Courses

RMT specific

Cardiac Regenerative Medicine

Period (from - till): 27 January 2020 - 7 February 2020
Lecturer(s):
Lectures are provided by (guest) lecturers from the Hubrecht Institute, UMCU, and other national cardiac RM experts. Working groups are administered by guest lecturers from UMCU. Laymen and/or patients are involved in assignment(s).

Course description:
In this course the student will get acquainted with the application of regenerative medicine in cardiac diseases. Subjects like cardiac development, reprogramming, RM treatment options including non-cell based therapies and translational cardiac RM are addressed. In addition, students are introduced in the interpretation and processing of study data, and get acquainted with the impact of research on society, in particular on patients. The course consists of lectures, interactive meetings, an exam, and a group assignment, supervised by experts and laymen.

Literature/study material used:
- Primary literature
- E-module
- Textbook Medical Physiology (background information)

Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.

Mandatory for students in own Master’s programme:
For BoD students: this course is one of the specific cardiovascular BoD-courses. Additional to the mandatory Kick off course, BoD students should accomplish 12 EC with specific (cardiovascular) BoD courses.

Optional for students in other GSLS Master’s programme:
Yes. RMT and BoD students have priority for enrollment.

Prerequisite knowledge:
Bachelor in Life Sciences and basic knowledge about cell biology and cardiac physiology.

Introduction to Regenerative Medicine and Technology

Period (from – till): (2 sept - 6 sept 2019 ILS) 2 September 2019 - 8 November 2019
Faculty
Lectures will be provided by course coordinators and guest lecturers from the UU, UMCU and TU/e. Working groups and tutorials will be administered by the guest lecturers and/or the course coordinators. Writing of research proposals will be supervised RM doctoral candidates from the UU, UMC and TU/e.

Description of contentThe course will consist of a programme for 10 weeks, divided in 2 major blocks (A and B). This course provides the students with a broad overview and background in ‘Regenerative Medicine and Technology’. Lectures, assignments and group projects will prepare the students for research using tissue regeneration technologies.

The lay-out of the ten weeks will be as follows:

Week 1: ILS Introduction week of the Graduate School of Life Sciences including specific RMT intro

Weeks 2-7: Block A: Lectures, journal clubs and peer teaching with focus on molecular cell biology, stem cells, biomaterials, tissues (expert lectures), biomechanics and biofabrication. Also, an individual ethics assignment is part of this block before it will be concluded by an exam.

Weeks 8-10: Block B: Writing of research proposal (in small groups) and closing session with poster presentation.

Contact hours will be equally distributed between Eindhoven and Utrecht.
In block A, daily classes in the form of lectures, peer teaching, and discussions will cover basic regenerative medicine and technology topics from textbooks, e.g. organogenesis, embryogenesis, biomechanics and imaging techniques (for a more detailed description the student is referred to the block book). Self-study/preparation time for the journal clubs (on literature provided by the experts on their topic) and expert lectures. In addition to this, groups will write a short opinion article on an ethical issue in RM.
The group project in Block B consists of writing a research proposal that is aimed at the regeneration of a specific tissue (e.g. heart valve, cartilage). Information from block A will be incorporated into the research proposals under supervision of a tissue specific expert so that the student can directly apply the knowledge obtained. At the end of the block, the groups will present their proposal to representatives of the Regenerative Medicine and Technology program committee and each other in the form of a poster session.

Literature/study material used:

Study material for this course:
Block book (will be provided).
Principles of Regenerative Medicine (Second Edition 2011). Atala et al. Academic Press, Elsevier.
For the journal clubs/expert lectures, literature will be provided by the individual lecturers.
Optional: Biomechanics: concepts and computation by Oomens, Brekelmans and Baaijens (2009)

Registration:
Students of RMT will be automatically enrolled in this course. Please send an email to rmt@umcutrecht.nl before August 30th, 2019 to confirm your participation in the programme.

Mandatory for students in own Master’s programme:
Yes

Optional for students in other GSLS Master’s programme:
No

Prerequisite knowledge:
You must have a study entrance permit for RMT.
Note: This is an overview course. If you notice that you are underqualified to understand what is taught at a particular part of the course, you should become acquainted through self-study or by following dedicated elective courses.

Pre-knowledge and/or self-study:
Molecular biology of the cell. Alberts et al, fifth edition (2007).
Principles of Regenerative Medicine (Second Edition 2011). Atala et al. Academic Press, Elsevier. Ch. 1,3,6,9,18,19

Introduction to Stem Cells

Period (from – till): 6 January 2020 - 17 January 2020

Faculty
Koen Braat, Cell Biology, UMC Utrecht, Course Director
Paul Coffer, Cell Biology, UMC Utrecht, Course Director
Niels Geijsen, Hubrecht Laboratory, Course Director
Geijsen, organizer theme day
Robin, organizer theme day
Van Rooij, organizer 0.5 theme day
Gawlitta, organizer 0.5 theme day
Middendorp, organizer theme day and “closing” seminar
Description of content
Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity. Second, under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions. In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions. Given their unique regenerative abilities, stem cells offer new potentials for treating disease.

This 5-day course will address both fundamental mechanisms regulating stem cell function as well as considerations concerning the use of stem cell therapies in the clinic.

Literature/study material used:
Primary literature to be provided by course directors and guest speakers

Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Maximum number of participants is 50 students.

Mandatory for students in Master’s programme
N.A.

Optional for students in other GSLS Master’s programme:
Yes. Registrations from Master and PhD students of the CSDB and RMT programs will be considered first
Prerequisite knowledge
Bsc BMW / Biology knowledge of molecular and cellular biology; interest in regenerative medicine and stem cell biology

Microfabrication Methods (4UM00)

Period (from – till): This course is taught twice: Quartiles 1 and 4, time slot B (Mo 5-8, Th 9-10, We 1-4); 2 sept - 8 nov 2019 and 20 april - 3 july 2020

Faculty
responsible lecturer: prof.dr.ir. J.M.J. den Toonder
co-lecturer: dr. R. Luttge
instructors: ir. F.G.A. Homburg, S. Sahebali MSc,
Information: Secr. Microsystems - GEM-Z 3.132 - 5706
prof.dr.ir. J.M.J. den Toonder - GEM-Z 3.130 – 2987

Description of contentPLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN.

Advanced products such as mobile phones and modern (bio-) medical devices are manufactured using special, modern technologies. These micro-fabrication methods make it possible to structure and combine materials on a (sub) micrometer scale. Knowledge and experience with these methods is essential for the advanced manufacturing industry, e.g. at companies like ASML, NXP, Philips, but also many small companies developing sensors, actuators, and other advanced components and devices. In this course, you will learn about the most important methods; the principles, advantages, and disadvantages, will be explained. As part of the course, you will design, make, and test a device yourself in the TU/e Microfab Lab.
Topics:

•scaling and mamufacturing thin film deposition
•lithography, etching
•soft lithography
•micro molding techniques
•additive manufacturing, 3D printing
•mechanical machining methods
•laser microfabrication with various lasertypes and materials
•applications
•practical sessions: design, fabricate, and test a microsystem

Literature/study material used:
Syllabus
Slides from lectures
Instructions for practical sessions
Selected review articles

Registration:
register in Eindhoven. Due to limitations regarding the practical sessions, enrolment in the course is limited to a maximum of 30 students.
Please register at the TU/e, course code: 4UM00. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No.

Optional for students in other GSLS Master’s programme:
No, only for RMTM students.

Prerequisite knowledge:
For this course no specific prior knowledge is required

Vascularized Tissue Engineering online course

Period (from – till): 4 February - 31 March 2019
Note: this is an online course stretching over 7 weeks with a study load of approximately 9-10 hours per week. Please take into account that the studyload is divided over the week so you will need to be able to login on various moments (taking into account vacation days).
The e-moderator will keep track of your progression. He/she will score the quality of the content and your responses on all required activities. This results in ‘insufficient, ‘sufficient’ or ‘good’. You need at least a 5.5 for all three individual components to pass the course. ​

Course coordinator: Dr. Caroline Cheng/Dr. Joost Fledderus
Lecturer: Merle Maas-Krebber, MSc

Course description:
Tissue engineering (TE) is an ever-growing multidisciplinary scientific field aiming at replacing injured, missing or damaged tissue. Current researchers in the field use different principles, knowledge and techniques from (stem) cell biology, vascular biology, medicine, biomaterials and bioengineering. Vascular and vascularized tissue engineering take prominent places within this field. The construction of blood vessels is both an independent target for replacement therapy as well as an integral part of larger constructs. A crucial challenge in obtaining large sized functional TE scaffolds (>1 milimeter in any dimensional space) is how to introduce a complex vascular tree that supplies a steady medium and blood stream for the expanding tissue to meet oxygen en nutrient demands.
This course teaches Master students’ in-depth and hands-on knowledge on developmental and adult blood vessel formation in health and disease and the current clinical treatments for which vascular(ized) TE is thought to be eligible. Moreover, we will address state of the art techniques of vascular(ized) TE, including the use of biomaterials and cell sources for bioreactor-cultured and in situ applications.

