Publications

Ayechu-Muruzabal, V., M. van de Kaa, R. Mukherjee, J. Garssen, B. Stahl, R.J. Pieters, B. Van't Land, A.D. Kraneveld, L.E.M. Willemsen. 2022. Modulation of the epithelial- immune cell crosstalk and related galectin secretion by DP3-5 galacto-oligosaccharides and beta-3'galactosyllactose. Biomolecules 12(3): 384 (DOI: 10.3390/biom12030384).

Bottin, J.H., S. Eussen, A.J. Igbinijesu, M. Mank, J.J. Koyembi, Y.T. Nyasenu, G. Ngaya, D. Mad-Bondo, J.B. Kongoma, B. Stahl, P.J. Sansonetti, R. Bourdet-Sicard, V. Moya- Alvarez. 2022. Food insecurity and maternal diet influence human milk composition between the infant's birth and 6 months after birth in Central-Africa. Nutrients 14(19): 4015 (DOI: 10.3390/nu14194015).

Cecotto, L., K. van Kessel, M.A. Wolfert, C. Vogely, B. van der Wal, H. Weinans, J. van Strijp, S. Amin Yavari. 2022. Antibacterial and anti-inflammatory properties of host defense peptides against Staphylococcus aureus. iScience 25(10): 105211 (DOI: 10.1016/j.isci.2022.105211).

Danielsson, A., M.M. Kogut, M. Maszota-Zieleniak, P. Chopra, G.J. Boons, S.A. Samsonov. 2022. Molecular dynamics-based descriptors of 3-O-sulfated heparan sulfate as contributors of protein binding specificity. Comput. Biol. Chem. 99: 107716 (DOI: 10.1016/j.compbiolchem.2022.107716).

de Jong, H., M.J. Moure, J.E.M. Hartman, G.P. Bosman, J.Y. Ong, B.W. Bardoel, G.J. Boons, M. Wosten, T. Wennekes. 2022. Selective exoenzymatic labeling of lipooligosaccharides of Neisseria gonorrhoeae with alpha2,6-sialoside analogues. ChemBioChem 23(19): e202200340 (DOI: 10.1002/cbic.202200340).

de Jong, H., M.M.S.M. Wosten, T. Wennekes. 2022. Sweet impersonators: Molecular mimicry of host glycans by bacteria. Glycobiology 32(1): 11-22 (DOI: 10.1093/glycob/cwab104).

de Jong, S.P.J., Z.C. Felix Garza, J.C. Gibson, A.X. Han, S. van Leeuwen, R.P. de Vries, G.J. Boons, M. van Hoesel, K. de Haan, L.E. van Groeningen, K.D. Hulme, H.D.G. van Willigen, E. Wynberg, G.J. de Bree, A. Matser, M. Bakker, L. van der Hoek, M. Prins, N.A. Kootstra, D. Eggink, B.E. Nichols, M.D. de Jong, C.A. Russell. 2022. Potential impacts of prolonged absence of influenza virus circulation on subsequent epidemics. medRxiv: (DOI: 10.1101/2022.02.05.22270494).

Aulaire, P.D., J. Hoogenboom, M.T. Uiterweerd, H. Zuilhof, T. Wennekes. 2022. Synthetic strategy towards a carbocyclic N-acetylneuraminic acid. Eur. J. Org. Chem. 2022(27): e202200297 (DOI: 10.1002/ejoc.202200297).

Di Maso, M., F. Bravi, M. Ferraroni, C. Agostoni, S. Eussen, T. Decsi, P.A. Quitadamo, P. Tonetto, C. Peila, C. Profeti, G. Salvatori, I. Kazmierska, A. Decarli, E. Vacca, E. Bertino, B. Stahl, G.E. Moro. 2022. Adherence to mediterranean diet of breastfeeding mothers and fatty acids composition of their human milk: Results from the Italian MEDIDIET study. Front. Nutr. 9: 891376 (DOI: 10.3389/fnut.2022.891376).

Duca, M., D. Haksar, J. van Neer, D.M.E. Thies-Weesie, D. Martinez-Alarcon, H. de Cock, A. Varrot, R.J. Pieters. 2022. Multivalent fucosides targeting beta-propeller lectins from lung pathogens with promising anti-adhesive properties. ACS Chem. Biol. 17(12): 3515- 3526 (DOI: 10.1021/acschembio.2c00708).

Gaide, N., M.N. Lucas, M. Delpont, G. Croville, K.M. Bouwman, A. Papanikolaou, R. van der Woude, I.A. Gagarinov, G.J. Boons, R.P. de Vries, R. Volmer, A. Teillaud, T. Vergne, C. Bleuart, G. Le Loc'h, M. Delverdier, J.L. Guérin. 2022. Pathobiology of highly pathogenic H5 avian influenza viruses in naturally infected Galliformes and Anseriformes in France during winter 2015-2016. Vet. Res. 53(1): 11 (DOI: 10.1186/s13567-022- 01028).

Hooijschuur, K., X. Liu, A. Grootendorst, I. Pieterman, J. Sastre Toraño. 2022. In-line sample trap columns with diatomite for large-volume injection in CZE–IM–MS. Electrophoresis: 1-8 (DOI: 10.1002/elps.202200189).

Hribernik, N., F. Chiodo, R.J. Pieters, A. Bernardi. 2022. Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies. Tetrahedron Lett. 99: 153843 (DOI: 10.1016/j.tetlet.2022.153843).

Kariyawasam, U., M. Gulati, Y. Wang, H. Bao, T. Shan, X. Li, X. Cao, N. Sumathipala, Y. Hu, X. Zhang, G.J. Boons, H. Jiang. 2022. Preferential binding of DAP-PGs by major peptidoglycan recognition proteins found in cell-free hemolymph of Manduca sexta. Insect Biochem. Mol. Biol. 148: 103827 (DOI: 10.1016/j.ibmb.2022.103827).

Konietzny, P.B., H. Peters, M.L. Hofer, U.I.M. Gerling-Driessen, R.P. de Vries, T. Peters, L. Hartmann. 2022. Enzymatic sialylation of synthetic multivalent scaffolds: From 3'- sialyllactose glycomacromolecules to novel neoglycosides. Macromol. Biosci. 22: e2200358 (DOI: 10.1002/mabi.202200358).

Kontopodi, E., B. Stahl, J.B. van Goudoever, S. Boeren, R.A.H. Timmermans, H.M.W. den Besten, R.M. Van Elburg, K. Hettinga. 2022. Effects of high-pressure processing, UV-C irradiation and thermoultrasonication on donor human milk safety and quality. Front. Pediatr. 10: 828448 (DOI: 10.3389/fped.2022.828448).

Kucukkose, E., B.A. Heesters, J. Villaudy, A. Verheem, M. Cercel, S. van Hal, S.F. Boj, I.H.M. Borel Rinkes, C.J.A. Punt, J.M.L. Roodhart, J. Laoukili, M. Koopman, H. Spits, O. Kranenburg. 2022. Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice. J. Immunother. Cancer 10(12): e005345 (DOI: 10.1136/jitc-2022-005345).

Laman, J.D., R. Huizinga, G.J. Boons, B.C. Jacobs. 2022. Guillain-Barre syndrome: expanding the concept of molecular mimicry. Trends Immunol. 43(4): 296-308 (DOI: 10.1016/j.it.2022.02.003).

Latchoumane, C.V., P. Chopra, L. Sun, A. Ahmed, F. Palmieri, H.F. Wu, R. Guerreso, K. Thorne, N. Zeltner, G.J. Boons, L. Karumbaiah. 2022. Synthetic heparan sulfate hydrogels regulate neurotrophic factor signaling and neuronal network activity. ACS Appl. Mater. Interfaces 14(25): 28476-28488 (DOI: 10.1021/acsami.2c01575).

Li, Z., R. Derking, W.H. Lee, G.P. Bosman, A.B. Ward, R.W. Sanders, G.J. Boons. 2022. Conjugation of a Toll-like receptor agonist to glycans of an HIV native-like envelope trimer preserves neutralization epitopes. ChemBioChem 23(16): e202200236 (DOI: 10.1002/cbic.202200236).

Li, Z., L. Liu, L. Unione, Y. Lang, R.J. de Groot, G.J. Boons. 2022. Synthetic O-acetyl-N- glycolylneuraminic acid oligosaccharides reveal host-associated binding patterns of coronaviral glycoproteins. ACS Infect. Dis. 8(5): 1041-1050 (DOI: 10.1021/acsinfecdis.2c00046).

Li, Z., L. Unione, L. Liu, Y. Lang, R.P. de Vries, R.J. de Groot, G.J. Boons. 2022.Synthetic O-acetylated sialosides and their acetamido-deoxy analogues as probes for coronaviral hemagglutinin-esterase recognition. J. Am. Chem. Soc. 144(1): 424-435 (DOI: 10.1021/jacs.1c10329).

Liu, Z., X. Li, Z. Lu, X. Qin, H. Hong, Z. Zhou, R.J. Pieters, J. Shi, Z. Wu. 2022. Repurposing the pentameric B-subunit of Shiga toxin for Gb3-targeted immunotherapy of colorectal cancer by rhamnose conjugation. J. Pharm. Sci. 111(10): 2719-2729 (DOI: 10.1016/j.xphs.2022.07.017).

Loi, E.M., T. Tomasic, C. Balsollier, K. van Eekelen, M. Weiss, M. Gobec, M.G. Alteen, D.J. Vocadlo, R.J. Pieters, M. Anderluh. 2022. Discovery of a new drug-like series of OGT inhibitors by virtual screening. Molecules 27(6): 1996 (DOI: 10.3390/molecules27061996).

Lu, Z., Z. Liu, X. Li, X. Qin, H. Hong, Z. Zhou, R.J. Pieters, J. Shi, Z. Wu. 2022. Nanobody- based bispecific neutralizer for Shiga toxin-producing E. coli. ACS Infect. Dis. 8(2): 321- 329 (DOI: 10.1021/acsinfecdis.1c00456).

Luijkx, Y.M.C.A., A.J. Henselijn, G.P. Bosman, D.A.T. Cramer, K. Giesbers, E.M. van 't Veld, G.J. Boons, A.J.R. Heck, K.R. Reiding, K. Strijbis, T. Wennekes. 2022. Detection of bacterial alpha-L-fucosidases with an ortho-quinone methide-based probe and mapping of the probe-protein adducts. Molecules 27(5): 1615 (DOI: 10.3390/molecules27051615).

