Publications

Publications are visible on the profile pages of the staff members.

 

Publications 2018

 

 

  • Sparidans RW, Li W, Schinkel AH, Schellens JHM, Beijnen JH. Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates. J Pharm Biomed Anal. 2018 Nov 30;161:136-143. doi: 10.1016/j.jpba.2018.08.038.
  • Li W, Sparidans RW, Wang Y, Lebre MC, Beijnen JH, Schinkel AH. P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability. Pharmacol Res. 2018 Sep 22;137:47-55. doi: 10.1016/j.phrs.2018.09.020.
  • Du, W., M. Dai, Z. Li, G.J. Boons, B. Peeters, F.J.M. van Kuppeveld, E. de Vries, and C.A.M. de Haan. 2018. Substrate binding by the second sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity. J. Virol. 92(20): e01243-18.
  • Moure, M.J., A. Eletsky, Q. Gao, L.C. Morris, J.-Y. Yang, D. Chapla, Y. Zhao, C. Zong, I.J. Amster, K.W. Moremen, G.J. Boons, and J.H. Prestegard. 2018. Paramagnetic tag for glycosylation sites in glycoproteins: Structural constraints on heparan sulfate binding to Robo1. ACS Chem. Biol. 13(9): 2560-2567.
  •  Yu, S.-H., P. Zhao, P.K. Prabhakar, T. Sun, A. Beedle, G.J. Boons, K.W. Moremen, L. Wells, and R. Steet. 2018. Defective mucin-type glycosylation on a-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases. J. Biol. Chem. 293(37): 14534-14544.
  • Brittoli, Alvaro, Fallarini, Silvia, Zhang, Hao, Pieters, Roland J. & Lombardi, Grazia (01-02-2018). “In vitro” studies on galectin-3 in human natural killer cells. Immunology Letters, 194, (pp. 4-12) (9 p.).
  • Zhang, Hao, Tomašič, Tihomir, Shi, Jie, Weiss, Matjaz, Ruijtenbeek, Rob, Anderluh, Marko & Pieters, Roland J. (2018). Inhibition of - O -GlcNAc transferase (OGT) by peptidic hybrids. MedChemComm, 9 (5), (pp. 883-887) (5 p.).
  • Mena-Barragán, Teresa, García-Moreno, M. Isabel, Sevšek, Alen, Okazaki, Tetsuya, Nanba, Eiji, Higaki, Katsumi, Martin, Nathaniel I., Pieters, Roland J., García Fernández, José M. & Mellet, Carmen Ortiz (17-04-2018). Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human β-glucocerebrosidase - A picomolar chaperone for gaucher disease. Molecules, 23 (4).
  • Haataja, Sauli, Verma, Priya, Fu, Ou, Papageorgiou, Anastassios C., Pöysti, Sakari, Pieters, Roland J., Nilsson, Ulf J & Finne, Jukka (2018). Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations. Chemistry-A European Journal, 24 (8), (pp. 1905-1912) (8 p.).
  • Yi, F., X. Hong, A.B. Kumar, C. Zong, G.J. Boons, C.R. Scott, F. Turecek, B.H. Robinson, and M.H. Gelb. 2018. Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. Mol. Genet. Metab. In press (DOI: 10.1016/j.ymgme.2018.05.005).
  • Liang Q., P. Chopra, G.J. Boons, and J.S. Sharp. 2018. Improved de novo sequencing of heparin/heparan sulfate oligosaccharides by propionylation of sites of sulfation. Carbohydr. Res. 465: 16-21.
  • Hogan, J.D., J.A. Klein, J. Wu, P. Chopra, G.J. Boons, L. Carvalho, C. Lin, and J. Zaia. 2018. Software for peak finding and elemental composition assignment for glycosaminoglycan tandem mass spectra. Mol. Cell. Proteomics 17(7): 1448-1456.
  • Chinoy, Z.S., F. Friscourt, C. Capicciotti, P. Chiu, and G.J. Boons. 2018. Chemo-enzymatic synthesis of asymmetrical multi-antennary N-glycans to dissect glycan-mediated interactions between human sperm and oocytes. Chem. Eur. J. 24(31): 7970-7975. Selected as a VIP paper.
  • Wu, J., J. Wei, J.D. Hogan, P. Chopra, A. Joshi, W. Lu, J.A. Klein, G.J. Boons, C. Lin, and J. Zaia. 2018. Negative electron transfer dissociation sequencing of 3-O-sulfation-containing heparan sulfate oligosaccharides. J. Am. Soc. Mass Spectrom. 29(6): 1262-1272.
