Liver
The liver filters waste products from the bloodstream, thereby cleansing the body. Hereditary abnormalities can seriously disrupt liver function, which can lead to various health problems. The Centre for Veterinary Genetics investigates the hereditary basis of liver disorders to gain a better understanding of their causes and progression, with the aim of early detection and effective prevention.
Research into hepatitis and copper accumulation
Some dog breeds have an increased risk of hereditary liver inflammation (hepatitis), which often only manifests itself at a late stage. Common underlying causes include autoimmune reactions, copper accumulation, or a combination of the two. By unraveling the genetic background, we hope to recognize and prevent these serious conditions earlier.
These dog breeds have an increased risk of hepatitis and copper accumulation:
The Labrador Retriever
The Doberman
The Bedlington Terrier
The Cavalier King Charles Spaniel
The West Highland White Terrier
The Welsh Corgi Pembroke and Cardigan
The Dalmatian
The Great Dane
What are we researching?
The Expertise Centre for Veterinary Genetics investigates the genetic predisposition to liver inflammation, particularly in Labradors and Dobermans. Findings are then also investigated in other breeds. We also focus on copper accumulation, a condition in which copper accumulates in the liver, and autoimmune-mediated liver inflammation.
Mutations in the ATP7B and ATP7A genes explain part of the development of copper accumulation, but not the whole picture. In addition, the same area of DNA in Labradors and Dobermans appears to be involved in autoimmune-mediated liver inflammation. Through additional genetic research, we aim to better understand these factors and identify new contributing factors. We also study whether the same factors play a role in other breeds.
How do we do that?
We collect DNA material from dogs with and without liver problems. We use this to perform Genome-Wide Association Studies (GWAS) to identify genetic variants that contribute to the development of hepatitis and copper accumulation. We also analyze liver biopsies and clinical data to link genetic findings to the course of the disease in practice.
What are the results?
We have identified a new region on the DNA that is associated with liver disease in both Labradors and Dobermans. This helps us to better understand the disease and benefits the development of DNA tests and targeted screenings.
Research into liver shunts
A congenital extrahepatic portosystemic shunt (liver shunt) is a common abnormality in small dog breeds. In this condition, part of the blood flows outside the liver, causing waste products to accumulate in the body. This can lead to serious neurological symptoms and growth retardation. Early detection and understanding of the genetic cause are essential to prevent this condition.
These dog breeds are at increased risk of liver shunt:
The Cairn Terrier
The Yorkshire Terrier
The Jack Russell Terrier
The Miniature Schnauzer
The Pug
What are we researching?
We investigating the genetic causes of liver shunts. This condition occurs in several small dog breeds. We know that there is a hereditary basis, but the exact genetic mutations are still unknown. With our research, we want to contribute to a healthier population through targeted breeding.
How do we do that?
We collect DNA material from dogs with and without liver shunts, originating from high-risk breeds. Using Genome-Wide Association Studies (GWAS), we identify genetic variants associated with this congenital condition. By combining data from multiple breeds, we investigate whether there is a common genetic cause.
What are the results?
The results indicate that the same genetic factor may be responsible for liver shunts in multiple breeds. This offers prospects for the development of a DNA test that can be widely used in breeding.