Madunic, K., O.A. Mayboroda, T. Zhang, J. Weber, G.J. Boons, H. Morreau, R. van Vlierberghe, T. van Wezel, G.S.M. Lageveen-Kammeijer, M. Wuhrer. 2022. Specific (sialyl-)Lewis core 2 O-glycans differentiate colorectal cancer from healthy colon epithelium. Theranostics 12(10): 4498-4512 (DOI: 10.7150/thno.72818).

Montez de Sousa, I.R., Z. Wang, R. Hu, B. Stahl, Y. Jin, S.R.B.M. Eussen, J. Li. 2022. Dietary intake of Chinese lactating women is associated with the fatty acid profile of their milk. Ann. Nutr. Metab. 78(1): 33-45 (DOI: 10.1159/000520515).

Moya-Alvarez, V., S. Eussen, M. Mank, J.J. Koyembi, Y.T. Nyasenu, G. Ngaya, D. Mad- Bondo, J.B. Kongoma, B. Stahl, P.J. Sansonetti, R. Bourdet-Sicard. 2022. Human milk nutritional composition across lactational stages in Central Africa. Front. Nutr. 9: 1033005 (DOI: 10.3389/fnut.2022.1033005).

Mukherjee, R., V.J. Somovilla, F. Chiodo, S. Bruijns, R.J. Pieters, J. Garssen, Y. van Kooyk, A.D. Kraneveld, J. van Bergenhenegouwen. 2022. Human milk oligosaccharide 2’- fucosyllactose inhibits ligand binding to C-type lectin DC-SIGN but not to langerin. Int. J. Mol. Sci. 23(23): 14745 (DOI: 10.3390/ijms232314745).

Nemanichvili, N., A.J. Berends, I. Tomris, K.N. Barnard, C.R. Parrish, A. Grone, J.M. Rijks, M.H. Verheije, R.P. de Vries. 2022. Influenza D binding properties vary amongst the two major virus clades and wildlife species. Vet. Microbiol. 264: 109298 (DOI: 10.1016/j.vetmic.2021.109298).

Nemanichvili, N., C.M. Spruit, A.J. Berends, A. Grone, J.M. Rijks, M.H. Verheije, R.P. de Vries. 2022. Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids. Glycobiology 32(9): 791-802 (DOI: 10.1093/glycob/cwac033).

Nguyen, L., K.A. McCord, D.T. Bui, K.M. Bouwman, E.N. Kitova, M. Elaish, D. Kumawat, G.C. Daskhan, I. Tomris, L. Han, P. Chopra, T.J. Yang, S.D. Willows, A.L. Mason, L.K. Mahal, T.L. Lowary, L.J. West, S.D. Hsu, T. Hobman, S.M. Tompkins, G.J. Boons, R.P. de Vries, M.S. Macauley, J.S. Klassen. 2022. Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2. Nat. Chem. Biol. 18(1): 81-90 (DOI: 10.1038/s41589-021-00924-1).

Rastall, R.A., M. Diez-Municio, S.D. Forssten, B. Hamaker, A. Meynier, F.J. Moreno, F. Respondek, B. Stahl, K. Venema, M. Wiese. 2022. Structure and function of non-digestible carbohydrates in the gut microbiome. Benef. Microbes 13(2): 95-168 (DOI: 10.3920/BM2021.0090).

Sheikh, M.O., C.J. Capicciotti, L. Liu, J. Praissman, D. Ding, D.G. Mead, M.A. Brindley, T. Willer, K.P. Campbell, K.W. Moremen, L. Wells, G.J. Boons. 2022. Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function. Nat. Commun. 13(1): 3617 (DOI: 10.1038/s41467-022-31205-7).

Siziba, L.P., M. Mank, B. Stahl, D. Kurz, J. Gonsalves, B. Blijenberg, D. Rothenbacher, J. Genuneit. 2022. Human milk oligosaccharide profiles and child atopic dermatitis up to 2 years of age: The Ulm SPATZ Health Study. Pediatr. Allergy Immunol. 33(2): e13740 (DOI: 10.1111/pai.13740).

Spruit, C.M., X. Zhu, I. Tomris, M. Rios-Carrasco, A.X. Han, F. Broszeit, R. van der Woude, K.M. Bouwman, M.M.T. Luu, K. Matsuno, Y. Sakoda, C.A. Russell, I.A. Wilson, G.J. Boons, R.P. de Vries. 2022. N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses. J. Virol. 96(5): e0212021 (DOI: 10.1128/jvi.02120-21).

Sun, L., P. Chopra, G.J. Boons. 2022. Chemoenzymatic synthesis of heparan sulfate oligosaccharides having a domain structure. Angew. Chem. Int. Ed. 61(47): e202211112 (DOI: 10.1002/anie.202211112).

Tomris, I., K.M. Bouwman, Y. Adolfs, D. Noack, R. van der Woude, G. Kerster, S. Herfst, R.W. Sanders, M.J. van Gils, G.J. Boons, B.L. Haagmans, R.J. Pasterkamp, B. Rockx, R.P. de Vries. 2022. Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns. PLoS Pathog. 18(3): e1010340 (DOI: 10.1371/journal.ppat.1010340).

Trattnig, N., Z. Li, G.P. Bosman, P. Kosma, G.J. Boons. 2022. Site-specific multi- functionalization of the carrier protein CRM(197) by disulfide rebridging for conjugate vaccine development. ChemBioChem 23(21): e202200408 (DOI: 10.1002/cbic.202200408).

Van der Put, R.M.F., A. Spies, B. Metz, D. Some, R. Scherrers, R. Pieters, M. Danial. 2022. Validation of an FFF-MALS method to characterize the production and functionalization of outer-membrane vesicles for conjugate vaccines. Anal. Chem. 94(35): 12033-12041 (DOI: 10.1021/acs.analchem.2c01590).

Van Stigt, A.H., K. Oude Rengerink, K.W.M. Bloemenkamp, W. de Waal, S.M.P.J. Prevaes, T.M. Le, F. van Wijk, M. Nederend, A.H. Hellinga, C.S. Lammers, G. den Hartog, M.J.C. van Herwijnen, J. Garssen, L.M.J. Knippels, L.M. Verhagen, C.G.M. de Theije, A. Lopez-Rincon, J.H.W. Leusen, B. Van't Land, L. Bont, Prima Initiative Group (Knulst, A.C., C..K. van der Ent, D. van Baarle, M.H.M. Wauben, N.Y. Rots, E.A.M. Sanders, M.J.N.L. Benders, L.A.M.P. Meulenbroek, B. Stahl, A.D. Kraneveld, B.J.M. Buiteman, T. Voogt, B. van der Meij, B. Lerkvaleekul, E. Voogd, C.S. Lammers, T.A. Lalmahomed, I.M. Brus, D.M.M. van Meerwijk, S.I.E. Jepma). 2022. Analysing the protection from respiratory tract infections and allergic diseases early in life by human milk components: the PRIMA birth cohort. BMC Infect. Dis. 22(1): 152 (DOI: 10.1186/s12879-022-07107-w).

Verheyen, S., J. Blatterer, M.R. Speicher, G.S. Bhavani, G.J. Boons, M.B. Ilse, D. Andrae, J. Spross, F.M. Vaz, S.G. Kircher, L. Posch-Pertl, D. Baumgartner, T. Lubke, H. Shah, A. Al Kaissi, K.M. Girisha, B. Plecko. 2022. Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency. J. Med. Genet.: (DOI: 10.1136/jmedgenet-2021- 108061).

Wei, X., W. Du, M. Duca, G. Yu, E. de Vries, C.A.M. de Haan, R.J. Pieters. 2022. Preventing influenza A virus infection by mixed inhibition of neuraminidase and hemagglutinin by divalent inhibitors. J. Med. Chem. 65(10): 7312-7323 (DOI: 10.1021/acs.jmedchem.2c00319).

Wu, J., P. Chopra, G.J. Boons, J. Zaia. 2022. Influence of saccharide modifications on heparin lyase III substrate specificities. Glycobiology 32(3): 208-217 (DOI: 10.1093/glycob/cwab023).

Xu, Y., V.M. Hernandez-Rocamora, J.H. Lorent, R. Cox, X. Wang, X. Bao, M. Stel, G. Vos, R.M. van den Bos, R.J. Pieters, J. Gray, W. Vollmer, E. Breukink. 2022. Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine. iScience 25(8): 104753 (DOI: 10.1016/j.isci.2022.104753).

Yang, X., J. Kemmink, D.T.S. Rijkers, R.M.J. Liskamp. 2022. Synthesis of a tricyclic hexapeptide –via two consecutive ruthenium-catalyzed macrocyclization steps– with a constrained topology to mimic vancomycin's binding properties toward D-Ala-D-Ala dipeptide. Bioorg. Med. Chem. Lett. 73: 128887 (DOI: 10.1016/j.bmcl.2022.128887).

Arunkumar, G.A., D. Bhavsar, T. Li, S. Strohmeier, V. Chromikova, F. Amanat, M. Bunyatov, P.C. Wilson, A.H. Ellebedy, G.J. Boons, V. Simon, R.P. de Vries, and F. Krammer. 2021. Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus. Nat. Commun. 12(1): 6161 (DOI: 10.1038/s41467-021-26409-2).

Asadpoor, M., Ithakisiou, G., Henricks, P.A.J., Pieters, R.J., Folkerts, G., Braber, S. 2021. Non-Digestible Oligosaccharides and Short Chain Fatty Acids as Therapeutic Targets against Enterotoxin-Producing Bacteria and Their Toxins. Toxins. 13: 175

Asadpoor, M., Ithakisiou, G.N., van Putten, J., Pieters, R.J., Folkerts, G., Braber, S. 2021. Antimicrobial Activities of Alginate and Chitosan Oligosaccharides Against Staphylococcus aureus and Group B Streptococcus. Front. Microbiol. 12: 700605

Asadpoor, M., Varasteh, S., Pieters, R.J., Folkerts, G., Braber, S. 2021. Differential Effects of Oligosaccharides on the Effectiveness of Ampicillin against Escherichia Coli in Vitro. PharmaNutrition. 16: 100264

Balsollier, C., Pieters, R.J., Anderluh, M. 2021. Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity. Molecules. 26: 1037.

