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Dr. C. (Cristian) Spitoni

Universitair docent 
Bètawetenschappen
Wiskunde
Mathematisch Instituut
Mathematical Modeling
Mathematical Modeling
Hans Freudenthalgebouw
Budapestlaan 6
Kamer 510
3584 CD Utrecht

Dr. C. (Cristian) Spitoni

Universitair docent
Mathematical Modeling
030 253 1530
c.spitoni@uu.nl
Profiel Publicaties Onderwijs Contact
Profiel Publicaties Onderwijs Contact
Expertises

Key publications:

 

  1. Cirillo, E.N.M., Nardi, F.R., Spitoni, C.

Metastability for reversible probabilistic cellular automata with self-interaction;
Journal of Statistical Physics, 132 (2008)

 

  1. Bovier, A., den Hollander, F., Spitoni, C.

Homogeneous nucleation for Glauber and Kawasaki dynamics in large volumes at low temperatures;
Annals of Probability, 38 (2010)

 

  1.  Van Vught, L.A.V., Klouwenberg, P.M.C.K., Spitoni, C. et al.

Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis;
Journal of the American Medical Association, 315 (2016)

 

  1. Putter, H., Spitoni, C.

Non-parametric estimation of transition probabilities in non-Markov multi-state models: The landmark Aalen–Johansen estimator; 
Statistical Methods in Medical Research, 27 (2018)

 

  1. van Enter, A.C.D., Kimura, B., Ruszel, W., Spitoni, C.

Nucleation for one-dimensional long-range Ising models; 

Journal of Statistical Physics, 174 (2019)

 

  1. Lancia, G., Varkila, M.R.J., Cremer, O.L., Spitoni, C. 

Two-step interpretable modeling of ICU-AIs;

Artificial Intelligence in Medicine, 151 (2024)

 

  1.  Cirillo, E.N.M., Jacquier, V., Spitoni, C.

Particle transport based study of nucleation in a ferromagnetic three-state spin system with conservative dynamics; 

Submitted (2024)

 

  1. Kamsma, T., van Roij, R., Spitoni, C.

A simple mathematical theory for Simple Volatile Memristors and their spiking circuits;
Chaos, Solitons and Fractals  (2024)

Publicaties

2024

Wetenschappelijke publicaties

Lancia, G., & Spitoni, C. (2024, Oct 16). Constructing Interpretable Prediction Models with 1D DNNs: An Example in Irregular ECG Classification. https://doi.org/10.48550/ARXIV.2410.12059
Cirillo, E. N. M., Lancia, G., & Spitoni, C. (2024). Block approximations for probabilistic mixtures of elementary cellular automata. Physica A: Statistical Mechanics and its Applications. https://doi.org/10.1016/j.physa.2024.130150
Cirillo, E. N. M., Lancia, G., & Spitoni, C. (2024). Block approximations for probabilistic mixtures of elementary cellular automata. arXiv. https://doi.org/10.48550/arXiv.2408.09201
Kamsma, T. M., van Roij, R., & Spitoni, C. (2024). A simple mathematical theory for Simple Volatile Memristors and their spiking circuits. Chaos, Solitons and Fractals, 186, Article 115320. https://doi.org/10.1016/j.chaos.2024.115320
Jacquier, V., Cirillo, E. N. M., & Spitoni, C. (2024). Particle transport based study of nucleation in a ferromagnetic three-state spin system with conservative dynamics. arXiv. https://doi.org/10.48550/ARXIV.2405.09198
https://dspace.library.uu.nl/bitstream/handle/1874/452290/2405.09198v1.pdf?sequence=1
Kamsma, T. M., Rossing, E. A., Spitoni, C., & Roij, R. V. (2024). Advanced iontronic spiking modes with multiscale diffusive dynamics in a fluidic circuit. Neuromorphic Computing and Engineering, 4(2), Article 024003. https://doi.org/10.1088/2634-4386/ad40ca
https://dspace.library.uu.nl/bitstream/handle/1874/452084/Kamsma_2024_Neuromorph._Comput._Eng._4_024003.pdf?sequence=1
Kamsma, T. M., Kim, J., Kim, K., Boon, W. Q., Spitoni, C., Park, J., & Roij, R. V. (2024). Brain-inspired computing with fluidic iontronic nanochannels. Proceedings of the National Academy of Sciences, 121(18), Article e2320242121. https://doi.org/10.1073/pnas.2320242121
https://dspace.library.uu.nl/bitstream/handle/1874/451594/kamsma-et-al-2024-brain-inspired-computing-with-fluidic-iontronic-nanochannels.pdf?sequence=1
Kamsma, T., Roij, R. V., & Spitoni, C. (2024, Feb). A simple mathematical theory for Simple Volatile Memristors and their spiking circuits. https://doi.org/10.13140/RG.2.2.13242.40640
Lancia, G., Varkila, M., Cremer, O. L., & Spitoni, C. (2024). Two-step interpretable modeling of ICU-AIs. Artificial Intelligence in Medicine, 151, Article 102862. https://doi.org/10.1016/j.artmed.2024.102862
Kamsma, T. M., Rossing, E. A., Spitoni, C., & Roij, R. V. (2024). Advanced iontronic spiking modes with multiscale diffusive dynamics in a fluidic circuit. arXiv. https://doi.org/10.48550/arXiv.2401.14921
https://dspace.library.uu.nl/bitstream/handle/1874/437871/2401.14921v1.pdf?sequence=1
Cirillo, E. M. N., Jacquier, V., & Spitoni, C. (2024). Homogeneous and heterogeneous nucleation in the three-state Blume–Capel model. Physica D: Nonlinear Phenomena, 461, Article 134125. https://doi.org/10.1016/j.physd.2024.134125

