Musculoskeletal Tissue Regeneration
Title of Project
The possible role of stem cell-derived extracellular vesicles in articular regeneration in an equine model
A 4-year PhD student position in the interdisciplinary area of regenerative medicine. THe project will focus on the role of extracellular vesicles (EVs) in regeneration of articular tissues and, related to this, regulation of joint homeostasis.
The Department of Equine Sciences at the Faculty of Veterinary Medicine of Utrecht University will be your home institution, but the work will be carried out in the strongly multidisciplinary environment of the Regenerative Medicine Center Utrecht (RMCU) and the wider conglomerate of Utrecht Life Sciences (ULS).
Joint disorders are a major and increasing burden in human healthcare. They are also of primary importance in equine medicine, which is one of the reasons why the horse is seen as one of the best animal models for human orthopaedic disorders. Recent research has shown that EVs play an important role in joints in the regulation of inflammation in particular and in the maintenance of homeostasis in a more general sense. Stem cells are thought to play an important role in tissue regeneration and are, with varying success, already applied in orthopaedic diseases in both the medical and the veterinary field. Little is known yet about the exact mechanisms through which stem cells exert their influence and there is increasing interest in the possible role of stem cell-derived EVs herein, as EVs have several practical and regulatory advantages for translation to the clinic compared to cell-based therapies. The current project focuses at elucidating possible roles and working mechanisms behind these of stem cell-derived EVs in both normal joint homeostasis and in a variety of approaches aiming at tissue regeneration. The research uses the horse as a model and aims to reach out towards both the equine and human clinic. The project will be carried out in a multidisciplinary setting including basic science and (human and veterinary) clinical sciences.
Contact person & more information
Prof. P.R. van Weeren, Utrecht University
This project is part of RESCUE, a multidisciplinary, intersectoral and interdisciplinary PhD training programme in Regenerative Medicine and Stem Cells organised by UMC Utrecht (coordinator) and Utrecht University. RESCUE is partly funded by the European Commission under Horizon 2020's Marie Skłodowska-Curie Actions COFUND scheme. There are specific requirements with regards to English language and mobility for candidates who would like to take part in this programme. More information