Bosman, G.P., Oliveira, S., Simons, P.J., Sastre Torano, J., Somsen, G.W., Knippels, L., Haselberg, R., Pieters, R.J., Garssen, J., Knipping, K. 2021. Limited Lactosylation of Beta-Lactoglobulin from Cow's Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells. Nutrients. 13: 2041

Bravi F., Di Maso M., Eussen S.R.B.M., Agostoni C., Salvatori G., Profeti C., Tonetto P., Quitadamo P. A., Kazmierska I., Vacca E., Decarli A., Stahl B., Bertino E., Moro G.E., Ferraroni M. 2021. Dietary Patterns of Breastfeeding Mothers and Human Milk Composition: Data from the Italian MEDIDIET Study. On Behalf Of The Medidiet Working Group. Nutrients. 13(5): 1722 (DOI: 10.3390/nu13051722).

Bouwman, K.M., I. Tomris, H.L. Turner, R. van der Woude, T.M Shamorkina, G.P. Bosman, S. Herfst, B. Rockx, J. Snijder, B.L. Haagmans, A.B. Ward, G.J. Boons, and R.P. de Vries. 2021. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins. PLoS Pathog. 17(2): e1009282 (DOI:10.1371/journal.ppat.1009282).

Chia L.W., Mank M., Blijenberg B., Bongers R.S., van Limpt K., Wopereis H., Tims S., Stahl B., Belzer C., Knol J. 2021. Cross-feeding between Bifidobacterium infantis and Anaerostipes caccae on lactose and human milk oligosaccharides. Benef Microbes. 12(1): 69-83 (DOI: 10.3920/BM2020.0005).

Chopra, P., A. Joshi, J. Wu, W. Lu, T. Yadavalli, M.A. Wolfert, D. Shukla, J. Zaia, and G.J. Boons. 2021. 3-O-Sulfation of heparan sulfate modulates protein binding and lyase degradation. Proc. Natl. Acad. Sci. U. S. A. 118(3): e2012935118 (DOI: 10.1073/pnas.2012935118).

Dai, M., W. Du, C. Martínez-Romero, T. Leenders, T. Wennekes, G. F. Rimmelzwaan, F. J. M. van Kuppeveld, R. A. M. Fouchier, A. Garcia-Sastre, E. de Vries, C. A. M. de Haan. 2021. Analysis of the Evolution of Pandemic Influenza A (H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics. Mbio. 12(3), e00287-21 2 (DOI: 10.1128/mBio.00287-21).

Di Maso M., Eussen S.R.B.M., Bravi F., Moro G.E., Agostoni C., Tonetto P., Quitadamo P.A., Salvatori G., Profeti C., Kazmierska I., Vacca E., Decarli A., Stahl B., Bertino E., Ferraroni M.J. 2021. Dietary Intake of Breastfeeding Mothers in Developed Countries: A Systematic Review and Results of the MEDIDIET Study. Nutr. 151(11): 3459-3482 (DOI: 10.1093/jn/nxab258).

Dingess K.A., van Dam P., Zhu J., Mank M., Knipping K., Heck A.J.R., Stahl B. 2021. Optimization of a human milk-directed quantitative sIgA ELISA method substantiated by mass spectrometry. Anal. Bioanal. Chem. 413(20): 5037-5049 (DOI: 10.1007/s00216-021-03468-4).

Dingess K.A., Gazi I., van den Toorn H.W.P., Mank M., Stahl B., Reiding K.R., Heck A.J.R. 2021. Monitoring Human Milk beta-Casein Phosphorylation and O-Glycosylation Over Lactation Reveals Distinct Differences between the Proteome and Endogenous Peptidome. Int J Mol Sci. 22(15): 8140 (DOI: 10.3390/ijms22158140).

Eussen S.R.B.M., Mank M., Kottler R., Hoffmann X.K., Behne A., Rapp E., Stahl B., Mearin M.L., Koletzko B. 2021. Presence and Levels of Galactosyllactoses and Other Oligosaccharides in Human Milk and Their Variation during Lactation and According to Maternal Phenotype. Nutrients. 13(7): 2324 (DOI: 10.3390/nu13072324).

Gaide, N., M.N. Lucas, M. Delpont, G. Croville, K.M. Bouwman, A. Papanikolaou, R. van der Woude, I. Gagarinov, G.J. Boons, R.P. de Vries, R. Volmer, A. Teillaud, T. Vergne, C. Bleuart, G, Le Loc'h, M, Delverdier, and J.L. Guérin. 2021. Pathobiology of highly pathogenic H5 avian influenza viruses in naturally infected Galliformes and Anseriformes in France during winter 2015-2016. Vet. Res. Accepted for publication.

Haksar, D., Asadpoor, M., Heise, T., Shi, J., Braber, S., Folkerts, G., Ballell, L., Rodrigues, J., Pieters, R. J. 2021. Fighting Shigella by Blocking Its Disease-Causing Toxin. J. Med. Chem. 64: 6059-6069

Heesterbeek, D. A. C., R. M. Muts,V. P. van Hensbergen,P. de Saint Aulaire,T. Wennekes,B. W. Bardoel,N. M. van Sorge, S. H. M. Rooijakkers. 2021. Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes. PLoS pathogens. 17(1), e1009227 8 (DOI: 10.1371/journal.ppat.1009227).

Heesters B.A., van Megesen K., Tomris I., de Vries R.P., Magri G., Spits H. 2021. Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells. J Exp Med. 218(10) (DOI: 10.1084/jem.20210790).

Hu R., Eussen S.R.B.M., Sijtsma F.P.C., Papi B., Stahl B., Jin Y., Mank M., Li J., Wang Z. 2021. Maternal dietary patterns are associated with human milk composition in Chinese lactating women. Nutrition. 91-92: 111392 (DOI: 10.1016/j.nut.2021.111392).

Huang, J., P. Chopra, L. Liu, T. Nagy, J. Murray, R.A. Tripp, G.J. Boons, and J.J. Mousa. 2021. Structure, immunogenicity, and conformation-dependent receptor binding of the postfusion human metapneumovirus F protein. J. Virol. 95(18): e00593-21 (DOI: 10.1128/JVI.00593-21).

Jong H., M.M.S.M. Wösten, T. Wennekes. 2021. Sweet impersonators: Molecular mimicry of host glycans by bacteria. Glycobiology (DOI 10.1093/glycob/cwab104).

Karlsson, R., P. Chopra, A. Joshi, Z. Yang, S.Y. Vakhrushev, T. Mandel Clausen, C.D. Painter, G.P. Szekeres, Y.-H. Chen, D.R. Sandoval, L. Hansen, J.D. Esko, K. Pagel, D.P. Dyer, J.E. Turnbull, H. Clausen*, G.J. Boons*, and R.L. Miller*. 2021. Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates. Sci. Adv. Sci. Adv. 7(52): eabl6026 (DOI: 10.1126/sciadv.abl6026).

Kontopodi E., Arslanoglu S., Bernatowicz-Lojko U., Bertino E., Bettinelli M.E., Buffin R., Cassidy T., van Elburg R.M., Gebauer C., Grovslien A., Hettinga K., Ioannou I., Klotz D., Mileusnić-Milenović R., Moro G.E., Picaud J.C., Stahl B., Weaver G., van Goudoever J.B., Wesolowska A. 2021. "Donor milk banking: Improving the future". A survey on the operation of the European donor human milk banks. PLoS One. 16(8):e0256435 (DOI: 10.1371/journal.pone.0256435).

Kontopodi E., Hettinga K., Stahl B., van Goudoever J.B., M van Elburg R. 2021. Testing the effects of processing on donor human Milk: Analytical methods. Food Chem. 373(Pt. A):131413 (DOI: 10.1016/j.foodchem.2021.131413).

Li, Z., Y. Lang, L. Liu, M.I. Bunyatov, A. Isaza Sarmiento, R.J. de Groot, and G.J. Boons. 2021. Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses. Nat. Chem. 13(5): 496-503 (DOI: 10.1038/s41557-021-00655-9).

Li, Z., L. Unione, L. Liu, Y. Lang, R.P. de Vries, R.J. de Groot, and G.J. Boons. 2021. Synthetic O-acetylated sialosides and their acetamido-deoxy analogs as probes for coronaviral hemagglutinin-esterase recognition. J. Am. Chem. Soc. In press (DOI: 10.1021/jacs.1c10329).

Liu, L., P. Chopra, X. Li, K.M. Bouwman, S.M Tompkins, M.A. Wolfert, R.P. de Vries, and G.J. Boons. 2021. Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2. ACS Cent. Sci. 7(6): 1009-1018 (DOI: 10.1021/acscentsci.1c00010).

Luijkx, Y.M.C.A., S. Jongkees, K. Strijbis, T. Wennekes. 2021. Development of a 1, 2-difluorofucoside activity-based probe for profiling GH29 fucosidases. Organic & Biomolecular Chemistry. 19(13):2968-2977 (DOI: 10.1039/D1OB00054C).

Martínez-Alarcón, D., Balloy, V., Bouchara, J. P., Pieters, R. J., Varrot, A. 2021. Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum. Sci. Rep. 11: 16109

Meng, X., M.M.S.M. Wösten, G.J. Boons, and T. Wennekes. 2021. Metabolic labeling of legionaminic acid in flagellin glycosylation of Campylobacter jejuni identifies Maf4 as a putative legionaminyl transferase. Angew. Chem. Int. Ed. 60(47): 24811-24816 (DOI: 10.1002/anie.202107181).

Montez de Sousa Í.R., Wang Z., Hu R., Stahl B., Jin Y., Eussen S.R.B.M., Li J. 2021. Dietary Intake of Chinese Lactating Women Is Associated with the Fatty Acid Profile of Their Milk. Ann. Nutr. Metab. Dec 2: 1-13 (DOI: 10.1159/000520515).

Moure, M.J., A. Gimeno, S. Delgado, T. Diercks, G.J. Boons, J. Jimenez-Barbero, and A. Arda. 2021. Selective 13C-labels on repeating glycan oligomers to reveal protein binding epitopes through NMR: polylactosamine binding to galectins. Angew. Chem. Int. Ed. 60(34): 18777-18782 (DOI: 10.1002/anie.202106056).

Nemanichvili N., Berends A.J., Tomris I., Barnard K.N., Parrish C.R., Grone A., Rijks J.M., Verheije M.H., de Vries R.P. 2021. Influenza D binding properties vary amongst the two major virus clades and wildlife species. Vet Microbiol. 264: 109298 (DOI: 10.1016/j.vetmic.2021.10929).

Nemanichvili N., Berends A.J., Wubbolts R.W., Grone A., Rijks J.M., de Vries R.P., Verheije M.H. 2021. Tissue Microarrays to visualize influenza D attachment to host receptors in the respiratory tract of farm animals. Viruses. 13(4) (DOI: 10.3390/v13040586).