2023

Wetenschappelijke publicaties

Kamsma, T. M., Boon, W. Q., Spitoni, C., & van Roij, R. (2023). Unveiling the capabilities of bipolar conical channels in neuromorphic iontronics. Faraday Discussions, 246, 125-140. https://doi.org/10.1039/d3fd00022b
Lancia, G., Durastanti, C., Spitoni, C., De Benedictis, I., Sciortino, A., Cirillo, E. N. M., Ledda, M., Lisi, A., Convertino, A., & Mussi, V. (2023). Learning models for classifying Raman spectra of genomic DNA from tumor subtypes. Scientific Reports, 13(1), Article 11370. https://doi.org/10.1038/s41598-023-37303-w
Kamsma, T. M., Boon, W. Q., Rele, T. T., Spitoni, C., & Roij, R. V. (2023). Iontronic Neuromorphic Signaling with Conical Microfluidic Memristors. Physical Review Letters, 130(26), 1-7. Article 268401. https://doi.org/10.1103/PhysRevLett.130.268401
Lancia, G., Durastanti, C., Spitoni, C., Benedictis, I. D., Sciortino, A., Cirillo, E. N. M., Ledda, M., Lisi, A., Convertino, A., & Mussi, V. (2023). Learning models for classifying Raman spectra of genomic DNA from tumor subtypes. (pp. 1-19). arXiv. https://doi.org/10.48550/arXiv.2302.08918
Lancia, G., Varkila, M., Cremer, O., & Spitoni, C. (2023). Two-step interpretable modeling of Intensive Care Acquired Infections. (pp. 1-30). arXiv. https://doi.org/10.48550/arXiv.2301.11146
Kamsma, T. M., Boon, W. Q., Spitoni, C., & Roij, R. V. (2023). Unveiling the capabilities of bipolar conical channels in neuromorphic iontronics. (pp. 1-9). arXiv. https://doi.org/10.48550/arXiv.2303.04277
Kamsma, T. M., Boon, W. Q., Rele, T. T., Spitoni, C., & Roij, R. V. (2023). Iontronic neuromorphic signalling with conical microfluidic memristors. (pp. 1-9). arXiv. https://doi.org/10.48550/arXiv.2301.06158

