Dr. D.L. (Daniel) Hurdiss
Universitair docent
An up-to-date list of our publications is available on Google Scholar.
Publicaties
2025
Wetenschappelijke publicaties
Hulswit, R. J. G., Shamorkina, T. M., van der Lee, J., Rosman, F., Wetzels, L. S., van Kuppeveld, F. J. M., Snijder, J., Bosch, B. J., & Hurdiss, D. L. (2025). Cetacean coronavirus spikes highlight S glycoprotein structural plasticity. bioRxiv, 2025.05.20.655071. [DOI]
Haas, M., Mills, J. T., Kelley, C., Das, A., Hóf, H., Niemel, C., Donselaar, T., Drulyte, I., van Kuppeveld, F. J. M., Dulin, D., Snijder, J., Herod, M. R., & Hurdiss, D. L. (2025). Integrative Structure of Norovirus NS3 Suggests a Role in RNA Transport. bioRxiv, 2025.06.17.659504. [DOI]
Drulyte, I., & Hurdiss, D. L. (2025). Cryo-Electron Microscopy-Based Epitope Mapping. Methods in molecular biology (Clifton, N.J.), 2937, 61-77. [DOI]
Dreyer, F. A., Schneider, C., Kovaltsuk, A., Cutting, D., Byrne, M. J., Nissley, D. A., Kenlay, H., Marks, C., Errington, D., Gildea, R. J., Damerell, D., Tizei, P., Bunjobpol, W., Darby, J. F., Drulyte, I., Hurdiss, D. L., Surade, S., Wahome, N., Pires, D. E. V., & Deane, C. M. (2025). Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations. mAbs, 17(1), 1-18. Article 2511220. [DOI] [Portal]
Laporte, M., Jochmans, D., Bardiot, D., Desmarets, L., Debski-Antoniak, O. J., Mizzon, G., Abdelnabi, R., Leyssen, P., Chiu, W., Zhang, Z., Nomura, N., Boland, S., Ohto, U., Stahl, Y., Wuyts, J., De Jonghe, S., Stevaert, A., van Hemert, M. J., Bontes, B. W., ... Neyts, J. (2025). A coronavirus assembly inhibitor that targets the viral membrane protein. Nature, 640(8058), 514–523. Article 4399. [DOI] [Portal]
Swart, I. C., Debski-Antoniak, O. J., Zegar, A., de Bouter, T., Chatziandreou, M., van den Berg, M., Drulyte, I., Pyrc, K., de Haan, C. A. M., Hurdiss, D. L., Bosch, B.-J., & Oliveira, S. (2025). A bivalent spike-targeting nanobody with anti-sarbecovirus activity. Journal of Nanobiotechnology, 23(1), Article 196. [DOI] [Portal]
2024
Wetenschappelijke publicaties
Du, W., Debski-Antoniak, O., Drabek, D., van Haperen, R., van Dortmondt, M., van der Lee, J., Drulyte, I., van Kuppeveld, F. J. M., Grosveld, F., Hurdiss, D. L., & Bosch, B.-J. (2024). Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein. Nature Communications, 15(1), Article 5330. [DOI] [Portal]
Pascha, M. N., Ballegeer, M., Roelofs, M. C., Meuris, L., Albulescu, I. C., van Kuppeveld, F. J. M., Hurdiss, D. L., Bosch, B. J., Zeev-Ben-Mordehai, T., Saelens, X., & de Haan, C. A. M. (2024). Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge. npj Vaccines, 9(1), Article 97. [DOI] [Repository]
Pascha, M. N., Ballegeer, M., Roelofs, M. C., Meuris, L., Albulescu, I. C., Kuppeveld, F. J. M. V., Hurdiss, D. L., Bosch, B.-J., Zeev-Ben-Mordehai, T., Saelens, X., & Haan, C. A. M. D. (2024). Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge in mice. Research Square. [DOI] [Repository]
2023
Wetenschappelijke publicaties
Pronker, M. F., Creutznacher, R., Drulyte, I., Hulswit, R. J. G., Li, Z., van Kuppeveld, F. J. M., Snijder, J., Lang, Y., Bosch, B.-J., Boons, G.-J., Frank, M., de Groot, R. J., & Hurdiss, D. L. (2023). Sialoglycan binding triggers spike opening in a human coronavirus. Nature, 624(7990), 201-206. [DOI] [Repository]
Thijssen, V., Hurdiss, D. L., Debski-Antoniak, O. J., Spence, M. A., Franck, C., Norman, A., Aggarwal, A., Mokiem, N. J., Dongen, D. A. A. V., Vermeir, S. W., Liu, M., Li, W., Chatziandreou, M., Donselaar, T., Du, W., Drulyte, I., Bosch, B.-J., Snijder, J., Turville, S., ... Jongkees, S. A. K. (2023). A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. (pp. 1-27). bioRxiv. [DOI] [Repository]