Nguyen, L., K.A. McCord, D.T. Bui, K.M. Bouwman, E.N. Kitova, M. Elaish, D. Kumawat, G.C. Daskhan, I. Tomris, L. Han, P. Chopra, T.-J. Yang, S.D. Willows, A.L. Mason, L.K. Mahal, T.L. Lowary, L.J. West, S.D. Hsu, T. Hobman, S.M. Tompkins, G.J. Boons, R.P. de Vries, M.S. Macauley, and J.S. Klassen. 2022. Sialic acid-dependent binding and viral entry of SARS-CoV-2. Nat. Chem. Biol. 18(1): 81-90 (DOI: 10.1038/s41589-021-00924-1).

Sadelhoff van J.H.J., Siziba L.P., Buchenauer L., Mank M., Wiertsema S.P., Hogenkamp A., Stahl B., Garssen J., Rothenbacher D., Genuneit J. 2021. Free and Total Amino Acids in Human Milk in Relation to Maternal and Infant Characteristics and Infant Health Outcomes: The Ulm SPATZ Health Study. Nutrients. 13(6):2009 (DOI: 10.3390/nu13062009).

Sastre Toraño, J., O. Aizpurua-Olaizola, N. Wei, T. Li, L. Unione, G. Jiménez-Osés, F. Corzana, V.J. Somovilla, J.M. Falcon-Perez, and G.J. Boons. 2021. Identification of isomeric N-glycans by conformer distribution fingerprinting using ion mobility-mass spectrometry. Chem. Eur. J. 26(6): 2149-2154 (DOI: 10.1002/chem.202004522).

Schuurmans, C.C.L., A.J. Brouwer, J.A.W. Jong, G.J.P.H. Boons, W.E. Hennink, and T. Vermonden. 2021. Hydrolytic (in)stability of methacrylate esters in covalently cross-linked hydrogels based on chondroitin sulfate and hyaluronic acid methacrylate. ACS Omega 6(40): 26302-26310 (DOI: 10.1021/acsomega.1c03395).

Sewgobind, N.V., Albers, S., Pieters, R.J. 2021. Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology. Biomolecules. 11:1720

Shi, J., Sharif,  S., Balsollier, C., Ruijtenbeek, R., Pieters, R. J., Jongkees, S. A. K. 2021. C‐terminal tag location hampers in vitro profiling of OGT peptide substrates by mRNA display. ChemBioChem. 22:666-671

Siziba L.P., Lorenz L., Brenner H., Carr P., Stahl B., Mank M., Marosvölgyi T., Decsi T., Szabó É., Rothenbacher D., Genuneit J. 2021. Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: a comparison between the two Ulm Birth Cohort Studies. Br J Nutr. 126(2): 228-235 (DOI: 10.1017/S0007114520004006).

Siziba L.P., Mank M., Stahl B., Kurz D., Gonsalves J., Blijenberg B., Rothenbacher D., Genuneit J. 2021. Associations of Human Milk Oligosaccharides With Otitis Media and Lower and Upper Respiratory Tract Infections up to 2 Years: The Ulm SPATZ Health Study. Front Nutr. 8: 761129 (DOI: 10.3389/fnut.2021.761129).

Siziba L.P, Mank M., Stahl B., Gonsalves J., Blijenberg B., Rothenbacher D., Genuneit J. 2021. Human Milk Oligosaccharide Profiles over 12 Months of Lactation: The Ulm SPATZ Health Study. Nutrients. 13(6): 1973 (DOI: 10.3390/nu13061973).

Spruit, C.M., N. Nemanichvili, M. Okamatsu, H. Takematsu, H., G.J. Boons, and R.P. de Vries. 2021. N-glycolylneuraminic acid in animal models for human influenza A virus. Viruses 15(5): 815 (DOI: 10.3390/v13050815).

Spruit, C.M., X. Zhu, I. Tomris, M. Rios Carrasco, A.X. Han, F. Broszeit, R. van der Woude, K.M. Bouwman, M.M.T. Luu, K. Matsuno, Y. Sakoda, C.A. Russell, I.A. Wilson, G.J. Boons, and R.P. de Vries. 2021. N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses. J. Vir. Accepted for publication.

Srivastava, A.D., L. Unione, M. Bunyatov, I.A. Gagarinov, S. Delgado, N.G.A. Abrescia, A. Ardá, and G.J. Boons. 2021. Chemoenzymatic synthesis of complex N-glycans of the parasite S. mansoni to examine the importance of epitope presentation on DC-SIGN recognition. Angew. Chem. Int. Ed. 60(35): 19287-19296 (DOI: 10.1002/anie.202105647).

Su, X., Ramírez-Escudero, M., Sun, F., van den Dikkenberg, J.B., van Steenbergen, M.J., Pieters, R.J., Janssen, B.J.C., van Hasselt, P.M., Hennink, W.E., van Nostrum, C.F. 2021. Internalization and Transport of PEGylated Lipid-Based Mixed Micelles across Caco-2 Cells Mediated by Scavenger Receptor B1. Pharmaceutics. 13: 2022

Tas R.P., V. Sampaio‐Pinto, T. Wennekes, L.W. van Laake, I.K. Voets. 2021. From the freezer to the clinic: Antifreeze proteins in the preservation of cells, tissues, and organs. EMBO reports. 22(3), e52162 2 (DOI: 10.15252/embr.202052162).

Toutounchi N.S., Braber S., Hogenkamp A., Varasteh S., Cai Y., Wehkamp T., Tims S., Leusink-Muis T., van Ark I., Wiertsema S., Stahl B., Kraneveld A.D., Garssen J., Folkerts G., Van't Land B. 2021. Human Milk Oligosaccharide 3'-GL Improves Influenza-Specific Vaccination Responsiveness and Immunity after Deoxynivalenol Exposure in Preclinical Models. Nutrients. 13(9): 3190 (DOI: 10.3390/nu13093190).

Verheyen S, J. Blatterer J, M.R. Speicher, G.S. Bhavani, G.J. Boons, M.B. Ilse, D. Andrae, J. Sproß, F.M. Vaz, S.G. Kircher, L. Posch-Pertl, D. Baumgartner, T. Lübke, H. Shah, A. Al Kaissi, K.M. Girisha, and B. Plecko. 2021. Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency. J. Med. Gen. In press (DOI: 10.1136/jmedgenet-2021-108061).

Wei, X., Pieters, R. J. 2021. Multivalency Effects in Neuraminidase Inhibitor Design for Influenza Virus. Arkivoc. 4:297-312

Weiss, M., Loi, E. M., Sterle, M., Balsollier, C., Tomašič, T., Pieters, R. J., Gobec, M., Anderluh, M. 2021. New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth. Front. Chem. 9:666122

Wu, J., P. Chopra, G.J. Boons, and J. Zaia.^. 2021. Influence of saccharide modifications on heparin lyase III substrate specificities. Glycobiology. In press (DOI: 10.1093/ glycob/cwab023).

Zaree P., Sastre Torano, J., de Haan, C. A. M., Scheltema, R. A., Barendregt, A., Thijssen, V., Yu, G., Flesch, F., Pieters, R. J. 2021. The assessment of Pseudomonas aeruginosa lectin LecA binding characteristics of divalent galactosides using multiple techniques. Glycobiology. 31:1490-1499

Zhu J., Dingess K.A., Mank M., Stahl B., Heck A.J.R. 2021. Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome. J. Nutr. 151(4):826-839 (DOI: 10.1093/jn/nxaa445).

Chopra, P., A. Joshi, J. Wu, W. Lu, T. Yadavalli, M.A. Wolfert, D. Shukla, J. Zaia, G.J. Boons. 2020. 2020. 3-O-Sulfation of heparan sulfate modulates protein binding and lyase degradation. Proc. Natl. Acad. Sci. U. S. A. Accepted for publication

Liu, M., V. Thijssen, S.A.K. Jongkees. 2020. Suppression of formylation provides an alternative approach to vacant codon creation in bacterial in vitro translation. Angew. Chem. Int. Ed.: In press (DOI: 10.1002/anie.202003779).  [PMID: 32840944]

Li, T., M.A. Wolfert, N. Wei, R. Huizinga, B.C. Jacobs, G.J. Boons. 2020. Chemoenzymatic synthesis of Campylobacter jejuni lipo-oligosaccharide core domains to examine Guillain-Barré syndrome serum antibody specificities. J. Am. Chem. Soc. 142(46): 19611-19621.  [PMID: 33164488]

Horn, V., S.A.K. Jongkees, H. van Ingen. 2020. Mimicking the nucleosomal context in peptide-based binders of a H3K36me reader increases binding affinity while altering the binding mode. Molecules 25(21): 4951.  [PMID: 33114657]

Williams, C.R., L. Chen, E.S. Sheppard, P. Chopra, J. Locklin, G.J. Boons, D.C. Krause. 2020. Distinct Mycoplasma pneumoniae interactions with sulfated and sialylated receptors. Infect. Immun. 88(11): e00392-00320.  [PMID: 32839185]

Sun, L., P. Chopra, G.J. Boons. 2020. Modular synthesis of heparan sulfate oligosaccharides having N-acetyl and N-sulfate moieties. J. Org. Chem. In press (DOI: 10.1021/acs.joc.0c01881).

Sastre Toraño, J., O. Aizpurua-Olaizola, N. Wei, T. Li, L. Unione, G. Jiménez-Osés, F. Corzana, V.J. Somovilla, J.M. Falcon-Perez, G.J. Boons. 2020. Identification of isomeric N-glycans by conformer distribution fingerprinting using ion mobility-mass spectrometry. Chem. Eur. J. In press (DOI: 10.1002/chem.202004522).  [PMID: 33047840]

Lang, Y., W. Li, Z. Li, D. Koerhuis, A.C.S. van den Burg, E. Rozemuller, B.J. Bosch, F.J.M. van Kuppeveld, G.J. Boons, E.G. Huizinga, H.M. van der Schaar, R.J. de Groot. 2020. Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity. Proc. Natl. Acad. Sci. U. S. A. 117(41): 25759-25770.  [PMID: 32994342]

Shi, J., S. Sharif, C. Balsollier, R. Ruijtenbeek, R.J. Pieters, S.A.K. Jongkees. 2020. C-terminal tag location hampers in vitro profiling of OGT peptide substrates by mRNA display. ChemBioChem In press (DOI: 10.1002/cbic.202000624).  [PMID: 33022805]

Verpalen, E.C.J.M., A.J. Brouwer, G.J. Boons. 2020. Synthesis of monophosphoryl lipid A using 2-naphtylmethyl ethers as permanent protecting groups. Carbohydr. Res. 498 In press (DOI: 10.1016/j.carres.2020.108152).