2022

Wetenschappelijke publicaties

Cirillo, E. N. M., Jacquier, V., & Spitoni, C. (2022). Metastability of Synchronous and Asynchronous Dynamics. Entropy, 24(4), 1-18. Article 450. https://doi.org/10.3390/e24040450
https://dspace.library.uu.nl/bitstream/handle/1874/434086/entropy-24-00450-v2.pdf?sequence=1
Lancia, G., Goede, I. J., Spitoni, C., & Dijkstra, H. (2022). Physics captured by data-based methods in El Niño prediction. Chaos, 32(10), Article 103115. https://doi.org/10.1063/5.0101668

2021

Wetenschappelijke publicaties

Cirillo, E. N. M., Nardi, F. R., & Spitoni, C. (2021). Phase transitions in random mixtures of elementary cellular automata. Physica A: Statistical Mechanics and its Applications, 573, 1-16. Article 125942. https://doi.org/10.1016/j.physa.2021.125942

2020

Wetenschappelijke publicaties

behalf of the MARS consortium (2020). Erratum: Predicting the clinical trajectory in critically ill patients with sepsis: A cohort study (Critical Care (2019) 2 (408) DOI: 10.1186/s13054-019-2687-z). Critical Care, 24(1), Article 41. https://doi.org/10.1186/s13054-020-2758-1
https://dspace.library.uu.nl/bitstream/handle/1874/434087/s13054-020-2758-1.pdf?sequence=1

2019

Wetenschappelijke publicaties

Klein Klouwenberg, P. M. C., Spitoni, C., Van Der Poll, T., Bonten, M. J., Cremer, O. L., Frencken, J. F., Van De Groep, K., Koster-Brouwer, M. E., Ong, D. S. Y., Verboom, D., De Beer, F. M., Bos, L. D. J., Glas, G. J., Van Hooijdonk, R. T. M., Schouten, L. R. A., Straat, M., Witteveen, E., Wieske, L., Hoogendijk, A. J., ... Van Vught, L. A. (2019). Predicting the clinical trajectory in critically ill patients with sepsis: A cohort study. Critical Care, 23(1), Article 408. https://doi.org/10.1186/s13054-019-2687-z
Lancia, C., Anninga, J., Spitoni, C., Sydes, M. R., Whelan, J., Hogendoorn, P. C. W., Gelderblom, H., & Fiocco, M. (2019). Method to measure the mismatch between target and achieved received dose intensity of chemotherapy in cancer trials: A retrospective analysis of the MRC BO06 trial in osteosarcoma. BMJ Open, 9(5), Article e022980. https://doi.org/10.1136/bmjopen-2018-022980
Lancia, C., Anninga, J. K., Sydes, M. R., Spitoni, C., Whelan, J., Hogendoorn, P. C. W., Gelderblom, H., & Fiocco, M. (2019). A novel method to address the association between received dose intensity and survival outcome: benefits of approaching treatment intensification at a more individualised level in a trial of the European Osteosarcoma Intergroup. Cancer Chemotherapy and Pharmacology, 83, 951-962. https://doi.org/10.1007/s00280-019-03797-3
van Enter, A. C. D., Kimura, B., Ruszel, W., & Spitoni, C. (2019). Nucleation for One-Dimensional Long-Range Ising Models. Journal of Statistical Physics, 174(6), 1327–1345. https://doi.org/10.1007/s10955-019-02238-y
Postma, D. F., Spitoni, C., van Werkhoven, C. H., van Elden, L. J. R., Oosterheert, J. J., & Bonten, M. J. M. (2019). Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial. BMC Infectious Diseases, 19, Article 17. https://doi.org/10.1186/s12879-018-3630-7
Lancia, C., & Spitoni, C. (2019). Marginal structural models with dose-delay joint-exposure for assessing variations to chemotherapy intensity. Statistical Methods in Medical Research, 28(9), 2787-2801. https://doi.org/10.1177/0962280218780619