  • Zhao Y., J.Y. Yang, D.F. Thieker, Y. Xu, C. Zong, G.J. Boons, J. Liu, R.J. Woods, K.W. Moremen, I.J. Amster. 2018. A traveling wave ion mobility spectrometry (TWIMS) study of the Robo1-heparan sulfate interaction. J. Am. Soc. Mass Spectrom. 29(6): 1153-1165.
  • Lu, W., C. Zong, P. Chopra, L. Pepi, Y. Xu, I.J. Amster, J. Liu,and G.J. Boons. 2018. Controlled chemoenzymatic synthesis of heparan sulfate oligosaccharides. Angew. Chem. Int. Ed. 57(19): 5340-5344.
  • Kadirvelraj, R., J.-Y. Yang, J.H. Sanders, L. Liu, A. Ramiah, P.K. Prabhakar, G.J. Boons, Z.A. Wood, and K.W. Moremen. 2018. Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc. Natl. Acad. Sci. U. S. A. 115(18): 4637-4642.
  • Sychantha, D., R. Chapman, N.C. Bamford, G.J. Boons, P.L. Howell, and A.J. Clarke. 2018. Molecular basis for the attachment of S-layer proteins to the cell wall of Bacillus anthracis. Biochemistry 57(13): 1949-1953.
  • Williams C., F. Royo, O. Aizpurua-Olaizola, R. Pazos, G.J. Boons, N.-C. Reichardt, and J.M. Falcon-Perez. 2018. Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives. J. Extracellular Vesicles. 7(1): 1442985.
  • Aizpurua-Olaizola O., J. Sastre Toraño, J.M. Falcon-Perez, C. Williams, N. Reichardt, and G.J. Boons. 2018. Mass spectrometry for glycan biomarker discovery. Trends Anal. Chem. 100: 7-14.
  • Aizpurua-Olaizola O., J. Sastre Toraño, A.V. Pukin, O. Fu, G.J. Boons, G.J. de Jong, and R.J. Pieters. 2018. Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. Electrophoresis 39(2): 344-347.
  • Supekar, N.T., V. Lakshminarayanan, C. Capicciotti, A. Sirohiwal, C.S. Madsen, M.A. Wolfert, P.A. Cohen, S.J. Gendler, and G.J. Boons. 2018. Synthesis and immunological evaluation of a multicomponent cancer vaccine candidate containing a long MUC1 glycopeptide. ChemBioChem 19(2): 121-125.
  • Sychantha, D., D.J. Little, R.N. Chapman, G.J. Boons, H. Robinson, P.L. Howell, and A.J. Clarke. 2018. PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides. Nat. Chem. Biol. 14(1): 79-85.
  • Martínez-Jothar, Lucía, Doulkeridou, Sofia, Schiffelers, Raymond M, Torano, Javier Sastre, Oliveira, Sabrina, van Nostrum, Cornelus F & Hennink, Wim E (2018). Insights into maleimide - thiol conjugation chemistry - conditions for efficient surface functionalization of nanoparticles for receptor targeting. Journal of Controlled Release Copyright © 2018. Published by Elsevier B.V.
  • Brittoli, Alvaro, Fallarini, Silvia, Zhang, Hao, Pieters, Roland J. & Lombardi, Grazia (01-02-2018). “In vitro” studies on galectin-3 in human natural killer cells. Immunology Letters, 194, (pp. 4-12) (9 p.).
  • Haataja, Sauli, Verma, Priya, Fu, Ou, Papageorgiou, Anastassios C., Pöysti, Sakari, Pieters, Roland J., Nilsson, Ulf J & Finne, Jukka (2018). Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations. Chemistry-A European Journal, 24 (8), (pp. 1905-1912) (8 p.).
  • van Heugten, A. J.P., de Boer, Wout, de Vries, Stefan P W, Pieters, R. J. & Vromans, H. (30-05-2018). Topically used corticosteroids - What is the big picture of drug product degradation? European Journal of Pharmaceutical Sciences, 117, (pp. 1-7) (7 p.).
  • Jamalpoor, Amer, Sparidans, Rolf W, Casellas, Carla Pou, Rood, Johannes J M, Joshi, Mansi, Masereeuw, Rosalinde & Janssen, Manoe J (2018). Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry. Biomedical Chromatography This article is protected by copyright. All rights reserved.

