PhD theses
Over the years many students have graduated from our department, writing wonderful PhD theses. Looking through the names of the graduates, familiar names pop up. Some have gone on to become professors, employees of the department or influential voices in the research community.
To celebrate the work of these students over the years, an exhaustive overview of the published PhD theses can now more easily be read here on the website. In our digital library NARCIS many of these PhD theses can be read in their entirety.
An overview of these PhD theses is included down below, organized by year of graduation.
PhD theses
Drug exposure assessment in pharmacoepidemiological database studies: Reporting and impact of exposure misclassification
Hempenius, M.
Supervisory team: prof. dr. O.H. Klungel, prof. dr. A. de Boer, dr. H. Gardarsdottir.
Utrecht University (Faculty of Science), 7 Mar 2022
Read on NARCIS
The pharmacokinetics of targeted anticancer drugs and food toxins: Roles of ABC efflux and OATP uptake transporters
Wang, J.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 21 Mar 2022
Read on NARCIS
Clinical development of anticancer treatment with oral taxanes in combination with ritonavir
Vermunt, M.A.C.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.M. Bergman, dr. S. Marchetti.
Utrecht University (Faculty of Science), 11 May 2022
Real-world data in cancer treatment: Bridging the gap between trials and clinical practice
Ismail, R.K.
Supervisory team: prof. dr. A. de Boer, prof. dr. M.W.J.M. Wouters, dr. D.L. Hilarius, dr. M. van Dartel.
Utrecht University (Faculty of Science), 18 May 2022
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The role of the community pharmacist in fall prevention: The ups and downs of implementation
Gemmeke. M.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. K. Taxis, dr. E.S. Koster.
Utrecht University (Faculty of Science), 25 May 2022
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Unraveling the functions of detoxification enzymes and drug transporters
Wang, Y.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 12 Jul 2022
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Quality of biopharmaceuticals: Comparability exercise and post-approval surveillance
Alsamil, A.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. H. Gardarsdottir, dr. T.J. Giezen.
Utrecht University (Faculty of Science), 3 Nov 2022
Read on NARCIS
The role of the community pharmacist in minor ailments, focus on uncomplicated urinary tract infection in women: Focus on uncomplicated urinary tract infection in women
Lelie- van der Zande, A.C.A.M.
Supervisory team: prof. dr. M.L. Bouvy, dr. E.S. Koster, dr. M. Teichert.
Utrecht University (Faculty of Science), 23 Nov 2022
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Real-world treatment outcomes in metastatic lung cancer: from efficacy-effectiveness gap evaluation to informed clinical decision-making
Van der Welle, C.M.
Supervisory team: dr. E.M.W. van de Garde, dr. F.M.N.H. Schramel, prof. dr. H.J.M. Groen, prof. dr. O.H. Klungel.
Utrecht University (Faculty of Science), 29 Mar 2021.
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Development, market authorization and market access of gene and cell-based therapies
Ten Ham, R.M.T.
Supervisory team: dr. J. Hoekman, dr. G.W.J. Frederix, prof. dr. H.G.M. Leufkens, prof. dr. O.H. Klungel.
Utrecht University (Faculty of Science), 4 Jun 2021.
Read on NARCIS
Post-marketing safety learning for biologicals: regulatory and clinical insights
Minnema, L.A.
Supervisory team: dr. H. Gardarsdottir, dr. T.J. Giezen, prof. dr. A.C.G. Egberts, prof. dr. H.G.M. Leufkens.
Utrecht University (Faculty of Science), 28 Jun 2021.
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Advanced pharmacoepidemiologic approaches to study the utilization, safety, and effectiveness of NOAC treatment in patients with atrial fibrillation
Komen, J.J.
Supervisory team: dr. T. Forslund, prof. dr. B. Wettermark, prof. dr. A.K. Mantel-Teeuwisse, prof. dr. O.H. Klungel.
Utrecht University (Faculty of Science), 30 Jun 2021.
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Clinical pharmacology of miltefosine
Palić, S.
Supervisory team: dr. T.P.C. Dorlo, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 10 Sep 2021.
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The changing face of community pharmacy practice: increasing time for our priorities
Van de Pol, J.M.
Supervisory team: dr. E.S. Koster, prof. dr. M.L. Bouvy.
Utrecht University (Faculty of Science), 27 Sep 2021.
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Psychotropic medication use in the armed forces: prescription patterns and treatment after trauma
Janssen-Knotnerus, D.A.
Supervisory team: dr. E.R. Heerdink, prof. dr. H.G.J.M. Vermetten, prof. dr. A.C.G. Egberts.
Utrecht University (Faculty of Medicine), 28 Sep 2021.
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Access to sexual and reproductive health medicines and supplies in Sub-Saharan Africa
Kibira, D.
Supervisory team: dr. H.A. van den Ham, T. Reed, prof. dr. H.G.M. Leufkens, prof. dr. A.K. Mantel-Teeuwisse.
Utrecht University (Faculty of Science), 10 Nov 2021.
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Cyclin-dependent kinase inhibitors in cancer: bioanalysis and pharmacokinetics
Martínez Chávez, D.A.
Supervisory team: dr. A.H. Schinkel, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 10 Nov 2021.
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Moral dilemmas of community pharmacists: reflection on professional values
Kruijtbosch, M.
Supervisory team: dr. A. Floor-Schreudering, prof. dr. E van Leeuwen, prof. dr. M.L. Bouvy.
Utrecht University (Faculty of Science), 17 Nov 2021.
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Evidence generation on benefits and risks of medicines and its impact
Bloem, L.T.
Supervisory team: Prof. dr. A.K. Mantel-Teeuwisse, prof. dr. O.H. Klungel, dr. J. Hoekman, dr. M.E. van der Elst.
Utrecht University (Faculty of Science), 24 Nov 2021.
Read on NARCIS
Functions and interplay of drug transporters and CYP3A enzymes
Li, W.
Supervisory team: Prof. dr. J.H. Beijnen, dr. A.H. S, dr. R.W. Sparidans.
Utrecht University (Faculty of Science) 15 Dec 2021.
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Development and validation of diagnostic and pharmacodynamic cancer biomarker methods and their (pre)clinical application
Pluim D.
Supervisory team: Prof. dr. J.H. Beijnen, dr. D. Brandsma.
Utrecht University (Faculty of Science) 20 Dec 2021.
Read on NARCIS
Methodological approaches to manage challenges to the implementation of HTA and economic evaluations in Low and Middle-Income Countries (LMICs)
Padmasawitri, A.
Supervisory team: prof. dr. O.H. Klungel, dr. A.M. Hövels, dr. G.W.J. Frederix.
Utrecht University (Faculty of Science), 6 Jan 2020.
Clinical pharmacology of anti-hormonal drugs and oncology - bioanalysis - therapeutic drug monitoring - gemcitabine in oncology - microdosing
Van Nuland, M.
