9(4), Article e95378. https://doi.org/10.1371/journal.pone.0095378
https://dspace.library.uu.nl/bitstream/handle/1874/295093/Rasid%2520O.%2520Enhanced%2520Inflammatory%2520feb.%25202014.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/295093/Rasid%2520O.%2520Enhanced%2520Inflammatory%2520feb.%25202014.pdf?sequence=1
2013
Wetenschappelijke publicaties
Meulenbroeks, C., van Weelden, H., Rutten, V., Willemse, T., Sijts, A., & Zaiss, D. (2013). Amphiregulin is essential for UVB mediated immunosuppression. The Journal of Immunology, 190(Suppl. 1), Article P6231. https://doi.org/10.4049/jimmunol.190.Supp.62.14
van Loosdregt, J., Fleskens, V., Tiemessen, M. M., Mokry, M., van Boxtel, R., Meerding, J. M., Pals, C. E. G. M., Kurek, D., Baert, M. R., Delemarre, E. M., Grone, A., Groot Koerkamp, M. J. A., Sijts, E. J. A. M., Nieuwenhuis, E. E. S., Maurice, M. M., van Es, J. H., Ten Berge, D., Holstege, F. C. P., Staal, F. J., ... Coffer, P. J. (2013). Canonical Wnt signaling negatively modulates regulatory T cell function. Immunity, 39(2), 298-310. https://doi.org/10.1016/j.immuni.2013.07.019
Zaiss, D. M. W., van Loosdregt, J., Gorlani, A., Bekker, C. P. J., Gröne, A., Sibilia, M., van Bergen en Henegouwen, P. M. P., Roovers, R. C., Coffer, P. J., & Sijts, E. J. A. M. (2013). Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor. Immunity, 38(2), 275-284. https://doi.org/10.1016/j.immuni.2012.09.023
van Loosdregt, J., Fleskens, V., Fu, J., Brenkman, A. B., Bekker, C. P. J., Pals, C. E. G. M., Meerding, J. M., Berkers, C. R., Barbi, J., Grone, A., Sijts, E. J. A. M., Maurice, M. M., Kalkhoven, E., Prakken, A. B. J., Ovaa, H., Pan, F., Zaiss, D. M. W., & Coffer, P. J. (2013). Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity, 39(2), 259-271. https://doi.org/10.1016/j.immuni.2013.05.018.
2012
Wetenschappelijke publicaties
Reemers, S. S. N., van Haarlem, D. A., Sijts, E. J. A. M., Vervelde, L., & Jansen, C. A. (2012). Identification of novel avian influenza virus derived CD8+ T cell epitopes. PLoS One, 7(2), 10.1371/journal.pone.0031953. https://doi.org/10.1371/journal.pone.0031953
https://dspace.library.uu.nl/bitstream/handle/1874/274557/Reemers%2520ea%2520Identification%2520of%2520novel.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/274557/Reemers%2520ea%2520Identification%2520of%2520novel.pdf?sequence=1
Sijts, E. J. A. M., & van Eden, W. (2012). The tricky balancing act of using heat shock proteins for cross-presentation. Frontiers in Immunology [E], 3, 114. https://doi.org/10.3389/fimmu.2012.00114
https://dspace.library.uu.nl/bitstream/handle/1874/274914/Sijts%2520ea%2520The%2520tricky.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/274914/Sijts%2520ea%2520The%2520tricky.pdf?sequence=1
van Helden, M. J. G., de Graaf, N., Boog, C. J. P., Topham, D. J., Zaiss, D. M. W., & Sijts, E. J. A. M. (2012). The bone marrow functions as the central site of proliferation for long-lived NK cells. Journal of Immunology, 189, 2333-2337.
