Cryo-electron microscopy

Cryo-electron microscopy (cryo-EM) is a key imaging modality for studying the structures of macromolecular complexes in their physiological environment. In the cryo-EM group we aim at a structural understanding of processes associated with cellular membranes. To this end we make use of single particle cryo-EM and in particular cryo-electron tomography (ET) approaches. While single particle cryo-EM is an excellent approach to study isolated complexes at near-atomic resolution, cryo-ET allows imaging complexes in their native settings, such as organelle and plasma membrane. We actively develop methodology for in situ structural biology and apply it to understand processes such as membrane-associated protein biogenesis and host-pathogen interactions.

Contact

H.R. Kruytbuilding
Padualaan 8
3584 CH Utrecht
The Netherlands

Phone: +31 30 253 3502

Email: science.secr.em@uu.nl

 

We aim at a structural understanding of processes at native cellular membranes
Friedrich Foerster
Friedrich Förster
Professor of Cryo-electron microscopy

News

Glycomics
23 June 2017
Geert-Jan Boons and colleagues developed a method that allows detailed research into the benefits of the complex sugars in human breast milk
Spinozalaureaten Alexander van Oudenaarden en Albert Heck.
15 June 2017
Both Albert Heck and Alexander van Oudenaarden from Utrecht University receive a Spinozaprize, the highest scientific award in the Netherlands.
DNA (blue) in a spindle, the protein ASPM is located at the ‘poles’ (yellow)
24 April 2017
Publication in Nature Cell Biology about new molecular insight into brain development disorder microcephaly

Pages

RSS

Events

28
Jun
28 June 2017 12:45 - 13:45
PhD Defence of Deni Mance
30
Jun
30 June 2017 09:30 - 18:00
40 Years of Sailing the Biomolecular NMR world
13
Jul
13 July 2017 12:45 - 13:45
PhD Defence of A. Jain
RSS