Membrane Fusion

Research in the group focuses on studying the mechanism of action of fusogens, i.e., proteins mediating biological membrane fusion.

Membrane fusion is a central process for all eukaryotic cells that are not only surrounded by a membrane but also using membranes to form cellular compartments. Membrane merging or fusion is important for organelle formation and trafficking within the cell but also some important cells fuse as part of their function. 

The research group studies fusion machineries in the context of membranes by combining innovative membrane model systems and applying multimodality imaging.

Interested in this subject ? look at our Research Projects     

Would like to join our team? contact us at z.zeev@uu.nl

 

Further reading

1. Zeev-Ben-Mordehai T, Vasishtan D, Siebert CA, Whittle C, & Grünewald K (2014) Extracellular Vesicles: A Platform for the Structure Determination of Membrane Proteins by Cryo-EM. Structure 22(11):1687-1692

2. Zeev-Ben-Mordehai T, Hagen C, & Grünewald K (2014) A cool hybrid approach to the herpesvirus 'life' cycle. Curr Opin Virol 5C:42-49

3. Zeev-Ben-Mordehai T, Vasishtan D, Siebert CA, & Grünewald K (2014) The full-length cell-cell fusogen EFF-1 is monomeric and upright on the membrane. Nat Commun 5:3912

4. Zeev-Ben-Mordehai T, et al. (2016) Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B. Proc. Natl. Acad. Sci. U. S. A. 113:4176-4181