Amidi, M., van Helden, M. J. G., Tabataei, N. R., de Goede, A. L., Schouten, M., de Bot, V., Lanzi, A. J. E., Gruters, R. A., Rimmelzwaan, G. F., Sijts, E. J. A. M., & Mastrobattista, E. (2012). Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes. Journal of Controlled Release, 164, 323-330.
van Helden, M. J. G., Zaiss, D. M. W., & Sijts, E. J. A. M. (2012). CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS One, 7(12), e52027. https://doi.org/10.1371/journal.pone.0052027
van Helden, M. J. G., van Kooten, P. J., Bekker, C. P. J., Grone, A., Topham, D. J., Easton, A. J., Boog, C. J. P., Busch, D. H., Zaiss, D. M. W., & Sijts, E. J. A. M. (2012). Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice. Vaccine, 30(45), 6382-6388. https://doi.org/10.1016/j.vaccine.2012.08.27
2011
Wetenschappelijke publicaties
van Helden, M. J. G., de Graaf, N., Bekker, C. P. J., Boog, C. J. P., Zaiss, D. M. W., & Sijts, E. J. A. M. (2011). Immunoproteasome-deficiency has no effects on NK cell education, but confers lymphocytes into targets for NK cells in infected wild-type mice. PLoS One, 6(8), 10.1371/journal.pone.0023769. https://doi.org/10.1371/journal.pone.0023769
https://dspace.library.uu.nl/bitstream/handle/1874/231658/vHelden%2520ea%2520Immunoproteasome.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/231658/vHelden%2520ea%2520Immunoproteasome.pdf?sequence=2
Zaiss, D. M. W., Bekker, C. P. J., Grone, A., Lie, B. A., & Sijts, E. J. A. M. (2011). Proteasome Immunosubunits Protect against the Development of CD8 T Cell-Mediated Autoimmune Diseases. Journal of Immunology, 187(5), 2302-2309. https://doi.org/10.4049/jimmunol.1101003
de Graaf, N., van Helden, M. J. G., Textoris-Taube, K., Chiba, T., Topham, D. J., Kloetzel, P. M., Zaiss, D. M. W., & Sijts, E. J. A. M. (2011). PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. European Journal of Immunology, 41, 926-935. https://doi.org/10.1002/eji.201041040
Sijts, E. J. A. M., & Kloetzel, P. M. (2011). The role of the proteasome in the generation of MHC class I ligands and immune responses. Cellular and Molecular Life Sciences, 68, 1491-1502. https://doi.org/10.1007/s00018-011-0657-y
https://dspace.library.uu.nl/bitstream/handle/1874/235404/Sijts%2520ea%2520The%2520role%2520of.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/235404/Sijts%2520ea%2520The%2520role%2520of.pdf?sequence=1
2010
Wetenschappelijke publicaties
Zaiss, D. M. W., Boog, C. J. P., van Eden, W., & Sijts, E. J. A. M. (2010). Considerations in the design of vaccines that induce CD8 T cell mediated immunity. Vaccine, 28(49), 7716-7722. https://doi.org/10.1016/j.vaccine.2010.08.101
2008
Wetenschappelijke publicaties
Zaiss, D. M. W., Sijts, E. J. A. M., & Mosmann, T. R. (2008). Enumeration of cytotoxic CD8 T cells ex vivo during the response to Listeria monocytogenes infection. Infection and Immunity, 76(10), 4609-4614.