Supervisory team: prof. dr. J.H. Beijnen, dr. H. Rosing, dr. A.M. Bergman.
Utrecht University (Faculty of Science), 22 Jan 2020.
Regulating gene and cell-based therapies as medicinal products
Coppens, D.G.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. M.L. De Bruin, dr. J. Hoekman, dr. H. Gardarsdottir.
Utrecht University (Faculty of Science), 27 Jan 2020.
Read on NARCIS
Intracellular quantification and pharmacokinetics of pyrimidine analogues used in oncology
Derissen, E.J.B.
Supervisory team: prof. dr. J.H. Beijnen, dr. H. Rosing.
Utrecht University (Faculty of Science), 29 Jan 2020.
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Translational research of combined anticancer therapies targeting the MAPK pathway
Huijberts, S.C.F.A.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. R. Bernards, dr. N. Steeghs, dr. F. Opdam.
Utrecht University (Faculty of Science), 14 Oct 2020.
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Health technology assessment throughout the drug lifecycle
Vreman, R.A.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.K. Mantel-Teeuwisse, dr. ir. W. Goettsch.
Utrecht University (Faculty of Science), 13 Nov 2020.
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A quest through diagnostics and predictive tools and the exploration of new treatment strategies in clinical trials to improve cancer therapy
Heinhuis, K.M.
Supervisory team: prof. dr. J.H. Beijnen, dr. N. Steeghs, dr. W.J. van Houdt.
Utrecht University (Faculty of Science), 30 Nov 2020.
Read on NARCIS
Evolving national pharmacovigilance systems in Africa
Ampadu, H.H.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.N.O. Dodoo, dr. J. Hoekman, dr. H. Gardarsdottir.
Utrecht University (Faculty of Science), 9 Jan 2019.
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Mounting an attack on the glioblastoma triad: proliferation, invasion and resistance
De Gooijer, M.C.
Supervisory team: prof. dr. J.H. Beijnen, dr. O. van Tellingen.
Utrecht University (Faculty of Science), 23 Jan 2019.
Read on NARCIS
Adolescents perspectives on chronic medication use: opportunities for mHealth
Kosse, R.C.
Supervisory team: prof. dr. M.L. Bouvy, dr. E.S. Koster, dr. T.W. de Vries.
Utrecht University (Faculty of Science), 20 Feb 2019.
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Clinical medication review: one step beyond: computer rules or personal goals?
Verdoorn, M.A.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. J. Gussekloo, dr. H.F. Kwint.
Utrecht University (Faculty of Science), 13 Mar 2019.
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Pharmacometrics for treatment optimization and drug development in oncology
De Vries Schultink, A.H.M.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. A.D.R. Huitema, dr. T.P.C. Dorlo.
Utrecht University (Faculty of Science), 29 May 2019.
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Non-inferiority studies: a methodological and regulatory perspective
Althunian, T.A.I.
Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel, prof. dr. R.H.H. Groenwold.
Utrecht University (Faculty of Science), 24 Jun 2019.
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Multidose dispensing for older patients in primary care
Mertens, B.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. R.J. van Marum, dr. H.F. Kwint.
Utrecht University (Faculty of Science), 3 Jul 2019.
Read on NARCIS
Clinical pharmacology of anticancer agents with focus on neuro-oncology and biomarker assessment
Van Bussel, M.T.J.
Supervisory team: prof. dr. J.H. Beijnen, dr. D. Brandsma.
Utrecht University (Faculty of Science), 11 Sept 2019.
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Appropriate access to opioid medicines: a legal & policy perspective
Vranken, M.J.M.
Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, prof. dr. H.G.M. Leufkens, dr. mr. M.D.B. Schutjens.
Utrecht University (Faculty of Science), 11 Sept 2019.
Personalized oral anticoagulant treatment: dosing algorithm, drug interactions and economic aspects
Zhang, Y.
Supervisory team: prof. dr. A. de Boer, prof. dr. A. H. Maitland-Van Der Zee, dr. P.C. Souverein.
Utrecht University (Faculty of Science), 16 Sept 2019.
Read on NARCIS
Early phase clinical studies of novel immunotherapeutics in oncology
Ros, W.
Supervisory team: prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 18 Sept 2019.
Read on NARCIS
The destiny of anti-cancer drugs: the impact of drug transporters and drug-metabolizing enzymes on the pharmacokinetics of anti-cancer therapies
Van Hoppe, S.S.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 25 Sept 2019.
Read on NARCIS
Death recording in the clinical practice research datalink
Gallagher, A.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. F. de Vries.
Utrecht University (Faculty of Science), 21 Oct 2019.
Read on NARCIS
Regulation in the dynamic environment of complex medicines
Klein, K.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. M.L. De Bruin, dr. P. Stolk.
Utrecht University (Faculty of Science), 23 Oct 2019.
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Bioanalysis and biotransformation of tyrosine kinase inhibitors in oncology
Rood, J.J.M.
Supervisory team: prof. dr. J.H. Beijnen, dr. ir. R.W. Sparidans.
Utrecht University (Faculty of Science), 28 Oct 2019.
Approaches to improve the quality and efficiency of clinical pharmacological trials in oncology
Roosendaal, J.
Supervisory team: prof. dr. J.H. Beijnen, dr. H. Rosing.
Utrecht University (Faculty of Science), 30 Oct 2019.
Safety profile of non-steroidal anti-inflammatory drugs in clinical practice
Bakhriansyah, M.
Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel.
Utrecht University (Faculty of Science), 6 Nov 2019.
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Affordability, cost-effectiveness and uncertainty: an integrated approach for decision-making on medicines
Geenen, J.W.
Supervisory team: prof. dr. O.H. Klungel, dr. A.M. Hövels, dr. C. Boersma.
Utrecht University (Faculty of Science), 11 Dec 2019.
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Non-dispensing clinical pharmacists in general practice: training, implementation and clinical effects
Hazen, A.C.M.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. N.J. de Wit, dr. A.A. de Bont, dr. D.L.M. Zwart.
Utrecht University (Faculty of Science), 29 Jan 2018.
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Precision medicine steps towards improving treatment with vitamin K antagonists and ACE-inhibitors
Baranova, E.V.
Supervisory team: prof. dr. A. de Boer, prof. dr. F.W. Asselbergs, prof. dr. A.H. Maitland-van Der Zee.
Utrecht University (Faculty of Science), 12 Mar 2018.
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Antipsychotics, delirium and glucose in older patients
Van Keulen, K.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. W. Knol.
Utrecht University (Faculty of Science), 10 Apr 2018.
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Real-world evidence for health technology assessment of pharmaceuticals: opportunities and challenges
Makady, A.A.M.A.