This course teaches fundamental knowledge on vascular and vascularized tissue engineering, adding significantly to the currently available curriculum concerning angiogenesis, vascular repair and remodeling, regenerative medicine and cardiovascular disease. Participants in this e-course will benefit from the flexible work hours, enabling participation parallel to writing a thesis or doing an internship abroad. This course was developed using collaborative partners leading in regenerative medicine and cardiovascular disease. Grading of this course will be based on handing in a graphical abstract (group assignment), an individual assignment and on individual participation during the course and in discussion forums.

Required Materials:
N.A.

Mandatory for students in Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Open as an elective to GSLS students from the programmes RM&T, BFAB & BOD.

Registration:
Please register via the Study guide. Deadline for registration is January 25th. The maximum of participants is 16.
Students from outside the Graduate School of Life Sciences can register for this course by sending an email to m.m.krebber@umcutrecht.nl (link sends e-mail). Please include your name, student number, Master’s programme and the course code.

Prerequisite knowledge:
Master student RMT, BOD, Biofab

Courses offered in Eindhoven

Biomaterials (8SM20)

Period:Quartile 3, timeslot C (C – Tu 1-4, Fr 5-8), 3 February - 17 April 2020

FacultyResponsible lecturer: dr. P.Y.W. Dankers
Information: Secr.Institute for Complex Molecular Systems - CE 1.31 - 2482
Co-lecturers:
dr. S. Hofmann Boss
dr. J.J.C. Arts
Visiting lecturer(s)

Course Discription
PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN

Interactions between (synthetic) biomaterials and tissues play a key role when a part of the body is replaced by an implant. At the surface of these implants (e.g. stents, sutures, hip prostheses, heart valves, blood vessels) molecular and microscopic processes determine their fate, so whether the implants ultimately fail or are successful.
This course will introduce you to different classes of biomaterials and will show you which processes play a role at the molecular level at the biomaterial-tissue interface.
Different (possible) subjects will be discussed which are listed below:
- History of biomaterials
- Classes of materials used in medicine
- Polymers, Ceramics, Metals, Biopolymers
- The extracellular matrix
- ECM-derived materials
- Biomaterial properties
- Mechanical properties
- Biocompatibility & host reaction to biomaterials
- In-vitro/in-vivo testing, Foreign Body Response - tissue response, Immune response, Inflammation, Wound healing, Complement system, Blood coagulation and blood-materials interactions, Biofilm formation and infections
- Processing of materials
- Electro-spinning, FDM, Gelation/cryo-gelation, Surface patterning
- Protein-biomaterial interactions
- Non-fouling surfaces
- Biomaterials for regenerative medicine/tissue engineering
- Cell/tissue-biomaterial interactions
- Bioactivation of biomaterials
- Self-assembled biomaterials
- Supramolecular chemistry
- Implants and devices

Literature/study material used:
Biomaterials Science - An Introduction to Materials in Medicine by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Third Edition, Elsevier, 2013 (recommended)
Besides the book Biomaterials Science by Ratner et al. we will discuss several articles from recent literature that will be handed out (or put on OASE) during the course.

Registration:
Please register at the TU/e, course code: 8SM20. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No.

Optional for students in other GSLS Master’s programme:
No.For RMTM students only

Prerequisite knowledge:
8SA00 - Introduction Organic Chemistry (recommended)
8SC00 - Materials science (recommended)
8TA00 - Cell and tissue (recommended)
Additionally advised: Basic tissue engineering, Basic knowledge of materials science (mechanical properties, polymers), of simple chemical structures, and of cell behavior in tissues.

Bone Structure and Function (8TM00)

Period: Quartile 3 - timeslot B (Mo 5-8, Th 9-10, We 1-4), 3 February - 17 April 2020

Faculty
Responsible lecturer: dr.ir. B. van Rietbergen, co-lecturer: Dr S. Hofmann Boss
Information:Secr. and Orthopaedic Biomechanics - GEM-Z 4.115 – 4350

Description of content

PLEASE NOTE THAT THIS COURSE IS TAUGHT AT TU/e

Bone has a load-carrying function in the body, and an associated (micro)structure, which makes it light, as well as stiff and strong. Owing to a stress-controlled biological regulatory mechanism the material is continuously 'maintained' (micro-fractures are removed, while the structure adapts to magnitude and orientation of the external loads). Perturbations in the regulatory mechanism, or the external loads, may cause serious affections, such as congenital deformities, osteoporosis, bone fractures and destruction of the joints. The elective course provides an introduction to the biological regulatory processes in bone, to imaging and mechanical analysis in the clinic and in research, to assessment of strength and the analysis of failure processes, to development, diagnosis and prevention of osteoporosis, to the application of fracture-fixation devices, and to the design, fixation and ingrowth of joint prostheses. The course extends knowlegde of elasticity theory, strength of materials, (micro)fluid transport, computer tomography, MRI, ultrasound, cell biology, computer simulation and animal-experimental models.

Literature/study material used:
Selected scientific publications which will be distributed during the course.

Registration:
Please register at the TU/e, course code: 8TM00. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
No, for RMTM students only

Biomechanics and mechanobiology of cartilaginous tissues (8TM10)

Period (from – till): Quartile 2, timeslot A (A - Mo 1-4, We 9-10, Th 5-8), 11 November 2019 - 31- January 2020

Faculty
Responsible lecturer: dr. C.C. van Donkelaar; co-lecturer: prof. K. Ito
Information:Secr. and Orthopaedic Biomechanics - GEM-Z 4.115 – 4350

Description of contentPLEASE NOTE THAT THIS COURSE IS TAUGHT AT TU/e

With every activity we undertake, there is motion in our joints while they are heavily loaded. In our bodies there are three kinds of joints: synovial, cartilaginous and fibrous. In the former two, a unique type of tissue, cartilage, helps us to overcome this adverse and mechanically challenging environment. In synovial joints, i.e. fluid filled joints, a thin layer of articular cartilage covers the bones and provides an almost frictionless bearing surface. In cartilaginous joints, a complex structure of fibrocartilage provides less mobility but is able to transmit high loads between the bone ends. This course addresses questions such as: how does healthy cartilage deal with these mechanically challenging conditions? What is the interplay between the biomechanics and biology in these tissues? What happens when cartilage damage occurs? What are the most common diseases affecting cartilage? What are current possibilities and challenges in treating joint degeneration?

Literature/study material used:
Will be distributed during the course.

Registration:
Please register at the TU/e, course code: 8TM10. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
No, for RMTM students only.

Prerequisite knowledge:
Basic biomechanics, Basic cell and molecular biology, Basic tissue anatomy and morphology.

Cell Mechanobiology and Engineering

Period (from-till): Quartiles 2, semester A, time slot B (- Mo 5-8, Th 9-10, We 1-4), 11 November 2019 – 31 January 2020

Facultyresponsible lecturer: dr. N.A. Kurniawan
co-lecturer: dr.ir. T.F.A. de Greef
Information: Secr. Soft Tissue Biomechanics and Engineering - GEM-Z 4.115 – 2279
dr. N.A. Kurniawan - GEM-Z 4.102 – 2347

Course Discription
PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN.

Graduate-level course on cellular mechanobiology, covering principles behind physical changes in cell or tissue mechanics during physiology and disease, and how these can be harnessed in regenerative medicine.

•Introduction to mechanobiology
•Mechanosensing and mechanotransduction
•Cell and matrix mechanics
•Cellular and mammalian gene engineering approaches
•Biophysical manipulation
•Measurement techniques
•Reconstructing cell–matrix interactions

The course consists of 7 weeks independent learning under supervision in 2 blocks of 2 hours per week plus 7 weeks lecture in 2 blocks of 2 hours per week.

Literature/study material used:
Study guide
Lecture handouts
Introduction to Cell Mechanics and Mechanobiology, by Jacobs, Huang, Kwon (recommended)
Articles and possible other materials communicated before/during the course

Registration:
Register in Eindhoven with code 8MM40. Osiris registration will be done retroactively when results from the TU/e are received.
​Max 60 students.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
No, for RMTM students only.