Boruah, B.M., R. Kadirvelraj, L. Liu, A. Ramiah, C. Li, G. Zong, G.P. Bosman, J.Y. Yang, L.X. Wang, G.J. Boons, Z.A. Wood, K.W. Moremen. 2020. Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases. J. Biol. Chem. In press (DOI: 10.1074/jbc.RA1120.014625).  [PMID: 33004438]

Steigenberger, B., H.W.P. van den Toorn, E. Bijl, J.F. Greisch, O. Rather, M. Lubeck, R.J. Pieters, A.J.R. Heck, R.A. Scheltema. 2020. Benefits of collisional cross section assisted precursor selection (caps-PASEF) for cross-linking mass spectrometry. Mol. Cell. Proteomics 19(10): 1677-1687.  [PMID: 32694122]

Gungor, E., P. Brouwer, L.W. Dijkhuizen, D.C. Shaffar, K.G.J. Nierop, R.C.H. de Vos, J. Sastre Torano, I.M. van der Meer, H. Schluepmann. 2020. Azolla ferns testify: seed plants and ferns share a common ancestor for leucoanthocyanidin reductase enzymes. New Phytol. In press (DOI: 10.1111/nph.16896).  [PMID: 32858769]

van Haren, M.J., Y. Zhang, N. Buijs, V. Thijssen, D. Sartini, M. Emanuelli, S. Jongkees, N. Martin. 2020. Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT). ChemRxiv Preprint (DOI: 10.26434/chemrxiv.12973130.v12973131).

Trabszo, C., B. Ramms, P. Chopra, R. Lullmann-Rauch, S. Stroobants, J. Spross, A. Jeschke, T. Schinke, G.J. Boons, J.D. Esko, T. Lubke, T. Dierks. 2020. Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate. Biochem. J. 477(17): 3433-3451.  [PMID: 32856704]

Bouwman, K.M., I. Tomris, H.L. Turner, R. van der Woude, G.P. Bosman, B. Rockx, S. Herfst, B.L. Haagmans, A. Ward, B., G.J. Boons, R.P. de Vries. 2020. Multimerization- and glycosylation-dependent receptor binding of SARS CoV-2 spike proteins. bioRxiv Preprint (DOI: 0.1101/2020.1109.1104.282558).

Du, W., M.A. Wolfert, B. Peeters, F.J.M. van Kuppeveld, G.J. Boons, E. de Vries, C.A.M. de Haan. 2020. Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PLoS Pathog. 16(8): e1008816.  [PMID: 32853241]

Luijkx, Y.M.C.A., N.M.C. Bleumink, J. Jiang, H.S. Overkleeft, M.M.S.M. Wosten, K. Strijbis, T. Wennekes. 2020. Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins. Cell. Microbiol.: e13252.  [PMID: 32827216]

Lettow, M., M. Grabarics, K. Greis, E. Mucha, D.A. Thomas, P. Chopra, G.J. Boons, R. Karlsson, J.E. Turnbull, G. Meijer, R.L. Miller, G. von Helden, K. Pagel. 2020. Cryogenic infrared spectroscopy reveals structural modularity in the vibrational fingerprints of heparan sulfate diastereomers. Anal. Chem. 92(15): 10228-10232.  [PMID: 32658472]

van der Woude, R., H.L. Turner, I. Tomris, K.M. Bouwman, A.B. Ward, R.P. de Vries. 2020. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells. Protein Sci.  [PMID: 32710576]

Loi, E.M., M. Weiss, S. Pajk, M. Gobec, T. Tomasic, R.J. Pieters, M. Anderluh. 2020. Intracellular hydrolysis of small-molecule o-linked N-acetylglucosamine transferase inhibitors differs among cells and is not required for its inhibition. Molecules 25(15): 3381.  [PMID: 32722493]

Jansen, A.J.G., T. Spaan, H.Z. Low, D. Di Iorio, J. van den Brand, M. Tieke, A. Barendrecht, K. Rohn, G. van Amerongen, K. Stittelaar, W. Baumgartner, A. Osterhaus, T. Kuiken, G.J. Boons, J. Huskens, M. Boes, C. Maas, E. van der Vries. 2020. Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity. Blood Adv. 4(13): 2967-2978.  [PMID: 32609845]

Shrestha, S., S. Katiyar, C.E. Sanz-Rodriguez, N.R. Kemppinen, H.W. Kim, R. Kadirvelraj, C. Panagos, N. Keyhaninejad, M. Colonna, P. Chopra, D.P. Byrne, G.J. Boons, E. van der Knaap, P.A. Eyers, A.S. Edison, Z.A. Wood, N. Kannan. 2020. A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily. Sc. Signaling 13(639): eaax6313.  [PMID: 32636308]

Srivastava, A.D., L. Unione, M.A. Wolfert, P. Valverde, A. Arda, J. Jimenez-Barbero, G.J. Boons. 2020. Mono- and di-fucosylated glycans of the parasitic worm S. mansoni are recognized differently by the innate immune receptor DC-SIGN. Chem. Eur. J.: In press (DOI: 10.1002/chem.202002619).  [PMID: 32957164]

Eggink, D., M. Spronken, R. van der Woude, J. Buzink, F. Broszeit, R. McBride, H.A. Pawestri, V. Setiawaty, J.C. Paulson, G.J. Boons, R.A.M. Fouchier, C.A. Russell, M.D. de Jong, R.P. de Vries. 2020. Phenotypic effects of substitutions within the receptor binding site of highly pathogenic avian influenza H5N1 virus observed during human infection. J. Virol. 94(13): e00195-00120.  [PMID: 32321815]

Asadpoor, M., C. Peeters, P.A.J. Henricks, S. Varasteh, R.J. Pieters, G. Folkerts, S. Braber. 2020. Anti-pathogenic functions of non-digestible oligosaccharides in vitro. Nutrients 12(6): 1789.  [PMID: 32560186]

Johansen-Leete, J., T. Passioura, S.R. Foster, R.P. Bhusal, D.J. Ford, M. Liu, S.A.K. Jongkees, H. Suga, M.J. Stone, R.J. Payne. 2020. Discovery of potent cyclic sulfopeptide chemokine inhibitors via reprogrammed genetic code mRNA display. J. Am. Chem. Soc. 142(20): 9141-9146.  [PMID: 32330017]

Liu, L., P. Chopra, X. Li, M.A. Wolfert, S.M. Tompkins, G.J. Boons. 2020. SARS-CoV-2 spike protein binds heparan sulfate in a length- and sequence-dependent manner. bioRxiv Preprint (DOI: 10.1101/2020.1105.1110.087288).  [PMID: 32511404]

Figueroa, T., P. Bessière, A. Coggon, K.M. Bouwman, R. van der Woude, M. Delverdier, M.H. Verheije, R.P. de Vries, R. Volmer. 2020. The microbiota contributes to the control of highly pathogenic H5N9 influenza virus replication in ducks. J. Virol. 94(10).  [PMID: 32102887]

Talsma, D.T., F. Poppelaars, W. Dam, A.H. Meter-Arkema, R.R. Vives, P. Gal, G.J. Boons, P. Chopra, A. Naggi, M.A. Seelen, S.P. Berger, M.R. Daha, C.A. Stegeman, J. van den Born, C. Consortium. 2020. MASP-2 is a heparin-binding protease; Identification of blocking oligosaccharides. Front. Immunol. 11: 732.  [PMID: 32425936]

Dumas, E.K., H. Demiraslan, R.J. Ingram, R.M. Sparks, E. Muns, A. Zamora, J. Larabee, L. Garman, J.D. Ballard, G.J. Boons, J.A. James, U. Kayabas, M. Doganay, A.D. Farris. 2020. Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes. PLoS ONE 15(4): e0230782.  [PMID: 32294093]

Liu, Y., L. Scrivano, J.D. Peterson, M. Fens, I.B. Hernandez, B. Mesquita, J. Sastre Toraño, W.E. Hennink, C.F. van Nostrum, S. Oliveira. 2020. EGFR-targeted nanobody functionalized polymeric micelles loaded with mTHPC for selective photodynamic therapy. Mol. Pharm. 17(4): 1276-1292.  [PMID: 32142290]

Kikutani, Y., M. Okamatsu, S. Nishihara, S. Takase-Yoden, T. Hiono, R.P. de Vries, R. McBride, K. Matsuno, H. Kida, Y. Sakoda. 2020. E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens. Microbiol. Immunol. 64(4): 304-312.  [PMID: 31943329]

Miller, R.L., S.E. Guimond, R. Schworer, O.V. Zubkova, P.C. Tyler, Y. Xu, J. Liu, P. Chopra, G.J. Boons, M. Grabarics, C. Manz, J. Hofmann, N.G. Karlsson, J.E. Turnbull, W.B. Struwe, K. Pagel. 2020. Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. Nat. Commun. 11(1): 1481.  [PMID: 32198425]

Parsons, L.M., Y. An, L. Qi, M. White, R. van der Woude, K. Hartshorn, J.K. Taubenberger, R.P. de Vries, J.F. Cipollo. 2020. Influenza viurs hemagglutinins H2, H5, H6, and H11 are not targets of pulmonary surfactant protein D: N-glycan subtypes in host-pathogen interactions. J. Virol. 94(5): In press.  [PMID: 31826991]

Haksar, D., L. Quarles van Ufford, R.J. Pieters. 2020. A hybrid polymer to target blood group dependence of cholera toxin. Org. Biomol. Chem. 18(1): 52-55.  [PMID: 31802094]

Bouwman, K.M., L.M. Parsons, A.J. Berends, R.P. de Vries, J.F. Cipollo, M.H. Verheije. 2020. Three amino acid changes in avian coronavirus spike protein allow binding to kidney tissue. J. Virol. 94(2).  [PMID: 31694947]

Singh, J., C. Her, N. Supekar, G.J. Boons, V.V. Krishnan, C.L. Brooks. 2020. Role of glycosylation on the ensemble of conformations in the MUC1 immunodominant epitope. J. Pept. Sc.: e3229.  [PMID: 31729101]

Sastre Toraño, J., I.A. Gagarinov, G.M. Vos, F. Broszeit, A.D. Srivastava, M. Palmer, J.I. Langridge, O. Aizpurua-Olaizola, V.J. Somovilla, G.J. Boons. 2019. Ion-mobility spectrometry can assign exact fucosyl positions in glycans and prevent misinterpretation of mass spectrometry data after gas-phase rearrangement. Angew. Chem. Int. Ed. 58(49): 17616-17620.  [PMID: 31544998]

Hoeksma, J., T. Misset, C. Wever, J. Kemmink, J. Kruijtzer, K. Versluis, R.M.J. Liskamp, G.J. Boons, A.J.R. Heck, T. Boekhout, J. den Hertog. 2019. A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out. Sc. Rep. 9(1): 17546.  [PMID: 31772307]

Liu, H., A. Joshi, P. Chopra, L. Liu, G.J. Boons, J.S. Sharp. 2019. Salt-free fractionation of complex isomeric mixtures of glycosaminoglycan oligosaccharides compatible with ESI-MS and microarray analysis. Sc. Rep. 9(1): 16566.  [PMID: 31719635]

van der Made, T.K., M. Fedecostante, D. Scotcher, A. Rostami-Hodjegan, J. Sastre Toraño, I. Middel, A.S. Koster, K.G. Gerritsen, V. Jankowski, J. Jankowski, J.G.J. Hoenderop, R. Masereeuw, A. Galetin. 2019. Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease. Mol. Pharm. 16(11): 4551-4562.  [PMID: 31525064]

Steigenberger, B., H.B. Schiller, R.J. Pieters, R.A. Scheltema. 2019. Finding and using diagnostic ions in collision induced crosslinked peptide fragmentation spectra. Int. J. Mass Spectrom. 444: 116184.