Supervisory team: prof. dr. A. de Boer, prof. dr. J.L. Hillege, prof. dr. O.H. Klungel, dr. W.G. Goettsch.
Utrecht University (Faculty of Science), 9 May 2018.
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Monitoring patients using psychotropic drugs
Nederlof, M.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 11 Jun 2018.
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Pharmaceutics of oral anticancer agents and stimulants
Herbrink, M.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen.
Utrecht University (Faculty of Science), 27 Jun 2018.
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The use and safety of antiretroviral medicines - lessons from Ghana
Tetteh, R.A.
Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, prof. dr. A.N.O. Dodoo.
Utrecht University (Faculty of Science), 11 Jul 2018.
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Safety of antihypertensive drugs in clinical practice
Alharbi, F.F.M.
Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel.
Utrecht University (Faculty of Science), 29 Aug 2018.
The added value of linked data in pharmacoepidemiology: solving the jigsaw puzzle
Williams, R.A.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. T.P. van Staa, dr. F. de Vries.
Utrecht University (Faculty of Science), 17 Sept 2018.
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Human mass balance and metabolite profiling studies of the new anticancer agents plitidepsin, lurbinectedin and niraparib
Van Andel, L.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing.
Utrecht University (Faculty of Science), 19 Sept 2018.
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Individualized dosing of fluoropyrimidines by genotyping and phenotyping of dihydropyrimidine dehydrogenase
Henricks, L.M.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. H.J. Guchelaar, prof. dr. J.H.M. Schellens, dr. A. Cats.
Utrecht University (Faculty of Science), 24 Sept 2018.
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Patient perspectives in pharmaceutical policy: information and influence in the diffusion of new medicines
Meneses Leonardo Alves, T.I.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.K. Mantel-Teeuwisse, dr. B.J. Mintzes.
Utrecht University (Faculty of Science), 15 Oct 2018.
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Precision anticoagulation with vitamin K antagonists in children
Maagdenberg, H.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.H. Maitland-van der Zee, dr. M.B. Bierings.
Utrecht University (Faculty of Science), 10 Dec 2018.
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Pharmaceutical policies and access to medicines: a hospital-pharmacy perspective from Ghana
Ankrah, D.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. I.A. Agyepong, prof. dr. A.K. Mantel-Teeuwisse.
Utrecht University (Faculty of Science), 11 Jan 2017.
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Priority medicines for children: exploring age-appropriate medicines and antibiotic use in children
Ivanovska, V.
Supervisory team: prof. dr. Leufkens, prof. dr. A.K. Mantel-Teeuwisse, dr. ir. C.E.M.J. van Dijk.
Utrecht University (Faculty of Science), 8 Mar 2017.
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Antiplatelet drugs for secondary prevention of cardiovascular diseases: drug utilization, effectiveness, and safety
Noorsyahdy, A.Y.
Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel, dr. V.H.M. Deneer.
Utrecht University (Faculty of Science), 13 Mar 2017.
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Solid dispersions in oncology: a solution to solubility-limited oral drug absorption
Sawicki, E.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen.
Utrecht University (Faculty of Science), 29 Mar 2017.
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Towards better fall prevention: examining the interplay between factor that influence gait in older patients
De Groot, M.H.
Supervisory team: prof. dr. J.H. Beijnen, dr. C.J.C. Lamoth.
Utrecht University (Faculty of Science), 10 May 2017.
Clinical pharmacology and bioanalysis of antileishmanial drugs: towards improved treatment strategies for leishmaniasis
Kip, A.E.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. T.P.C. Dorlo.
Utrecht University (Faculty of Science), 21 Jun 2017.
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Pediatric asthma and allergy: an epidemiological approach
Arabkhazaeli, A.
Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. C.K. van der Ent, prof. dr. A.H. Maitland-van der Zee, dr. S.J.H. Vijverberg.
Utrecht University (Faculty of Science), 26 Jun 2017.
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Globally applicable facilitated regulatory pathways to improve equitable access to medicines
Liberti, L.E.L.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.M. Breckenridge, dr. P. Stolk, dr. N.M. Auslane.
Utrecht University (Faculty of Science), 13 Jul 2017.
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Unravelling the link between diabetes, insulin treatment and breast cancer
Bronsveld, H.K.
Supervisory team: prof. dr. A. de Boer, prof. dr. M.L. De Bruin, prof. dr. M.K. Schmidt.
Utrecht University (Faculty of Science), 24 Aug 2017.
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Optimizing the safety of multidrug-resistant tuberculosis therapy in Namibia
Sagwa, E.L.
Supervisory team: prof. dr. Leufkens, prof. dr. A.K. Mantel-Teeuwisse.
Utrecht University (Faculty of Science), 24 Aug 2017.
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The pursuit of user-friendly medicines: older people in the hot seat
Notenboom, K.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. H.G.M. Leufkens.
Utrecht University (Faculty of Science), 27 Sept 2017.
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The role of motivation in continuing education for pharmacists
Schouten-Tjin A Tsoi, S.
Supervisory team: prof. dr. A. de Boer, prof. dr. G. Croiset, dr. A.S. Koster, dr. R. Kusurkar.
Utrecht University (Faculty of Science), 4 Oct 2017.
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Trials and tribulations: studies on the fate, transparency and efficiency of clinical drug trials
Van den Bogert, C.A.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. P.C. Souverein, dr. S.W.J. Janssen.
Utrecht University (Faculty of Science), 4 Oct 2017.
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Variation in health technology assessment of new medicines: processes and outcomes
Lipska, I.L.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.M. Hövels, dr. N. M. Auslane.
Utrecht University (Faculty of Science), 11 Oct 2017.
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Readmission to primary care: the role of community pharmacists post-discharge
Ensing, H.T.
Supervisory team: prof. dr. M.L. Bouvy, dr. E.S. Koster, dr. A.A. van Dooren.
Utrecht University (Faculty of Science), 25 Oct 2017.
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Clinical decision support in community pharmacy
Heringa, M.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. P.A.G.M. de Smet, dr. A. Floor-Schreudering.
Utrecht University (Faculty of Science), 30 Oct 2017.
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Clinical pharmacology of kinase inhibitors in oncology
Verheijen, R.B.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, prof. dr. A.D.R. Huitema, dr. N. Steeghs.
Utrecht University (Faculty of Science), 29 Nov 2017.
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Early development of targeted anticancer agents
Van Brummelen, E.M.J.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 18 Dec 2017.
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Clinical pharmacology of novel anticancer agents
De Weger, V.A.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. S. Marchetti.
Utrecht University (Faculty of Science), 20 Dec 2017.
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Assessing long-term and rare adverse effects of medicines
Duijnhoven, R.G.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, dr. M.L. De Bruin, dr. S.M.J.M. Straus.
Utrecht University (Faculty of Science), 18 Jan 2016.