Prerequisite knowledge:
Recommended:
8RB00 - Molecular cell biology
8TA00 - Cell and tissue
8TB00 - Continuum mechanics
8WC00 - Regeneration

Clinical Chemistry (8SM00)

Period (from – till): Quartile 1, timeslot B1 (Mo 5-6, We 1-2) - 2 september 2019 - 8 november 2019
​Faculty
Responsible lecturer: prof.dr. V. Scharnhorst - STO 3.39 - 3737
Information: Secr. Biomedical Chemistry - STO 3.39 - 3737
Course descriptionPLEASE NOTE THAT THIS COURSE IS TAUGHT AT TU/e

This course addresses the role of laboratory medicine in health care.
First, the principles of medical decision making with concepts as test specificity and sensitivity and predictive value of laboratory data in relation to prevalence of the disease are reviewed. The influence of physiology and pathophysiology on the concentration of specific analytes in body fluids and methods to analyse these components in modern clinical laboratories are considered. Case histories will be used to illustrate and discuss concepts and applications of clinical chemistry in the diagnostic process. Optional is to visit the clinical laboratory of Catharina Ziekenhuis.

Literature/study material used:
Studyweb BMT (information and hand-outs with power-point presentations) (compulsory)

William J Marshall & Stephen K Bangert, Clinical Chemistry 7th edition (2012), Mosby Elsevier, ISBN-13: 978-0723437031, 50 euro (recommended)

Registration:
Please register at the TU/e, course code: 8SM00. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
No, only open for RMTM students.

Prerequisite knowledge:
•Basic knowledge (bio)chemistry, (cell)biology and (patho)physiology

Microfabrication Methods (4UM00)

Period (from – till): This course is taught twice: Quartiles 1 and 4, time slot B (Mo 5-8, Th 9-10, We 1-4); 2 sept - 8 nov 2019 and 20 april - 3 july 2020

Faculty
responsible lecturer: prof.dr.ir. J.M.J. den Toonder
co-lecturer: dr. R. Luttge
instructors: ir. F.G.A. Homburg, S. Sahebali MSc,
Information: Secr. Microsystems - GEM-Z 3.132 - 5706
prof.dr.ir. J.M.J. den Toonder - GEM-Z 3.130 – 2987

Description of contentPLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN.

Advanced products such as mobile phones and modern (bio-) medical devices are manufactured using special, modern technologies. These micro-fabrication methods make it possible to structure and combine materials on a (sub) micrometer scale. Knowledge and experience with these methods is essential for the advanced manufacturing industry, e.g. at companies like ASML, NXP, Philips, but also many small companies developing sensors, actuators, and other advanced components and devices. In this course, you will learn about the most important methods; the principles, advantages, and disadvantages, will be explained. As part of the course, you will design, make, and test a device yourself in the TU/e Microfab Lab.
Topics:

•scaling and mamufacturing thin film deposition
•lithography, etching
•soft lithography
•micro molding techniques
•additive manufacturing, 3D printing
•mechanical machining methods
•laser microfabrication with various lasertypes and materials
•applications
•practical sessions: design, fabricate, and test a microsystem

Literature/study material used:
Syllabus
Slides from lectures
Instructions for practical sessions
Selected review articles

Registration:
register in Eindhoven. Due to limitations regarding the practical sessions, enrolment in the course is limited to a maximum of 30 students.
Please register at the TU/e, course code: 4UM00. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No.

Optional for students in other GSLS Master’s programme:
No, only for RMTM students.

Prerequisite knowledge:
For this course no specific prior knowledge is required

Microscopy for Biological Samples 8MM10

Period (from – till): Quartile 4, timeslot B1 (B1 - ma 5-6, wo 1-2), 20 April - 3 July 2020
Faculty
Responsible lecturer: dr.ir. M.C. van Turnhout - GEM-Z 4.107 - 2797
Co-lecturer: dr.ir. J.P.M. Hoefnagels
Information:Secr. Soft Tissue Biomechanics and Engineering - GEM-Z 4.115 - 2279

Description of content
PLEASE NOTE THAT THIS COURSE IS TAUGHT AT TU/e
The course is meant for students that may have to do light microscopy on biological samples for their internship(s) or MSc-project, and for students that are interested in biomedical applications of optics in general. After completion of this course one has obtained a thorough background in the possibilities and limitations of various optical-microscopic techniques, in particular the possibilities and limitations related to biological samples.

Literature/study material used:
Handouts of lectures, Extra information handed out during the lectures. Students are expected to find their own way in literature (recommended).

Douglas B. Murphy & Michael W. Davidson; Fundamentals of light microscopy and electronic imaging (2nd edition); Wiley-Blackwell, October 2012; ISBN 978-0-471-69214-0 (recommended)

Registration:
Please register at the TU/e, course code: 8MM10. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
No, for RMTM students only.

Prerequisite knowledge:
8NC00 - Electromagnetism and optics (recommended)

Protein Engineering (8SM10)

Period (from – till): Quartile 2, timeslot D (D - wo 5-8, di 9-10, vr 1-4), 11 November 2019 - 31- January 2020

Faculty
dr. M. Merkx (Biomedical Chemistry, Biomedical Engineering, Eindhoven University of Technology)
Visiting lecturers.
Description of content
PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN

In this course important methods and techniques (both molecular-biological and chemical) will be discussed that can be used to develop new proteins with new and biomedically attractive properties. The course starts with a renewed introduction to protein structure, followed by some analytical techniques that are important for protein characterization (circular dichrosim, mass spectrometry, X-ray, and NMR). After this general introduction the following subjects will be treated:

•biological synthesis of proteins (recombinant expression systems, use of affinity tags)
•chemical synthesis of peptides and proteins
•chemical modifications of proteins, non-natural amino acids
•protein folding
•rational design of new proteins (strategy, site-directed mutagenesis, chimeric proteins)
•directed evolution and high-throughput library screening

All techniques will be illustrated by giving examples of applications. No specific book is used in this course. The general Biochemistry textbook will be used to treat general aspects of protein chemistry. For specific subjects, review papers will be handed-out. An important part of the course is a seminar that will be organized at the end of the course. In this seminar students will present recent papers on new development in protein engineering and discuss their strengths and weaknesses.

Literature/study material used:
reader (recommended)

Registration:
Please register at the TU/e, course code: 8SM10. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No.

Optional for students in other GSLS Master’s programme:
No, for RMTM students only

Prerequisite knowledge:
When foreign students participate the lectures will be in English, otherwise they are in Dutch.
8RA00 - Biochemistry (compulsory)
8RB00 - Molecular cell biology (compulsory)
8RB20 - Chemical biology (recommended)

Stem Cells 8MM00

Period:Quartile 3, timeslot A

Faculty
Lecturer(s):
Responsible lecturer: C.M. Sahlgren, co-lecturers: dr. D.W.J. van der Schaft, Visiting lecturer(s)

Extended course description (for Osiris):
PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN

Stem cells play an important role in the development, maintenance and regeneration of biological tissues and hence form an attractive source of material for future clinical treatments, such as in regenerative medicine. This course deals with the current scientific knowledge of stem cells and their relevance for (bio)medical research and application. A first series of lectures focuses on the different types and sources of stem cells, as well as the relevance of the stem cell micro-environment (the stem cell 'niche') for cell functioning and differentiation. Next, the relevance of stem cell research in the area of Biomedical Engineering will be highlighted. Special attention is given to the analysis and characterization of stem cells using a variety of techniques.

Literature/study material used: study guide, lecture handouts, Stem cells the handbook, second edition, edited by Stewart Sell, and articles and possible other material is communicated before/during the course

Registration:
Please register at the TU/e, course code: 8MM05. Osiris registration will be done retroactively when results from the TU/e are received.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
No

Prerequisite knowledge:
8A840 - Molecular cell biology (recommended)
8W210 - Structure and function of cells and tissues (recommended)
8W240 - Structure and adaptation of cell and tissue (recommended)
8WC00 - Regeneration (recommended)

Elective courses in Utrecht

Academic Writing

Period (from – till): This course will be given three times a year. See dates below for start and end dates of the course editions. FacultyCourse coordinator: Eva Herold, MSc, programme advisor BMS, UMC Utrecht, - If you have any questions regarding the content of the course, please contact the lecturer.Lecturer: Frans van Dam, Lecturer science communication, Faculty of Science

Course description
This mini-course will focus on the demands of ‘academic’ writing in English, and will include topics such as writing strategies, text plans, revision and structure. It is particularly helpful for students embarking on a research thesis or an internship report.