Theses

Kleijn, L.H.J.
"Synthetic and Mechanistic Studies with Lipopeptide Antibiotics". Utrecht University. January 9,  2018.

Zhang, H.
"Inhibition of Galectins and O-GLcNAc Transferase with Di-and Multivalent Ligands". Utrecht University. April 18, 2018.

Yang, X.
"Synthesis of Vancomycin Mimics Using Ruthenium-Catalyzed Macrocyclization". Utrecht University. April 23, 2018.

Shi, J.
"Peptide Substrate-assisted Study of O-GlcNAc Transferase and O-GlcNAcylation". Utrecht University. April 25, 2018.
 

 

Publications 2017

  • Moure, M.J., Y. Zhuo, G. J. Boons*, and J. H. Prestegard*. 2017. Perdeuterated and 13enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase. Chem. Commun. 53(92): 12398-12401.
  • Liu, L., A.R. Prudden, G.P. Bosman, and G.J. Boons. 2017. Improved isolation and characterization procedure of sialylglycopeptide from egg yolk powder. Carbohydr. Res. 452: 122-128.
  • Klamer, Z., B. Staal, A.R. Prudden, L. Liu, D.F. Smith, G.J. Boons, and B. Haab. 2017. Mining high-complexity motifs in glycans: a new language to uncover the fine-specificities of lectins and glycosidases. Anal. Chem. 89(22): 12342-12350.
  • Benedetti, E., M. Pučić-Baković, T. Keser, A. Wahl, A. Hassinen, J.Y. Yang, L. Lui, I. Trbojević Akmačić, G. Razdorov, J. Štambuk, L. Klarić, I. Ugrina, M.H.J. Selman, M. Wuhrer, I. Rudan, O. Polasek, C. Hayward, H. Grallert, K. Strauch, A. Peters, T. Meitinger, C. Gieger, M. Vilaj, , G.J. Boons, K.W. Moremen, T. Ovchinnikova, N. Bovin, S. Kellokumpu, F.J. Theis, G. Lauc, and J. Krumsiek. 2017. Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Nat. Commun. 8: 1483. (Erratum author affiliation in: Nat. Commun. 2018 9(1): 706).
  • Simonides I. van de Wakker, Marcel J.E. Fischer, Ronald S. Oosting. 2017. New drug-strategies to tackle viral-host interactions for the treatment of influenza virus infections. European Journal of Pharmacology. 809: 178-190 (https://doi.org/10.1016/j.ejphar.2017.05.038)
  • Capicciotti, C.J., C. Zong, M.O. Sheikh, T. Sun, L. Wells, and G.J. Boons. 2017. Cell-surface glyco-engineering by exogenous enzymatic transfer using a bi-functional CMP-Neu5Ac derivative. J. Am. Chem. Soc. In press (DOI: 10.1021/jacs.7b05358).
  • Agyekum, I., C. Zong, G.J. Boons, J, and I.J. Amster. 2017. Single stage tandem mass spectrometry assignment of the C-5 uronic acid stereochemistry in heparan sulfate tetrasaccharides using electron detachment dissociation. J. Am. Soc. Mass Spectrom. 28(9): 1741-1750.
  • Ding, N., X. Li, Z.S. Chinoy, and G.J. Boons. 2017. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovanithat can be functionalization by Cu-catalyzed azide-alkyne cycloadditions. Org. Lett. 19(14): 3827-3830.
  • Zong, C.,A. Venot,X. Li,W. Lu,W. Xiao,J.L. Wilkes,C.L. Salanga, T.M. Handel,L. Wang,M.A. Wolfert,and G.J. Boons. 2017. Heparan sulfate microarray reveals that heparan sulfate-protein binding exhibits different ligand requirements J. Am. Chem. Soc. 139(28): 9534-9543.
  • Lin, A.E., C.A. Autran, A. Szyszka, T. Escajadillo, M. Huang, K. Godula, A.R. Prudden, G.J. Boons, A.L. Lewis, K.S. Doran, V. Nizet, and L. Bode. 2017. Human milk oligosaccharides inhibit growth of group B Streptococcus. J. Biol. Chem. 292(27): 11243-11249.
  • Prudden, A.R., L. Liu, C.J. Capicciotti, M.A. Wolfert, S. Wang, Z. Gao, L. Meng, K.W. Moremen, and G.J. Boons. 2017. Synthesis of asymmetrical multiantennary human milk oligosaccharides. Proc. Natl. Acad. Sci. U. S. A. 114(27): 6954-6959.
