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Dr. B.R. (Bas) Leeflang

Projectmanager 
Geowetenschappen
Faculteitsbureau
Onderzoekszaken
Onderzoekszaken
Vening Meineszgebouw A
Princetonlaan 8a
Kamer 5.52
3584 CB Utrecht

Dr. B.R. (Bas) Leeflang

Projectmanager
Onderzoekszaken
030 253 4980
b.r.leeflang@uu.nl
Profiel Publicaties Contact
Profiel Publicaties Contact
Vaardigheden
Onderzoeksthema's

Sleutelpublicaties

van Meer, G., Leeflang, B. R., Liebisch, G., Schmitz, G., & Goñi, F. M. (2007). The European Lipidomics Initiative: enabling technologies. Methods in Enzymology, 213-232. https://doi.org/10.1016/S0076-6879(07)32009-0
van Leeuwen, S. S., Leeflang, B. R., Gerwig, G. J., & Kamerling, J. P. (2008). Development of a 1H NMR structural-reporter-group concept for the primary structural characterisation of α-D-glucans. Carbohydrate Research, 343(6), 1114-1119. https://doi.org/10.1016/j.carres.2008.01.043
https://dspace.library.uu.nl/bitstream/handle/1874/33239/6CAR4568.pdf?sequence=1
von der Lieth, C-W., Freire, A. A., Blank, D., Campbell, M. P., Ceroni, A., Damerell, D. R., Dell, A., Dwek, R. A., Ernst, B., Fogh, R., Frank, M., Geyer, H., Geyer, R., Harrison, M. J., Henrick, K., Herget, S., Hull, W. E., Ionides, J., Joshi, H. J., ... Haslam, S. M. (2011). EUROCarbDB: An open-access platform for glycoinformatics. Glycobiology, 21(4), 493-502. https://doi.org/10.1093/glycob/cwq188
De Beer, T., Van Zuylen, C. W., Leeflang, B. R., Hård, K., Boelens, R., Kaptein, R., Kamerling, J. P., & Vliegenthart, J. F. (1996). NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit. European Journal of Biochemistry, 241(1), 229-42.
Leeflang, B. R., Vliegenthart, J. F. G., Kroon-Batenburg, L. M. J., Van Eijck, B. P., & Kroon, J. (1992). A1H-NMR and MD study of intramolecular hydrogen bonds in methyl β-cellobioside. Carbohydrate Research, 230(1), 41-61. https://doi.org/10.1016/S0008-6215(00)90512-3
Kamerling, J. P., Geyer, R., Leeflang, B. R., Altmann, F., Dell, A., Holst, O., Jerala, R., Puzo, G., Sonnino, S., & Widmalm, G. (2006). Structural medicine: the Importance of glycomics for health and disease. European Science Foundation Policy Briefing, 27, 1-6.
https://dspace.library.uu.nl/bitstream/handle/1874/20059/ESFStructuralMedicine.pdf?sequence=1
Kroon, J., Kroon-Batenburg, L. M. J., Leeflang, B. R., & Vliegenthart, J. F. G. (1994). Intramolecular versus intermolecular hydrogen bonding in solution. Journal of Molecular Structure, 322(1), 27-31. https://doi.org/10.1016/0022-2860(94)87018-7
DEWAARD, P., Leeflang, B. R., Vliegenthart, J., BOELENS, R., VUISTER, GW., & KAPTEIN, R. (1992). APPLICATION OF 2D AND 3D NMR EXPERIMENTS TO THE CONFORMATIONAL STUDY OF A DIANTENNARY OLIGOSACCHARIDE. Journal of Biomolecular NMR, 2(3), 211-226.
Blanchard, V., Frank, M., Leeflang, B. R., Boelens, R., & Kamerling, J. P. (2008). The structural basis of the difference in sensitivity for PNGase F in the De-N-glycosylation of the native bovine pancreatic ribonucleases B and BS. Biochemistry, 47(11), 3435-3446.
https://dspace.library.uu.nl/bitstream/handle/1874/33297/532.pdf?sequence=1

