Chemie Magazine: Geneesmiddelen hebben de maatschappij ingrijpend veranderd (2018)
Publicaties
2021
Wetenschappelijke publicaties
Scherpenzeel, M., Conte, F., Büll, C., Ashikov, A., Hermans, E., Willems, A., Tol, W., Kragt, E., Noga, M., Moret, E. E., Heise, T., Langereis, J. D., Rossing, E., Zimmermann, M., Rubio-Gozalbo, M. E., de Jonge, M. I., Adema, G. J., Zamboni, N., Boltje, T., & Lefeber, D. J. (2021). Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs. Glycobiology. https://doi.org/10.1093/glycob/cwab106
2019
Wetenschappelijke publicaties
Gao, Y., Van Haren, M. J., Moret, E. E., Rood, J. J. M., Sartini, D., Salvucci, A., Emanuelli, M., Craveur, P., Babault, N., Jin, J., & Martin, N. I. (2019). Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity. Journal of Medicinal Chemistry, 62(14), 6597-6614. https://doi.org/10.1021/acs.jmedchem.9b00413
2017
Wetenschappelijke publicaties
Sevsek, A., Sastre Toraño, J., Quarles Van Ufford, L., Moret, E. E., Pieters, R. J., & Martin, N. I. (2017). Orthoester functionalized: N -guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase. MedChemComm, 8(11), 2050-2054. https://doi.org/10.1039/c7md00480j
van Haren, M. J., Taig, R., Kuppens, J., Sastre Toraño, J., Moret, E. E., Parsons, R. B., Sartini, D., Emanuelli, M., & Martin, N. I. (2017). Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state. Organic and Biomolecular Chemistry, 15(31), 6656-6667. https://doi.org/10.1039/c7ob01357d
Sevsek, A., Šrot, L., Rihter, J., Čelan, M., van Ufford, L. Q., Moret, E. E., Martin, N. I., & Pieters, R. J. (2017). N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase. ChemMedChem, 12(7), 483–486. https://doi.org/10.1002/cmdc.201700050
2016
Wetenschappelijke publicaties
Sevšek, A., Čelan, M., Erjavec, B., Quarles van Ufford, L., Sastre Toraño, J., Moret, E. E., Pieters, R. J., & Martin, N. I. (2016). Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic & Biomolecular Chemistry, 14(37), 8670-3. https://doi.org/10.1039/c6ob01735e
2015
Wetenschappelijke publicaties
van Haren, M., van Ufford, L. Q., Moret, E. E., & Martin, N. I. (2015). Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites. Organic & Biomolecular Chemistry, 13, 549-560. https://doi.org/10.1039/c4ob01734j
2014
Wetenschappelijke publicaties
Mooney, C. A., Johnson, S. A., 'T Hart, P., Quarles Van Ufford, L., De Haan, C. A. M., Moret, E. E., & Martin, N. I. (2014). Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors. Journal of Medicinal Chemistry, 57(7), 3154-3160. https://doi.org/10.1021/jm401977j
2013
Wetenschappelijke publicaties
de Mol, N. J., Kruijtzer, J. A. W., Moret, E. E., Broutin, I., & Liskamp, R. M. J. (2013). Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding. Biochimica et Biophysica Acta, 1834(2), 524-535. https://doi.org/10.1016/j.bbapap.2012.11.001
van Hattum, H., Branderhorst, H. M., Moret, E. E., Nilsson, U. J., Leffler, H., & Pieters, R. J. (2013). Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. Journal of Medicinal Chemistry, 56(3), 1350-1354. https://doi.org/10.1021/jm301677r
Meijerman, I., Storm, G., Moret, E. E., & Koster, A. S. (2013). Development and student evaluation of an inquiry-based elective course on drug discovery and preclinical drug development. Currents in Pharmacy Teaching and Learning, 5, 14-22. https://doi.org/10.1016/j.cptl.2012.09.009
Mooiman, K. D., Maas-Bakker, R. F. M., Moret, E. E., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2013). Milk Thistle's Active Components Silybin and Isosilybin: Novel Inhibitors of PXR-Mediated CYP3A4 Induction. Drug Metabolism and Disposition, 41, 1494-1504.
2010
Wetenschappelijke publicaties
van Hell, A. J., Klymchenko, A., Burgers, P. P., Moret, E. E., Jiskoot, W., Hennink, W. E., Crommelin, D. J. A., & Mastrobattista, E. (2010). Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles. Journal of Physical Chemistry. B, 114(34), 11046-52.
https://dspace.library.uu.nl/bitstream/handle/1874/258658/jp103440d.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/258658/jp103440d.pdf?sequence=1
2009
Wetenschappelijke publicaties
van Scherpenzeel, M., Moret, E. E., Ballell, L., Liskamp, R. M. J., Nilsson, U. J., Leffler, H., & Pieters, R. J. (2009). Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. ChemBioChem, 10, 1724-1733.
