dr. ir. B.J.C. (Bert) Janssen
Gegenereerd op 2018-09-22 13:08:52


Bert Janssen studied Molecular Sciences at Wageningen University (MSc 2002), followed by a PhD (2007) in structural biology at Utrecht University that was awarded cum laude. During his PhD he addressed questions central to human immunology by solving crystal structures of the large complement component C3 and its activation products C3b and C3c. This revealed in detail the intricate architecture of C3 consisting of 13 domains that act in unison to protect a highly reactive group from activation and marked conformational changes of 12 domains that fully expose the reactive group upon activation of C3 into C3b. From 2008 until 2011 he was a postdoctoral fellow at the University of Oxford in the lab of Prof. Yvonne Jones, funded by a HFSP fellowship. In Oxford he elucidated the molecular mechanism underlying semaphorin-plexin function in neuronal connectivity. In July 2011 he returned to Utrecht University to start his own group to work on molecular signalling processes that are critical for the homeostasis and functioning of the central nervous system. In 2012 he was awarded a starting independent researcher grant (VIDI) from the Netherlands Organisation for Scientific Research (NWO) and he became a team leader in the Marie Curie Initial Training Network "ManiFold". In 2015 he was awarded a Starting Grant from the European Research Council (ERC) to further strengthen his research team and he was one of the UU Young Investigators Forum founders.

Gegenereerd op 2018-09-22 13:08:52
Curriculum vitae

Positions and degrees

09/2012 – Present

Group leader (Assist. Prof.)

Utrecht University, Molecular mechanisms of intercellular signalling

07/2011 – 08/2012

Junior principal investigator

Utrecht University, Molecular mechanisms of neuropilin-semaphorin-plexin axon guidance signalling

07/2008 – 06/2011

Postdoctoral fellow

University of Oxford, Structural and biophysical analyses of semaphorin-plexin axon guidance signalling

04/2007 – 06/2008

Postdoctoral researcher

Utrecht University, Structural studies on the complement convertase complexes



Structural biology at Utrecht University, title: Conformational Complexity of Complement Component C3 (cum laude)

10/2002 – 03/2007

PhD candidate

Utrecht University, Conformational Complexity of Complement Component C3

07/2000 – 06/2002


Molecular Sciences at Wageningen University, focus on biochemistry and structural biology

09/1997 – 06/2000


Molecular Sciences at Wageningen University, focus on chemistry and biochemistry


Awards and selected grants

  • ERC starting grant (2015)
  • VIDI starting independent researcher grant from NWO (2012)
  • PUG prize, for best thesis in the past five years from the Faculties of Science and Geosciences at Utrecht University (2011)
  • Human Frontier Science Program (HFSP) Long-Term Fellowship (2009)
  • Marie Curie Intra European Fellowship (2009) (awarded but not used)
  • Research Fellow, Wolfson College, Oxford University, January 2009-June 2011
  • HGK Westenbrink prize, for best thesis in biochemistry and molecular biology in the year 2007-2008 in the Netherlands awarded by the Netherlands Society for Biochemistry and Molecular Biology
  • Ph.D. awarded cum laude (highest possible grade, top 5%)
  • IUCr Journals Prize for best poster, 38th Course, Structure and function of large molecular assemblies, Erice Italy, 2006
  • Best Ph.D. Student, Bijvoet Graduate School for Biomolecular Chemistry, Utrecht NL, 2006


Full publication list in PubMed

For citations see ResearcherID

Gegenereerd op 2018-09-22 13:08:52

Selected Publications


N. Leloup, L.M.P. Chataigner and B.J. Janssen. (2018) ‘Structural insights into SorCS2-Nerve Growth Factor complex formation.’ Nature Comms 9:2979 1-10


N. Leloup, P. Lössl, D.H. Meijer, M. Brennich, A.J. Heck, D.M. Thies-Weesie and B.J. Janssen. (2017) ‘Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.’ Nature Comms 8:1708 1-16


L.H.J. Kleijn*, H.C Vlieg*, T.M. Wood, J. Sastre Toraño, B.J. Janssen# and N.I. Martin#. (2017) ‘High-resolution crystal structure reveals molecular details of target recognition by the calcium-dependent lipopeptide antibiotic laspartomycin C.’ Angew Chem Int Ed  56 16546-16549 *Equal contribution, #Co-corresponding


M.F. Pronker, S. Lemstra, J. Snijder, A.J. Heck, D.M. Thies-Weesie, R.J. pasterkamp and B.J. Janssen. (2016) ‘Structural basis of myelin-associated glycoprotein adhesion and signalling.’ Nature Comms 7 1-13


Y. Kong*, B.J. Janssen*, T. Malinauskas, V.R. Vangoor, C.H. Coles, R. Kaufmann, T. Ni, R.J. Gilbert, S. Padilla-Parra, R.J. Pasterkamp and E.Y Jones. (2016) ‘Structural Basis for Plexin Activation and Regulation.’ Neuron 91 548-560

