Publicaties
2026
Wetenschappelijke publicaties
Lewis, O. C., Leopold, C., Hoek, J. M., Schiffelers, R. M., & De Bruin, M. L. (2026). Decoding RNA regulation: Challenges and opportunities for RNA-based therapies in Europe. British Journal of Clinical Pharmacology. [DOI]
Ogar, C. K., Sisay, M. M., Roque-Pereira, L., Leopold, C., Souverein, P. C., Mantel-Teeuwisse, A. K., & De Bruin, M. L. (2026). Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase. British Journal of Clinical Pharmacology. Advance online publication. [DOI]
Versteeg, J.-W., Bruin, M. D., Schermer, M., Najafabadi, S. N., Mitra, M., Leopold, C., Mantel-Teeuwisse, A., Goettsch, W., & Bloem, L. T. (2026). Text Mining Methods for Automated Data Extraction from Health Technology Assessment Reports of Medicines Using Classical Natural Language Processing and Generative Artificial Intelligence. JAMIA Open, 9(2), Article ooag051. [DOI] [Repository]
Versteeg, J.-W., Goettsch, W. G., Mantel-Teeuwisse, A. K., Ollendorf, D., & Leopold, C. (2026). A multi-stakeholder survey on communicating cost-effectiveness uncertainties to stakeholders: a case study of ICER. Health Affairs, 4(3), Article qxag009. [DOI] [Repository]
Leopold, C., Huisman, A. H., Vlaar, K. J. G. M., Bloemendal, H. J., & Barjesteh van Waalwijk van Doorn-Khosrovani, S. (2026). Stakeholders' experiences with a clinician-led access programme linking evidence generation and reimbursement for precision cancer treatments: the drug access protocol in the Netherlands. Acta Oncologica, 65, 22-31. [DOI], [DOI] [Repository]
2025
Wetenschappelijke publicaties
Versteeg, J.-W., Leopold, C., Mantel-Teeuwisse, A., Goettsch, W., & Ollendorf, D. (2025). EE593 Multistakeholder Survey on Communication of Uncertainties in Cost-Effectiveness Analysis by the Institute of Clinical and Economic Review. Value in Health, 28(12), S225. [DOI]
Versteeg, J.-W., Stam, N., Mantel-Teeuwisse, A. K., Timmers, L., Goettsch, W., & Leopold, C. (2025). Coverage With Evidence Development For Medicines with Insufficient Evidence Of Clinical Benefit: Experience From The Netherlands. International Journal of Technology Assessment in Health Care, 41(1), Article e83. [DOI] [Repository]
Callenbach, M. H. E., van den Berg, S., Hulsbosch, A., Hollak, C. E. M., Leopold, C., Mantel-Teeuwisse, A. K., & Goettsch, W. G. (2025). Drivers of managed entry agreements to reduce reimbursement challenges of orphan medicinal products: the development of a matrix. Orphanet Journal of Rare Diseases, 20(1), Article 540. [DOI] [Repository]
Callenbach, M. H. E., Vreman, R. A., Leopold, C., Mantel-Teeuwisse, A. K., & Goettsch, W. G. (2025). Managed Entry Agreements for High-Cost, One-Off Potentially Curative Therapies: A Framework and Calculation Tool to Determine Their Suitability. PharmacoEconomics, 43(1), 53-66. Article 103433. [DOI] [Repository]
2024
Wetenschappelijke publicaties
Callenbach, M., van den Berg, S., Hulsbosch, A., Hollak, C., Leopold, C., Mantel-Teeuwisse, A., & Goettsch, W. (2024). Managed Entry Agreements to Mitigate Uncertainties and Reimbursement Challenges for Orphan Drugs: A Matrix to Determine Their Suitability. Value in Health, 27(12).