Registration
This course is (in first instance) open to all second year Master’s students of the Graduate School of Life Sciences. It is important that you are already experienced or starting with writing an internship report or Master's thesis.
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide and placement for the course is on a "first come, first served" basis.
The maximum number of participants is 15, the minimum 6.
Course datesGroup 1 Dates 12 Sept 2019 – 31 Oct 2019 (Osiris Student starting block: BMS_P1_A):
Meeting 1: Thursday 12 September 2019 - 10:00 – 13:00h
Meeting 2: Thursday 26 September 2019 – 9:30 – 12:30h
Meeting 3: Thursday 10 October 2019 – 9:30 – 12:30h
Meeting 4: Thursday 31 October 2019 – 9:30 – 12:30h

Group 2 dates will follow at a later stage
Meeting 1:
Meeting 2:
Meeting 3:
Meeting 4:

Group 3 dates will follow at a later stage
Meeting 1:
Meeting 2:
Meeting 3:
Meeting 4:
Literature/study material used
Will be handed out during the meetings.
Mandatory for students in own Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Yes.
Testimonials
"This short course is very useful and instructive"
"The teacher is very enthusiastic"
"You work on your own report"
"Useful advise about the writing process and common pitfalls"
"Eye-opener"

Basics of Biostatistics

Period (from – till): 11 November 2019 - December 2019

Programme:
The more detailed programme of the course (including the exact enddate) will follow when available.
Faculty
Paul Westers, GNK (coordinator)
Cas Kruitwagen, GNK (weblecturer)
Rebecca Stellato, GNK (weblecturer)

Course description
Please note:Basic of Biostatistics is a 'Blended course'. The lectures of this course are offered online via Elevate and are self-studies. During the course there are some optional face-to-face meetings with the lecturers. These meetings are held at UMC Utrecht.

The four week course(4,5 ECTS, 32 hours per week) provides an introduction to statistical methodology and supplies a number of statistical techniques important for practical data analysis. Examples from the medical and biological fields will be used in exercises. Datasets will be analyzed on the computer using the statistical package SPSS. The first part covers the "Basics of Biostatistics", statistical testing for one and two samples, confidence intervals, simple linear regression and correlation, one way analysis of variance, binomial distribution and proportions, analysis of contingency tables and non-parametric statistics. The second part covers an "Introduction to Modeling" and introduces the most important regression models used in biomedical research, that can be used in the study of the relation between a number of explanatory variables on the one hand, and the occurrence of an outcome on the other: multiple regression and logistic regression.
Note: Some basic statistical notions will be assumed known, such as measures of location (mean, median) and scale (variance, standard deviation), the normal distribution, standard error of the mean. They will not explicitly be repeated in the course, but will be used implicitly. If necessary, participants should refresh their knowledge using a statistics book used in previous courses, or using the statistics e-books.

Literature/study material used:
During the course all the course material will be online available. Besides this online material you can use also one of the following statistical books:

  • W.W. Daniel, Biostatistics: Basic Concepts and Methodology for the Health Sciences, International student version, 9th Edition. John Wiley & Sons, 2010;
  • P. Armitage, G. Berry and J.N.S. Matthews, Statistical Methods in Medical Research, 4th edition. Wiley-Blackwell, 2001;
  • M.C. Whitlock and D. Schluter. The Analysis of Biological Data. Roberts and Company Publishers, 2009;
  • J.H. Zar, Biostatistical Analysis, 5th Edition. Pearson Education International, 2010.

The first two books have more medical examples, whereas the last two books more biological examples. These reference books remain useful long after you have completed the course. They can be obtained from scientific bookstores. You are not obliged to use any of these books during the course.
Brief manuals of SPSS are included in the workbook of the course. If you are interested in more detailed manuals we recommend one of the following books:

  • A. de Vocht, Basishandboek SPSS 16, Bijleveld, 2008;
  • A. Field, Discovering Statistics Using SPSS, 3rd edition. SAGE Publications Ltd, 2009;
  • The very extended help function of SPSS itself.

An overview of all kinds of statistical hyperlinks (books, applets, software et cetera) on the internet is also given in the online course manual.

Examination
The examination consists of two parts, namely:

  1. a case study (25% of final grade)
  2. a final test (75% of final grade) consisting of open and multiple choice questions.

The grades for both parts should be at least 5the final test must be at least 5. To pass for the course the final grade should be at least 5.5. If the final grade is lower than 4 it is not allowed to do the re-exam, except if there is a permission from the exam committee.
Furthermore active (online) attendance is mandatory.

Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Students will be dived into four groups. The number of students per group is limited to 15 (60 students in total).
Mandatory for students in own Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Yes.
Prerequisite knowledge
Although active statistical knowledge is not a prerequisite, we assume some basic knowledge on statistics and mathematics acquired through, for example, courses in biostatistics in the bachelor programme or self study.

The basic knowledge we assume are:
1) the concepts of population and sample;
2) histogram, boxplot, frequency table, scatterplot, contingency table;
3) mean, median, mode;
4) variance, standard deviation, range, interquartile range, standard error of the mean;
5) probability, probability distributions (especially the normal distribution).

If you want to refresh your basic knowledge we recommend one of the following sources of information (see also study material):

  • Chapters 1 till 5 of the book of W.W. Daniel;
  • Chapters 1 till 3 of the book of P. Armitage, G. Berry and J.N.S. Matthews;
  • Chapters 1 2, 3, 5 and 10 of the book of M.C. Whitlock and D. Schluter;
  • Chapters 1 till 6 of the book of J.H. Zar;
  • Module A and B of the Dutch E-learning software COSO (ComputerOndersteund StatistiekOnderwijs). It requires the (free) software authorware to run;
  • Module I, II, III, V of the very advanced online textbook Online Statbook;
  • Modules 1 and 2 (e-book) and/or module 1 (exercises) of CAST (Computer-Assisted Statistics Textbooks) that consists of a collection of electronic textbooks (e-books).

Several weeks before the start of the course there will be a test available for testing your basic knowledge on statistics and mathematics. It is then also possible to ask questions with respect to the basic knowledge to the lecturers. Both will be features of the Elevate environment of this course.

Bio-inspiration Essentials

The subjects being addressed
This is a course that introduces the field of Bio-Inspiration. We start to elucidate the philosophical and historical roots of the concept of bio-inspiration. We will touch upon movements like: deep ecology and permaculture and illustrious predecessors such as, Leonardo da Vinci, Buckminster fuller, Viktor Schauberger, Jay Harman and Bill Mollison.
Next, we will give an overview of the main bio-inspired approaches, being: biomimicry, bionics, nature inspired design, natural capitalism, biophilia, Circular Economy and CtoC. Moreover, you will learn to see similarities and differences, by to comparing and classifying different bio-inspired approaches.
Finally, we will address Design as a discipline and process. In this way you can start to formulate and explore possibilities for innovation as a product, process or systems innovation.
You learn how to define the function you want to ‘biologize’. By doing so, you will describe the scope and hoped-for-outcome in such a way that a biologist can deliver the information as an important co-creative step in an innovation process.

This is an online course stretching over 10 weeks with a study load of approximately 7 hours per week. The course consists of web lectures as well as articles, group assignments, individual assignments, peer feedback and feedback from teachers. During the course you interact with other participants through assignments and discussions. The course is moderated actively by a professional moderator and teaching staff.

The added value for the participants
For students with a chemical biological or bio-medical background it gives a first introduction into a whole new and promising field that combines economic values and methods (innovation) with nature based approaches.
For entrepreneurs, programme & project managers, policymakers, trade and industry professionals: the course will help you to understand the main concepts within bio-inspiration that allow you initiate and direct bio-inspired innovation-trajectories.

Summary of course content (max 75 words)
This course introduces a new field in Science and Design: Bio-Inspiration you will learn to look at nature as source of knowledge that will help to make our products, processes and systems part of nature, compatible with and supporting a transition to a circular economy instead of designing for the ‘dump’. After an overview of different Biologically Inspired approaches you will learn to define the scope and function of an innovation and write a first design-brief.

Cardiac Regenerative Medicine

Period (from - till): 27 January 2020 - 7 February 2020
Lecturer(s):
Lectures are provided by (guest) lecturers from the Hubrecht Institute, UMCU, and other national cardiac RM experts. Working groups are administered by guest lecturers from UMCU. Laymen and/or patients are involved in assignment(s).

Course description:
In this course the student will get acquainted with the application of regenerative medicine in cardiac diseases. Subjects like cardiac development, reprogramming, RM treatment options including non-cell based therapies and translational cardiac RM are addressed. In addition, students are introduced in the interpretation and processing of study data, and get acquainted with the impact of research on society, in particular on patients. The course consists of lectures, interactive meetings, an exam, and a group assignment, supervised by experts and laymen.

Literature/study material used:
- Primary literature
- E-module
- Textbook Medical Physiology (background information)

Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.