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Understanding differences in findings from pharmacoepidemiological studies: the case of antidepressant and benzodiazepine use and hip fracture
Abbing-Karahagopian, V.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. M.L. De Bruin, dr. T.P. van Staa.
Utrecht University (Faculty of Science), 19 Jan 2016.
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Improving safety and effectiveness of fluoropyrimidine-based chemotherapy
Meulendijks, D.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A Cats.
Utrecht University (Faculty of Science), 3 Feb 2016.
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Access to essential medicines in low and middle income countries
Taghipour Bazargani, Y.
Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, dr. A.K. Mantel-Teeuwisse.
Utrecht University (Faculty of Science), 9 May 2016.
Patients at increased fracture risk: identification and pharmacological treatment
Klop, C.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.W.J. Bijlsma, dr. F. de Vries, dr. P.M.J. Welsing.
Utrecht University (Faculty of Science), 23 May 2016.
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Benefits and risks for the individual, anticoagulation for patients with atrial fibrillation
van den Ham, H.A.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. O.H. Klungel, prof. dr. T.P. van Staa.
Utrecht University (Faculty of Science), 25 May 2016.
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Harmonising relative effectiveness assessments of medicines in Europe
Kleijnen, S.
Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, dr. W.G. Goettsch.
Utrecht University (Faculty of Science), 30 May 2016.
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Clinical pharmacology of novel anticancer agents: bioanalysis - clinical pharmacokinetics - mass balance studies
Nijenhuis, C.M.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing.
Utrecht University (Faculty of Science), 15 Jun 2016.
Adverse drug reactions of angiotensin converting enzyme inhibitors: towards precision medicin
Mahmoud Pour, S.H.
Supervisory team: prof. dr. A. de Boer, prof. dr. F.W. Asselbergs, dr. A.H. Maitland-van der Zee.
Utrecht University (Faculty of Science), 29 Jun 2016.
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Adjusted indirect treatment comparisons of bioequivalence studies
Gwaza, L.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. M. Maliepaard, dr. A. Garcia-Arieta.
Utrecht University (Faculty of Science), 8 Jul 2016.
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Pharmacokinetic-pharmacodynamic modelling & simulation for anticancer drugs with complex absorption characteristics
Yu, H.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, prof. dr. A.D.R. Huitema.
Utrecht University (Faculty of Science), 31 Aug 2016.
Etiological studies in complex diseases
Peeters, P.J.H.L.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. M.L. de Bruin.
Utrecht University (Faculty of Science), 26 Sept 2016.
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Clinical pharmacology of genotype-directed anticancer therapy: towards rational combination strategies
van Geel, R.M.J.M.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 5 Oct 2016.
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Risk factors and treatment of pediatric chronic diseases: type 1 diabetes, asthma and allergy
Ahmadizar, F.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.H. Maitland-van der Zee.
Utrecht University (Faculty of Science), 23 Oct 2016.
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Evaluating pharmaceutical policies using cross-national comparisons and time series analysis
Santa Ana Tellez, Y.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.K. Mantel-Teeuwisse, dr. V.J. Wirtz.
Utrecht University (Faculty of Science), 26 Oct 2016.
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Methods for improving the safety of fluoropyrimidine anticancer drugs
Jacobs, B.A.W.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. B. Nuijen.
Utrecht University (Faculty of Science), 30 Nov 2016.
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Continuous innovation in the drug life cycle
Langedijk, J.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.K. Mantel, dr. mr. M.D.B. Schutjens.
Utrecht University (Faculty of Science), 19 Dec 2016.
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Revisiting health system performance assessment in Africa
Achoki, T.N.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.M. Hövels.
Utrecht University (Faculty of Science), 21 Dec 2016.
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Challenges and opportunities in pharmacogenomics: studies in cardiovascular disease and asthma
Leusink, M.
Supervisory team: prof. dr. A. de Boer, prof. dr. P.I.W. de Bakker, dr. A.H. Maitland, dr. N.C. Onland-Moret.
Utrecht University (Faculty of Science), 7 Jan 2015.
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Access to medicines: common problems, common solutions?
Stephens, P.N.
Supervisory team: prof. dr. H.G.M. Leufkens.
Utrecht University (Faculty of Science), 12 Jan 2015.
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Pediatric type 1 and 2 diabetes mellitus: epidemiology, comorbidities, and medication utilization
Fazelifarsani, S.
Supervisory team: prof. dr. A. de Boer, prof. dr. C.A.J. Knibbe, dr. M van der Vorst, dr. A.K. Mantel-Teeuwisse.
Utrecht University (Faculty of Science), 19 Jan 2015.
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Challenges in the clinical development of orphan drugs
Kreeftmeijer-Vegter, A.R.
Supervisory team: prof. dr. A. de Boer, dr. P.J. de Vries.
Utrecht University (Faculty of Science), 9 Feb 2015.
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Novel systemic treatment options for advanced solid tumors with or without central nervous system metastases or malignant glioma
Milojkovic Kerklaan, B.M.K.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. D. Brandsma.
Utrecht University (Faculty of Science), 25 Mar 2015.
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Antidepressant use in pregnancy: knowledge transfer and translation of research findings
Einarson, A.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 8 Apr 2015.
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Continuity of pharmaceutical care for psychiatric patients
Abdullah-Koolmees, H.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. H. Gardarsdottir.
Utrecht University (Faculty of Science), 29 Apr 2015.
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Trust in the pharmaceutical sector: analysis of drug safety controversies by means of drug life cycles
Hernandez, J.F.
Supervisory team: prof. dr. A.H.L.M. Pieters, prof. dr. J.A.M. Raaijmakers, dr. A.K. Mantel-Teeuwisse, dr. G.J.M.W. van Thiel.
Utrecht University (Faculty of Science), 3 Jun 2015.
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Supporting patients: pharmacy based interventions to improve medication adherence
Kooij, M.J.
Supervisory team: prof. dr. M.L. Bouvy, dr. E.R. Heerdink, dr. ir. C.E.M.J. van Dijk.
Utrecht University (Faculty of Science), 9 Sept 2015.
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Psychotropic drug use in people with intellectual disability: patterns of use and critical evaluation: patterns of use and critical evaluation
Scheifes, A.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H. Nijman, dr. E.R. Heerdink, dr. J.J. Stolker.
Utrecht University (Faculty of Science), 7 Oct 2015.
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Pharmacovigilance of biologicals: dynamics in post-approval safety learning
Vermeer, N.S.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. M.L. De Bruin, dr. S.M.J.M. Straus.
Utrecht University (Faculty of Science), 14 Oct 2015.
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The RT-18: a new instrument to assess adolescent and young adult risk-taking behavior
Haan, de L.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 16 Dec 2015.
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Pharmaceutical policy analysis – a European perspective on pricing and reimbursement in challenging times
Leopold, C.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing, dr. A.K. Mantel-Teeuwisse, dr. S. Vogler.
