Urology

The urinary tract system is responsible for removing waste products from the body via urine. Hereditary abnormalities can disrupt this system and lead to complaints such as incontinence, urinary tract infections, or kidney damage. The Expertise Centre for Veterinary Genetics investigates the genetic basis of urological disorders in dogs in order to better understand them. In this way, we contribute to early detection and prevention.

Research into ectopic ureters

Some dog breeds have an increased risk of ectopic ureters (EU), or abnormally positioned ureters. Ureters are the tubes that transport urine from the kidneys to the bladder. If the point where these tubes enter the bladder is abnormal, for example because they enter the urethra, dogs can become incontinent, easily develop urinary tract infections, or suffer kidney damage. That is why we conduct research into the causes and consequences of this condition.

Which dog breeds have an increased risk of ectopic ureters?

• The Labrador Retriever

• The Golden Retriever

• The Entlebucher Mountain Dog

• The Briard

What are we investigating?

We investigate which genetic mutations underlie ectopic ureters. We study the hereditary predisposition, the distribution within breeds and in crossbreeds, and which factors influence the clinical symptoms. This helps us to recognise the condition at an early stage, treat patients as effectively as possible, and ultimately prevent it.

How do we do that?

We analyse DNA from Belgian Shepherd Dogs, compare genetic profiles, and collaborate with researchers in the US. This has led to the identification of risk factors in DNA. We develop a reliable DNA test to determine the risk of stomach cancer at an early stage.

What are the results?

The study shows that stomach cancer in Belgian shepherds is highly hereditary. The genetic risk factors are now known, and a DNA test will soon be available to help owners and breeders better assess the risk.