Steigenberger, B., R.J. Pieters, A.J.R. Heck, R.A. Scheltema. 2019. PhoX: an IMAC-enrichable cross-linking reagent. ACS Cent. Sci. 5(9): 1514-1522.  [PMID: 31572778]

Chopra, P., M.T. Logun, E.M. White, W. Lu, J. Locklin, L. Karumbaiah, G.J. Boons. 2019. Fully synthetic heparan sulfate-based neural tissue construct that maintains the undifferentiated state of neural stem cells. ACS Chem. Biol. 14(9): 1921-1929.  [PMID: 31389687]

Gray, C.J., L.G. Migas, P.E. Barran, K. Pagel, P.H. Seeberger, C.E. Eyers, G.J. Boons, N.L.B. Pohl, I. Compagnon, G. Widmalm, S.L. Flitsch. 2019. Advancing solutions to the carbohydrate sequencing challenge. J. Am. Chem. Soc. 141(37): 14463-14479.  [PMID: 31403778]

Wu, J., J. Wei, P. Chopra, G.J. Boons, C. Lin, J. Zaia. 2019. Sequencing heparan sulfate using HILIC LC-NETD-MS/MS. Anal. Chem. 91(18): 11738-11746.  [PMID: 31423779]

Chao, L., S. Jongkees. 2019. High-throughput approaches in carbohydrate-active enzymology: Glycosidase and glycosyl transferase inhibitors, evolution, and discovery. Angew. Chem. Int. Ed. 58(37): 12750-12760.  [PMID: 30913359]

Yu, G., A.C. Vicini, R.J. Pieters. 2019. Assembly of divalent ligands and their effect on divalent binding to Pseudomonas aeruginosa lectin LecA. J. Org. Chem. 84(5): 2470-2488.  [PMID: 30681333]

Zhang, H., H. Ippel, M.C. Miller, T.J. Wong, A.W. Griffioen, K.H. Mayo, R.J. Pieters. 2019. Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity. Org. Chem. Front. 6(16): 2981-2990.

Goldbach, L., B.J.A. Vermeulen, S. Caner, M. Liu, C. Tysoe, L. van Gijzel, R. Yoshisada, M. Trellet, H. van Ingen, G.D. Brayer, A. Bonvin, S.A.K. Jongkees. 2019. Folding then binding vs folding through binding in macrocyclic peptide inhibitors of human pancreatic alpha-amylase. ACS Chem. Biol. 14(8): 1751-1759.  [PMID: 31241898]

t’ Hart, I.M.E., T. Li, M.A. Wolfert, S. Wang, K.W. Moremen, G.J. Boons. 2019. Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide. Org. Biomol. Chem. 17(31): 7304-7308.  [PMID: 31339142]

Jansen, J., K. Jansen, E. Neven, R. Poesen, A. Othman, A. van Mil, J. Sluijter, J. Sastre Toraño, E.A. Zaal, C.R. Berkers, D. Esser, H.J. Wichers, K. van Ede, M. van Duursen, S. Burtey, M.C. Verhaar, B. Meijers, R. Masereeuw. 2019. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc. Natl. Acad. Sci. U. S. A. 116(32): 16105-16110.  [PMID: 31341083]

Gagarinov, I.A., T. Li, N. Wei, J. Sastre Toraño, R.P. de Vries, M.A. Wolfert, G.J. Boons. 2019. Protecting-group-controlled enzymatic glycosylation of oligo-N-acetyllactosamine derivatives. Angew. Chem. Int. Ed. 58(31): 10547-10552.  [PMID: 31108002]

Gao, Y., M.J. van Haren, E.E. Moret, J.J.M. Rood, D. Sartini, A. Salvucci, M. Emanuelli, P. Craveur, N. Babault, J. Jin, N.I. Martin. 2019. Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity. J. Med. Chem. 62(14): 6597-6614.  [PMID: 31265285]

Mahon, C.S., G.C. Wildsmith, D. Haksar, E. de Poel, J.M. Beekman, R.J. Pieters, M.E. Webb, W.B. Turnbull. 2019. A 'catch-and-release' receptor for the cholera toxin. Faraday Discuss.: 112-127.  [PMID: 31313796]

Lu, W., W. Du, V.J. Somovilla, G. Yu, D. Haksar, E. de Vries, G.J. Boons, R.P. de Vries, C.A.M. de Haan, R.J. Pieters. 2019. Enhanced inhibition of influenza A virus adhesion by di- and trivalent hemagglutinin inhibitors. J. Med. Chem. 62(13): 6398-6404.  [PMID: 31251606]

De Groof, T.W.M., V. Mashayekhi, T.S. Fan, N.D. Bergkamp, J. Sastre Toraño, J.R. van Senten, R. Heukers, M.J. Smit, S. Oliveira. 2019. Nanobody-targeted photodynamic therapy selectively kills viral GPCR-expressing glioblastoma cells. Mol. Pharm. 16(7): 3145-3156.  [PMID: 31244224]

Sastre Toraño, J., R. Ramautar, G. de Jong. 2019. Advances in capillary electrophoresis for the life sciences. J. Chrom. B 1118-1119: 116-136.  [PMID: 31035134]

Broszeit, F., N. Tzarum, X. Zhu, N. Nemanichvili, D. Eggink, T. Leenders, Z. Li, L. Liu, M.A. Wolfert, A. Papanikolaou, C. Martinez-Romero, I.A. Gagarinov, W. Yu, A. Garcia-Sastre, T. Wennekes, M. Okamatsu, M.H. Verheije, I.A. Wilson, G.J. Boons, R.P. de Vries. 2019. N-Glycolylneuraminic acid as a receptor for influenza A viruses. Cell Rep. 27(11): 3284-3294 e3286.  [PMID: 31189111]

Du, W., H. Guo, V.S. Nijman, J. Doedt, E. van der Vries, J. van der Lee, Z. Li, G.J. Boons, F.J.M. van Kuppeveld, E. de Vries, M. Matrosovich, C.A.M. de Haan. 2019. The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathog. 15(6): e1007860.  [PMID: 31181126]

Tortorici, M.A., A.C. Walls, Y. Lang, C. Wang, Z. Li, D. Koerhuis, G.J. Boons, B.J. Bosch, F.A. Rey, R.J. de Groot, D. Veesler. 2019. Structural basis for human coronavirus attachment to sialic acid receptors. Nat. Struct. Mol. Biol. 26(6): 481-489.  [PMID: 31160783]

Parsons, L.M., K.M. Bouwman, H. Azurmendi, R.P. de Vries, J.F. Cipollo, M.H. Verheije. 2019. Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding. J. Biol. Chem. 294(19): 7797-7809.  [PMID: 30902814]

Hu, Y., X. Cao, X. Li, Y. Wang, G.J. Boons, J. Deng, H. Jiang. 2019. The three-dimensional structure and recognition mechanism of Manduca sexta peptidoglycan recognition protein-1. Insect Biochem. Mol. Biol. 108: 44-52.  [PMID: 30905759]

Bouwman, K.M., M. Delpont, F. Broszeit, R. Berger, E.A.W.S. Weerts, M.N. Lucas, M. Delverdier, S. Belkasmi, A. Papanikolaou, G.J. Boons, J.L. Guerin, R.P. de Vries, M.F. Ducatez, M.H. Verheije. 2019. Guinea fowl coronavirus diversity has phenotypic consequences for glycan and tissue binding. J. Virol. 93(10): e00067-00019.  [PMID: 30842318]

van der Beek, S.L., A. Zorzoli, E. Canak, R.N. Chapman, K. Lucas, B.H. Meyer, D. Evangelopoulos, L.P.S. de Carvalho, G.J. Boons, H.C. Dorfmueller, N.M. van Sorge. 2019. Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification. Mol. Microbiol. 111(4): 951-964.  [PMID: 30600561]

Sharif, S., J. Shi, R. Ruijtenbeek, R.J. Pieters. 2019. Study of cross talk between phosphatases and OGA on a ZO-3-derived peptide. Amino Acids 51(4): 739-743.  [PMID: 30725225]

Lu, W., R.J. Pieters. 2019. Carbohydrate-protein interactions and multivalency: implications for the inhibition of influenza A virus infections. Expert Opin. Drug Discov. 14(4): 387-395.  [PMID: 30722704]

Aldosari, M.H., R.P. de Vries, L.R. Rodriguez, N.A. Hesen, N. Beztsinna, A.B.P. van Kuilenburg, C.E.M. Hollak, H. Schellekens, E. Mastrobattista. 2019. Liposome-targeted recombinant human acid sphingomyelinase: Production, formulation, and in vitro evaluation. Eur. J. Pharm. Biopharm. 137: 185-195.  [PMID: 30818011]

Haksar, D., E. de Poel, L.C. Quarles van Ufford, S. Bhatia, R. Haag, J. Beekman, R.J. Pieters. 2019. Strong inhibition of cholera toxin B subunit by affordable, polymer-based multivalent inhibitors. Bioconjug. Chem. 30(3): 785-792.  [PMID: 30629410]

Yu, G., D.M.E. Thies‐Weesie, R.J. Pieters. 2019. Tetravalent Pseudomonas aeruginosa adhesion lectin LecA inhibitor for enhanced biofilm inhibition. Helv. Chim. Acta 102(3): e1900014.