  • Movahedin, M., T.M. Brooks, N.T. Supekar, N. Gokanapudi, G.J. Boons, and C.L. Brooks. 2017. Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen. Glycobiology 27(7): 677-687.
  • Dhamale, O.,R.E. Lawrence, E.M. Wiegmann, B.A. Shah, K. al-Mafraji, W.C. Lamanna, T. Lübke, T. Dierks, G.J. Boons, and J.D. Esko. 2017. Arylsulfatase K is the lysosomal 2-sulfogluronate sulfatase. ACS Chem. Biol. 12(2): 367-373.
  • Halmo, S.M., D. Singh, S. Patel, S. Wang, M. Edlin, G.J. Boons, K.W. Moremen, D. Live, and L. Wells. 2017. Protein O-linked mannose β-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) is a gatekeeper enzyme for functional glycosylation of α-dystroglycan. J. Biol. Chem. 292(6): 2101-2109.
  • Gagarinov, I.A., T. Li, J. Sastre Toraño, T. Caval, A.D. Srivastava, J.A.W. Kruijtzer, A.J.R. Heck, and G.J. Boons. 2017. Chemoenzymatic approach for the preparation of asymmetric bi-, tri- and tetra-antennary N-glycans from a common precursor. J. Am. Chem. Soc. 139(2): 1011–1018.
  • Zhao, Y., A. Singh, Y. Xu, C. Zong, F. Zhang, G.J. Boons, J. Liu, R.J. Linhardt, R.J. Woods, and I.J. Amster. 2017. Gas-phase analysis of the complex of fibroblast growth factor 1 with heparan sulfate: a traveling wave ion mobility spectrometry (TWIMS) and molecular modeling study. J. Am. Soc. Mass Spectrom. 28(1): 96-109.
  • Sharif, Suhela, Shi, Jie, Mostafa, Bourakba, Ruijtenbeek, Rob & Pieters, Roland J (2017). Measuring O-GlcNAc cleavage by OGA and cell lysates on a peptide microarray. Analytical Biochemistry Copyright © 2017. Published by Elsevier Inc.
  • Sevsek, Alen, Šrot, Luka, Rihter, Jakob, Čelan, Maša, van Ufford, Linda Quarles, Moret, Ed E, Martin, Nathaniel I & Pieters, Roland J (2017). N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase. ChemMedChem, 12 (7), (pp. 483–486). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • Shi, Jie, Tomašič, Tihomir, Sharif, Suhela, Brouwer, Arwin J, Anderluh, Marko, Ruijtenbeek, Rob & Pieters, Roland J (05-06-2017). Peptide Microarray Analysis of the Cross-talk Between O-GlcNAcylation and Tyrosine Phosphorylation. FEBS Letters This article is protected by copyright. All rights reserved..
  • van Harten, R.M.; Willems, R.J.L.; Martin, N.I.; Hendrickx, A.P.A. Multidrug Resistant Enterococcal Infections: (2017) New Compounds, Novel Antimicrobial Therapies? Trends in Microbiology, Accepted (manuscript in press).
  • Oude Blenke, E.; Sleszynska,M.; Evers, M.J.W.; Storm, G.; Martin, N.I. Mastrobattista, E. (2017) Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger. Bioconjugate Chemistry, Accepted (manuscript in press). DOI: 10.1021/acs.bioconjchem.6b00677.
  • Cura, V., Marechal, N., Troffer-Charlier, N., Strub, J-M., van Haren, M.J., Martin, N.I. Cianferani, S., Bonnefond, L., Cavarelli, J. (2017) Functional insights from structural studies of protein arginine methyltransferase 2. The FEBS Journal284, 77-96. DOI: 10.1111/febs.13953.
  • Parsons, Lisa M, An, Yanming, de Vries, Robert P, de Haan, Cornelis A M & Cipollo, John F (2017). Glycosylation Characterization of an Influenza H5N7 Hemagglutinin Series with Engineered Glycosylation Patterns - Implications for Structure-Function Relationships. Journal of Proteome Research, 16 (2), (pp. 398–412).
  • Peng, Wenjie, de Vries, Robert P, Grant, Oliver C, Thompson, Andrew J, McBride, Ryan, Tsogtbaatar, Buyankhishig, Lee, Peter S, Razi, Nahid, Wilson, Ian A, Woods, Robert J & Paulson, James C (11-01-2017). Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity. Cell Host and Microbe, 21 (1), (pp. 23-34) (12 p.). Copyright © 2017 Elsevier Inc. All rights reserved.