Aloise, C., Schipper, J. G., van Vliet, A., Oymans, J., Donselaar, T., Hurdiss, D. L., de Groot, R. J., & van Kuppeveld, F. J. M. (2023). SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b. PLoS Pathogens, 19(8), Article e1011582. [DOI] [Repository]
Thijssen, V., Hurdiss, D. L., Debski-Antoniak, O. J., Spence, M. A., Franck, C., Norman, A., Aggarwal, A., Mokiem, N. J., van Dongen, D. A. A., Vermeir, S. W., Liu, M., Li, W., Chatziandreou, M., Donselaar, T., Du, W., Drulyte, I., Bosch, B.-J., Snijder, J., Turville, S. G., ... Jongkees, S. A. K. (2023). A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. Proceedings of the National Academy of Sciences of the United States of America, 120(26), Article e2303292120. [DOI] [Repository]
Du, W., Janssens, R., Mykytyn, A. Z., Li, W., Drabek, D., van Haperen, R., Chatziandreou, M., Rissmann, M., van der Lee, J., van Dortmondt, M., Martin, I. S., van Kuppeveld, F. J. M., Hurdiss, D. L., Haagmans, B. L., Grosveld, F., & Bosch, B.-J. (2023). Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants. Frontiers in Immunology, 14, Article 1111385. [DOI] [Repository]
2022
Wetenschappelijke publicaties
Rothenberger, S., Hurdiss, D. L., Walser, M., Malvezzi, F., Mayor, J., Ryter, S., Moreno, H., Liechti, N., Bosshart, A., Iss, C., Calabro, V., Cornelius, A., Hospodarsch, T., Neculcea, A., Looser, T., Schlegel, A., Fontaine, S., Villemagne, D., Paladino, M., ... Trimpert, J. (2022). The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants. Nature Biotechnology, 40(12), 1845-1854. [DOI] [Repository]
Wang, C., Hesketh, E. L., Shamorkina, T. M., Li, W., Franken, P. J., Drabek, D., van Haperen, R., Townend, S., van Kuppeveld, F. J. M., Grosveld, F., Ranson, N. A., Snijder, J., de Groot, R. J., Hurdiss, D. L., & Bosch, B.-J. (2022). Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nature Communications, 13(1), 1-15. Article 2921. [DOI] [Repository]
Du, W., Hurdiss, D. L., Drabek, D., Mykytyn, A. Z., Kaiser, F. K., González-Hernández, M., Muñoz-Santos, D., Lamers, M. M., van Haperen, R., Li, W., Drulyte, I., Wang, C., Sola, I., Armando, F., Beythien, G., Ciurkiewicz, M., Baumgärtner, W., Guilfoyle, K., Smits, T., ... Bosch, B.-J. (2022). An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Science immunology, 7(73), 1-15. Article eabp9312. [DOI] [Repository]
Hurdiss, D. L., El Kazzi, P., Bauer, L., Papageorgiou, N., Ferron, F. P., Donselaar, T., Van Vliet, A. L. W., Shamorkina, T. M., Snijder, J., Canard, B., Decroly, E., Brancale, A., Zeev-Ben-Mordehai, T., Förster, F., Van Kuppeveld, F. J. M., & Coutard, B. (2022). Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex. Science advances, 8(1), 1-12. Article abj7615. [DOI] [Repository]
2021
Wetenschappelijke publicaties
Johansson, E., Caraballo, R., Hurdiss, D. L., Mistry, N., Andersson, C. D., Thompson, R. F., Ranson, N. A., Zocher, G., Stehle, T., Arnberg, N., & Elofsson, M. (2021). Exploring the Effect of Structure-Based Scaffold Hopping on the Inhibition of Coxsackievirus A24v Transduction by Pentavalent N-Acetylneuraminic Acid Conjugates. International Journal of Molecular Sciences, 22(16), Article 8418. [DOI] [Portal]
Fedry, J., Hurdiss, D. L., Wang, C., Li, W., Obal, G., Drulyte, I., Du, W., Howes, S. C., van Kuppeveld, F. J. M., Förster, F., & Bosch, B.-J. (2021). Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science advances, 7(23), 1-11. Article eabf5632. [DOI] [Repository]
Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., Li, W., Okba, N. M. A., Albulescu, I., Widjaja, I., van Dieren, B., Fernandez-Delgado, R., Sola, I., Hurdiss, D. L., Daramola, O., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B.-J. (2021). A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies. Nature Communications, 12(1), 1-15. Article 1715. [DOI] [Repository]
2020
Wetenschappelijke publicaties
Johansson, E., Caraballo, R., Mistry, N., Zocher, G., Qian, W., Andersson, C. D., Hurdiss, D. L., Chandra, N., Thompson, R., Frangsmyr, L., Stehle, T., Arnberg, N., & Elofsson, M. (2020). Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37-Viruses That Cause Highly Contagious Eye Infections. ACS Chemical Biology, 15(10), 2683–2691. [DOI] [Portal]
Snowden, J. S., Chiu, W., Hurdiss, D. L., Adeyemi, O. O., Ranson, N. A., Herod, M. R., & Stonehouse, N. J. (2020). Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM. PLoS Biology, 18(3), Article e3000649. [DOI] [Repository]
Bauer, L., Manganaro, R., Zonsics, B., Hurdiss, D. L., Zwaagstra, M., Donselaar, T., Welter, N. G. E., van Kleef, R. G. D. M., Lopez, M. L., Bevilacqua, F., Raman, T., Ferla, S., Bassetto, M., Neyts, J., Strating, J. R. P. M., Westerink, R. H. S., Brancale, A., & van Kuppeveld, F. J. M. (2020). Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLoS Biology, 18(11), Article e3000904. [DOI] [Repository]
Hurdiss, D. L., Drulyte, I., Lang, Y., Shamorkina, T. M., Pronker, M. F., van Kuppeveld, F. J. M., Snijder, J., & de Groot, R. J. (2020). Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans. Nature Communications, 11(1), 1-10. Article 4646. [DOI] [Repository]
Manganaro, R., Zonsics, B., Bauer, L., Lorenzo Lopez, M., Donselaar, T., Zwaagstra, M., Saporito, F., Ferla, S., Strating, J. R. P. M., Coutard, B., Hurdiss, D. L., van Kuppeveld, F. J. M., & Brancale, A. (2020). Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors. Antiviral Research, 178, Article 104781. [DOI] [Repository]
2019
Wetenschappelijke publicaties
Baggen, J., Thibaut, H. J., Hurdiss, D. L., Wahedi, M., Marceau, C. D., van Vliet, A. L. W., Carette, J. E., & van Kuppeveld, F. J. M. (2019). Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. mBio, 10(4), Article e01780-19. [DOI] [Repository]
2018
Wetenschappelijke publicaties
Rawson, S., Bisson, C., Hurdiss, D. L., Fazal, A., McPhillie, M. J., Sedelnikova, S. E., Baker, P. J., Rice, D. W., & Muench, S. P. (2018). Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proceedings of the National Academy of Sciences, 115(8), 1795-1800. [DOI] [Repository]
Baggen, J., Hurdiss, D. L., Zocher, G., Mistry, N., Roberts, R. W., Slager, J. J., Guo, H., van Vliet, A. L. W., Wahedi, M., Benschop, K., Duizer, E., de Haan, C. A. M., de Vries, E., Casasnovas, J. M., de Groot, R. J., Arnberg, N., Stehle, T., Ranson, N. A., Thibaut, H. J., & van Kuppeveld, F. J. M. (2018). Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. Proceedings of the National Academy of Sciences of the United States of America, 115(2), 397-402. [DOI] [Repository]
2016
Wetenschappelijke publicaties
Hurdiss, D. L., Morgan, E. L., Thompson, R. F., Prescott, E. L., Panou, M. M., Macdonald, A., & Ranson, N. A. (2016). New Structural Insights into the Genome and Minor Capsid Proteins of BK Polyomavirus using Cryo-Electron Microscopy. Structure, 24(4), 528-536. [DOI] [Repository]