Mandatory for students in own Master’s programme:
For BoD students: this course is one of the specific cardiovascular BoD-courses. Additional to the mandatory Kick off course, BoD students should accomplish 12 EC with specific (cardiovascular) BoD courses.

Optional for students in other GSLS Master’s programme:
Yes. RMT and BoD students have priority for enrollment.

Prerequisite knowledge:
Bachelor in Life Sciences and basic knowledge about cell biology and cardiac physiology.

Co-create: life’s professional challenges

Period (from – till): 4 Februari - 15 Februari 2019.

Course Coordinator: Ing. Michèle Gerbrands (m.c.gerbrands@umcutrecht.nl)

Facluty and Lecturer(s):
Heleen van Ravenswaaij Msc, Biomedical Sciences.
Heleen and Michele developed this elective course in co-operation with Career Services.
A diverse groups of lecturers and professionals from the educational and corporate world will share their knowledge and skills during this elective course

Course description:
As a bachelor year 3 / master student of the University Utrecht (UU) you are not far away from graduating, taking your first steps into the professional world. You will be challenged to work with a diverse group of colleagues, co-operate, and solve complex problems that fit users and society’s needs. This implicates that you need insights in how to grow as a professional in a fast changing world, be able to attain the right knowledge and skills.
Gaining new skills implicates the ability to actively plan, reflect, learn and experience your way into these skills to keep on track in a world where ‘life-long learning’ has become the standard.

This two-week elective course offers you a challenge to create a concept for a client in co-operation and co-creation with peers from several bachelor (year 3) and master programmes and professionals from the educational and corporate world. You are offered short inspirational sessions and workshops to discover which team- and individual based (soft)skills, techniques and tools are needed to deliver a concept. At a networking event you will pitch the concept and receive feedback. Several coaches are available if you need help (on-demand coaching). You will present your final concept to the client and a jury using a pitch and a report.

You will create an elevator pitch. Being able to pitch your own unique set of skills can assist you in your future employability. Therefore, a coach will guide you through the process of making this pitch, and you will hand in a video of the pitch.

For more Information visit: www.co-challenge.comwww.co-challenge.comwww.co-challenge.com

This course is inspired on a co-creation event EduChallenge. A video of this challenge can be watched on: https://www.youtube.com/watch?v=_iyCVDV9ACw

Literature/study material used:
-

Registration:
The registration is via Osiris Student. Please find additional information about the registration on the Study Guide.
UU students need to register for the course via Osiris Student (Osiris Student starting block: BMS P3 A).
In addition, UU students need to send an email to Michèle Gerbrands (m.c.gerbrands@umcutrecht.nl) with the following information:
-Available full time (9:00- 16:30) during the course: O yes/ O No
-Short motivation (1 A4 page) why you want to participate, addressing the following topics:

  • What is, according to you, entrepreneurship?
  • What do you think you can learn from this course and what do you expect in general?
  • What do you think you can offer your peers in this course (in terms of knowledge, skills, personality etc.)?

PLEASE NOTE: the Osiris registration is closed but there are still places available. UU students can register via the registration period on 10/11 January. You can already send you motivation by email.

Other (non-UU) students who want to apply for this course, need to send an email to Michèle Gerbrands (m.c.gerbrands@umcutrecht.nl).
Please include the following information:
Surname
Initials
First name
Master/beachelor programme:
Student number
Phone number
Mail address
Available full time (9:00- 16:30) during the course: O yes/ O No
Short motivation (1 A4 page) why you want to participate, addressing the following topics:

  • What is, according to you, entrepreneurship?
  • What do you think you can learn from this course and what do you expect in general?
  • What do you think you can offer your peers in this course (in terms of knowledge, skills, personality etc.)?

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
Yes

Remarks
There is a limit of 25 students. Registration is on first come, first served basis (max. 6 students per bachelor/master) if the applicant will meet the following criteria:

  • You are available (full time) during the course (9:00-16:30).
  • Short motivational letter why you want to attend this elective course.

Every master student and bachelor year 3 from the UU can participate in this elective course. The theme of this real-world problem you will be solving is Healthy Urban living. You will be developing a concept for the City of Utrecht. A detailed description of the assignment will be presented online before the start of the course and face-to-face on day 1 of the course.
The course will be offered in English.

Schedule
A detailed schedule will be online before the start of the course and handed at the first meeting. We will start every day at 09:00 a.m. with an informal activity and end around 16:30 p.m. On day 4 the day ends at 18:30 p.m. due to the networking event.

Communicating Life Sciences

Period (from – till): 12 September 2019 – 21 November 2019.
Faculty
Course coordinator: Eva Herold, Msc, programme advisor BMS, UMC Utrecht, - If you have any questions regarding the content of the course, please contact the lecturer.
Lecturer: Connie Engelberts, MSc, science editor, UMC Utrecht
Course description
During this course, the participants will write and edit articles for three editions of a digital newsmagazine from the Graduate School of Life Sciences. The course starts with three meetings in which the students learn to identify interests of their target group, practice interview techniques and exercise in popular science writing. In the second half of the course, the students will form an editorial board and write at least three popular science articles about Utrecht life sciences research. The course is available for 4-10 students.

Previous issues of Master for life magazine can be found here.

Programme12-9-2019Thursday13:1517:0019-9-2019Thursday13:1517:003-10-2019Thursday13:1517:0017-10-2019Thursday13:1517:0031-10-2019Thursday13:1517:0021-11-2019Thursday13:1517:00
Literature/study material
N.A.
RegistrationYou can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Registration is on a "first come, first served" basis. The maximum number of participants is 10, with a minimum of 4.

Mandatory for students in own Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Yes.

English for Academic Purposes

Period (from – till): Seven times a year. The exact dates are displayed in the table below. Dates for groups 1 and 2 available, other groups to be announced.
Faculty
Teachers from Babel Talen, Utrecht

Course description
The Babel Language Institute organises an 'English for academic purposes' course specifically for Life Sciences students. You can take this course as part of your elective component, if your programme coordinator agrees.

This English for Academic Purposes course focuses on giving academic presentations and writing an academic paper. The students’ own subjects will be used as a basis for language work. We will consider some essential elements of a presentation: opening, closing, signposting the organisation, referring to visuals, handling questions, adopting the right body language, and involving the audien­ce. Students will learn how to give feedback and will improve their oral fluency and their vocabulary throughout the course.Furthermore, we will focus on language aspects relating to writing an academic paper. We will analyse its information and look at language conventions. Moreover, we will discuss some issues involving punctuation, formal and informal English, wordiness and the use of linking words. This course aims to develop and improve the writing and presenting skills students need in their master programme. In addition, students will activate and expand their vocabulary and improve their fluency in English.

The course length is 10 meetings of 2 hours. Students need to invest 3-5 hours of self-study per week. Students will pass the course if they attend at least nine meetings, have given a presentation, and have handed in a paper.
Literature/study material used
Textbook (writing and presenting scientific papers) and loose-leaf material will be handed out during the meetings.
RegistrationRegistration is on a "first come, first served" basis. Registration for the courses will be through OSIRIS Studet. In the table below the corresponding registration periods for each edition have been added under the group number, to indicate which one you should use when registering via Osiris Student. More information about the registration procedure can be found here on the Studyguide.The maximum number of participants per group is 10, the minimum 6.
Mandatory for students in Master’s programme
N.A.

Optional for students in other GSLS Master’s programme:
Yes.

Prerequisite knowledge
The English proficiency is of an upperintermediate to advanced level.

Teaching Schedule:
The course is taught from 19:15-21:15 in the Hijmans van den Bergh building.Group:
Osiris:group 1
BMS_P1_Agroup 2
BMS_P1_Bgroup 3
tbagroup 4
tbagroup 5
tbagroup 6
tbagroup 7
tba mondaytuesday 12-9-20193-9-2019 29-9-201910-9-2019 316-9-201917-9-2019 423-9-201924-9-2019 530-9-20191-10-2019 67-10-20198-10-2019 714-10-201915-10-2019 821-10-201922-10-2019 928-10-201929-10-2019 104-11-20195-11-2019 reservetbatba reservetbatba

Essentials of Neuroscience

Period (from – till):
Essentials of Neuroscience Face-to-face course: 20 January 2020 - 31 January 2020
Essentials of Clinical Neuroscience Online course: 11 November 2019 following through Period 2.
Faculty
Ramakers, Adan, Burbach, Pasterkamp, Hol; UMC Utrecht Brain Center, Department of Translational Neuroscience.
Course descriptionOverall aim
The aim of the course is to provide sufficient background in molecular and cellular neuroscience to understand mechanisms underlying psychiatiric and neurological diseases.

