MBB News

Zon-Mw Open Competition Grant

In December 2022, Ody Sibon (UMCG) and Toon de Kroon were awarded a Zon-MW Open Competition grant for carrying out the collaborative research project CAMELOT: Coenzyme A & MEmbrane Lipids, an Opportunity for Treatment. Research teams will join forces to understand the complex interrelationship between CoA and membrane lipids with the aim of developing treatments for CoA-linked diseases. <Read more>

NWO ENW-XS grant - Tessa Sinnige

In November 2022, Tessa Sinnige was awarded the ENW-XS grant from NWO for her research on protein aggregation in C. elegans as a model organism. Her team will investigate how protein aggregation develops around the time of death of the organism, which could have major implications for our understanding of disease mechanisms. <Read more>  

MBB Lab Outing

On October 12th 2022, MBB organized the annual lab outing. The group was challenged to be creative like Picasso. In the afternoon, we did some nice games like kubb, laser gaming, frisbee golf and cheese rolling outside in the forest of De Bilt. It was a nice and relaxing day! 

Gold for Eefjan Breukink @ Hockey Masters World Cup

Eefjan speelt hockey

In October 2022, Eefjan Breukink won a gold medal with the Dutch national team at the Hockey Masters World Cup in Cape Town South Africa.
Congratulations Eefjan!

You can read more about Eefjan's hockey adventure at the UU website

Enzymology Symposium - Maarten Egmond

On the occasion of the retirement of emeritus professor Maarten Egmond, after more than 50 years of research in Enzymology, we organized the Symposium ‘Enzymology, Past, Present, Future’ on October 6th, 2022. Current understanding of structure-function relationships of enzymes were shared and highlighted by 10 experts in the area of Enzymology. Also insight has been presented to strengthen understanding of enzymes for further application in Academia and Industry.
We look back on a wonderful day! 

Welcome to Vera

On October 1st 2022, Vera van Schijndel joined MBB as PhD candidate in the C. elegans team of Tessa Sinnige. 

Welcome Vera!

PhD Defence Adrian Kopf

On Monday 26 September 2022, Adrian Kopf successfully defended his PhD thesis 'Membrane Solubilization by Amphipathic Copolymers - Expanding the Toolbox for the Study of Membrane Proteins'.

Congratulations dr. Adrian!

 

Welcome to Zexi

September 1st 2022, Zexi Xu started as postdoc at MBB in the Plasma project. 

Welcome Zexi!  

Co-publication in Nature

Several group members of MBB have together with the group of Markus Weingarth, Kim Lewis from the US and others published in the August 11, 2022 issue of Nature. In this article the NMR structure of the complex of a rather novel antibiotic teixobactin in interaction with its target Lipid II is shown. Besides this, we demonstrate that it forms, together with Lipid II, fibrillar like structures on the membrane that are likely to be responsible for the additional membrane perturbation that teixobactin causes. You can read the article HERE.
Congratulations to Rhythm and all co-authors!

Interview Maik Derks - about Nature Publication

Maik Derks (MBB & NMR PhD candidate) was interviewed by the Dutch Radio station NPO1 about the Nature publication mentioned above.  
This is the link to the 5 minute interview, from minute 31'20 onwards. 
Moreover RTV Utrecht has written a Dutch article about the publication

Chemistry Worm Lab Tour - 1 September

Tessa Sinnige

The nematode C. elegans has made its way into the Chemistry department as a new model organism! 
You are very welcome to visit the lab of Tessa Sinnige's group.
DATE: Thursday 1 September 2022
TIME: 16h-17h - Lab tour with 4 different demonstrations starting every 15 minutes & at 17h Drinks
LOCATION: Kruyt building 8th floor, East wing
 

ICPM9

From 27 June to 1 July 2022, the Plasma Group of Joseph Lorent co-organized the 9th edition of the International Conference on Plasma Medicine in Utrecht. 
At ICPM9, MBB PhD candidate Min Xie received the 'Best Student Paper Award' for her oral presentation. More information can be found at the ICPM9 conference website

Award ceremony with Min Xie

Retirement Antoinette Killian

On April 29th 2022, Antoinette Killian has become emeritus professor at Utrecht University. Eefjan Breukink has succeeded Antoinette as MBB group head.
Thank you very much Antoinette for all the wonderful work you did for MBB, Chemistry and Utrecht University!