Publicaties

2011

Wetenschappelijke publicaties

von der Lieth, C-W., Freire, A. A., Blank, D., Campbell, M. P., Ceroni, A., Damerell, D. R., Dell, A., Dwek, R. A., Ernst, B., Fogh, R., Frank, M., Geyer, H., Geyer, R., Harrison, M. J., Henrick, K., Herget, S., Hull, W. E., Ionides, J., Joshi, H. J., ... Haslam, S. M. (2011). EUROCarbDB: An open-access platform for glycoinformatics. Glycobiology, 21(4), 493-502. https://doi.org/10.1093/glycob/cwq188

2010

Wetenschappelijke publicaties

Juan Hernandez-Gay, J., Arda, A., Eller, S., Mezzato, S., Leeflang, B. R., Unverzagt, C., Javier Canada, F., & Jimenez-Barbero, J. (2010). Insights into the Dynamics and Molecular Recognition Features of Glycopeptides by Protein Receptors: The 3D Solution Structure of Hevein Bound to the Trisaccharide Core of N-Glycoproteins. Chemistry-A European Journal, 16(35), 10715-10726. https://doi.org/10.1002/chem.201000939

2008

Wetenschappelijke publicaties

van Meer, G., Spener, F., Leeflang, B. R., Beisiegel, U., Bougnoux, P., Goñi, F. M., Griffiths, W., Hartmann, T., Helms, J. B., Hoekstra, D., Julià-Sapé, M., Larijani, B., Moschetta, A., Mouritsen, O. G., Danilo Norata, G., Payrastre, B., Record, M., Schmitz, G., Simons, K., ... Wanders, R. J. A. (2008). Structure Medicine II: The Importance of Lipidomics for Health and Disease. In European Science Foundation Policy Breefing European Science Foundation Policy Briefing. http://www.esf.org/fileadmin/Public_documents/Publications/SPB31_StructuralMedicineII.pdf
Blanchard, V., Frank, M., Leeflang, B. R., Boelens, R., & Kamerling, J. P. (2008). The structural basis of the difference in sensitivity for PNGase F in the De-N-glycosylation of the native bovine pancreatic ribonucleases B and BS. Biochemistry, 47(11), 3435-3446.
https://dspace.library.uu.nl/bitstream/handle/1874/33297/532.pdf?sequence=1
Blanchard, V., Gadkari, R. A., George, A. V. E., Roy, S., Gerwig, G. J., Leeflang, B. R., Dighe, R. R., Boelens, R., & Kamerling, J. P. (2008). High-level expression of biologically active glycoprotein hormones in Pichia pastoris strains : selection of strain GS115, and not X-33, for the production of biologically active N-glycosylated 15N-labeled phCG. Glycoconjugate Journal, 25, 245-257.
van Leeuwen, S. S., Leeflang, B. R., Gerwig, G. J., & Kamerling, J. P. (2008). Development of a 1H NMR structural-reporter-group concept for the primary structural characterisation of α-D-glucans. Carbohydrate Research, 343(6), 1114-1119. https://doi.org/10.1016/j.carres.2008.01.043
https://dspace.library.uu.nl/bitstream/handle/1874/33239/6CAR4568.pdf?sequence=1

2007

Wetenschappelijke publicaties

van Meer, G., Leeflang, B. R., Liebisch, G., Schmitz, G., & Goñi, F. M. (2007). The European Lipidomics Initiative: enabling technologies. Methods in Enzymology, 213-232. https://doi.org/10.1016/S0076-6879(07)32009-0
Blanchard, V., Chevalier, F., Imberty, A., Leeflang, B. R., Sugahara, K., & Kamerling, J. P. (2007). Conformational studies on five octasaccharides isolated from chondroitin sulfate using NMR spectroscopy and molecular modeling. Biochemistry, 46, 1167-1175.
https://dspace.library.uu.nl/bitstream/handle/1874/27470/4.%2520Blanchard.pdf?sequence=1
Blanchard, V., Gadkari, R. A., Gerwig, G. J., Leeflang, B. R., Dighe, R. R., & Kamerling, J. P. (2007). Characterization of the N-linked oligosaccharides from human chorionic gonadotropin expressed in the methylotrophic yeast Pichia pastoris. Glycoconjugate Journal, 24, 33-47.
https://dspace.library.uu.nl/bitstream/handle/1874/27466/1.%2520Blanchard.pdf?sequence=1
Jongen, S. P., Gerwig, G. J., Leeflang, B. R., Koles, K., Mannesse, M. L. M., van Berkel, P. H. C., Pieper, F. R., Kroos, M. A., Reuser, A. J. J., Zhou, Q., Jin, X., Zhang, K., Edmunds, T., & Kamerling, J. P. (2007). N-glycans of recombinant human acid α-glucosidase expressed in the milk of transgenic rabbits. Glycobiology, 17(6), 600-619.
https://dspace.library.uu.nl/bitstream/handle/1874/27471/6.%2520Jongen%2520.pdf?sequence=1

