• Cryo-electron microscopy

    Cryo-electron microscopy (cryo-EM) is a key imaging modality for studying the structures of macromolecular complexes in their physiological environment. In the cryo-EM group we aim at a structural understanding of processes associated with cellular membranes. To this end we make use of single particle cryo-EM and in particular cryo-electron tomography (ET) approaches. While single particle cryo-EM is an excellent approach to study isolated complexes at near-atomic resolution, cryo-ET allows imaging complexes in their native settings, such as organelle and plasma membrane. We actively develop methodology for in situ structural biology and apply it to understand processes such as membrane-associated protein biogenesis and host-pathogen interactions.

  • Contact

    H.R. Kruytbuilding
    Padualaan 8
    3584 CH Utrecht
    The Netherlands

    Phone: +31 30 253 3502

    Email: science.secr.em@uu.nl

     

We aim at a structural understanding of processes at native cellular membranes

Friedrich Foerster
Friedrich Förster
Professor of Cryo-electron microscopy

The inside of a cell - in 3D

Ribosomes associated to the membranes of Endoplasmic Reticulum and nuclear envelope in a cell.

Using advanced microscopy approaches we visualize biochemical processes at cellular membranes.