Utrecht University (Faculty of Science), 8 Jan 2014.
Complications of hip and knee replacement surgery: a pharmaco-epidemiological approach
Lalmohamed, A.
Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, prof. dr. T.P. van Staa, dr. F. de Vries.
Utrecht University (Faculty of Science), 27 Jan 2014.
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Population-based studies on risk of fracture in patients with neurological disorders
Pouwels, S.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A. de Boer, prof. dr. T.P. van Staa, dr. F. de Vries.
Utrecht University (Faculty of Science), 27 Jan 2014.
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Integrated quantitative pharmacology for treatment optimization in oncology
Van Hasselt, J.G.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A.D.R. Huitema.
Utrecht University (Faculty of Science), 29 Jan 2014.
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Disease and drug-induced arrhythmias: the example of obstructive pulmonary disease
Warnier, M.J.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, dr. M.L. de Bruin, dr. F.H. Rutten.
Utrecht University (Faculty of Science), 10 Feb 2014.
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Treatment response in childhood asthma. An interplay of genes and inflammatory signals
Vijverberg, S.J.H.
Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. L. Koenderman, dr. A.H. Maitland-van der Zee.
Utrecht University (Faculty of Science), 9 Apr 2014.
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Translational pharmacology and bioanalysis of oral taxanes
Hendrikx, J.J.M.A.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 16 Apr 2014.
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Lithium in older patients: treatment patterns and somatic adverse effects
Van Melick, E.J.M.
Supervisory team: prof. dr. A.C.G. Egberts, dr. I. Wilting.
Utrecht University (Faculty of Science), 17 Apr 2014.
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Anti-cancer drug disposition: in vitro and in vivo functions of ABC efflux and OATP uptake transporters
Durmus, S.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 5 Sept 2014.
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Childhood obesity: medical, cultural and psychological factors
Radhakishun, N.N.E.
Supervisory team: Prof. dr. J.H. Beijnen, prof. dr. M.H.H. Kramer, prof. dr. D.P.M. Brandjes.
Utrecht University (Faculty of Science), 10 Sept 2014.
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Safety, pharmacokinetics and preliminary anti-tumor activity of novel (combinations of) targeted anti-cancer drugs
Van Noll, R.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 15 Sept 2014.
Bioanalysis and clinical pharmacology of tamoxifen in breast cancer.
Jager, N.G.L.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens
Utrecht University (Faculty of Science), 17 Sept 2014.
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Improving propensity score methods in pharmacoepidemiology
Ali, M.S.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, prof. dr. O.H. Klungel, dr. R.H.H. Groenwold.
Utrecht University (Faculty of Science), 1 Oct 2014.
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Child friendly medicines. Availability, pharmaceutical design, usability and patient outcomes
Riet-Nales, D.A.
Supervisory team: prof. dr. A.F.A.M. Schobben, prof. dr. A.C.G. Egberts, dr. C.M.A. Rademaker.
Utrecht University (Faculty of Science), 26 Nov 2014.
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Performance of statistical methods to control for unmeasured confounding in pharmacoepidemiology. Focus on instrumental variable analysis
Uddin, M.J.
Supervisory team: prof. dr. A. de Boer, prof. dr. K.C.B. Roes, dr. R.H.H. Groenwold, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 15 Dec 2014.
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Understanding access to medicines in low- and middle-income countries through the use of price and availability indicators
Cameron, A.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing, dr. A.K. Mantel-Teeuwisse.
Utrecht University (Faculty of Science), 10 Jan 2013.
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Bioanalysis and clinical pharmacology of tyrosine kinase inhibitors
Lankheet, A.G.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. A.D.R. Huitema.
Utrecht University (Faculty of Science), 13 Feb 2013.
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Targeted therapies for malignant gliomas: novel agents, same barrier
Lin, F.
Supervisory team: prof. dr. J.H. Beijnen, dr. O. van Tellingen.
Utrecht University (Faculty of Science), 1 Mar 2013.
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Development of combination therapy with anti-cancer drugs
Leijen, S.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 15 Mar 2013.
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Cross-country variation in medicines use: a pharmaceutical system perspective
Hoebert, J.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing, dr. A.K. Mantel-Teeuwisse, dr. ir. C.E.M.J. van Dijk.
Utrecht University (Faculty of Science), 8 Apr 2013.
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Towards optimal dosing of coumarin derivatives: the role of pharmacogenetics
Van Schie, R.M.F.
Supervisory team: prof. dr. A. de Boer, dr. A.H. Maitland-van der Zee, dr. F.J.M. van der Meer.
Utrecht University (Faculty of Science), 10 Apr 2013.
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Bioanalysis and clinical pharmacology of antiviral drugs - focus on HIV and influenza
Kromdijk, W.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. A.D.R. Huitema, dr. J.W. Mulder.
Utrecht University (Faculty of Science), 24 Apr 2013.
Clinical pharmacokinetic interactions between herbal supplements and anticancer drugs
Goey, A.K.L.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. ir. I. Meijerman.
Utrecht University (Faculty of Science), 15 May 2013.
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Improving appropriate medication use for older people in primary care
Kwint, H.F.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. J. Gussekloo, dr. A. Faber.
Utrecht University (Faculty of Science), 29 May 2013.
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Disease specific methods for economic evaluations of breast cancer therapies
Frederix, G.W.J.
Supervisory team: prof. dr. J.H.M. Schellens, dr. J.L. Severens, dr. A.M. Hövels.
Utrecht University (Faculty of Science), 12 Jun 2013.
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Marketing authorisation of new medicines in the EU: towards evidence-based improvement
Putzeist, M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.W. Hoes, dr. A.K. Mantel-Teeuwisse, dr. C.C. Gispen-de Wied.
Utrecht University (Faculty of Science), 19 Jun 2013.
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Medicine on demand, medication patterns and glycemic control in patients with type 2 diabetes
Lamberts, E.J.F.
Supervisory team: prof. dr. M.L. Bouvy, prof. dr. M.G.A.A.M. Nijpels, dr. P.C. Souverein, dr. J.G. Hugtenburg.
Utrecht University (Faculty of Science), 19 Jun 2013.
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Exploring the regulatory decision-making process for medicines
Tafuri, G.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing.
Utrecht University (Faculty of Science), 1 Jul 2013.
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Impact of apical ABC transporters on pharmacokinetics of targeted anticancer drugs
Tang, S.C.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 3 Jul 2013.
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Drug trafficking in mice: in vivo functions of OATP uptake and ABC efflux transporters
Iusuf, D.
Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 11 Sept 2013.
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Clinical pharmacology of novel anticancer drug formulations
Stuurman, F.E.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 18 Sept 2013.
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Development of an oral dosage form of capecitabine with modified release characteristics
Meulenaar, J.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen.