2018

Wetenschappelijke publicaties

Kimura, B., Ruszel, W. M., & Spitoni, C. (2018). Ergodicity versus non-ergodicity for Probabilistic Cellular Automata on rooted trees. Markov Processes and Related Fields, 25(2), 189-216. https://doi.org/10.48550/arXiv.1710.00084
https://dspace.library.uu.nl/bitstream/handle/1874/387199/Ergodicity_versus_non_ergodicity_for_Probabilistic.pdf?sequence=1
Cirillo, E. M. N., Nardi, F. R., & Spitoni, C. (2018). Basic Ideas to Approach Metastability in Probabilistic Cellular Automata. In Probabilistic Cellular Automata, Theory, Applications and Future Perspectives (pp. 37-51). (Emergence, Complexity and Computation; Vol. 27). Springer. https://doi.org/10.1007/978-3-319-65558-1_3
https://dspace.library.uu.nl/bitstream/handle/1874/372763/Cirillo2018_Chapter_BasicIdeasToApproachMetastabil.pdf?sequence=1
Frencken, J. F., Donker, D. W., Spitoni, C., Koster-Brouwer, M. E., Soliman, I. W., Ong, D. S. Y., Horn, J., van der Poll, T., van Klei, W. A., Bonten, M. J. M., & Cremer, O. L. (2018). Myocardial Injury in Patients With Sepsis and Its Association With Long-Term Outcome. Circulation. Cardiovascular quality and outcomes, 11(2), 1-9. Article e004040. https://doi.org/10.1161/CIRCOUTCOMES.117.004040
https://dspace.library.uu.nl/bitstream/handle/1874/363256/frencken.pdf?sequence=1
Frencken, J. F., Wittekamp, B. H. J., Plantinga, N. L., Spitoni, C., van de Groep, K., Cremer, O. L., & Bonten, M. J. M. (2018). Associations Between Enteral Colonization With Gram-Negative Bacteria and Intensive Care Unit-Acquired Infections and Colonization of the Respiratory Tract. Clinical Infectious Diseases, 66(4), 497–503. https://doi.org/10.1093/cid/cix824
https://dspace.library.uu.nl/bitstream/handle/1874/377854/Associations.pdf?sequence=1
Spitoni, C., Lammens, V., & Putter, H. (2018). Prediction errors for state occupation and transition probabilities in multi-state models. Journal of Biometrics & Biostatistics, 60(1), 34-48. https://doi.org/10.1002/bimj.201600191
Putter, H., & Spitoni, C. (2018). Non-parametric estimation of transition probabilities in non-markov multi-state model: The landmark Aalen-Johansen Estimator. Statistical Methods in Medical Research, 27(7), 2081–2092. https://doi.org/10.1177/0962280216674497
https://dspace.library.uu.nl/bitstream/handle/1874/383745/estimation.pdf?sequence=1

2017

Wetenschappelijke publicaties

Lancia, C., Spitoni, C., Anninga, J. K., Whelan, J., Sydes, M. R., Jovic, G., & Fiocco, M. (2017). Causal inference with randomised clinical trials of chemotherapy: The importance of well-documented treatment side-effects. Trials, 18(suppl 1), 214. Article 200. https://doi.org/10.1186/s13063-017-1902-y
Kimura, B., Ruszel, W. M., & Spitoni, C. (2017). Ergodicity versus non-ergodicity for Probabilistic Cellular Automata on rooted trees. arXiv.org.
https://dspace.library.uu.nl/bitstream/handle/1874/358095/ergodicity.pdf?sequence=1
Cirillo, E. N. M., Nardi, F. R., & Spitoni, C. (2017). Sum of exit times in a series of two metastable states. European Physical Journal: Special Topics, 226(10), 2421-2438. https://doi.org/10.1140/epjst/e2017-70070-6
https://dspace.library.uu.nl/bitstream/handle/1874/356503/sumofexit.pdf?sequence=1
Ong, D. S. Y., Bonten, M. J. M., Spitoni, C., Lunel, F. M. V., Frencken, J. F., Horn, J., Schultz, M. J., van der Poll, T., Klouwenberg, P. M. C. K., & Cremer, O. L. (2017). Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock. Clinical Infectious Diseases, 64(9), 1204–1210. https://doi.org/10.1093/cid/cix120
https://dspace.library.uu.nl/bitstream/handle/1874/432755/cix120.pdf?sequence=1