Li, T., L. Liu, N. Wei, J.Y. Yang, D.G. Chapla, K.W. Moremen, G.J. Boons. 2019. An automated platform for the enzyme-mediated assembly of complex oligosaccharides. Nat. Chem. 11(3): 229-236.  [PMID: 30792508]

Nemanichvili, N., I. Tomris, H.L. Turner, R. McBride, O.C. Grant, R. van der Woude, M.H. Aldosari, R.J. Pieters, R.J. Woods, J.C. Paulson, G.J. Boons, A.B. Ward, M.H. Verheije, R.P. de Vries. 2019. Fluorescent trimeric hemagglutinins reveal multivalent receptor binding properties. J. Mol. Biol. 431(4): 842-856.  [PMID: 30597163]

Hulswit, R.J.G., Y.F. Lang, M.J.G. Bakkers, W.T. Li, Z.S. Li, A. Schouten, B. Ophorst, F.J.M. van Kuppeveld, G.J. Boons, B.J. Bosch, E.G. Huizinga, R.J. de Groot. 2019. Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A. Proc. Natl. Acad. Sci. U. S. A. 116(7): 2681-2690.  [PMID: 30679277]

Thompson, A.J., R.P. de Vries, J.C. Paulson. 2019. Virus recognition of glycan receptors. Curr. Opin. Virol. 34: 117-129.  [PMID: 30849709]

Liu, L., A.R. Prudden, C.J. Capicciotti, G.P. Bosman, J.Y. Yang, D.G. Chapla, K.W. Moremen, G.J. Boons. 2019. Streamlining the chemoenzymatic synthesis of complex N-glycans by a stop and go strategy. Nat. Chem. 11(2): 161-169.  [PMID: 30532014]

Marcelo, F., N. Supekar, F. Corzana, J.C. van der Horst, I.M. Vuist, D. Live, G.P.H. Boons, D.F. Smith, S.J. van Vliet. 2019. Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands. J. Biol. Chem. 294(4): 1300-1311.  [PMID: 30504228]

Mukherjee, R., M. van de Kaa, J. Garssen, R.J. Pieters, A.D. Kraneveld, L.E.M. Willemsen. 2019. Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk. Food Funct 10(1): 33-37.  [PMID: 30632580]

Shi, H., W.N. Leonhard, N.J. Sijbrandi, M.J. van Steenbergen, M. Fens, J.B. van de Dikkenberg, J.S. Torano, D.J.M. Peters, W.E. Hennink, R.J. Kok. 2019. Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys. J. Control Release 293: 113-125.  [PMID: 30472374]

Chapman, R.N., L. Liu, G.J. Boons. 2018. 4,6- O-Pyruvyl ketal modified N-acetylmannosamine of the secondary cell wall polysaccharide of Bacillus anthracis is the anchoring residue for its surface layer proteins. J. Am. Chem. Soc. 140(49): 17079–17085.  [PMID: 30452253]

Shi, J., R. Ruijtenbeek, R.J. Pieters. 2018. Demystifying O-GlcNAcylation: hints from peptide substrates. Glycobiology 28(11): 814-824.  [PMID: 29635275]

Du, W., M. Dai, Z. Li, G.J. Boons, B. Peeters, F.J.M. van Kuppeveld, E. de Vries, C.A.M. de Haan. 2018. Substrate binding by the second sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity. J. Virol. 92(20): e01243-01218.  [PMID: 30089692]

Moure, M.J., A. Eletsky, Q. Gao, L.C. Morris, J.Y. Yang, D. Chapla, Y. Zhao, C. Zong, I.J. Amster, K.W. Moremen, G.J. Boons, J.H. Prestegard. 2018. Paramagnetic tag for glycosylation sites in glycoproteins: Structural constraints on heparan sulfate binding to Robo1. ACS Chem. Biol. 13(9): 2560-2567.  [PMID: 30063822]

Yu, S.H., P. Zhao, P.K. Prabhakar, T. Sun, A. Beedle, G.J. Boons, K.W. Moremen, L. Wells, R. Steet. 2018. Defective mucin-type glycosylation on alpha-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases. J. Biol. Chem. 293(37): 14534-14544.  [PMID: 30049793]

Yi, F., X. Hong, A.B. Kumar, C. Zong, G.J. Boons, C.R. Scott, F. Turecek, B.H. Robinson, M.H. Gelb. 2018. Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. Mol. Genet. Metab. 125(1-2): 59-63.  [PMID: 30006231]

Guardiola, S., R. Prades, L. Mendieta, A.J. Brouwer, J. Streefkerk, L. Nevola, T. Tarrago, R.M.J. Liskamp, E. Giralt. 2018. Targeted covalent inhibition of prolyl oligopeptidase (POP): Discovery of sulfonylfluoride peptidomimetics. Cell Chem. Biol. 25(8): 1031-1037.  [PMID: 29779956]

Liang, Q., P. Chopra, G.J. Boons, J.S. Sharp. 2018. Improved de novo sequencing of heparin/heparan sulfate oligosaccharides by propionylation of sites of sulfation. Carbohydr. Res. 465: 16-21.  [PMID: 29920400]

Martínez-Jothar, L., S. Doulkeridou, R.M. Schiffelers, J. Sastre Toraño, S. Oliveira, C.F. van Nostrum, W.E. Hennink. 2018. Insights into maleimide-thiol conjugation chemistry: Conditions for efficient surface functionalization of nanoparticles for receptor targeting. J. Control. Release 282: 101-109.  [PMID: 29526739]

Hogan, J.D., J.A. Klein, J. Wu, P. Chopra, G.J. Boons, L. Carvalho, C. Lin, J. Zaia. 2018. Software for peak finding and elemental composition assignment for glycosaminoglycan tandem mass spectra. Mol. Cell. Proteomics 17(7): 1448-1456.  [PMID: 29615495]

Chevtchik, N.V., M. Mihajlovic, M. Fedecostante, L. Bolhuis-Versteeg, J. Sastre Toraño, R. Masereeuw, D. Stamatialis. 2018. A bioartificial kidney device with polarized secretion of immune modulators. J. Tissue Eng. Regen. Med. 12(7): 1670-1678.  [PMID: 29764003]

Artschwager, R., D.J. Ward, S. Gannon, A.J. Brouwer, H. van de Langemheen, H. Kowalski, R.M.J. Liskamp. 2018. Potent and highly selective inhibitors of the proteasome trypsin-like site by incorporation of basic side chain containing amino acid derived sulfonyl fluorides. J. Med. Chem. 61(12): 5395-5411.  [PMID: 29782167]

Chinoy, Z.S., F. Friscourt, C.J. Capicciotti, P. Chiu, G.J. Boons. 2018. Chemoenzymatic synthesis of asymmetrical multi-antennary N-glycans to dissect glycan-mediated interactions between human sperm and oocytes. Chem. Eur. J. 24(31): 7970-7975.  [PMID: 29603480]

Zhao, Y., J.Y. Yang, D.F. Thieker, Y. Xu, C. Zong, G.J. Boons, J. Liu, R.J. Woods, K.W. Moremen, I.J. Amster. 2018. A traveling wave ion mobility spectrometry (TWIMS) study of the Robo1-heparan sulfate interaction. J. Am. Soc. Mass Spectrom. 29(6): 1153-1165.  [PMID: 29520710]

Wu, J., J. Wei, J.D. Hogan, P. Chopra, A. Joshi, W. Lu, J. Klein, G.J. Boons, C. Lin, J. Zaia. 2018. Negative electron transfer dissociation sequencing of 3-O-sulfation-containing heparan sulfate oligosaccharides. J. Am. Soc. Mass Spectrom. 29(6): 1262-1272.  [PMID: 29564812]

van Heugten, A.J.P., W. de Boer, W.S. de Vries, R.J. Pieters, H. Vromans. 2018. Topically used corticosteroids: What is the big picture of drug product degradation? Eur. J. Pharm. Sci. 117: 1-7.  [PMID: 29407556]

Peng, W., K.M. Bouwman, R. McBride, O.C. Grant, R.J. Woods, M.H. Verheije, J.C. Paulson, R.P. de Vries. 2018. Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation. J. Virol. 92(10): pii: JVI.02016-02017.  [PMID: 29491160]

Kordalivand, N., D.D. Li, N. Beztsinna, J. Sastre Toraño, E. Mastrobattista, C.F. van Nostrum, W.E. Hennink, T. Vermonden. 2018. Polyethyleneimine coated nanogels for the intracellular delivery of RNase A for cancer therapy. Chem. Eng. J. 340: 32-41.

Lu, W., C. Zong, P. Chopra, L.E. Pepi, Y. Xu, I.J. Amster, J. Liu, G.J. Boons. 2018. Controlled chemoenzymatic synthesis of heparan sulfate oligosaccharides. Angew. Chem. Int. Ed. 57(19): 5340-5344.  [PMID: 29512241]

Zhang, H., T. Tomasic, J. Shi, M. Weiss, R. Ruijtenbeek, M. Anderluh, R.J. Pieters. 2018. Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids. MedChemComm 9(5): 883-887.  [PMID: 30108977]

Kadirvelraj, R., J.Y. Yang, J.H. Sanders, L. Liu, A. Ramiah, P.K. Prabhakar, G.J. Boons, Z.A. Wood, K.W. Moremen. 2018. Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc. Natl. Acad. Sci. U. S. A. 115(18): 4637-4642.  [PMID: 29666272]

Zhang, H., D. Laaf, L. Elling, R.J. Pieters. 2018. Thiodigalactoside-bovine serum albumin conjugates as high-potency inhibitors of Galectin-3: An outstanding example of multivalent presentation of small molecule inhibitors. Bioconjug. Chem. 29(4): 1266-1275.  [PMID: 29474087]

Sychantha, D., R.N. Chapman, N.C. Bamford, G.J. Boons, P.L. Howell, A.J. Clarke. 2018. Molecular basis for the attachment of S-layer proteins to the cell wall of Bacillus anthracis. Biochemistry 57(13): 1949-1953.  [PMID: 29522326]

van Heugten, A.J.P., W.S. de Vries, M.M.A. Markesteijn, R.J. Pieters, H. Vromans. 2018. The role of excipients in the stability of triamcinolone acetonide in ointments. AAPS PharmSciTech 19(3): 1448-1453.  [PMID: 29450828]

Mena-Barragán, T., M.I. García-Moreno, A. Sevšek, T. Okazaki, E. Nanba, K. Higaki, N.I. Martin, R.J. Pieters, J.M.G. Fernández, C.O. Mellet. 2018. Probing the Inhibitor versus chaperone properties of sp(2)-Iminosugars towards human beta-glucocerebrosidase: A picomolar chaperone for Gaucher disease. Molecules 23(4).  [PMID: 29673163]

Williams, C., F. Royo, O. Aizpurua-Olaizola, R. Pazos, G.J. Boons, N.C. Reichardt, J.M. Falcon-Perez. 2018. Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives. J. Extracell. Vesicles 7(1).  [PMID: 29535851]

Aizpurua-Olaizola, O., J. Sastre Toraño, J.M. Falcon-Perez, C. Williams, N. Reichardt, G.J. Boons. 2018. Mass spectrometry for glycan biomarker discovery. Trends Anal. Chem. 100: 7-14.