*Equal contribution


M.F. Pronker, T.G. Bos, T.H. Sharp, D.M. Thies-Weesie and B.J. Janssen. (2015) ‘Olfactomedin-1 has a V-shaped disulfide-linked tetrameric structure.’ J Biol Chem 290 15092-15101

B.J. Janssen*, T. Malinauskas*, G.A. Weir, M.Z. Cader, C. Siebold and E.Y. Jones. (2012) ‘Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.’ Nat Struct Mol Biol 19 1293-1299
*Equal contribution

B.J. Janssen*, R.A. Robinson*, F. Perez-Branguli, C.H. Bell, K.J. Mitchell, C. Siebold and E.Y. Jones. (2010) ‘Structural basis of semaphorin-plexin signalling.’ Nature 467 1118-1122
*Equal contribution

B.J. Janssen, A. Christodoulidou, A. McCarthy, J.D. Lambris and P. Gros. (2006) 'Structure of C3b reveals conformational changes that underlie complement activity.' Nature 444 213-216

B.J. Janssen, E.G. Huizinga, H.C. Raaijmakers, A. Roos, M.R. Daha, K. Nilsson-Ekdahl, B. Nilsson and P. Gros. (2005) 'Structures of complement component C3 provide insights into the function and evolution of immunity.' Nature 437 505-511

Full publication list in PubMed


Alle publicaties
  2017 - Wetenschappelijke publicaties
Kleijn, Laurens H. J., Vlieg, Hedwich C., Wood, Thomas M., Sastre Torano, Javier, Janssen, Bert J. C. & Martin, Nathaniel I. (22-12-2017). A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C. Angewandte Chemie-International Edition, 56 (52), (pp. 16546-16549).
Leloup, Nadia, Lössl, Philip, Meijer, Dimphna H, Brennich, Martha, Heck, Albert J R, Thies-Weesie, Dominique M E & Janssen, Bert J C (22-11-2017). Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nature Communications, 8 (1), (pp. 1708).
Pronker, Matti F., Tas, Roderick P., Vlieg, Hedwich C. & Janssen, Bert J. C. (01-11-2017). Nogo Receptor crystal structures with a native disulfide pattern suggest a novel mode of self-interaction. Acta Crystallographica Section D Structural Biology, 73 (11), (pp. 860-876).
  2016 - Wetenschappelijke publicaties
Van 't Veer, Inge Leonie, Leloup, Nadia, Egan, Alexander, Janssen, Bert, Martin, Nathaniel, Vollmer, Waldemar & Breukink, Eefjan (2016). Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem, (pp. 1-8) (9 p.). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
Kong, Youxin, Janssen, Bert J C, Malinauskas, Tomas, Vangoor, Vamshidhar R., Coles, Charlotte H., Kaufmann, Rainer, Ni, Tao, Gilbert, Robert J C, Padilla-Parra, Sergi, Pasterkamp, R. Jeroen & Jones, E. Yvonne (03-08-2016). Structural Basis for Plexin Activation and Regulation. Neuron, 91 (3), (pp. 548-560) (13 p.).
Pronker, M.F., Lemstra, Suzanne, Snijder, J., Heck, A.J.R., Thies - Weesie, Dominique, Pasterkamp, R Jeroen & Janssen, B.J.C. (06-12-2016). Structural basis of myelin-associated glycoprotein adhesion and signalling. Nature Communications, 7, (pp. 1-13) (13 p.).
Burgers, Pepijn P, Bruystens, Jessica, Burnley, Rebecca J, Nikolaev, Viacheslav O, Keshwani, Malik, Wu, Jian, Janssen, Bert J C, Taylor, Susan S, Heck, Albert J R & Scholten, Arjen (2016). Structure of smAKAP and its regulation by PKA-mediated phosphorylation. The FEBS journal This article is protected by copyright. All rights reserved..
  2015 - Wetenschappelijke publicaties
Pronker, Matti F, Bos, Trusanne G A A, Sharp, Thomas H, Thies-Weesie, Dominique M E & Janssen, Bert J C (21-04-2015). Olfactomedin-1 has a V-shaped disulfide-linked tetrameric structure. Journal of Biological Chemistry
^ naar boven
Gegenereerd op 2018-09-22 13:08:52

Afgesloten projecten

ManiFold 01-09-2012 tot 31-08-2016
Algemene projectbeschrijving

ManiFold is an Innovative Doctoral Programme organised by members of the Bijvoet Center for Biomolecular Research and its Graduate Research School, at Utrecht University in the Netherlands. The European Union selected the most innovative doctoral programmes in Europe for funding in the prestigious Marie-Curie Initial Training Networks scheme. ManiFold was the only Innovative Doctoral Programme in the Life Sciences funded in 2012.

Rol: Uitvoerder Financiering
3e geldstroom - EU
Gegenereerd op 2018-09-22 13:08:52


Gegenereerd op 2018-09-22 13:08:52
Volledige naam
dr. ir. B.J.C. Janssen Contactgegevens
Hugo R. Kruytgebouw

Padualaan 8
Kamer N810

Telefoonnummer direct 030 253 2866
Ma Di Wo Do Vr
Gegenereerd op 2018-09-22 13:08:52
Laatst bijgewerkt op 16-08-2018