Description of the Essentials of Neuroscience Face-to-face course:
This intense two weeks course is intended for non-neuroscience master students who want to get more background into neuroscience. The lectures during the course cover a broad range of neuroscience topics from gene to neurological disease and include neuro-anatomy, neurodevelopment, synaptic plasticity, neurogenetics and diseases. The lectures are given by experts from the UMC Utrecht Brain Center. During the afternoons the students will work in couples on an assignment on a neurological disease. This assignment will results in a scientific presentation of a research proposal on the disease, which will discuss all aspects covered in the lectures, ranging from clinical symptoms and treatment, to molecular and cellular mechanisms, to genetic studies and genes involved. These presentations will be held on the last Friday during a symposium.

Description of the Essentials of Clinical Neuroscience Online course:
This online course gives you a unique opportunity to study the state of the art insights in Neurosciences, discover the research strengths of UMC Utrecht and experience our educational philosophy.With participants from all over the world you will follow weblectures by top UMC Utrecht neuroscientists, discuss recent developments in this field and make assignments and group projects online. This course gives you a unique opportunity to study the state of the art insights in Neurosciences, discover the research strengths of UMC Utrecht and experience our educational philosophy. Wherever you are, whenever you are available you can join our academic community of eager, young minds from behind your computer!
The course will consist of web lectures by renowned experts as well as articles, group assignments, individual assignments, peer feedback and feedback from teachers. During the course you will interact with other participants through assignments and discussions. The course will be moderated actively by professional moderators and teaching staff of the Brain Center Rudolf Magnus of UMC Utrecht.

Literature/study material used:
Parts of Neuroscience (Purves et al., Sinauer Ass.Inc., Sunderland, Massachusetts, 4e editie, 2004 (ISBN 978-0-87893-697-7)) and recent reviews and original articles.

Registration:
Essentials of Neuroscience Face-to-face course: You can register for this course via Osiris Student via BMS_P2_B. More information about the registration procedure can be found here on the Studyguide. The maximum number of participants is 40.
Essentials of Clinical Neuroscience Online course: You can register for this course via Osiris Student via BMS_P2_A. More information about the registration procedure can be found here on the Studyguide. The maximum number of participants is 16.

Mandatory for students in own Master’s programme:
BoD students: This course is one of the specific cardiovascular BoD-courses. Additional to the mandatory Kick off course, BoD students should accomplish 12 EC with specific (cardiovascular) BoD courses.
This is not applicable for the online variant of this course.

Optional for students in other GSLS Master’s programme:
Yes, except for NSCN students.

Prerequisite knowledge:
No special requirements.

Fundamentals of Biofabrication, online course

Note: this is an online course stretching over 9 weeks with a study load of approximately 10 hours per week. The course contains weekly deadlines for group and individual assignments, as well as constant participation and peer interactions in group discussions. Students should take this into account when registering for the course based on other workload (courses/internships).

Period: 18 November 2019 - 2 February 2020 (2-week Christmas holiday)

Course coordinator: Prof. dr. ir. Jos Malda
Lecturer: Paulina Nunez Bernal, MSc. (p.nunezbernal@umcutrecht.nl)

Course content
Biofabrication combines advanced 3D fabrication techniques with biological systems to create designed tissue constructs, which can be applied for tissue engineering, as 3D in vitro biological models or as medical therapeutic products. This e-­course aims to provide the student with the fundamental knowledge on the various aspects of biofabrication, including 3D printing techniques, biomaterials, tissue engineering, applications, translation and ethics.

The subjects being addressed:

  • 3D printing history, techniques, applications
  • CAD/CAM, 3D modelling, STL, G-code
  • Medical imaging to printing
  • 3D printing techniques: additive manufacturing, robotic
    dispensing, fused deposition modelling, electrospinning,
    stereolithography, powder printing
  • 3D printing in the clinic: devices and implants
  • Biomaterials: polymers, bioinks, tissue­-derived matrices
  • Cells and stem cells
  • Cell printing
  • Applications: cartilage, liver, cardiovascular system,
    organ­-on-­a-­chip, in vitro models
  • Translation, bench-­to­-bedside
  • Automation, implementation, and regulation of these technologies
  • Ethics

The added value for the participants:
This course provides fundamental knowledge on biofabrication and is developed by a leading research group within the biofabrication field. Weblectures are given by experts in the fields of tissue engineering, materials science, mechanical engineering, medicine, biology and ethics.

Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Students must send a short motivation letter (200-300 words) before the 29th of September, describing their reasons for taking the course, as well as their willingness to participate in its discussions and assignments and to meet deadlines. Please send this letter in an email to p.nunezbernal@umcutrecht.nl after completing the registration process via OSIRIS.

Entry requirements
None

History of Medicine and the Biomedical Sciences

Period (from – till): 14 February 2019 - 18 April 2019
Faculty:
Prof. dr. F.G. Huisman, Julius Centre UMC Utrecht
Course description:
This is a nine-week course that is part of the Research Master History and Philosophy of Science, offered by the Descartes Centre for the History and Philosophy of the Sciences and the Humanities. In principle, it is open to all MA students of the Graduate School of the Life Sciences.
Modern biomedical science and modern medicine originated - both epistemologically and institutionally – in the period between 1850 and 1950. The epoch not only witnessed the birth of the modern hospital and the laboratory, but there was a growing awareness that the state had an important role to play in public health as well. Taken together, the hospital, the laboratory and the caring state can be considered as the symbols of modernity.

Over the course of time, the medical scientist and the clinician have become valuable citizens, who transformed our health care system profoundly. At the same time, scientific progress has come with problems and drawbacks. In order to understand modern medicine and health care, it makes sense to take a look at its historical roots.
This course is an introduction to the birth of modern medicine, looking at developments over the course of the ‘long nineteenth century’. After an introduction of five weeks, you are expected to choose a topic that particularly interests you and write a paper about it. Topics may be chosen from any period between Classical Antiquity and contemporary biomedicine.
You will find out that history is not about presenting dry facts about the past, but rather about reflecting the human condition. Medical history is thinking about the ways in which man is dealing with health and illness, with pain and death – both in the past and in the present.

Literature/study material used:
- W.F. Bynum, Science and the practice of medicine in the nineteenth century (Cambridge: Cambridge University Press, 1994).
- M. Jackson ed., The Oxford handbook of the history of medicine (Oxford: Oxford university press, 2011):
* R. Cooter, ‘Medicine and modernity’ (pp. 100-116)
* H.J. Cook, ‘Medicine in western Europe’ (pp. 190-207)
* M. Gorsky, ‘The political economy of health care’ (pp. 429-449)
* R. Bivins, ‘Histories of heterodoxy’ (pp. 578-597)
- Chr. Hamlin, Cholera: the biography (Oxford UP, 2009).

Schedule:
PART 1
Week 7 (Thursday 14/2/2019)
Week 8 (21/2)
Week 9 (28/2)
Week 10 (7/3)
Week 11 (14/3)

PART 2
Week 12 (21/3)
Week 13 (28/3)
Week 14 (4/4)
Week 15 (11/4)
Week 16 (18/4) – Tuinzaal, all day

Time and location
Time: on Thursdays, 13.15-17.00 (= 1.15 p.m. to 5 p.m.).
Location: Heijmans van den Bergh Building (HvdB), Uithof (to be reached by bus no. 12 or 28). Rooms differ (power point facilities are available everywhere).

Registration:
The maximum number of participants is 15. Please register via Osiris Student in Period 3 (Please note that this is a small exception in regards to start dates and corresponding Period. Use starting block BMS P3 A). More information can be found here in the Study guide.

Mandatory for students in own Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
This course is an elective course for all Master’s student of the Graduate School of Life Sciences. It is open to all students enrolled in the Research Master History and Philosophy of Science.

Prerequisite knowledge:
Bachelor’s degree and admission granted to a GSLS Master’s programme or Research Master History and Philosophy of Science.

International Genetically Engineered Machine Competition

Period (from – till): February - November

Course coordinator: Prof. Niels Geijsen (n.geijsen@hubrecht.eu)

Faculty:
Prof. Niels Geijsen (n.geijsen@hubrecht.eu)
Dr. Margot Koster (M.C.Koster@uu.nl)
Prof. Dr. Guido van den Ackerveken
Prof. Dr. Roos Masereeuw
Dr. Ton Peeters
Course description:The iGEM (international Genetically Engineered Machine competition), http://igem.org/Main_Page, is an international organization that stimulates students to work together to solve real-world challenges by building genetically engineered biological systems with standard, interchangeable parts. The competition already involves more than 100 teams from many universities and institutes. This course offers students the unique possibility to work in an interdisciplinary team on a very challenging project. The students do not only have to design and build a genetically engineered biological system, but also need to get sponsors, attract media attention and finally present their work on different occasions, including the iGEM jamboree in November in Boston.