Haataja, S., P. Verma, O. Fu, A.C. Papageorgiou, S. Poysti, R.J. Pieters, U.J. Nilsson, J. Finne. 2018. Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations. Chem. Eur. J. 24(8): 1905-1912.  [PMID: 29094420]

Brittoli, A., S. Fallarini, H. Zhang, R.J. Pieters, G. Lombardi. 2018. "In vitro" studies on galectin-3 in human natural killer cells. Immunol. Lett. 194: 4-12.  [PMID: 29248489]

Supekar, N.T., V. Lakshminarayanan, C.J. Capicciotti, A. Sirohiwal, C.S. Madsen, M.A. Wolfert, P.A. Cohen, S.J. Gendler, G.J. Boons. 2018. Synthesis and immunological evaluation of a multicomponent cancer vaccine candidate containing a long MUC1 glycopeptide. ChemBioChem 19(2): 121-125.  [PMID: 29120508]

Stel, M.H., R.J. Pieters. Blocking disease linked lectins with multivalent carbohydrates. In: Huskens J, Prins LJ, Haag R, Ravoo BJ, editors. Multivalency - Concepts, Research & Applications. Hoboken, New Jersey: Wiley, Inc.; 2018. p. 345-380.

Sychantha, D., D.J. Little, R.N. Chapman, G.J. Boons, H. Robinson, P.L. Howell, A.J. Clarke. 2018. PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides. Nat. Chem. Biol. 14(1): 79-85.  [PMID: 29083419]

Aizpurua-Olaizola, O., J. Sastre Toraño, A. Pukin, O. Fu, G.J. Boons, G.J. de Jong, R.J. Pieters. 2018. Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. Electrophoresis 39(2): 344-347.  [PMID: 28905402]

Kleijn, L.H.J., H.C. Vlieg, T.M. Wood, J. Sastre Toraño, B.J.C. Janssen, N.I. Martin. 2017. A high-resolution crystal structure that reveals molecular details of target recognition by the calcium-dependent lipopeptide antibiotic Laspartomycin C. Angew. Chem. Int. Ed. 56(52): 16546-16549.  [PMID: 29108098]

Yoshisada, R., L. van Gijzel, S.A.K. Jongkees. 2017. Towards tuneable retaining glycosidase-inhibiting peptides by mimicry of a plant flavonol warhead. ChemBioChem 18(23): 2333-2339.  [PMID: 28984404]

Yang, X., L.P. Beroske, J. Kemmink, D.T.S. Rijkers, R.M.J. Liskamp. 2017. Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries. Tetrahedron Lett. 58(48): 4542-4546.

Moure, M.J., Y. Zhuo, G.J. Boons, J.H. Prestegard. 2017. Perdeuterated and (13)C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase. Chem. Commun. 53(92): 12398-12401.  [PMID: 29067365]

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Gagarinov, I.A., A.D. Srivastava, G.J. Boons, S. Visansirikul. Simplifying access to 3,4-di-O-acetyl-D-fucal. In: Vogel C, Murphy P, editors. Carbohydrate Chemistry: Proven Synthetic Methods. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2017. p. Chapter 24.

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Singh, A., M.B. Tessier, K. Pederson, X.C. Wang, A.P. Venot, G.J. Boons, J.H. Prestegard, R.J. Woods. 2016. Extension and validation of the GLYCAM force field parameters for modeling glycosaminoglycans. Can. J. Chem. 94(11): 927-935.  [PMID: 28603292]

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Sun, T., S.H. Yu, P. Zhao, L. Meng, K.W. Moremen, L. Wells, R. Steet, G.J. Boons. 2016. One-step selective exoenzymatic labeling (SEEL) strategy for the biotinylation and identification of glycoproteins of living cells. J. Am. Chem. Soc. 138(36): 11575-11582.  [PMID: 27541995]

Prior, A., L. Sánchez-Hernández, J. Sastre-Toraño, M.L. Marina, G.J. de Jong, G.W. Somsen. 2016. Enantioselective analysis of proteinogenic amino acids in cerebrospinal fluid by capillary electrophoresis-mass spectrometry. Electrophoresis 37(17-18): 2410-2419.  [PMID: 27465690]

Brouwer, A.J., N. Herrero Alvarez, A. Ciaffoni, H. van de Langemheen, R.M. Liskamp. 2016. Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides. Bioorg. Med. Chem. 24(16): 3429-3435.  [PMID: 27316540]

Li, X., S.J. Martin, Z.S. Chinoy, L. Liu, B. Rittgers, R.A. Dluhy, G.J. Boons. 2016. Label-free detection of glycan-protein interactions for array development by surface enhanced Raman spectroscopy (SERS). Chem. Eur. J. 22(32): 11180-11185.  [PMID: 27304194]

Zomer-van Ommen, D.D., A.V. Pukin, O. Fu, L.C. Quarles van Ufford, H.M. Janssens, J.M. Beekman, R.J. Pieters. 2016. Functional characterization of cholera toxin inhibitors using human intestinal organoids. J. Med. Chem. 59(14): 6968-6972.  [PMID: 27347611]

Alaarg, A., K.H. Zheng, F.M. van der Valk, A.E. da Silva, M. Versloot, L.C. Quarles van Ufford, D.M. Schulte, G. Storm, J.M. Metselaar, E.S. Stroes, A.A. Hamers. 2016. Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques. Vascul. Pharmacol. 82: 51-59.  [PMID: 27189780]

Bakkers, M.J.G., Q. Zeng, L.J. Feitsma, R.J.G. Hulswit, Z. Li, A. Westerbeke, F.J.M. van Kuppeveld, G.J.P.H. Boons, M.A. Langereis, E.G. Huizinga, R.J. de Groot. 2016. A coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proc. Natl. Acad. Sci. U. S. A. 113(22): E3111-E3119.  [PMID: 27185912]

McBride, R., J.C. Paulson, R.P. de Vries. 2016. A miniaturized glycan microarray assay for assessing avidity and specificity of influenza A virus hemagglutinins. J. Vis. Exp. (111).  [PMID: 27284789]

Huang, R., C. Zong, A. Venot, Y. Chiu, D. Zhou, G.J. Boons, J.S. Sharp. 2016. De novo sequencing of complex mixtures of heparan sulfate oligosaccharides. Anal. Chem. 88(10): 5299-5307.  [PMID: 27087275]

Allijn, I.E., S.F. Vaessen, L.C. Quarles van Ufford, K.J. Beukelman, M.P. de Winther, G. Storm, R.M. Schiffelers. 2016. Head-to-head comparison of anti-inflammatory performance of known natural products in vitro. PLoS One 11(5): e0155325.  [PMID: 27163931]

Naksuriya, O., M.J. van Steenbergen, J.S. Torano, S. Okonogi, W.E. Hennink. 2016. A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles. AAPS J. 18(3): 777-787.  [PMID: 27038456]

Wang, K., F. Friscourt, C. Dai, L. Wang, Y. Zheng, G.J. Boons, S. Wang, B. Wang. 2016. A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides. Bioorg. Med. Chem. Lett. 26(7): 1651-1654.  [PMID: 26944613]

Broekgaarden, M., R. van Vught, S. Oliveira, R.C. Roovers, P.M. van Bergen en Henegouwen, R.J. Pieters, T.M. van Gulik, E. Breukink, M. Heger. 2016. Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale 8(12): 6490-6494.  [PMID: 26954515]

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Martínez-Sáez, N., N.T. Supekar, M.A. Wolfert, I.A. Bermejo, R. Hurtado-Guerrero, J.L. Asensio, J. Jiménez-Barbero, J.H. Busto, A. Avenoza, G.J. Boons, J.M. Peregrina, F. Corzana. 2016. Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment. Chem. Sci. 7(3): 2294-2301.  [PMID: 29910919]

Shirangi, M., M. Najafi, D.T.S. Rijkers, R.J. Kok, W.E. Hennink, C.F. van Nostrum. 2016. Inhibition of octreotide acylation inside plga microspheres by derivatization of the amines of the peptide with a self-immolative protecting group. Bioconjugate Chem. 27(3): 576-585.  [PMID: 26726953]

Yu, S.H., P. Zhao, T. Sun, Z. Gao, K.W. Moremen, G.J. Boons, L. Wells, R. Steet. 2016. Selective exo-enzymatic labeling detects increased cell surface sialoglycoprotein expression upon megakaryocytic differentiation. J. Biol. Chem. 291(8): 3982-3989.  [PMID: 26733198]

Hiono, T., M. Okamatsu, M. Igarashi, R. McBride, R.P. de Vries, W. Peng, J.C. Paulson, Y. Sakoda, H. Kida. 2016. Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X. Arch. Virol. 161(2): 307-316.  [PMID: 26542967]

Hudlikar, M.S., X. Li, I.A. Gagarinov, N. Kolishetti, M.A. Wolfert, G.J. Boons. 2016. Controlled multi-functionalization facilitates targeted delivery of nanoparticles to cancer cells. Chemistry 22(4): 1415-1423.  [PMID: 26683093]

Lakshminarayanan, V., N.T. Supekar, J. Wei, D.B. McCurry, A.C. Dueck, H.E. Kosiorek, P.P. Trivedi, J.M. Bradley, C.S. Madsen, L.B. Pathangey, D.B. Hoelzinger, M.A. Wolfert, G.J. Boons, P.A. Cohen, S.J. Gendler. 2016. MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice. PLoS One 11(1): e0145920.  [PMID: 26788922]

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