Stenger, R. M., Poelen, M. C. M., Moret, E. E., Kuipers, B., Bruijns, S. C. M., Hoogerhout, P., Hijnen, M., King, A. J., Mooi, F. R., Boog, C. J. P., & van Els, C. A. C. M. (2009). Immunodominance in mouse and human CD4+ T-cell responses specific for the bordetella pertussis virulence factor P.69 pertactin. Infection and Immunity, 77, 896-903.
2007
Wetenschappelijke publicaties
Hijnen, M., de Voer, R., Mooi, F. R., Schepp, R., Moret, E. E., van Gageldonk, P., Smits, G., & Berbers, G. A. M. (2007). The role of peptide loops of the Bordetella pertussis protein P.69 pertactin in antibody recognition. Vaccine, 25, 5902-5914.
2006
Vakpublicaties
Moret, E. E. (2006). Dirty Drugs. Conceptuur, 46, 6-7.
2005
Wetenschappelijke publicaties
Haan, E., Wagenaar-Hilbers, J. P. A., Liskamp, R. M. J., Moret, E. E., & Wauben, M. H. M. (2005). Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides. Molecular Immunology, 42(3), 355-364.
Haan, E., Moret, E. E., Wagenaar-Hilbers, J. P. A., Liskamp, R. M. J., & Wauben, M. H. M. (2005). Possibilities and limitations in the rational design of modified peptides for T cell mediated immunotherapy. Molecular Immunology, 42(3), 365-373.
Vakpublicaties
Moret, E. E., & Gestel, D. (2005). Molecular Modeling. In W. Jiskoot, & D. J. A. Crommelin (Eds.), Methods for structural analysis of protein pharmaceuticals (Biotechnology: Pharmaceutical aspects series vol. III) American Association of Pharmaceutical Scientist 2005.
2004
Wetenschappelijke publicaties
Haan, E., Wauben, M. H. M., Wagenaar-Hilbers, J. P. A., Grosfeld, M. C., Rijkers, D. T. S., Moret, E. E., & Liskamp, R. M. J. (2004). Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies. Molecular Immunology, 40(13), 943-948.
Vakpublicaties
Moret, E. E. (2004). Malaria: geneesmiddelonderzoek uit idealisme. Conceptuur, 39, 8-9.
Moret, E. E., & Tollenaere, J. P. A. E. (2004). Glossary, in computational medicinal chemistry for drug discovery. In P. Bultinck, H. de Winter, W. Langenaeker, & J. P. A. E. Tollenaere (Eds.), Computational medicinal chemistry for drug discovery Marcel Dekker.
2002
Wetenschappelijke publicaties
de Haan, E. C., Wauben, M. H. M., Grosfeld-Stulemeyer, M. C., Kruijtzer, J. A. W., Liskamp, R. M. J., & Moret, E. E. (2002). Major histocompatibility complex class II binding characteristics of peptoid-peptide hybrids. Bioorganic & Medicinal Chemistry, 10, 1939-1945.
Bultinck, P. R. E., Augustynen, S., Hilbers, H. W., Moret, E. E., & Tollenaere, J. P. A. E. (2002). Generate: A program for 3-D structure generation and conformational analysis of peptides and peptidomimetics. Journal of Computational Chemistry, 23, 746-754.
2001
Wetenschappelijke publicaties
Fischer, M. J. E., Kuipers, C., Hofkes, R. P., Hofmeyer, L. J. F., Moret, E. E., & de Mol, N. J. (2001). Exploring computational lead optimisation with affinity constants obtained by surface plasmon resonance for the interaction of PorA epitope peptides with antibody against Neisseira meningitidis. Biochimica et Biophysica Acta-General Subjects, 1568, 205-215.
Huls, G., Gestel, D., van der Linden, J., Moret, E. E., & Logtenberg, T. (2001). Tumor cell killing by in vitro affinity-matured recombinant human monoclonal antibodies. Cancer Immunology, Immunotherapy, 50, 163-171.
de Haan, E. C., Wauben, M. H. M., Grosfeld-Stulemeyer, M. C., & Moret, E. E. (2001). Structure-based design and evaluation of MHC class II binding peptides. Biologicals, 29, 289-292.
Vakpublicaties
Moret, E. E. (2001). Tussen droom en werkelijkheid staat virtualiteit. Computational chemistry anno 2001. Conceptuur, 27, 12-13.
Overige resultaten
de Haan, E. C., Wauben, M. H. M., Grosveld-Stulemeyer, M. C., Kruijtzer, J. A. W., Liskamp, R. M. J., & Moret, E. E. (2001). Peptoid-peptide hybrids: design, synthesis and MHC binding. 1045-1046. Abstract from Unknown event, Asilomar, USA.
2000
Wetenschappelijke publicaties
Vries, L. D., Dijkhuizen, F. P. H. L. J., Mol, B. W. J., Brölmann, H. A. M., Moret, E. E., & Heintz, A. P. M. (2000). Comparison of transvaginal ultrasonography, saline infusion and hysteroscopy in the work-up of premenopausal women with abnormal uterine bleeding. Journal of Clinical Ultrasound, 28, 217-223.