Assessment is based on participation, the quality of the final report and an individual report to be judged by at least two instructors/teachers.
Literature/study material:
N.A.

Registration
For application and or information you can contact Prof. Niels Geijsen or Dr. Margot Koster. Deadline for the application is February 1. The team is selected from motivated students in a face-to-face interview. (July-august min. 75 % availability is required). For application and or information you can contact Prof. Niels Geijsen (n.geijsen@hubrecht.eu ) or Dr. Margot Koster (M.C.Koster@uu.nl).

Mandatory for GSLS students.
No.
Optional for students from other GSL Master's programmes:Yes.

Prerequisite knowledge:
N.A.

Laboratory Animal Sciences

Period (from – till): several times a year.
Faculty
Teachers from the Department of Animals in Science and Society , Faculty of Veterinary Medicine, Universiteit Utrecht

NOTE: There are different courses offered please read the information on the websites carefully. You should take the laboratory animal sciences course only if you need it for your research project; you must have permission from your supervisor and your programme coordinator.

You can find the exact course dates and information for the English taught course here.
More information about the Dutch taught course can be foud here.
Course description
This course is a requirement for conducting animal experiments and teaches you the basics on animal research.
The objective of the course is to present basic facts and principles that are essential for the humane use and care of animals and for the quality of research. From the beginning of the course, emphasis is placed on the fact that the scientist is the central person in the design and performance of animal experiments, and that he/she has specific responsibilities with respect to the welfare of the animals used. It is made clear that the use of animals can be accepted only under a set of strict conditions. Among these are that the experiment must be approved by an ethics committee, and must be conducted by persons who are fully competent.Please note:

  • You should take the laboratory animal sciences course only if you need it for your research project; you must have permission from your supervisor and your programme coordinator.
  • Because this course is expensive, you need to fill the rest of your elective component with modules which are free of extra costs, in exceptional cases more than one course may be allowed. You have to ask prior approval from the Board of Examiners if you want to take more than one of these courses.

Registration:

  • For BMS students BIFM, BIDM, CSND, EPIM, IMIF, NSCN, RMTM, TXEH: please use the registration form which can be found in the here.
  • For students from ENVB, MCLS, SBM and DINN: please use the standard form of the LAS course which you can find here.

Fill out the form and first hand it in at your Master's programme’s administration desk for approval. You need a signature and financial account number in order to have the form accepted at the LAS administration. In order to get approval from the Board of Examiners please add a signed statement of your examiner that this course is mandatory for your researchproject. After obtaining the approval you can sent the form to the LAS administration.
Mandatory for students in GSLS Master’s programme
No.

Optional for students in GSLS Master’s programme
Yes.
More information in Dutch: click here, in English: click here.

Career Orientation & Professionalisatio

This course is in Dutch only!De mastercursus Loopbaanoriëntatie en Professionalisering is een cursus voor masterstudenten van de Utrecht University, Graduate School of Life Sciences. De cursus wordt sinds 2001 gegeven door Jan van den Broek, managementtrainer en o.a. werkzaam bij de Bètafaculteit van de Radboud Universiteit Nijmegen.
Cursusomschrijving
De student analyseert zichzelf en de arbeidsmarkt en stelt een plan van aanpak op om zijn/haar doel te bereiken. Daarnaast wordt een aantal managementvaardigheden getraind. De cursus beoogt zelfreflectie en externe oriëntatie actief te stimuleren, o.a. door presentaties van individuele competentieprofielen, beroepsprofielen, netwerkervaringen, zoekrichtingen en actieplannen. Verder biedt de cursus de mogelijkheid om kennis, inzicht en vaardigheden met betrekking tot een aantal algemene professionele functievereisten (verder) te ontwikkelen: o.a. multidisciplinair samenwerken, projectmanagement, probleem solving, persoonlijke effectiviteit en leren omgaan met belangentegenstellingen (onderhandelingstechnieken en conflicthantering). De cursus wordt gegeven in het Nederlands. De cursusdagen zijn 7 hele dagen (9.00-17.00).
De cursus kent geen tentamen maar wordt afgerond met een persoonlijk werkstuk. Studenten ontvangen een beoordeling in de vorm van een cijfer. Mandatory for students in Master’s programme: NO.
Optional for students in other Master’s programmes GS-LS: Optional for all GSLS students who have a good command of the Dutch language.

Wat reacties van studenten na afloop van de cursus vorig jaar:
“In deze cursus heb ik geleerd hoe ik mijzelf moet presenteren, hoe ik professioneel overkom. Zelfreflectie vond ik een belangrijk onderdeel. Door deze cursus is mijn koers duidelijker geworden.”
“Ik liep te twijfelen over wat ik kon doen na mijn studie. Deze cursus heeft inzicht gegevens in wat ik wil, wat ik kan en wat ik waard ben op de arbeidsmarkt. Dankzij deze cursus heb ik het aangedurfd op meerdere posities te solliciteren en heb ik een geweldige baan in het bedrijfsleven gevonden”.

Nanomed

Characteristics of nanoparticles such as size, surface area and internal composition make them attractive candidates for use in therapeutic and diagnostic applications. The aim of this course is to provide an overview of the nanomedicine field. Every week a theme will be discussed in which nanomedicine is involved: therapeutics (both synthetic and bio-inspired) and diagnostics. We will focus on the applications of nanomedicine in cardiovascular disease and cancer.
 
After an introductory lecture on a specific theme, you will have an interactive meet up with two experts of the cardiovascular and cancer field, respectively. During the week you will work on an assignment together with one of the other students. During the course you will write a research proposal, present a paper and present the unique selling point of a nanomedicine company.  

Philosophy of Neuroscience

Period (from - till): June 2020

Course description
This course is offers compact, rigorous and practical journey in the philosophy of neuroscience, the interdisciplinary study of neuroscience, philosophy, cognition and mind. Philosophy of neuroscience explores the relevance of neuroscientific studies in the fields of cognition, emotion, consciousness and philosophy of mind, by applying the conceptual rigor and methods of philosophy of science. The teaching will start with the basics of philosophy of science including the work of Popper, Lakatos, Kuhn and Feyerabend, and use a methodological evaluation scheme developed from this work that allows rigorous evaluating neuroscientificresearch as science or pseudoscience. Furthermore, there will be attention for the historical routes of neuroscience starting with Aristotle, and the conceptual problems in neuroscience, methodological confusions in neuroscience, dualism and fysicalism. The main aim of the course is provide wide-ranging understanding of the significance, strengths and weaknesses of fields of neuroscience, which helps in critical thinking, creativity, methodological precision and scientific writing.

Literature/study material used
Book Chapters and Articles on Neurophilosophy and Philosophy of Neuro(science).
Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide. Max. 40 students.

Mandatory for students in own Master’s programme:
No

Optional for students in other GSLS Master’s programme:
Yes

Radiation Safety 5B

Period (from – till): Several times a year. The exact dates will be published on the website of TU Delft.
Faculty
W.F. Wiersma, PhD, head of the training centre/tutor in Utrecht, NCSV
Course description
This course can be followed in English and in Dutch. Go to the website for detailed information (select the 2,5 day course. PDF with details available).
Unfortunately there seems to be no English page available. If anything is unclear, please contact the person under "informatie" in the PDF with details on the website via the link above.

The radiation safety course 5B level is open to MSc students who need it for their research project. You must have permission from your supervisor and your programme coordinator.
Please note: Because this course is expensive, you need to fill the rest of your elective component with modules which are free of extra costs. The costs of the radiation safety course at level 4B will not be reimbursed.
The course Health Physics expert level 5B is meant for radiation experts in situations where radioactive sources with a low risk of exposure are used. The course offers a useful introduction in working with ionizing radiation for all kinds of radiation workers, such as laboratory personnel, technical staff, medical personnel and workers in industry. Because of the diversity in work environment of the participants, the course will not focus on one specific radioisotope.
A Virtual Learning Environment (VLE) is used for this course. Participants will have to study before the start of the training. This can be done independently and all students are fee to choose their own study moments.
The course level 5B is open to MSc students who will have to work with radioactive material during their research project. You must have permission from your supervisor and your program coordinator.
The exam consists of 50 multiple choice questions. After passing this exam, you will receive the certificate Health Physics expert level 5B and are allowed to work independently with radioisotopes.

The courses will be taught at the Ornstein Laboratory, Princetonplein 1, De Uithof, Utrecht.
More information, contact details and registration form can be found in the PDF mentioned above in the course description.
Literature/study material
Practical Radiation Protection (J. van den Eijnde, M. Schouwenburg)
(in the course fee included)

Registration
To register:
1. Fill in the General application form for electives;

After approval fill in the from of the TU Delft found via the links in the PDF
2. Go to the website for detailed information (select the 2,5 day course., select the PDF with details, select the registration form and fill it in for the course at the dates you want to participate).