2016

Wetenschappelijke publicaties

Cirillo, E. N. M., Nardi, F. R., & Spitoni, C. (2016). Basic Ideas to Approach Metastability in Probabilistic Cellular Automata. arXiv.
https://dspace.library.uu.nl/bitstream/handle/1874/344452/1607.01289v1?sequence=1
Anninga, J. K., Lancia, C., Spitoni, C., Gelderblom, H., & Fiocco, M. (2016). Causal effects of methotrexate reductions/delays in treatment of high-grade resectable osteosarcoma. Journal of Clinical Oncology, 34(15_suppl), Article e22502. https://doi.org/10.1200/JCO.2016.34.15_suppl.e22502
van Mansfeld, R., de Vrankrijker, A., Brimicombe, R., Heijerman, H., Teding van Berkhout, F., Spitoni, C., Grave, S., van der Ent, C., Wolfs, T., Willems, R., & Bonten, M. (2016). The Effect of Strict Segregation on Pseudomonas aeruginosa in Cystic Fibrosis Patients. PLoS One, 11(6), 1-14. Article e0157189. https://doi.org/10.1371/journal.pone.0157189
Cirillo, E. N. M., Nardi, F. R., & Spitoni, C. (2016). Sum of exit times in series of metastable states in Probabilistic Cellular Automata. Lecture Notes in Computer Science, 9664, 105-119. https://doi.org/10.1007/978-3-319-39300-1_9
https://dspace.library.uu.nl/bitstream/handle/1874/330724/Automata.pdf?sequence=1
van Vught, L. A., Klein Klouwenberg, P. M. C., Spitoni, C., Scicluna, B. P., Wiewel, M. A., Horn, J., Schultz, M. J., Nürnberg, P., Bonten, M. J. M., Cremer, O. L., van der Poll, T., & MARS Consortium (2016). Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. JAMA - The Journal of The American Medical Association, 315(14), 1469-1479. https://doi.org/10.1001/jama.2016.2691

2015

Wetenschappelijke publicaties

Ong, D. S. Y., Bonten, M. J. M., Safdari, K., Spitoni, C., Frencken, J. F., Witteveen, E., Horn, J., Klein Klouwenberg, P. M. C., Cremer, O. L., & MARS Consortium (2015). Epidemiology, Management, and Risk-Adjusted Mortality of ICU-Acquired Enterococcal Bacteremia. Clinical Infectious Diseases. https://doi.org/10.1093/cid/civ560
https://dspace.library.uu.nl/bitstream/handle/1874/329429/1413.full.pdf?sequence=1
Ong, D. S. Y., Spitoni, C., Klein Klouwenberg, P. M. C., Verduyn Lunel, F. M., Frencken, J. F., Schultz, M. J., van der Poll, T., Kesecioglu, J., Bonten, M. J. M., & Cremer, O. L. (2015). Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome. Intensive Care Medicine. https://doi.org/10.1007/s00134-015-4071-z
Ong, D. S. Y., Klein Klouwenberg, P. M. C., Verduyn Lunel, F. M., Frencken, J. F., Dekker, H. A. T., Schultz, M. J., Bonten, M. J. M., Spitoni, C., & Cremer, O. L. (2015). Cytomegalovirus Seroprevalence as a Risk Factor for Poor Outcome in Acute Respiratory Distress Syndrome. Critical Care Medicine, 43(2), 394-400. https://doi.org/10.1097/CCM.0000000000000712