Theses

Haren van M.J.
Transition state mimics as inhibitors of methyltransferase enzymes. University Utrecht, October 23, 2017. 218 p.Sevšek A.
Guanidinium Iminosugars as Glycosidase Inhibitors. University Utrecht, October 30, 2017. 170 p.

    Book chapters

    Gagarinov, I.A., A.D. Srivastava, G.J. Boons, and S. Visansirikul. 2017. Simplifying access to 3,4-di-O-acetyl-D-fucal (Chapter 24). In: Carbohydrate Chemistry: Proven Synthetic Methods, Volume 4 (C. Vogel and P. Murphy, eds). CRC Press, Taylor & Francis Group, Boca Raton, FL, Chapter 24.

    Gagarinov, I.A., A.D. Srivastava, G.J. Boons, and Z. Wang. 2017. A multigram synthesis of phenyl 2-azido-3-O-benzyl-2-deoxy-4,6-O-benzylidene-1-thio-α-D-mannopyranoside (Chapter 21). In: Carbohydrate Chemistry: Proven Synthetic Methods, Volume 4 (C. Vogel and P. Murphy, eds). CRC Press, Taylor & Francis Group, Boca Raton, FL, Chapter 21.

     

    Publications 2016

    • DJ Card, R Huisjes, K Deuchande, P Clarke, FM Flesch and DJ Harrington. Measurement of vitamin K metabolites in neonatal faecal matter by HPLC with electrochemical detection. Curr.Chromatogr. (2016) 3: 24-33.
    • Li, T., M. Huang, L. Liu, S. Wang, K.W. Moremen, G.J. Boons. 2016. Divergent chemoenzymatic synthesis of asymmetrical core fucosylated and core-unmodified N-glycans. Chem. Eur. J. In press (DOI: 10.1002/chem.201604999).
    • Gao, Q., C.-Y. Chen, C. Zong, S. Wang, A. Ramiah, P. Prabhakar, L. Morris, G.J. Boons, K. Moremen, and J. Prestegard. 2016. Structural aspects of heparan sulfate binding to Robo1-Ig1-2. ACS Chem. Biol. In press (DOI: 10.1021/acschembio.6b00692).
    • Zhao, Y., A. Singh, Y. Xu, C. Zong, F. Zhang, G.J. Boons, J. Liu, R.J. Linhardt, R.J. Woods and I.J. Amster. 2016. Gas-phase analysis of the complex of fibroblast growth factor 1 with heparan sulfate: a traveling wave ion mobility spectrometry (TWIMS) and molecular modeling study. J. Am. Soc. Mass Spectrom. In press (DOI: 10.1007/s13361-016-1496-8).
    • Singh, A., M.B. Tessier, K. Pederson, X. Wang, A.P. Venot, G.J. Boons, J.H. Prestegard, and R.J Woods. 2016. Extension and validation of the GLYCAM force field parameters for modeling glycosaminoglycans. Can. J. Chem. In press (DOI:10.1139-cjc-2015-0606).
    • Zong, C., R. Huang, E. Condac, Y. Chiu, W. Xiao, X. Li, W. Lu, M. Ishahara, S. Wang, A. Ramiah, M. Stickney, P. Azadi, I.J. Amster, K.W. Moremen, L. Wang, J.S. Sharp, and G.J. Boons. 2016. Integrated approach to identify heparan sulfate ligand requirements of Robo1. J. Am. Chem. Soc. 138(39): 13059−13067.
    • Bode, L., N. Contractor, D. Barile, N. Pohl, A. Prudden, G.J. Boons, Y.-S. Jin, and S. Jennewein. 2016. Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application. Nutr. Rev. 74(10): 635-644.
    • Sun, T.,S.-H. Yu,P. Zhao, L. Meng, K.W. Moremen, L. Wells, R. Steet, and G.J. Boons.. 2016. One-step selective exoenzymatic labeling (SEEL) strategy for the biotinylation and identification of glycoproteins of living cells. J. Am. Chem. Soc. 138(36): 11575-11582.
    • Li, X., S.J.H. Martin, Z.S. Chinoy, L. Liu, B. Rittgers, R.A. Dluhy, and G.J. Boons. 2016. Label free detection of glycan-protein interactions for array development by Surface Enhanced Raman Spectroscopy (SERS). Chem. Eur. J. 22(32): 11180-11185.
