The research of the NMR group aims at gaining fundamental insight into biological processes using solution and solid-state NMR spectroscopy as the main biophysical experimental techniques in combination with molecular biology and computational structural biology methods. Novel research concepts are being developed and applied to complex biomolecular systems including protein-protein and protein-nucleic acid complexes or membrane proteins.
NMR Spectroscopy Research Group
Research in the solution-state NMR group focusses on the processes operating on the smallest units of chromatin, called nucleosomes. Using a combination of state-of-the-art NMR , biochemical and computational methods, we aim to decipher the molecular basis of chromatin function at atomic detail.
Our research focuses on the development of modern sensitivity-enhanced solid-state NMR methods and their integration with computational techniques. We use our methods to study pharmaceutically important systems such as membrane-embedded drug-receptor complexes and nanoscale drug-vectors. We strive to study these complex biological assemblies at truly physiological conditions and at the atomic level.