2006

Wetenschappelijke publicaties

AB, E., Atkinson, A. R., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, K., Diercks, T., Doetsch, V., Engelke, F., Folkers, G. E., Griesinger, C., Gronwald, W., Gunther, U., Habeck, M., de Jong, R. N., Kalbitzer, H. R., Kieffer, B., Leeflang, B. R., Loss, S., ... Kaptein, R. (2006). NMR in the SPINE Structural Proteomics project. Acta crystallographica. Section D, biological crystallography, D62, 1150-1161.
https://dspace.library.uu.nl/bitstream/handle/1874/20122/514.pdf?sequence=1
van Kuik, J. A., Vincent, S. J. F., Leeflang, B. R., Kroon-Batenburg, L. M. J., & Kamerling, J. P. (2006). Conformational analysis in aqueous solution and estimation of the persistence length of exopolysaccharides produced by Lactobacillus helveticus Lh59 and Streptococcus macedonicus Sc136. Canadian Journal of Chemistry, 84(4), 730-742.
https://dspace.library.uu.nl/bitstream/handle/1874/20060/Can%2520J%2520Chem%2520%2520730%2520742.pdf?sequence=1
Leeflang, B. R., van Kuik, J. A., & Kroon-Batenburg, L. M. J. (2006). Oligosaccharides and cellulose crystal surfaces: computer simulations. A.C.S. symposium series, 930, 133-155.
Kamerling, J. P., Geyer, R., Leeflang, B. R., Altmann, F., Dell, A., Holst, O., Jerala, R., Puzo, G., Sonnino, S., & Widmalm, G. (2006). Structural medicine: the Importance of glycomics for health and disease. European Science Foundation Policy Briefing, 27, 1-6.
https://dspace.library.uu.nl/bitstream/handle/1874/20059/ESFStructuralMedicine.pdf?sequence=1

2002

Wetenschappelijke publicaties

Gerwig, G. J., Van Albert Kuik, J., Leeflang, B. R., Kamerling, J. P., Vliegenthart, J. F. G., Karr, C. D., & Jarroll, E. L. (2002). The Giardia intestinal filamentous cyst wall contains a novel β(1-3)-N-acetyl-D-galactosamine polymer: A structural and conformational study. Glycobiology, 12(8), 499-505. https://doi.org/10.1093/glycob/cwf059
van der Stelt, M., van Kuik, J. A., Bari, M., van Zadelhoff, G., Leeflang, B. R., Veldink, G. A., Finazzi-Agro, A., Vliegenthart, J. F. G., & Maccarone, M. (2002). Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. Journal of Medicinal Chemistry, 45, 3709-3720.
Gerwig, G. J., van Kuik, J. A., Leeflang, B. R., Kamerling, J. P., Vliegenthart, J. F. G., Karr, C. D., & Jaroll, E. L. (2002). The Giardia intestinalis filamentous cyst wall contains a novel b(1-3)-N-acetyl-D-galactosamine polymer: a structural and conformational study. Glycobiology, 12, 499-505.

2000

Wetenschappelijke publicaties

Jiménez Blanco, J. L., Van Rooijen, J. J. M., Erbel, P. J. A., Leeflang, B. R., Kamerling, J. P., & Vliegenthart, J. F. G. (2000). Conformational analysis of the Sd(a) determinant-containing tetrasaccharide and two mimics in aqueous solution by using 1H NMR ROESY spectroscopy in combination with MD simulations. Journal of Biomolecular NMR, 16(1), 59-77. https://doi.org/10.1023/A:1008300916721
Jimenez Blanco, J. L., van Rooijen, J. J. M., Erbel, P. J. A., Leeflang, B. R., Kamerling, J. P., & Vliegenthart, J. F. G. (2000). Conformational analysis of the Sda determinant-containing tetrasaccharide and two mimics in aqeous solution by using 1H NMR ROESY spectroscopy in combination with MD simulations. Journal of Biomolecular NMR, 16, 59-77.
Leeflang, B. R., Faber, E. J., Erbel, P. J. A., & Vliegenthart, J. F. G. (2000). Structure elucidation of glycoprotein glycans and of polysaccharides by NMR spectroscopy. Journal of Biotechnology, 77, 115-122.
Setten, D. C., Zomer, G., Werken, G., Wiertz, E. J. H. J., Leeflang, B. R., & Kamerling, J. P. (2000). Ion trap multiple-stage tandem mass spectrometry as a pre-NMR tool in the structure elucidation of saponins. Phytochemical Analysis, 11, 190-198.