    • Bakkers, M.J.G., Q. Zeng, L.J. Feitsma, R.J.G. Hulswit, Z. Li, A. Westerbeke, F.J.M. van Kuppeveld, G.J. Boons, M.A. Langereis, E.G. Huizinga, and R.J. de Groot. 2016. Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proc. Natl. Acad. Sci. U. S. A. 113(22): E3111-E3119.
    • Huang, R., C. Zong, A. Venot, Y. Chiu, D. Zhou, G.J. Boons, and J.S. Sharp. 2016. De novo sequencing of complex mixtures of heparan sulfate oligosaccharides. Anal. Chem. 88(10): 5299-5307.
    • Wang, K., F. Friscourt, C. Dai, L. Wang, Y. Zheng, G.J. Boons, S. Wang, and B. Wang. 2016. A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides. Bioorg. Medicinal Chem. Lett. 26(7): 1651-1654.
    • Coverage in Synform: Synform 2016/09: A131–A134. G.J. Boons
    • Fang, T.,  Y. Gu,W. Huang, and G.J. Boons. 2016. Mechanism of glycosylation of anomeric sulfonium ions. J. Am. Chem. Soc. 138(9): 3002-3011.
    • Ríos, P., T.S. Carter, T.J. Mooibroek, M.P. Crump, M. Lisbjerg, M. Pittelkow, N.T. Supekar, G.J. Boons, and A.P. Davis. 2016. Synthetic receptors for high-affinity recognition of O-GlcNAc derivatives. Angew. Chem. Int. Ed. 55(10): 3387-3392.
    • Martínez-Sáez, N., N.T. Supekar, M.A. Wolfert, I.A. Bermejo, R. Hurtado-Guerrero, J.L.Asensio, J. Jiménez-Barbero, J.H. Busto, A. Avenoza, G.J. Boons, J.M. Peregrina, and F. Corzana. 2016. Mucin architecture behind the immune response: design and evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment. Chem. Sc. 7(3): 2294-2301.
    • Yu, S.-H., P. Zhao, T. Sun, Z. Gao, K.W. Moremen, G.J. Boons, L. Wells, and R. Steet. 2016. Selective exo-enzymatic labeling detects increased cell surface sialoglycoprotein expression upon megakaryocytic differentiation. J. Biol. Chem. 291(8): 3982-3989.
    • Hudlikar, M.S., X. Li, I.A. Gagarinov, N. Kolishetti, M.A. Wolfert, and G.J. Boons. 2016. Controlled multi-functionalization facilitates targeted delivery of nanoparticles to cancer cells. Chem. Eur. J. 22(4): 1415-1423.
    • Lakshminarayanan V., N.T. Supekar, J. Wei, D.B. McCurry, A.C. Dueck, H.E. Kosiorek, P.P. Trivedi, J.M. Bradley, C.S. Madsen, L.B. Pathangey, D. Hoelzinger, M.A. Wolfert, G.J. Boons, P.A. Cohen, and S.J. Gendler. 2016. MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice. PLoS ONE 11(1): e0145920.
    • van 't Veer, I.L., Leloup, N.O.L., Egan, A.J.F., Janssen, B.J.C., Martin, N.I., Vollmer, W., Breukink, E. (2016) Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem, Accepted. In Press. DOI: 10.1002/cbic.201600461.
    • van Haren, M.J., Sastre Toraño, J., Sartini, D., Emanuelli, M., Parsons, R.B., *Martin, N.I. (2016) A rapid and efficient assay for the characterization of substrates and inhibitors of nicotinamide N-methyltransferase. Biochemistry55, 5307-5315. DOI: 10.1021/acs.biochem.6b00733.
    • Sevšek, A., Celan, M., Erjavec, B., Quarles van Ufford, L., Sastre Toraño, J., Moret, E.E., *Pieters, R.J, *Martin, N.I. (2016) Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic and Biomolecular Chemistry14, 8670-8673. DOI: 10.1039/C6OB01735E.
    • Thomas, M.G., Sartini, D., Emanuelli, M., van Haren, M.J., Martin, N.I., Mountford, D.M., Barlow, D.J., Klamt, F., Ramsden, D.B., Reza, M., Parsons, R.B. (2016) Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway. Biochemical Journal473, 3253-3267. DOI: 10.1042/BCJ20160219.
