Ex vivo osteochondral defect model
The throughput platform consists of viable and functional osteochondral biopsies, which can be (mechanically) conditioned and monitored in a controlled manner, allowing for cost-efficient long-term assessment of regenerative cartilage and bone therapies.
- Evaluation of cell- and/or material-based treatments for repair of focal cartilage defects;
- Assessment of bone tissue response and ingrowth after implantation of, for example, bone grafts and bone fixation devices;
- Dose-response testing and screening of therapeutics for cartilage and/or bone repair, targeting the specific tissue of interest enabled by the separated tissue compartments;
- Evaluating up to 100 biopsies in parallel allowing for testing of multiple conditions for up to 12 weeks.