Zaiss, D. M. W., de Graaf, N., & Sijts, A. J. A. M. (2008). The proteasome immunosubunit multicatalytic endopeptidase complex-like 1 is a T-cell-intrinsic factor influencing homeostatic expansion. Infection and Immunity, 76(3), 1207-1213. https://doi.org/10.1128/IAI.01134-07
2007
Wetenschappelijke publicaties
Textoris-Taube, K., Henklein, P., Pollmann, S., Bergann, T., Weisshoff, H., Seifert, U., Drung, I., Mügge, C., Sijts, A., Kloetzel, P.-M., & Kuckelkorn, U. (2007). The N-terminal flanking region of the TRP2360-368 melanoma antigen determines proteasome activator PA28 requirement for epitope liberation. Journal of Biological Chemistry, 282(17), 12749-12754. https://doi.org/10.1074/jbc.M611644200
https://dspace.library.uu.nl/bitstream/handle/1874/26209/PIIS0021925818950490.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/26209/PIIS0021925818950490.pdf?sequence=2
Deol, P., Zaiss, D. M. W., Monaco, J. J., & Sijts, A. J. A. M. (2007). Rates of processing determine the immunogenicity of immunoproteasome-generated epitopes. Journal of Immunology, 178(12), 7557-7562. https://doi.org/10.4049/jimmunol.178.12.7557
2006
Wetenschappelijke publicaties
Divekar, A. A., Zaiss, D. M. W., Lee, F. E.-H., Liu, D., Topham, D. J., Sijts, A. J. A. M., & Mosmann, T. R. (2006). Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells. Journal of Immunology, 176(3), 1465-73.
Divekar, A. A., Zaiss, D. M. W., Lee, F., Liu, D., Topham, D. J., Sijts, E. J. A. M., & Mosmann, T. R. (2006). Protein vaccines induce uncommitted IL-2-secreting human and mouse cells, whereas infections induce more IFN-gamma-secreting cells. Journal of Immunology, 176(3), 1465-1473.
https://dspace.library.uu.nl/bitstream/handle/1874/20242/divekar%2520ea%2520Protein%2520vaccines.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/20242/divekar%2520ea%2520Protein%2520vaccines.pdf?sequence=1
2005
Wetenschappelijke publicaties
Ossendorp, F. A., Fu, N., Camps, M., Granucci, F., Gobin, S. J., van den Elsen, P. J., Schuurhuis, D., Adema, G. J., Lipford, G. B., Chiba, T., Sijts, E. J. A. M., Kloetzel, P. M., Ricciardi-Castagnoli, P., & Melief, C. J. M. (2005). Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. Journal of Immunology, 174(12), 7815-7822.
2004
Wetenschappelijke publicaties
Seifert, U., Liermann, H., Racanelli, V., Halenius, A., Wiese, M., Wedemeyer, H., Ruppert, T., Rispeter, K., Henklein, P., Sijts, A., Hengel, H., Kloetzel, P. M., & Rehermann, B. (2004). Hepatitis C virus mutation affects proteasomal epitope processing. Journal of Clinical Investigation, 114(2), 250-9. https://doi.org/10.1172/JCI20985
2003
Wetenschappelijke publicaties
Krüger, E., Kuckelkorn, U., Sijts, A., & Kloetzel, P. M. (2003). The components of the proteasome system and their role in MHC class I antigen processing. Reviews of physiology, biochemistry and pharmacology, 148, 81-104. https://doi.org/10.1007/s10254-003-0010-4
2002
Wetenschappelijke publicaties
Sun, Y., Sijts, A. J. A. M., Song, M., Janek, K., Nussbaum, A. K., Kral, S., Schirle, M., Stevanovic, S., Paschen, A., Schild, H., Kloetzel, P. M., & Schadendorf, D. (2002). Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Research, 62(10), 2875-82.
Zaiss, D. M. W., Standera, S., Kloetzel, P. M., & Sijts, A. J. A. M. (2002). PI31 is a modulator of proteasome formation and antigen processing. Proceedings of the National Academy of Sciences of the United States of America, 99(22), 14344-9. https://doi.org/10.1073/pnas.212257299
Sijts, A., Sun, Y., Janek, K., Kral, S., Paschen, A., Schadendorf, D., & Kloetzel, P. M. (2002). The role of the proteasome activator PA28 in MHC class I antigen processing. Molecular Immunology, 39(3-4), 165-9.