    • Kleijn, L.H.J., Oppedijk, S.F., 't Hart, P., van Harten, R.M., Martin-Visscher, L.A., Kemmink, J., Breukink, E., *Martin, N.I. (2016) Total Synthesis of Laspartomycin C and Characterization of its Antibacterial Mechanism of Action. Journal of Medicinal Chemistry59, 3569–3574. DOI: 10.1021/acs.jmedchem.6b00219.
    • ’t Hart, P., Oppedijk, S.F., Breukink, E., *Martin, N.I. (2016) New insights into nisin’s antibacterial mechanism revealed by binding studies with synthetic lipid II analogues. Biochemistry55, 232–237. DOI: 10.1021/acs.biochem.5b01173.
    • Manásková, S.H., Nazmi, K., van ’t Hof, W., van Belkum, A., Martin, N.I., Bikker, F.J., van Wamel, W.J.B., Veerman, E.C.I. (2016) Staphylococcus aureus Sortase A-Mediated Incorporation of Peptides: Effect of Peptide Modification on Incorporation. PLoS ONE, 11, e0147401. DOI: 10.1371/journal.pone.0147401.
    • Werkhoven, P. R., Elwakiel, M., Meuleman, T. J., Quarles Van Ufford, H. C., Kruijtzer, J. A W & Liskamp, R. M J (2016). Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold. Organic and Biomolecular Chemistry, 14 (2), (pp. 701-710) (10 p.).
    • Shi, Jie, Sharif, Suhela, Ruijtenbeek, Rob & Pieters, Roland J (2016). Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. PLoS ONE, 11 (3).
    • Delaine, Tamara, Collins, Patrick, Mackinnon, Alison, Sharma, G., Stegmayr, John, Rajput, Vishal K., Mandal, Santanu, Cumpstey, Ian, Larumbe, Amaia, Salameh, Bader A., Kahl-Knutsson, Barbro, van Hattum, Hilde, van Scherpenzeel, Monique, Pieters, Roland J., Sethi, Tariq, Schambye, Hans, Oredsson, Stina, Leffler, Hakon, Blanchard, Helen & Nilsson, Ulf J. (2016). Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. ChemBioChem
    • Broekgaarden, M., Van Vught, R., Oliveira, S., Roovers, R. C., Van Bergen En Henegouwen, P. M P, Pieters, R. J., Van Gulik, T. M., Breukink, E. & Heger, M. (28-03-2016). Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale, 8 (12), (pp. 6490-6494) (5 p.).
    • Shirangi, Mehrnoosh, Najafi, Marzieh, Rijkers, Dirk T S, Kok, Robbert Jan, Hennink, Wim E & van Nostrum, Cornelus F (19-01-2016). Inhibition of Octreotide Acylation Inside PLGA Microspheres by Derivatization of the Amines of the Peptide with a Self-Immolative Protecting Group. Bioconjugate Chemistry, (pp. 576-585) (10 p.).
    • Prior, Amir, Sánchez-Hernández, Laura, Sastre-Toraño, Javier, Marina, Maria Luisa, de Jong, Gerhardus J. & Somsen, Govert W. (01-09-2016). Enantioselective analysis of proteinogenic amino acids in cerebrospinal fluid by capillary electrophoresis–mass spectrometry. Electrophoresis, 37 (17-18), (pp. 2410-2419) (10 p.).
    • van de Loo, A. J. A. E., Vanneer, R. H. P., Wang, X., Nguyen, T. T., Flesh, F. M., Korte-Bouws, G. A. H., Torano, J. Sastre, Hogewoning, A., Raasveld, S. J., Garssen, J. & Verster, J. C. (2016). URINE ETHYL GLUCURONIDE (ETG) AND ETHYL SULPHATE (ETS) CONCENTRATIONS THE DAY AFTER HEAVY ALCOHOL CONSUMPTION. Alcoholism: Clinical and Experimental Research, 40, (pp. 100A-100A).
    • Hoogenboom, Jorin, Lutz, Martin, Zuilhof, Han & Wennekes, Tom (2016). Exploring the Chemistry of Bicyclic Isoxazolidines for the Multicomponent Synthesis of Glycomimetic Building Blocks. Journal of Organic Chemistry, 81 (19), (pp. 8826-8836) (11 p.).