2014

Wetenschappelijke publicaties

Ong, D. S. Y., Safdari, K., Klouwenberg, P. M. C. K., Spitoni, C., Frencken, J. F., Witteveen, E., Horn, J., Bonten, M. J. M., & Cremer, O. L. (2014). Epidemiology, management and clinical outcomes of ICU-acquired enterococcal bacteraemias. Critical Care, 1-53. https://doi.org/10.1186/cc14040
Klouwenberg, P. M. C. K., Zaal, I. J., Ong, D. S. Y., Van Der Kooi, A. W., Bonten, M. J. M., Slooter, A. J. C., Cremer, O. L., & Spitoni, C. (2014). The attributable mortality of delirium in critically ill patients: Prospective cohort study. BMJ (International edition), 349, Article g6652. https://doi.org/10.1136/bmj.g6652
Cirillo, E. N. M., Louis, P. Y., Ruszel, W. M., & Spitoni, C. (2014). Effect of self-interaction on the phase diagram of a Gibbs-like measure derived by a reversible Probabilistic Cellular Automata. Chaos, solitons & fractals, 64, 36-47. https://doi.org/10.1016/j.chaos.2013.12.001

Overige resultaten

Ong, D., Spitoni, C., Klein Klouwenberg, P., Verduyn Lunel, F., Schultz, M., Bonten, M., & Cremer, O. (2014). Cytomegalovirus reactivation in critically ill patients with acute respiratory distress syndrome. Intensive Care Medicine, 40(1 supplement), S127. Article 0444. https://doi.org/10.1007/s00134-014-3451-0

2013

Wetenschappelijke publicaties

Ong, D. S. Y., MC Klein Klouwenberg, P., Spitoni, C., Bonten, M. J. M., & Cremer, O. L. (2013). Nebulised amphotericin B to eradicate Candida colonisation from the respiratory tract in critically ill patients receiving selective digestive decontamination: A cohort study. Critical Care, 17(5), Article R233. https://doi.org/10.1186/cc13056
Klouwenberg, P. K., Slooter, A., Spitoni, C., Ong, D., Bonten, M., Zaal, I., & Cremer, O. (2013). Attributable mortality of delirium in critically ill patients. Critical Care Medicine, 41(12), 150-151. https://doi.org/10.1097/01.ccm.0000439854.13391.6d

2012

Wetenschappelijke publicaties

Nardi, F. R., & Spitoni, C. (2012). Sharp Asymptotics for Stochastic Dynamics with Parallel Updating Rule. Journal of Statistical Physics, 146(4), 701-718. https://doi.org/10.1007/s10955-011-0413-6
Spitoni, C., Verduijn, M., & Putter, H. (2012). Estimation and Asymptotic Theory for Transition Probabilities in Markov Renewal Multi-State Models. International Journal of Biostatistics, 8(1), Article 1375. https://doi.org/10.1515/1557-4679.1375

Overige resultaten

Ong, D. S. Y., Klein Klouwenberg, P. M. C., Spitoni, C., Bonten, M. J. M., & Cremer, O. L. (2012). Effectiveness of nebulized amphotericin B to eradicate Candida colonization from the lower respiratory tracts of ICU patients.. Poster session presented at European Society of Intensive Care, Lissabon, Portugal.

2010

Wetenschappelijke publicaties

Cirillo, E. M. N., Nardi, F. R., & Spitoni, C. (2010). Competitive nucleation in metastable systems. https://doi.org/10.1142/9789814280303_0019
Bovier, A., den Hollander, F., & Spitoni, C. (2010). HOMOGENEOUS NUCLEATION FOR GLAUBER AND KAWASAKI DYNAMICS IN LARGE VOLUMES AT LOW TEMPERATURES. Annals of Probability, 38(2), 661-713. https://doi.org/10.1214/09-AOP492

2008

Wetenschappelijke publicaties

Cirillo, E. N. M., Nardi, F. R., & Spitoni, C. (2008). Metastability for reversible probabilistic cellular automata with self-interaction. Journal of Statistical Physics, 132(3), 431-471. https://doi.org/10.1007/s10955-008-9563-6
Cirillo, E. N. M., Nardi, F. R., & Spitoni, C. (2008). Competitive nucleation in reversible probabilistic cellular automata. Physical review. E, 78(4). https://doi.org/10.1103/PhysRevE.78.040601

2005

Wetenschappelijke publicaties

Cavallaro, G., Marchioro, C., & Spitoni, C. (2005). Dynamics of Infinitely Many Particles Mutually Interacting in Three Dimensions via a Bounded Superstable Long-Range Potential. Journal of Statistical Physics, 120.

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