Postdoctoral Researcher in Bio-organic Chemistry and Biological Soft Matter (1.0 FTE)
- Hours per week:
- 38 to 40
- Faculty of Science
- Department of Pharmaceutical Sciences, Chemical Biology and Drug Discovery
- Application deadline:
In the collaborative project called “Freezing Hearts” a team of scientists from the four Alliance institutes (UU, TU/e, UMC and WUR) aim to develop potent bio-inspired cryoprotectants to extend heart “life-time” ex vivo. We are looking for an enthusiastic, communicative and highly motivated Postdoctoral Researcher with experience in bio-organic synthesis and quantitative microscopy. Your 3-year project within this collaboration will focus on elucidating and optimizing the structure-activity relationship (SAR) of novel glycopeptide cryoprotectants. The first half of your project will start at UU with the development of a strategy for the efficient synthesis of a range of native and novel modified glycopeptides. The second phase of your project – for what we now expect to be a period of 1.5 years – will be carried out at TU/e, where you will perform an in-depth bio-physical characterization and structure–activity study of the developed glycopeptide derivatives. You will be directly supervised by Dr Tom Wennekes and Prof Ilja Voets, and work intensively with the other Postdoctoral Researcher at UMC and a PhD student at WUR, also hired for the project. Within the project you will use a variety of techniques (solid phase peptide synthesis, chemical and enzymatic synthesis, peptide characterization tools and optical microscopy), and be entrusted with developing and executing experiments, data analysis, presentations and writing manuscripts.
We are seeking a driven, creative and collaborative candidate with a keen interest to learn and the motivation to work in an ambitious and interdisciplinary research team.
You also meet the following essential requirements:
- MSc and PhD in an appropriate field (chemistry and/or molecular life sciences) and a record of relevant publications;
- expertise in (physical) organic chemistry, chemical biology techniques, and microscopy;
- strong communication and English language skills;
- the ability to think critically and creatively with a strong work ethic (organised, efficient and rigorous).
We also would like for you to have previous experience in organic synthesis, solid phase peptide synthesis and peptide characterization and experience in quantitative microscopy including image analysis.
- a full-time position for 3 years;
- a full-time gross salary depending on previous qualifications and experience ranging between €2,790 and €4,402 per month (scale 10 of the Collective Labour Agreement of Dutch Universities);
- benefits including 8% holiday bonus and 8.3% end-of-year bonus;
- a pension scheme, partially paid parental leave, and flexible employment conditions based on the Collective Labour Agreement Dutch Universities.
In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model. This is how we like to encourage you to continue to grow.
More information about working at the Faculty of Science can be found here.
About the organisation
At Utrecht University, the Chemical Biology and Drug Discovery group focuses on the design, chemo- or biosynthesis of compounds with biological or (potential) medicinal applications and interactions with their receptors. Insights thus obtained could lead to new bio-active compounds, new approaches for the treatment of still incurable diseases and new approaches to unsatisfactory treatments. The research programme is part of the Utrecht Institute for Pharmaceutical Sciences (UIPS) and the Bijvoet Center for Biomolecular Research. At Eindhoven University of Technology, the Self-Organizing Soft Matter group studies self-assembly and interfacial adsorption in (biological) soft matter. The goal is to understand the simple design rules that orchestrate how complex functionalities emerge from hierarchical self-organization processes aiming ultimately to manufacture and apply innovative lifelike materials. Understanding and mimicking the cryoprotective activity of antifreeze proteins is one of the principle research directions. The group is embedded in the Department of Chemical Engineering and Chemistry and the Institute for Complex Molecular Systems.
At the Faculty of Science there are 6 departments to make a fundamental connection with: Biology, Chemistry, Information and Computing Sciences, Mathematics, Pharmaceutical Sciences and Physics. Each of these is made up of distinct institutes which work together to focus on answering some of humanity’s most pressing problems. More fundamental still are the individual research groups – the building blocks of our ambitious scientific projects.
Utrecht University is a friendly and ambitious university at the heart of an ancient city. We love to welcome new scientists to our city – a thriving cultural hub that is consistently rated as one of the world’s happiest cities. We are renowned for our innovative interdisciplinary research and our emphasis on inspirational research and excellent education. We are equally well-known for our familiar atmosphere and the can-do mentality of our people. This lively and inspiring academic environment attracts Professors, Researchers and PhD candidates from all over the globe, making both the university and the Faculty of Science a vibrant international and wonderfully diverse community.
If you have any questions about the vacancy or require additional information, please contact:
- Dr Tom Wennekes (firstname.lastname@example.org) of Utrecht University
- or Prof Ilja Voets (I.Voets@tue.nl) of Technical University Eindhoven
As part of the selection procedure, the candidate is expected to give an outline of her/his research experience and plans in an oral presentation.
Do you have a question about the application procedure? Please send an email to email@example.com.
Everyone deserves to feel at home at our university. We welcome employees with a wide variety of backgrounds and perspectives. If you have the expertise and the experience to excel in this role, then simply respond via the “Apply now” button! Please enclose:
- your letter of motivation;
- your curriculum vitae;
- the name, telephone number and email address of a reference.
If this specific opportunity isn’t for you, but you know someone who may be interested, please forward the link to them.
Please note: Due to the current situation regarding the Corona virus (COVID-19) the process of selection and interviews is subject to change. Initial interviews will most likely be conducted online.
Some connections are fundamental – Be one of them
The application deadline is 6 December 2020.