Leopold, C., Vogler, S., Suleman, F., & Wirtz, V. J. (2024). P38 Strengthening primary health care through a stronger emphasis on patient and community centered medicines and pharmaceutical services. Journal of Pharmaceutical Policy and Practice, 17(1), Article 2331920. [DOI]
Ogar, C. K., Gilbert, H. N., Bloem, L. T., Leopold, C., Bassi, P. U., Katagum, Y. M., Osakwe, A. I., Opadeyi, A. O., Oreagba, I., Mbo, D. N. D., Mantel-Teeuwisse, A. K., & De Bruin, M. L. (2024). Patient-reported outcomes of adverse events after COVID-19 vaccination in Nigeria: A mixed methods study. Vaccine, 42(23), Article 126196. [DOI] [Repository]
Vakpublicaties
Leopold, C., Hagens, A., Dai, J., Tordrup, D., Dolgorsuren, S., Grafton, D., Huikuri, S., Jung, J., Roberts, E., Stanton, R., Tarlton, D., & Webb, D. (2024). Investment Case for Air Pollution Reduction in Mongolia. UNDP. https://www.undp.org/mongolia/publications/investment-case-air-pollution-reduction-mongolia [Repository]
Vogler, S., Leopold, C., Suleman, F., & Wirtz, V. J. (2024). Medicines and pharmaceutical services. In Implementing the Primary Health Care approach: a primer (pp. 249-273). European Observatory on Health Systems and Policies, WHO Headquarters (HQ). https://eurohealthobservatory.who.int/publications/i/implementing-the-primary-health-care-approach-a-primer [Repository]
2023
Wetenschappelijke publicaties
Leopold, C., Poblete, S., & Vogler, S. (2023). How to Price and to Reimburse Publicly Funded Medicines in Latin America? Lessons Learned from Europe. Medicolegal news, 51(S1), 76-91. [DOI]
2020
Wetenschappelijke publicaties
Tordrup, D., van den Ham, R., Leopold, C., Glanville, J., Kotas, E., & Mantel - Teeuwisse, A. (2020). Web Annex A: Systematic reviews for the update of the WHO Guideline on country pharmaceutical pricing policies. In WHO guideline on country pharmaceutical pricing policies World Health Organization. http://ncbi.nlm.nih.gov/books/NBK570141/
Leopold, C., Araujo-Lane, C., Rosenberg, C., Gilkey, M., & Wagner, A. K. (2020). Out-of-Pocket Cancer Care Costs and Value Frameworks: A Case Study in a Community Oncology Practice with a Financial Navigator Program. PharmacoEconomics - Open, 4(2), 389-392. [DOI]
Leopold, C., Lu, C. Y., & Wagner, A. K. (2020). Integrating public preferences into national reimbursement decisions: a descriptive comparison of approaches in Belgium and New Zealand. BMC Health Services Research, 20(1), Article 351. [DOI]
Leopold, C., Haffajee, R. L., Lu, C. Y., & Wagner, A. K. (2020). The Complex Cancer Care Coverage Environment - What is the Role of Legislation? A Case Study from Massachusetts. Medicolegal news, 48(3), 538-551. [DOI]
2019
Wetenschappelijke publicaties
Ozawa, S., Shankar, R., Leopold, C., & Orubu, S. (2019). Access to medicines through health systems in low- and middle-income countries. Health Policy and Planning, 34(Supplement_3), iii1-iii3. [DOI]
Vargas, V., Leopold, C., Castillo-Riquelme, M., & Darrow, J. J. (2019). Expanding Coverage of Oncology Drugs in an Aging, Upper-Middle-Income Country: Analyses of Public and Private Expenditures in Chile. Journal of Global Oncology, 5, 1-17. [DOI]
2018
Wetenschappelijke publicaties
Leopold, C., Peppercorn, J. M., Zafar, S. Y., & Wagner, A. K. (2018). Defining Value of Cancer Therapeutics-A Health System Perspective. Journal of the National Cancer Institute, 110(7), 699-703. [DOI]
Leopold, C., Wagner, A. K., Zhang, F., Lu, C. Y., Earle, C. C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2018). Total and out-of-pocket expenditures among women with metastatic breast cancer in low-deductible versus high-deductible health plans. Breast Cancer Research and Treatment, 171(2), 449-459. [DOI]
Morgan, S. G., Good, C. B., Leopold, C., Kaltenboeck, A., Bach, P. B., & Wagner, A. (2018). An analysis of expenditures on primary care prescription drugs in the United States versus ten comparable countries. Health Policy, 122(9), 1012-1017. [DOI]
2017
Wetenschappelijke publicaties
Leopold, C., Wagner, A. K., Zhang, F., Lu, C., Earle, C. C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2017). Burden of out-of-pocket spending among high-deductible health plan members with metastatic breast cancer. Journal of Clinical Oncology, 35(15 suppl.), Article 1029. [DOI]
Leopold, C., Morgan, S. G., & Wagner, A. K. (2017). A rapidly changing global medicines environment: How adaptable are funding decision-making systems? Health Policy, 121(6), 637-643. [DOI]
Leopold, C., Park, E. R., & Nekhlyudov, L. (2017). The Impact of the Affordable Care Act on Cancer Survivorship. Cancer journal (Sudbury, Mass.), 23(3), 181-189. [DOI]
