Research on dilated cardiomyopathy

We conduct research into dilated cardiomyopathy (DCM), a serious hereditary heart muscle disease that affects more than half of all Dobermans. DCM weakens the heart muscle, causing the heart to enlarge and pump blood less effectively. Symptoms range from fatigue and fainting to sudden cardiac death.

These dog breeds have an increased risk of dilated cardiomyopathy:

• The Doberman

• The English Cocker Spaniel

• The Irish Wolfhound

• The Great Dane

• The Newfoundland

Cardioscreenings en DNA-tests

For both Dobermans and English Cocker Spaniels, cardiac screening and DNA testing are available to detect DCM at an early stage.

What are we researching?

Our goal is to detect dilated cardiomyopathy earlier, better understand the progression of the disease, and contribute to more targeted treatment and prevention. With these insights, we aim to improve screening, enable timely diagnosis, and ultimately achieve effective prevention.

How do we do that?

Our genetic research focuses on identifying risk genes that cause DCM. We combine this with analyses of signaling substances in the blood and advanced imaging, enabling us to better monitor the development of harmful changes in heart tissue.

In the ELECTRODE research project, we collaborate with the Department of Human Cardiogenetics at UMC Utrecht. DNA research has shown that a genetically similar variant is involved in DCM in both Dobermans and humans. This breakthrough marks an important step in the development of a DNA test for early detection and prevention of DCM.

Are you interested in participating?

Take part in the DCM research with Dobermans – find out how (in Dutch)