Dijkhuizen, F. P. H. L. J., Vries, L. D., Mol, B. W. J., Brölmann, H. A. M., Peters, H. M., Moret, E. E., & Heintz, A. P. M. (2000). Comparison of transvaginal sonography and saline infusion sonography for the detection of intracavitary abnormalities. Ultrasound in Obstetrics and Gynecology, 15(5), 372-376. https://doi.org/10.1046/j.1469-0705.2000.00115.x
Vakpublicaties
de Haan, E. C., Wauben, M. H. M., Grosfeld-Stulemeyer, M. C., Kruijtzer, J. A. W., Liskamp, R. M. J., & Moret, E. E. (2000). MHC class II binding of peptoid-peptide hybrids. Immunobiology, 203, 30.
1999
Wetenschappelijke publicaties
van de Wetering, P., Moret, E. E., Schuurmans-Nieuwenbroek, N. M. E., van Steenbergen, M. J., & Hennink, W. E. (1999). Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery. Bioconjugate Chemistry, 10, 687-692.
Moret, E. E., van Wijk, M. C., Kostense, A. S., & Gillies, M. B. (1999). Scoring peptide(mimetic)-protein interactions. Medicinal Chemistry Research, 9, 604-620.
https://dspace.library.uu.nl/bitstream/handle/1874/257982/Scoring_MCR_2.copy.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/257982/Scoring_MCR_2.copy.pdf?sequence=1
Overige resultaten
Fischer, M. J. E., Kuipers, C., Moret, E. E., & de Mol, N. J. (1999). Analysis of the interaction of epitope peptides with antibody against neisseria meningtidisby surface plasmon resonance. Abstract from FIGON Geneesmiddeldagen, April 1999, Lunteren.
de Haan, E. C., van Rensen, A. J. M. L., Wauben, M. H. M., & Moret, E. E. (1999). Structure-based design of altered peptide ligands. Poster session presented at SON Discussiegroep Farmacochemie, Lunteren.
de Haan, E. C., van Rensen, A. J. M. L., Wauben, M. H. M., & Moret, E. E. (1999). Structure-based design of altered peptide ligands. Abstract from SON Discussiegroep Farmacochemie, Lunteren.
1998
Wetenschappelijke publicaties
van der Swaan, G. J., Koops, B. W., Moret, E. E., & Tukker, J. J. (1998). Mapping the binding site of the small intestinal peptide carrier (PepT1) using comparative molecular field analysis. Receptors & Channels, 6, 189-200.
1997
Wetenschappelijke publicaties
Moret, E. E., Liskamp, R. M. J., & Tollenaere, J. P. (1997). Structure-based design of epitope mimetics. In Pharmacochemistry Library: Proceedings XIVth International Symposium on Medicinal Chemistry (C ed., Vol. 28, pp. 371-381). (Pharmacochemistry Library). https://doi.org/10.1016/S0165-7208(97)80079-7
1996
Wetenschappelijke publicaties
Moret, E. E., de Boer, M., Hilbers, H. W., Tollenaere, J. P. A. E., Janssen, L. H. M., Driebergen, J. J. M., Verboom, W., & Reinhoudt, D. N. (1996). In vivo activity and hydropho-bicity of cytostatic aziridinylquinones. Journal of Medicinal Chemistry, 39, 720-728.
Moret, E. E., Liskamp, R. M. J., & Tollenaere, J. P. A. E. (1996). Structure-based design of epitope mimetics. Physiology, 6, 68-68.
Vakpublicaties
Moret, E. E. (1996). De Moleculaire Microscoop. Computational Medicinal Chemistry in Utrecht. Conceptuur, 9, 4-5.
1993
Wetenschappelijke publicaties
Driebergen, R. J., Moret, E. E., Janssen, L. H. M., Beijnen, J. H., Holthuis, J. J. M., Kelder, S. J. P., Verboom, W., Reinhoudt, N. D., & Lelieveld, P. (1993). Electrochemistry of potentially bioreductive alkylating quinones. Part 4. Qualitative and quantitative structure‐activity relationships of aziridinylquinones. Recueil des Travaux Chimiques des Pays‐Bas, 112(2), 174-185. https://doi.org/10.1002/recl.19931120216
1992
Wetenschappelijke publicaties
Driebergen, R. J., Moret, E. E., Janssen, L. H. M., Blauw, J. S., Holthuis, J. J. M., Postma Kelder, S. J., Verboom, W., Reinhoudt, D. N., & van der Linden, W. E. (1992). Electrochemistry of potentially bioreductive alkylating quinones. Part 3. Quantitative structure-electrochemistry relationships of aziridinylquinones. Analytica Chimica Acta, 257(2), 257-273. https://doi.org/10.1016/0003-2670(92)85179-A
1989
Wetenschappelijke publicaties
De Boer, M., Moret, E. E., Janssen, L. H., Holthuis, J. J., Driebergen, R. J., Reinhoudt, D. N., & Verboom, W. (1989). Lipophilicity of a series of cytostatic aziridinyl quinones. In Progress in Clinical and Biological Research (Vol. 291, pp. 87-90). (Progress in clinical and biological research).