Ex vivo osteochondral defect model

The throughput platform consists of viable and functional osteochondral biopsies, which can be (mechanically) conditioned and monitored in a controlled manner, allowing for cost-efficient long-term assessment of regenerative cartilage and bone therapies.


  • Evaluation of cell- and/or material-based treatments for repair of focal cartilage defects;
  • Assessment of bone tissue response and ingrowth after implantation of, for example, bone grafts and bone fixation devices;
  • Dose-response testing and screening of therapeutics for cartilage and/or bone repair, targeting the specific tissue of interest enabled by the separated tissue compartments;
  • Evaluating up to 100 biopsies in parallel allowing for testing of multiple conditions for up to 12 weeks.

Principal Investigator

Linda Kock