Utrecht University (Faculty of Science), 25 Sept 2013.
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Production and pharmaceutical formulation of plasmid DNA vaccines
Van der Heijden, I.
Supervisory team: prof. dr. J.H. Beijnen, dr. B. Nuijen.
Utrecht University (Faculty of Science), 16 Oct 2013.
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Development and clinical application of oral dosage forms of taxanes
Moes, J.J.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen.
Utrecht University (Faculty of Science), 30 Oct 2013.
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Personalised treatment with oral anticoagulant drugs: clinical and economic issues
Verhoef, T.I.
Supervisory team: prof. dr. A. de Boer, dr. A.H. Maitland-van der Zee, dr. W.K. Redekop.
Utrecht University (Faculty of Science), 20 Nov 2013.
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Effects of Complementary and Alternative Medicines (CAM) on the metabolism and transport of anticancer drugs
Mooiman, K.D.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. ir. I. Meijerman.
Utrecht University (Faculty of Science), 18 Dec 2013.
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Measuring and prediction medication adherence using dispensing data and patient beliefs
Geers, H.C.J.
Supervisory team: prof. dr. M.L. Bouvy, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 1 Feb 2012.
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Genetic determinants for metabolic abnormalities
Risselada, A.J.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. H. Mulder.
Utrecht University (Faculty of Science), 8 Feb 2012.
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Transitional pharmaceutical care for patients discharged from the hospital
Karapinar, F.
Supervisory team: prof. dr. A.C.G. Egberts, dr. P.M.L.A. van den Bemt, dr. S.D. Borgsteede.
Utrecht University (Faculty of Science), 25 Apr 2012.
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Bioanalysis and metabolite identification of anticancer drugs in mass balance studies
Dubbelman, A.C.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. H. Rosing.
Utrecht University (Faculty of Science), 23 May 2012.
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Pandemic influenza A (H1N1) and other respiratory pathogens: clinical insights - from epidemiology to treatment
Smit, P.M.
Supervisory team: prof. dr. J.H. Beijnen, dr. J.W. Mulder, dr. D.P.M. Brandjes.
Utrecht University (Faculty of Science), 11 Jun 2012.
Antineoplastic drugs in veterinary oncology: excretion in dogs, contamination of the environment and exposure assessment of people at risk
Janssens, T.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. E.E.M. Brouwers.
Utrecht University (Faculty of Science), 5 Oct 2012.
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Non-inferiority trials: methodological and regulatory challenges
Wangge, G.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, dr. M.J. Knol, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 5 Nov 2012.
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Genetic determinants of antipsychotic drug response
Gregoor, J.G.
Supervisory team: prof. dr. A.C.G. Egberts, dr. J. van der Weide, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 14 Nov 2012.
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Laboratory markers in personalized drug therapy
Geerts, A.F.J.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. W.W. van Solinge, prof. dr. P.G.A.M. de Smet, dr. G.H.P. de Koning.
Utrecht University (Faculty of Science), 28 Nov 2012.
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A combinatorial approach to electronic healthcare records in pharmacoepidemiology
Bazelier, M.T.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. T.P. van Staa, dr. F. de Vries.
Utrecht University (Faculty of Science), 19 Dec 2012.
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Treatment optimization of fluoropyrimidines as single agent and in combination therapy
Deenen, M.J.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A. Cats.
Utrecht University (Faculty of Science), 26 Jan 2011.
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Intravenous-to-oral switch in anticancer chemotherapy: focus on taxanes and gemcitabine
Koolen, S.L.W.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A.D.R. Huitema.
Utrecht University (Faculty of Science), 16 Feb 2011.
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Influence of genetic variants and drug interactions on the response to antiplatelet drugs
Harmsze, A.M.
Supervisory team: prof. dr. A. de Boer, dr. V.H.M. Deneer, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 9 Mar 2011.
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Evaluation and management of side effects of breast cancer treatment
Boekhout, A.H.
Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen.
Utrecht University (Faculty of Science), 16 Mar 2011.
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Risk management of biologicals: a regulatory and clinical perspective
Giezen, T.J.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. A.K. Mantel, dr. S.M.J.M. Straus.
Utrecht University (Faculty of Science), 21 Mar 2011.
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Pharmacogenetics of antihypertensive drugs and the risk of diabetes
Bozkurt, O.
Supervisory team: prof. dr. A. de Boer, prof. dr. D.E. Grobbee, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 30 Mar 2011.
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The context of medicines’ use in benefit-risk evaluation
Willemen, M.J.C.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. A.K. Mantel-Teeuwisse, dr. S.M.J.M. Straus.
Utrecht University (Faculty of Science), 20 Apr 2011.
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Melatonin in sleepless children: everything has a rhythm?
Van Geijlswijk, I.M.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H. Vaarkamp, dr. M.G. Smits.
Utrecht University (Faculty of Science), 27 Apr 2011.
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Bioanalysis and metabolism of tamoxifen and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - applications in pharmacology
Teunissen, S.F.
Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing, dr. A.H. Schinkel.
Utrecht University (Faculty of Science), 25 May 2011.
Balancing the benefits and risks of antipsychotic use in elderly patients
Kleijer, B.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. M.W. Ribbe, dr. R.J. van Marum, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 19 Oct 2011.
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Antipsychotic induced parkinsonism in the elderly: assessment, causes and consequences
Knol, W.
Supervisory team: prof. dr. A.F.A.M. Schobben, prof. dr. A.C.G. Egberts, dr. R.J. van Marum, dr. P.A.F. Jansen.
Utrecht University (Faculty of Science), 21 Oct 2011.
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Medication changes in patients transitioning between health care settings
Stuffken, R.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 23 Nov 2011.
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Towards better treatment outcomes in childhood asthma
Koster, E.S.
Supervisory team: prof. dr. J.A.M. Raaijmakers, dr. A.H. Maitland-van der Zee.
Utrecht University (Faculty of Science), 26 Oct 2011.
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Innovative approaches for pharmaceutical policy research in developing countries: the view through a market lens
Waning, B.J.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing.
Utrecht University (Faculty of Science), 19 Dec 2011.
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Comparative information on new medicines: availability, quality and usage
Van Luijn, J.C.F.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. F.W.J. Gribnau.
Utrecht University (Faculty of Science), 13 Jan 2010.
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From research on rare diseases to new orphan drug development
Heemstra, H.E.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. H.A. Büller, dr. S van Weely, dr. R.L.A. Vrueh.
Utrecht University (Faculty of Science), 3 Feb 2010.
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Markers for disease severity: pharmacoepidemiological studies on obstructive lung disease
Velthove, K.J.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. W.W. van Solinge, dr. R.C. Schweizer, dr. P.C. Souverein.
Utrecht University (Faculty of Science), 19 Feb 2010.