Huang, X., Seifert, U., Salzmann, U., Henklein, P., Preissner, R., Henke, W., Sijts, A. J., Kloetzel, P.-M., & Dubiel, W. (2002). The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. Journal of Molecular Biology, 323(4), 771-82.
2001
Wetenschappelijke publicaties
Kessler, J. H., Beekman, N. J., Bres-Vloemans, S. A., Verdijk, P., van Veelen, P. A., Kloosterman-Joosten, A. M., Vissers, D. C. J., ten Bosch, G. J., Kester, M. G., Sijts, A., Wouter Drijfhout, J., Ossendorp, F., Offringa, R., & Melief, C. J. (2001). Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis. Journal of Experimental Medicine, 193(1), 73-88.
Sijts, A., Zaiss, D., & Kloetzel, P. M. (2001). The role of the ubiquitin-proteasome pathway in MHC class I antigen processing: implications for vaccine design. Current Molecular Medicine, 1(6), 665-76.
2000
Wetenschappelijke publicaties
Beekman, N. J., van Veelen, P. A., Hall, T., Neisig, A., Sijts, A., Camps, M., Kloetzel, P. M., Neefjes, J., Melief, C. J., & Ossendorp, F. (2000). Abrogation of CTL epitope processing by single amino acid substitution flanking the C-terminal proteasome cleavage site. Journal of Immunology, 164(4), 1898-905.
Sijts, A. J., Ruppert, T., Rehermann, B., Schmidt, M., Koszinowski, U., & Kloetzel, P. M. (2000). Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes. Journal of Experimental Medicine, 191(3), 503-14.
van Hall T, Sijts, A., Camps, M., Offringa, R., Melief, C. J., Kloetzel, P. M., & Ossendorp, F. (2000). Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28. Journal of Experimental Medicine, 192(4), 483-94.
Sijts, A. J., Standera, S., Toes, R. E., Ruppert, T., Beekman, N. J., van Veelen, P. A., Ossendorp, F. A., Melief, C. J., & Kloetzel, P. M. (2000). MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells. Journal of Immunology, 164(9), 4500-6.
Stoltze, L., Nussbaum, A. K., Sijts, A., Emmerich, N. P., Kloetzel, P. M., & Schild, H. (2000). The function of the proteasome system in MHC class I antigen processing. Immunology Today, 21(7), 317-9.
1999
Wetenschappelijke publicaties
Salzmann, U., Kral, S., Braun, B., Standera, S., Schmidt, M., Kloetzel, P. M., & Sijts, A. (1999). Mutational analysis of subunit i beta2 (MECL-1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes. FEBS Letters, 454(1-2), 11-5.
Zaiss, D. M., Standera, S., Holzhütter, H., Kloetzel, P. M., & Sijts, A. J. (1999). The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes. FEBS Letters, 457(3), 333-8.
1997
Wetenschappelijke publicaties
Sijts, A. J., & Pamer, E. G. (1997). Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes. Journal of Experimental Medicine, 185(8), 1403-11.
Sijts, A. J., Pilip, I., & Pamer, E. G. (1997). The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class I antigen processing of bacterial proteins. Journal of Biological Chemistry, 272(31), 19261-8.
Pamer, E. G., Sijts, A. J., Villanueva, M. S., Busch, D. H., & Vijh, S. (1997). MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses. Immunological Reviews, 158, 129-36.
1996
Wetenschappelijke publicaties
Sijts, A. J., Neisig, A., Neefjes, J., & Pamer, E. G. (1996). Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies. Journal of Immunology, 156(2), 683-92.
Sijts, A. J., Villanueva, M. S., & Pamer, E. G. (1996). CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen. Journal of Immunology, 156(4), 1497-503.
Ossendorp, F., Eggers, M., Neisig, A., Ruppert, T., Groettrup, M., Sijts, A., Mengedë, E., Kloetzel, P. M., Neefjes, J., Koszinowski, U., & Melief, C. J. (1996). A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. Immunity, 5(2), 115-24.