Morgan, S. G., Leopold, C., & Wagner, A. K. (2017). Drivers of expenditure on primary care prescription drugs in 10 high-income countries with universal health coverage. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 189(23), E794-E799. [DOI]
2016
Wetenschappelijke publicaties
Leopold, C., Zhang, F., Wagner, A. K., Lu, C., Earle, C. C., Ross-Degnan, D., & Wharam, J. F. (2016). Disparities in all-cause mortality among younger commercially insured women with metastatic breast cancer. Journal of Clinical Oncology, 34(15 suppl), Article 18069. [DOI]
Habl, C., & Leopold, C. (2016). What Happens To Originator Medicines When (Generic) Followers Enter The Public Market. Value in Health, 19(7), A443-A444. [DOI]
Leopold, C., Chambers, J. D., & Wagner, A. K. (2016). Thirty Years of Media Coverage on High Drug Prices in the United States: A Never-Ending Story or a Time for Change? Value in Health, 19(1), 14-16. [DOI]
Leopold, C., Wagner, A. K., Zhang, F., Lu, C. Y., Earle, C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2016). Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer. Breast Cancer Research and Treatment, 158(2), 333-340. [DOI]
Leopold, C. (2016). Author's response to "letter to the editor: lower vitamin D status may explain racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer". Breast Cancer Research and Treatment, 159(1), 175. [DOI]
Leopold, C., Wagner, A. K., Zhang, F., Lu, C. Y., Earle, C., Nekhlyudov, L., Ross-Degnan, D., & Wharam, J. F. (2016). Erratum to: Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer. Breast Cancer Research and Treatment, 160(2), 385. [DOI]
2014
Wetenschappelijke publicaties
Vogler, S., Leopold, C., Zimmermann, N., Habl, C., & de Joncheere, K. (2014). The Pharmaceutical Pricing and Reimbursement Information (PPRI) initiative-Experiences from engaging with pharmaceutical policy makers. Health Policy and Technology, 3(2), 139-148. [DOI]
Vogler, S., Leopold, C., Zuidberg, C., & Habl, C. (2014). Medicines discarded in household garbage: Analysis of a pharmaceutical waste sample in Vienna. Journal of Pharmaceutical Policy and Practice, 7, Article 6. [DOI]
Leopold, C., Zhang, F., Mantel-Teeuwisse, A. K., Vogler, S., Valkova, S., Ross-Degnan, D., & Wagner, A. K. (2014). Impact of pharmaceutical policy interventions on utilization of antipsychotic medicines in Finland and Portugal in times of economic recession: interrupted time series analyses. International Journal for Equity in Health, 13, Article 13:53. [DOI] [Repository]
Leopold, C., Mantel-Teeuwisse, A. K., Vogler, S., Valkova, S., de Joncheere, K., Leufkens, H. G. M., Wagner, A. K., Ross-Degnan, D., & Laing, R. (2014). Effect of the economic recession on pharmaceutical policy and medicine sales in eight European countries. Bulletin of the World Health Organization, 92(9), 630-640D. [DOI]
Leopold, C. (2014). Pharmaceutical policy analysis – A European perspective on pricing and reimbursement in challenging times. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University. [Repository]
2013
Wetenschappelijke publicaties
Sabine, V., Nina, Z., Christine, L., Claudia, H., & Jan, M. (2013). Discounts and rebates granted for medicines for hospital use in five European countries. Open Pharmacoeconomics and Health Economics Journal, 5(1), 1-25. [DOI]
Leopold, C., Mantel - Teeuwisse, A., Vogler, S., de Joncheere, K., Laing, R. O., & Leufkens, H. G. M. (2013). Is Europe still heading to a common price level for on-patent medicines? An exploratory study among 15 Western European countries. Health Policy, 112(3), 209-16. [DOI]
Leopold, C., Vogler, S., Habl, C., Mantel-Teeuwisse, A. K., & Espin, J. (2013). Personalised medicine as a challenge for public pricing and reimbursement authorities – A survey among 27 European countries on the example of trastuzumab. Health Policy, 113(3), 313-22.
2012
Wetenschappelijke publicaties
Leopold, C., Vogler, S., Mantel-Teeuwisse, A. K., de Joncheere, K., Leufkens, H. G. M., & Laing, R. (2012). Differences in external price referencing in Europe: a descriptive overview. Health Policy, 104(1), 50-60. [DOI]
Leopold, C., Mantel-Teeuwisse, A. K., Seyfang, L., Vogler, S., de Joncheere, K., Laing, R. O., & Leufkens, B. (2012). Impact of external price referencing on medicine prices - a price comparison among 14 European countries. Southern Med Review, 5(2), 34-41.
2011
Wetenschappelijke publicaties
Vogler, S., Zimmermann, N., Leopold, C., & de Joncheere, K. (2011). Pharmaceutical policies in European countries in response to the global financial crisis. Southern Med Review, 4(2), 22-32. [DOI]
2007
Wetenschappelijke publicaties
Fröschl, B., Arts, D., & Leopold, C. (2007). Corticosteroid therapy in the treatment of pediatric patients with atopic dermatitis. GMS. Health technology assessment, 3, Article Doc09.