Cryo-electron microscopy (cryo-EM) is a key imaging modality for studying the structures of macromolecular complexes in their physiological environment. In the cryo-EM group we aim at a structural understanding of processes associated with cellular membranes. To this end we make use of single particle cryo-EM and in particular cryo-electron tomography (ET) approaches. While single particle cryo-EM is an excellent approach to study isolated complexes at near-atomic resolution, cryo-ET allows imaging complexes in their native settings, such as organelle and plasma membrane. We actively develop methodology for in situ structural biology and apply it to understand processes such as membrane-associated protein biogenesis and host-pathogen interactions.
3584 CH Utrecht
Phone: +31 30 253 3502
We aim at a structural understanding of processes at native cellular membranes
Professor of Cryo-electron microscopy
21 March 2017
In two short videos, biology researcher Mike Boxem and chemistry researcher Friedrich Förster present the research that earned them their Vici grants
20 February 2017
Friedrich Förster, professor of Cryo-Electron Microscopy, publishes in Nature Communications.
1 July 2016
Researchers have successfully unravelled the structure of a large human proteasome down to the atomic level.
18 December 2017 16:15 - 17:15
PhD Defence: Dynamics of the neuroproteome: protein signaling and translation in neurological disorders
PhD Defence of Renske Penning
20 December 2017 12:45 - 13:45
PhD Defence: From data to knowledge: a bioinformatics approach to study the role of proteins and their modifications in network biology
PhD Defence of Linsey Raaijmakers
25 - 29
25 June 2018 09:00 - 29 June 2018 17:00
A one-week course to jumpstart your business career in life sciences!