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Pharmacotherapy and aggressive behaviour in psychiatric patients
Goedhard, L.E.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H.L.I. Nijman, dr. E.R. Heerdink, dr. J.J. Stolker.
Utrecht University (Faculty of Science), 16 Jun 2010.
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Mechanism-based drug exposure classification in pharmacoepidemiological studies
Verdel, B.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. P.C. Souverein.
Utrecht University (Faculty of Science), 29 Sept 2010.
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Methodological approaches to the pharmacogenomics of statins
Peters, B.J.M.
Supervisory team: prof. dr. A. de Boer, dr. A.H. Maitland-van der Zee, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 12 Dec 2010.
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Laboratory markers in drug safety research: studies on drug-induced thrombocytopenia
Ten Berg, M.J.
Supervisory team: prof. dr. W.W. van Solinge, prof. dr. A.C.G. Egberts, dr. P.M.L.A. van den Bemt, dr. A. Huisman.
Utrecht University (Faculty of Science), 17 Jun 2009.
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Pharmacogenetics of antihypertensive drug treatment - design and conduct of an observational study
Van Wieren-de Wijer, B.M.A.
Supervisory team: prof. dr. A. de Boer, prof. dr. B.H.Ch. Stricker, dr. O.H. Klungel, dr. A.H. Maitland-van der Zee.
Utrecht University (Faculty of Science), 7 Oct 2009.
Drug treatment episodes in pharmacoepidemiology - antidepressant use as a model
Gardarsdottir, H.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 21 Oct 2009.
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Influence of antidepressants on glucose homeostasis: effects and mechanisms
Derijks, H.J.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. G.H.P. de Koning, dr. R. Janknegt.
Utrecht University (Faculty of Science), 11 Nov 2009.
Costs and effects of statin therapy in daily practice
Gumbs, P.D.
Supervisory team: prof. dr. A. de Boer, dr. O.H. Klungel, dr. W.M.M. Verschuren.
Utrecht University (Faculty of Science), 19 Mar 2008.
Adherence to inhaled corticosteroids and patient perception: towards a better understanding and individualised care
Menckeberg, T.T.
Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. J.W.J. Lammers, dr. M.L. Bouvy, dr. M. Bracke.
Utrecht University (Faculty of Science), 20 Mar 2008.
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Patterns and clinical outcomes of lithium treatment
Wilting, I.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. W.A. Nolen, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 9 Apr 2008.
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From new molecules to leads for innovation: studies on the post-innovation learning cycle for pharmaceuticals
Stolk, P.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 15 Sept 2008.
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Children and asthma medication: when is that inhaler just a breath away?
Zuidgeest, M.G.P.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. ir. B. Brunekreef, dr. M. Bracke, dr. H.A. Smit.
Utrecht University (Faculty of Science), 8 Oct 2008.
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Initiation, execution and discontinuation of antidepressant therapy: considerations and decisions of patients
Van Geffen, E.C.G.
Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. R.P. Van Hulten.
Utrecht University (Faculty of Science), 29 Oct 2008.
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Systemic inflammatory responses in asthma
Ten Hove, W.
Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. L. Koenderman, dr. M. Bracke.
Utrecht University (Faculty of Science), 31 Jan 2007.
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Unintended effects of inhaled corticosteroids: disease or drugs?
De Vries, F.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.W.J. Lammers, dr. T.P. van Staa, dr. M. Bracke.
Utrecht University (Faculty of Science), 15 Feb 2007.
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Effects of CYP2C9 and VKORC1 polymorphisms and drug interactions on coumarin anticoagulation control
Schalekamp, T.
Supervisory team: prof. dr. A. de Boer.
Utrecht University (Faculty of Science), 7 May 2007.
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CYP2D6 and HTR2C polymorphisms in psychiatric pharmacotherapy
Mulder, J.
Supervisory team: prof. dr. A.C.G. Egberts, dr. F.W. Wilmink.
Utrecht University (Faculty of Science), 2 Jul 2007.
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The gastrointestinal and cardiovascular safety of COX-2 selective inhibitors in general practice: the contribution of prescription-event monitoring
Layton, D.
Supervisory team: prof. dr. A.C.G. Egberts.
Utrecht University (Faculty of Science), 29 Oct 2007.
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Drug effects on the risk and prognosis of community-acquired pneumonia
Van de Garde, E.M.W.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.M.M. van den Bosch, dr. P.C. Souverein, dr. V.H.M. Deneer.
Utrecht University (Faculty of Science), 21 Nov 2007.
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Methods to adjust for confounding. Propensity scores and instrumental variables
Martens, E.P.
Supervisory team: prof. dr. A. de Boer, dr. O.H. Klungel, dr. W.R. Pestman.
Utrecht University (Faculty of Science), 10 Dec 2007.
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Pharmaceutical care in diabetes
Storimans, M.J.
Supervisory team: prof. dr. C.J. de Blaey, dr. H. Talsma, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 18 Jan 2006.
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Prevention of cardiovascular diseases
Van der Elst, M.E.
Supervisory team: prof. dr. A. de Boer, prof. dr. C.J. de Blaey, dr. M.L. Bouvy.
Utrecht University (Faculty of Science), 16 Feb 2006.
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New drugs in general practice: prescribing patterns and external influences
Florentinus, S.R.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. P.P. Groenewegen, dr. E.R. Heerdink, dr. ir. C.E.M.J. van Dijk.
Utrecht University (Faculty of Science), 18 May 2006.
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Clinical risk management in community pharmacy
Buurma, H.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. P.G.A.M. de Smet.
Utrecht University (Faculty of Science), 4 Oct 2006.
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Adherence and persistence with antihypertensive drugs
Van Wijk, B.L.G.
Supervisory team: prof. dr. A. de Boer, dr. O.H. Klungel, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 6 Dec 2006.
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Antipsychotics in daily clinical practice: patterns, choices and consequences
Hugenholtz, G.W.K.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. W.A. Nolen, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 7 Dec 2005.
Molecular mechanisms of disease in hereditary red blood cell enzymopathies
Van Wijk, H.A.
Supervisory team: prof. dr. W.W. van Solinge, prof. dr. J.J.M. Marx, dr. G. Rijksen.
Utrecht University (Faculty of Science), 9 Mar 2004.
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Quality and safety aspects of lipid-lowering drug use
Mantel-Teeuwisse, A.K.
Supervisory team: prof. dr. A. de Boer, prof. dr. A.J. Porsius, dr. O.H. Klungel, dr. W.M.M. Verschuren.
Utrecht University (Faculty of Science), 26 May 2004.
Drug-induced arrhythmias, quantifying the problem
De Bruin, M.L.
Supervisory team: prof. dr. H.G.M. Leufkens, H.G.M, prof. dr. A.W. Hoes.
Utrecht University (Faculty of Science), 12 Dec 2004.