     

       

      Publications 2015

      • Agyekum I, AB Patel, CL Zong, GJ Boons and IJ Amster. Assignment of hexuronic acid stereochemistry in synthetic heparan sulfate tetrasaccharides with 2-O-sulfo uronic acids using electron detachment dissociation. Int. J. Mass Spectrom. 2015 390: 163-169
      • Chinoy ZS, CM Schafer, CM West and GJ Boons. Chemical synthesis of a glycopeptide derived from Skp1 for probing protein specific glycosylation. Chem. Eur. J. 2015 21(33): 11779-11787
      • Corradini E, G Klaasse, U Leurs, AJR Heck, NI Martin and A Scholten. Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach. Mol Biosyst. 2015 11(10): 2786-2797
      • Dominquez-Vega E, R Haselberg, GW Somsen and GJ de Jong. Simultaneous assessment of protein heterogeneity and affinity by capillary electrophoresis-mass spectrometry. Anal Chem 2015 87(17):8781-8
      • Forestier CL, Q Gao and Boons GJ. Leishmania lipophosphoglycan: how to establish structure-activity relationships fort his highly complex and multifunctional glycoconjugate? Front. Cell Infect Microbiol 2015 4(Article 193): 1-7
      • Friscourt F, CJ Fahrni and GJ Boons. Fluorogenic strain-promoted alkyne-diazo cycloadditions. Chem. Eur. J. 2015 21(40): 13996-14001
      • Fu O, HC van Ufford, TR Branson, DM Thies-Weesie, WB Turnbull, GM Visser and RJ Pieters. Tetra-versus pentavalent inhibitors of cholera toxin. Chemistry Open. 2015 4(4): 471-477
      • Fu O, AV Pukin, HC Quarles van Ufford, J Kemmink, NJ de Mol and RJ Pieters. Functionalization of a rigid divalent LecA ligand. Chemistry Open 2015 4(4): 463-470
      • Gagarinov IA, T Fang, L Liu, AD Srivastava and GJ Boons. Synthesis of Staphylococcus aureus Type 5 trisaccharide repeating unit: solving the problem of lactamization. Org. Lett. 2015 17(4): 928-931
      • Gruba N, M Wysocka, M Brzezinska, D Debowski, K Rolka, NI Martin and A Lesner. Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome. Anal Biochem. 2015, Doi: 10.016/j.ab.2015.08.019
      • Huang W, Q Gao and GJ Boons. Assembly of a complex branched oligosaccharide by combining fluorous-supported synthesis and stereoselective glycosylations using anomeric sulfonium ions. Chem. Eur. J. 2015 21(37): 12920-12926
      • Huang Y, Y Mao, C Zhong, C Lin, GJ Boons and J Zaia. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal. Chem. 2015 87(1): 592-600
      • Jordan NY, JY Mimpen, WJ van den Bogaard, FM Flesch, MH van de Meent and JS Torano. Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 995: 70-73
      • Koopmans T, TM Wood, P ’t Hart, LHJ Kleijn, APA Hendrickx, RJL Willems, E Breukink and NI Martin. Semisynthetic lipopeptides derived from nisin display antibacterial activity and lipid II binding on Par with that of the parent compound. J Am Chem Soc 2015 137(29): 9382-9389
      • Ledin PA, W Xu, F Friscourt, GJ Boons and V Tsukruk. Branched polyhedral oligomeric silsesquioxane nanoparticles prepared via strain-promoted 1,3-dipolar cycloadditions. Langmuir 31(29): 8146-8155
      • Liu F, DTS Rijkers, H Post and AJR Heck. Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nat Methods 2015 12: 1179-1184
      • Liu L, J Zha, A DiGiandomenico, D McAllister, CK Stover, Q Wang and GJ Boons. Synthetic enterobacterial common antigen (ECA) for the development of a universal immunotherapy for drug-resistant Enterobacteriaceae. Angew. Chem. Int. Ed. 2015 54(37): 10953-10957
      • Oppedijk SF, NI Martin and E Breukink. Hit ‘em where it hurts: the growing and structurally diverse family of peptides that target lipid-II. Biochim Biophys Acta Biomembr. 2015 1858 (5) 947-957. 2015 Doi: 10.1016/j.bbamem. 2015. 10.024
      • Oude Blenke E, G Klaasse, H Merten, A Pluckthun, E Mastrobattista and NI Martin. Liposome functionalization with copper-free “click chemistry”. J Control Release. 2015 202: 14-20.
      • Pukin AV, AJ Brouwer, L Koomen, HC Quarles van Ufford, J Kemmink, NJ de Mol and RJ Pieters. Thiourea-based spacers in potent divalent inhibitors of Pseudomonas aeruginosa virulence lectin LecA. Org Biomol Chem. 2015 13(44): 10923-10928
      • Rijkers DTS. Synthesis of cyclic peptides and peptidomimetics by metathesis reactions. Top Heterocycl Chem 2015 DOI: 10.1007/7081_2015_142
      • Shirangi M, J Sastre Torano, B Sellergren, WE Hennink, GW Somsen and CF van Nostrum. Methyleneation of peptides by N,N,N,N-tetramethylethylenediamine (TEMED) under conditions used for free radical polymerization: a mechanistic study. Bioconjug Chem 2015 26(1): 90-100
      • Slootweg JC, EF van Herwerden, MFM van Doremalen, E Breukink, RMJ Liskamp and DTS Rijkers. Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp3 versus sp2 hybridization of the alfa-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity. Org Biomol Chem  2015 13: 5997-6009
      • Thompson P, L Lakshminarayanan, NT Supekar, J.M. Bradley, P.A. Cohen, M.A. Wolfert, S.J. Gendler and G.J. Boons. Linear synthesis and immunological properties of a fully synthetic vaccine containing a sialylated MUC1 glycopeptide. Chem. Commun 2015 51(50): 10214-10217
      • Van der Beek SL, Y Le Breton, AT Ferenbach, RN Chapman, DMF van Aalten, I Navratilova, GJ Boons, KS McIver, NM van Sorge and HC Dorfmueller. GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmID). Mol. Microbiol.  2015 98(5): 946-962
      • Van Haren M, LQ van Ufford, EE Moret and NI Martin. Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites. Org Biomol Chem. 2015 13(2): 549-560
      • Visini R, X Jin, M Bergmann, G Michaud, F Pertici, O Fu, A Pukin; TR Branson, DM Thies-Weesie, J Kemmink, E Gillon, A Imberty, A Stocker, T Darbre, RJ Pieters and JL Reymond. Structural insight into multivalent galactoside binding to Pseudomonas aeruginosa lectin LecA. ACS Chem Biol  2015 10(11): 2455-622
      • Werkhoven PR, M Elwakiel, TJ Meuleman, HC Quarles van Ufford, JA Kruijtzer and RM Liskamp. Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold. Org Biomol Chem 2015 14(2): 701-10

      Theses

      • Fu O. 
        Multivalent carbohydrate inhibitors of bacterial lectins and toxins. Utrecht University, 2015. 140 p.
      • Tak  YH.
        Advances in capillary electrophoresis: in line- preconcentration for biomedical analysis impurity profiling of heparin.
        Utrecht University, 2015. 178 p.

      Book chapters

      West CM, H van der Wel, Z Chinoy, GJ Boons, TJ Gauthier, CM Taylor and Y. Xu. 2015 Generating isoform-specific antibodies: Lessons from nucleocytoplasmic glycoprotein Skp1. In: Glycoscience: Biology and Medicine (N. Taniguchi, T End, GW Hart, PH Seeberger, C.-H Wong, eds) Springer, Japan, pp. 927-934

      Boltje TJ, L Liu and GJ Boons. Controlling anomeric selectivity, reactivity, and regioselectivity in glycosylations using protecting groups. 2015 In: Glycochemical
      Synthesis: Strategies and Applications (S.-C Hung, ed) Wiley, Inc., Chapter 4.

       

         

        Publications older than 2015