Spetses Advanced Lecture Course

Eefjan Breukink successfully co-organized the EMBO-FEBS Advanced Lecture Course: 
“Lipids, proteins and their interactions in organelle biology”

DATE: Sunday May 29th – Saturday June 4th, 2022
LOCATION: Isle of Spetses, Greece
WEBSITE: spetses2022.sites.uu.nl

 

MBB lab filmed

In March 2022, our lab was used as background in an item on doping in sports by the Dutch Broadcasting Company (NOS). You can watch the video here.

NOS at MBB lab

Publication Mike Renne & MBB co-authors

Former PhD student Mike Renne published part of his PhD research in the January 17, 2022 issue of the EMBO Journal. In collaboration with the lab of Christer Ejsing (SDU, Odense), Mike demonstrated that mitochondrial phospholipid import is molecular species selective.
You can read the article here.
Congratulations to Mike and co-authors!

Eefjan Breukink - MBB Group Head

Due to the upcoming retirement of Antoinette Killian, Eejan Breukink has taken over as head of MBB starting January 1st, 2022.

Publication Xue Bao & MBB co-authors

In October 2021, our study on yeast suppressor mutants devoid of the major membrane lipid phosphatidylcholine has now been published in the EMBO Journal.
You can read the article here.
Congratulations to Xue Bao and co-authors!

ICBL2021

From 12 till 15 October 2021, MBB co-organized the 61st International Conference on the Bioscience of Lipids in Utrecht. The meeting included plenary lectures by established and young scientists, the Van Deenen lecture, poster presentations, as well as opportunities for networking and social activities. We thank all the participants and speakers for their contributions to make this a successful live conference. You can read more about the conference on the ICBL2021 website

Welcome to Mehmet Akdag & Maithili Joshi

On March 1st 2021, Mehmet Akdag joined MBB as PhD candidate in the C. elegans team of Tessa Sinnige.
On April 1st 2021, PhD candidate Maithili Joshi joined the MBB C. elegans team too. 
Welcome Mehmet and Maithili!

New MBB group picture

New: our 1,5m proof MBB group picture!

Welcome to Ramon van den Bos

On 15 November 2020, Ramon van den Bos started in a postdoc position at MBB in the team of Eefjan Breukink.

Welcome Ramon! 

Welcome to Jorieke Tiggelaar

On November 1st 2020, Jorieke Tiggelaar has started at MBB as technician in the C. elegans team of Tessa Sinnige.

Welcome Jorieke!

Welcome to Tessa Sinnige

Tessa Sinnige

On September 1st 2020, Tessa Sinnige has started at MBB as Assistant Professor.
Tessa studies protein aggregation using C. elegans as a model organism.
You can read more about her research on Tessa's MBB profile page and the website of the Sinnige lab.

Visit Eveline Koch primary school

Visit Eveline Koch primary school

Eveline Koch, MBB’s research technician, visited primary school Fatima in IJsselstein in February 2020.
Eveline entertained the youngest classes with various fascinating chemical experiments.
The visit was organized because of the school theme ‘Laboratory & Experiments’.
The children were incredibly enthusiastic and impressed.

Welcome to Maik Derks

Maik Derks

In February 2020, PhD candidate Maik started working on the 'Optimization of antibiotics targeting Lipid II' research under supervision of Eefjan Breukink (MBB) and Markus Weingarth (NMR). Via determining the structure of antibiotic-Lipid II complexes to the atomic detail, information on the mechanism of action is gained.
This will lead to novel ideas how to optimize the structure either chemically or via modern chemoenzymatic or bioconjugation methods, such that novel and improved antibiotics are obtained.