1995
Wetenschappelijke publicaties
Neisig, A., Roelse, J., Sijts, A. J., Ossendorp, F., Feltkamp, M. C., Kast, W. M., Melief, C. J., & Neefjes, J. (1995). Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences. Journal of Immunology, 154(3), 1273-9.
Villanueva, M. S., Sijts, A. J., & Pamer, E. G. (1995). Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells. Journal of Immunology, 155(11), 5227-33.
1994
Wetenschappelijke publicaties
Sijts, A. J., Ossendorp, F., Mengedé, E. A., van den Elsen, P. J., & Melief, C. J. (1994). Immunodominant mink cell focus-inducing murine leukemia virus (MuLV)-encoded CTL epitope, identified by its MHC class I-binding motif, explains MuLV-type specificity of MCF-directed cytotoxic T lymphocytes. Journal of Immunology, 152(1), 106-16.
Sijts, E. J., Leupers, C. J., Mengedé, E. A., Loenen, W. A., van den Elsen, P. J., & Melief, C. J. (1994). Cloning of the MCF1233 murine leukemia virus and identification of sequences involved in viral tropism, oncogenicity and T cell epitope formation. Virus Research, 34(3), 339-349.
Sijts, A. J., Bruijn, L. L. M., Ressing, M. E., Nieland, J. D., Mengedé, E. A., Boog, C. J., Ossendorp, F., Kast, W. M., & Melief, C. J. (1994). Identification of an H-2 Kb-presented Moloney murine leukemia virus cytotoxic T-lymphocyte epitope that displays enhanced recognition in H-2 Db mutant bm13 mice. Journal of Virology, 68(9), 6038-46.
1993
Wetenschappelijke publicaties
Ossevoort, M. A., Sijts, A. J., van Veen, K. J., Momburg, F., Hämmerling, G. J., Seelig, A., Butcher, G. W., Howard, J. C., Kast, W. M., & Melief, C. J. (1993). Differential effect of transporter Tap 2 gene introduction into RMA-S cells on viral antigen processing. European Journal of Immunology, 23(12), 3082-8. https://doi.org/10.1002/eji.1830231206
1992
Wetenschappelijke publicaties
Sijts, A. J., Bruijn, L. L. M., Nieland, J. D., Kast, W. M., & Melief, C. J. (1992). Cytotoxic T lymphocytes against the antigen-processing-defective RMA-S tumor cell line. European Journal of Immunology, 22(6), 1639-1642. https://doi.org/10.1002/eji.1830220644
1990
Wetenschappelijke publicaties
Versteeg, R., van der Minne, C., Plomp, A., Sijts, A., van Leeuwen, A., & Schrier, P. (1990). N-myc expression switched off and class I human leukocyte antigen expression switched on after somatic cell fusion of neuroblastoma cells. Molecular and Cellular Biology, 10(10), 5416-23.
1989
Wetenschappelijke publicaties
Melief, C. J., Vasmel, W. L., Offringa, R., Sijts, E. J., Matthews, E. A., Peters, J. G. P., Meloen, R. H., van der Eb, A. J., & Kast, W. M. (1989). Immunosurveillance of virus-induced tumors. Cold Spring Harbor Symposia on Quantitative Biology, 54 Pt 1, 597-603.
Vasmel, W. L., Sijts, E. J., Leupers, C. J., Matthews, E. A., & Melief, C. J. (1989). Primary virus-induced lymphomas evade T cell immunity by failure to express viral antigens. Journal of Experimental Medicine, 169(4), 1233-54.
1988
Wetenschappelijke publicaties
Smit, M., de Knijff, P., Sijts, A., Klasen, E. C., Frants, R. R., & Havekes, L. M. (1988). Rare apolipoprotein E variant cosegregating with a unique APOE-C1-C2 haplotype in a normolipidemic family. Human Heredity, 38(5), 277-82.