Mandatory for GSLS students.
No.
Optional for students from other GSL Master's programmes:Yes.

Prerequisite knowledge:
The course is based on participants with a technical, medical or scientific education on university level. A good knowledge of physics, chemistry and mathematics is necessary.

Science and Society

Period (from – till): 11 January 2019 - 7 June 2019
Note: The Course schedule is: January 11, February 22, March 15, May 17, June 7 and optional date November 22 (a lecture from the PhD course open for students of this course), 2019. The exact schedule of lectures is available in the detailed desciption through the link below.
Faculty
Prof. dr. F.G. Huisman, Julius Centre UMC Utrecht;
Dr Annemieke Meijer
Guest lecturers
Course description
A detailed description of the course can be found here on the Study Guide.

In modern life, science is everywhere. The products of biomedical science and technology may help achieve a healthy society and economic progress. They may even prolong life and make it more agreeable at the same time. But how much do we really know about the production, implementation and evaluation of scientific knowledge? What, exactly, is the basis for our belief in science? What sets it apart from common knowledge? Who should we trust in case two scientists disagree in a hotly debated issue? Is science a vocation or just another profession? Is scientific knowledge something special to be emulated, or ‘just another opinion’? Are scientific facts discovered or socially constructed? How are science and technology embedded in society and how do they change over time?

Whoever wants to become a scientist, should be aware of these and similar questions; (s)he should not just know about the contents of scientific knowledge, but about its context as well. This course sets out to create that awareness. Until recently, it was only available to PhD students. Now, an abridged version is offered to graduate students. In six Friday afternoon sessions, the historical, philosophical, sociological and ethical dimensions of the biomedical sciences will be discussed.

For those of you who are interested in a public debate that is now going on with regard to science and the university, see www.scienceintransition.nl and http://www.wetenschapsagenda.nl/.

The course will be assessed by means of a writing assignment: you will be asked to submit a 1500 word paper on any topic, related to the theme of the course.

You will write an argumentative essay: one in which you discuss a controversial issue, take up a position and give supporting arguments aimed to persuade your readers to accept your claim(s). It is different from the types of text that you may be used to writing (lab reports, research papers) in that the writer has a clear voice – he or she is present in the text, which allows for (or indeed, requires) a considerable amount of creativity and personal choice. You may use a variety of sources, both scholarly and popular (newspapers, magazine articles).

Your essay will be graded on the basis of the following criteria:

  • information: detailed, accurate, relevant
  • structure: rigorously argued, logical, easy to follow
  • interpretation: evidence of independent thought and critical analysis
  • use of evidence: key points supported with evidence, critically evaluated
  • academic referencing: good use of academic referencing conventions
  • style & use of language

Literature/study material used:
Three articles, taken from the Golem-series by Harry Collins and Trevor Pinch:

- ‘Introduction: the Golem’ and ‘The Germs of Dissent: Louis Pasteur and the Origins of Life’ in: Collins and Pinch, The Golem. What You Should Know about Science (Cambridge UP 1993), 1-3 and 79-90.
- ‘ACTing UP: AIDS Cures and Lay Expertise’ in: Collins and Pinch, The Golem at Large. What You Should Know about Technology (Cambridge UP 1998), 126-150.
- ‘Vaccination and Parents’Rights. Measles, Mumps, Rubella (MMR), and Pertusis’ and ‘The Themes Revisited’ in: Collins and Pinch, Dr. Golem. How to Think about Medicine (The University of Chicago Press 2005), 180-204 and 205-224.

In addition to these articles, speakers will provide one or two articles on the topic of their lecture. When possible, we will send an email with these attachments before the meetings, so that you can prepare the topics to be discussed. Students should print the documents themselves.

Registration:
The Course schedule is: January 11, February 22, March 15, May 17, June 7 and optional date November 22 (a lecture from the PhD course open for students of this course), 2019.
Please register via Osiris Student in Period 3 (Please note that this is a small exception in regards to start dates and corresponding Period. Use starting block BMS P3 A) Please also be aware that the course starts on January 11th and therefore the re-registration for this course is only available on January 10th since afterwards the course has already started. More information can be found here and by sending an email before November 25th 2018 to Ms M. van Dijk-Okla: m.vandijk-okla@umcutrecht.nl, including the following information:

  • Name
  • Email address
  • Home Address
  • Zip code and City
  • A short motivation

The maximum number of students is 25.
All Master’s students of the Graduate School of Life Sciences are welcome to attend the course. There is, however, a maximum capacity of 25 participants. Should there be more applicants, the final 25 will be selected on the basis of their application letter.
You are expected to be an active participant, i.e. to prepare the topic and to take part in the general discussion.

Mandatory for students in own Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Yes.

Prerequisite knowledge:
Bachelor’s degree and admission granted to a GSLS Master’s programme

Societal Challenges for Life Science Scientists: Exploring Interdisciplinarity

Period (from - till): 9-20 December 2019

Course coordinators:
Dr. ir. M.E.G.L. Lumens
Dr. G.M.J. Ramakers

Course description:
One overarching interdisciplinary theme will be chosen each year. This year the theme is Food and health. In the first few days, lecture/discussion will be organized with experts in the field to help students familiarize with the topic, get an overview of the current debate, and the problems to solve. In the meantime, students will be instructed on the principles of interdisciplinary research.
Students form interdisciplinary groups of 3/4 and develop a research question within the theme that captured their interest. After presenting their plans and receiving (peer) feedback on the feasibility of their plans, students make a concrete plan for the rest of the course period and divide tasks. Each team has a supervisor.

Examination:AssessmentDescriptionWeightONDERZResearch proposal40%OPDRACHTAssignment30%PRESENTPresentation30%
Literature/study material used:
-
Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.

Mandatory for students in own Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Yes.
Prerequisite knowledgeStudents should be enrolled in a master's programme of the Graduate School of Life Sciences.

Vascularized Tissue Engineering online course

Period (from – till): 4 February - 31 March 2019
Note: this is an online course stretching over 7 weeks with a study load of approximately 9-10 hours per week. Please take into account that the studyload is divided over the week so you will need to be able to login on various moments (taking into account vacation days).
The e-moderator will keep track of your progression. He/she will score the quality of the content and your responses on all required activities. This results in ‘insufficient, ‘sufficient’ or ‘good’. You need at least a 5.5 for all three individual components to pass the course. ​

Course coordinator: Dr. Caroline Cheng/Dr. Joost Fledderus
Lecturer: Merle Maas-Krebber, MSc

Course description:
Tissue engineering (TE) is an ever-growing multidisciplinary scientific field aiming at replacing injured, missing or damaged tissue. Current researchers in the field use different principles, knowledge and techniques from (stem) cell biology, vascular biology, medicine, biomaterials and bioengineering. Vascular and vascularized tissue engineering take prominent places within this field. The construction of blood vessels is both an independent target for replacement therapy as well as an integral part of larger constructs. A crucial challenge in obtaining large sized functional TE scaffolds (>1 milimeter in any dimensional space) is how to introduce a complex vascular tree that supplies a steady medium and blood stream for the expanding tissue to meet oxygen en nutrient demands.
This course teaches Master students’ in-depth and hands-on knowledge on developmental and adult blood vessel formation in health and disease and the current clinical treatments for which vascular(ized) TE is thought to be eligible. Moreover, we will address state of the art techniques of vascular(ized) TE, including the use of biomaterials and cell sources for bioreactor-cultured and in situ applications.

This course teaches fundamental knowledge on vascular and vascularized tissue engineering, adding significantly to the currently available curriculum concerning angiogenesis, vascular repair and remodeling, regenerative medicine and cardiovascular disease. Participants in this e-course will benefit from the flexible work hours, enabling participation parallel to writing a thesis or doing an internship abroad. This course was developed using collaborative partners leading in regenerative medicine and cardiovascular disease. Grading of this course will be based on handing in a graphical abstract (group assignment), an individual assignment and on individual participation during the course and in discussion forums.

Required Materials:
N.A.

Mandatory for students in Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Open as an elective to GSLS students from the programmes RM&T, BFAB & BOD.

Registration:
Please register via the Study guide. Deadline for registration is January 25th. The maximum of participants is 16.
Students from outside the Graduate School of Life Sciences can register for this course by sending an email to m.m.krebber@umcutrecht.nl (link sends e-mail). Please include your name, student number, Master’s programme and the course code.

Prerequisite knowledge:
Master student RMT, BOD, Biofab