1998

Wetenschappelijke publicaties

Thijssen-Van Zuylen, C. W. E. M., De Beer, T., Leeflang, B. R., Boelens, R., Kaptein, R., Kamerling, J. P., & Vliegenthart, J. F. G. (1998). Mobilities of the inner three core residues and the Man(α1→6) branch of the glycan at Asn78 of the α-subunit of human chorionic gonadotropin are restricted by the protein. Biochemistry, 37(7), 1933-1940. https://doi.org/10.1021/bi9718548

1996

Wetenschappelijke publicaties

De Beer, T., Van Zuylen, C. W. E. M., Leeflang, B. R., Hård, K., Boelens, R., Kaptein, R., Kamerling, J. P., & Vliegenthart, J. F. G. (1996). NMR studies of the free or subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the β subunit on the conformation of the α subunit. European Journal of Biochemistry, 241(1), 229-242.
De Beer, T., Van Zuylen, C. W., Leeflang, B. R., Hård, K., Boelens, R., Kaptein, R., Kamerling, J. P., & Vliegenthart, J. F. (1996). NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit. European Journal of Biochemistry, 241(1), 229-42.
van den Berg, A. J. J., Horsten, S. F. A. J., Kettenes-van den Bosch, J. J., Beukelman, C. J., Kroes, B. H., Leeflang, B. R., & Labadie, R. P. (1996). Podacycline A and B, two cyclic peptides in the latex of Jatropha Podagrica. Phytochemistry, 42, 129-133.
Horsten, S. F. A. J., van den Berg, A. J. J., Kettenes-van den Bosch, J. J., Leeflang, B. R., & Labadie, R. P. (1996). Cyclogossine A: a novel cyclic hepta-peptide isolated from the latex of Jatropha gossypifolia. Planta Medica, 62, 46-50.

1994

Wetenschappelijke publicaties

Kroon, J., Kroon-Batenburg, L. M. J., Leeflang, B. R., & Vliegenthart, J. F. G. (1994). Intramolecular versus intermolecular hydrogen bonding in solution. Journal of Molecular Structure, 322(1), 27-31. https://doi.org/10.1016/0022-2860(94)87018-7

1993

Wetenschappelijke publicaties

Timmermans, J. W., De Waard, P., Tournois, H., Leeflang, B. R., & Vliegenthart, J. F. G. (1993). NMR spectroscopy of nystose. Carbohydrate Research, 243(2), 379-384. https://doi.org/10.1016/0008-6215(93)87041-P
Kroon-Batenburg, L. M. J., Kroon, J., Leeflang, B. R., & Vliegenthart, J. F. G. (1993). Conformational analysis of methyl β-cellobioside by ROESY NMR spectroscopy and MD simulations in combination with the CROSREL method. Carbohydrate Research, 245(1), 21-42. https://doi.org/10.1016/0008-6215(93)80057-L

1992

Wetenschappelijke publicaties

DEWAARD, P., Leeflang, B. R., Vliegenthart, J., BOELENS, R., VUISTER, GW., & KAPTEIN, R. (1992). APPLICATION OF 2D AND 3D NMR EXPERIMENTS TO THE CONFORMATIONAL STUDY OF A DIANTENNARY OLIGOSACCHARIDE. Journal of Biomolecular NMR, 2(3), 211-226.
Leeflang, B. R., Vliegenthart, J. F. G., Kroon-Batenburg, L. M. J., Van Eijck, B. P., & Kroon, J. (1992). A1H-NMR and MD study of intramolecular hydrogen bonds in methyl β-cellobioside. Carbohydrate Research, 230(1), 41-61. https://doi.org/10.1016/S0008-6215(00)90512-3

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