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Transitions in migraine treatment: barriers and opportunities
Rahimtoola, H.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H.G.M. Leufkens, dr. C.C. Tijssen.
Utrecht University (Faculty of Science), 7 Apr 2003.
Pharmacoepidemiological studies with cancer as outcome
Beiderbeck, A.B.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. B.H.Ch. Stricker, dr. M.C.J.M. Sturkenboom.
Utrecht University (Faculty of Science), 2 Jun 2003.
Pharmacoepidemiological determinants of exacerbations of chronic obstructive lung diseases
Gerrits, C.M.J.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.W.J. Lammers, dr. R.M.C. Herings.
Utrecht University (Faculty of Science), 2 Sept 2003.
Pharmacogenetics of HMG-CoA reductase inhibitors
Maitland-van der Zee, A.H.
Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, dr. O.H. Klungel.
Utrecht University (Faculty of Science), 17 Sept 2003.
Quality of the pharmacological treatment of patients with Parkinson's disease
Van de Vijver, D.A.M.C.
Supervisory team: prof. dr. A.J. Porsius, prof. dr. R.A.C. Roos, Prof. Dr. A. de Boer.
Utrecht University (Faculty of Science), 30 Jan 2002.
Drug-induces extrapyramidal syndromes
Schillevoort, I.E.R.M.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R.A.C. Roos, dr. R.M.C. Herings.
Utrecht University (Faculty of Science), 28 Feb 2002.
Drug therapy in heart failure: studies on prescribing, drug induced problems and compliance
Bouvy, M.L.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.W. Hoes, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 18 Mar 2002.
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Assessment and diffusion of biotechnology drugs
Zwart-van Rijkom, J.E.F.
Supervisory team: prof. dr. A.W. Broekmans, prof. dr. F.F.H. Rutten.
Utrecht University (Faculty of Science), 8 Apr 2002.
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Pharmacotherapy in type 2 diabetes mellitus patients: beyond glycaemic control
Erkens, J.A.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. D.E. Grobbee, dr. O.H. Klungel, dr. R.P. Stolk.
Utrecht University (Faculty of Science), 21 May 2002.
The value of observational research on antidepressant use: a broadened perspective
Meijer, W.E.E.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. W.A. Nolen, dr. E.R. Heerdink.
Utrecht University (Faculty of Science), 16 Oct 2002.
Implementation of patient education in Dutch community pharmacies
Pronk, M.C.M.
Supervisory team: prof. dr. A. Bakker, prof. dr. E.M. Rogers, dr. A.T.G. Blom, dr. R. Jonkers.
Utrecht University (Faculty of Science), 28 Oct 2002.
Detection and elucidation of adverse neuropsychiatric drug effects
Movig, K.L.L.
Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H.G.M. Leufkens.
Utrecht University (Faculty of Science), 28 Nov 2002.
Drug effects in high-risk patients
Souverein, P.C.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts.
Utrecht University (Faculty of Science), 16 Dec 2002.
Effects of outreach strategies on quality of pharmacotherapy
Van Eijk, M.E.C.
Supervisory team: prof. dr. A.J. Porsius, dr. A. de Boer.
Utrecht University (Faculty of Science), 19 Jun 2001.
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Quantitative signal detection in pharmacovigilance
Van Puijenbroek, E.P.
Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts.
Utrecht University (Faculty of Science), 1 Oct 2001.
Postmarketing Surveillance of Proton Pump Inhibitors in Perspective: The Case of Lansoprazole
Bodewes-Claessens, A.
Supervisory team: Prof. dr. H.G.M. Leufkens, prof. dr. C.B.H.W. Lamers, dr. E.R. Heerdink.
Utrecht University (Faculty of Science),6 Nov 2000.
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Pharmacoepidemiologic risk evaluation in bone diseases
Van Staa, T.P.
Supervisory team: prof. dr. H.G.M. Leufkens, dr. C. Cooper.
Utrecht University (Faculty of Science), 9 Jun 1999.
Studies on the quality of the pharmacolgical treatment of hypertension in the general population: Differences between women and men
Klungel, O.H.
Supervisory team: Prof. dr. A. Bakker, dr. A. de Boer, dr. A.H.P. Paes, dr. ir. J.C. Seidell.
Utrecht University (Faculty of Science), 4 Mar 1999.
Blue Boy - why not? Studies of benzodiazepine use in a Dutch community
Van Hulten, R.P.
Supervisory team: prof. dr. A. Bakker, prof. dr. H.G.M. Leufkens, dr. K.B. Teeuw.
Utrecht University (Faculty of Science), 1 Sept 1998.
Drug related problems in the elderly. Studies on occurrence and interventions
Lau, H.S.
Supervisory team: prof. dr. A.J. Porsius, dr. A. de Boer.
Utrecht University (Faculty of Science), 2 Dec 1998.
Pharmacoepidemiologic approaches to the evaluation of antidepressant drugs
Egberts, A.C.G.
Supervisory team: prof. dr. A. Bakker, prof. dr. H.G.M. Leufkens, dr. G.H.P. de Koning.
Utrecht University (Faculty of Science), 8 Oct 1997.
Clustering of drug use in the elderly: population based studies into prevalence and outcomes
Heerdink, E.R.
Supervisory team: Prof. dr. A. Bakker, prof. dr. J. Glerum, dr. H.G.M. Leufkens.
Utrecht University (Faculty of Science), 9 Oct 1995.
A Regionalized Spontaneous Surveillance Program for Adverse Drug Reactions as a Tool to Improve Pharmacotherapy
De Koning, G.H.P.
Supervisory team: Prof. dr. A. Bakker, prof. dr A.J. Porsius, dr. A. van der Kuy.
Utrecht University (Faculty of Science), 24 Mar 1994.
PHARMO A record linkage system for postmarketing surveillance of prescription drugs in The Netherlands
Herings, R.M.C.
Supervisory team: Prof. dr. A. Bakker, prof. dr. F. Sturmans, dr. B.H.Ch. Stricker.
Utrecht University (Faculty of Science), 16 Jun 1993
Altered vascular reactivity in hypertension and atherosclerosis. The role of the endothelium
Riezebos, J.
Supervisory team: Prof. dr. A.J. Porsius, dr. J. Wemer.
Utrecht University (Faculty of Science), 9 Nov 1992.
Pharmacy records in Pharmacoepidemiology. Studies on antiinflammatory and antirheumatic drugs
Leufkens, H.G.M.
Supervisory team: Prof. dr. A. Bakker, dr. Y.A. Hekster.
Utrecht University (Faculty of Science), 18 Oct 1990.
Apotheker en artsen in overleg?
Paes, A.H.P.
Supervisory team: Prof. dr. F.A. Nelemans, prof. dr. A. Bakker
Utrecht University (Faculty of Science), 25 Apr 1989.