Research in the group of Hugo van Ingen focusses primarily on the molecular basis of chromatin function. We are mostly interested in the interactions of histone proteins and nucleosomes with other chromatin factors such as chaperones, remodelers or proteins that control epigenetics. Using a combination of state-of-the-art NMR, biochemical and computational methods, we aim to decipher the structural basis of nucleosome recognition as well as the role protein motions herein. We aspire to create a new perspective on protein-nucleosome complexes, afforded by the unique sensitivity of NMR spectroscopy to structure, dynamics and interactions. We apply and develop new approaches to tackle these challenging systems. Next to the nucleosome-focused research, we also engage in collaborative projects ranging from protein interaction studies to NMR theory.