Toxicological mechanisms and effects
Utrecht University researchers investigate the cellular and molecular mechanisms of action of toxic substances (food-related products, health products, drugs and environmental contaminants) on the nervous system. Research focuses on adverse effects of toxic substances on neuronal network activity, membrane signaling through membrane receptors and ion channels, and on cellular communication through exocytosis. Additionally, intracellular signaling cascades and neurodevelopment are studied for further hazard characterization of various classes of environmental toxicants.
Projects focus on those exposures that are associated with strong societal concern (e.g., alternative flame retardants, drugs of abuse and electromagnetic fields) and/or neurodegenerative disorders, such as Parkinson's Disease (e.g., pesticides and chemical mixtures) and/or developmental neurological disorders, such as ADHD/ASD (chemical mixtures of pesticides and persistent organic pollutants).
- Nano and Microplastics
Exposure to micro- and nanoplastics (MNPs) is nowadays unavoidable. It is however unclear if there are any adverse effects associated with exposure to MNPs. As the brain is amongst the most sensitive organs of our body, the aim of this project is to determine the potential neurotoxic effects of exposure to (environmentally relevant) micro- and nanoplastics (MNPs).
Coordinator: Remco Westerink
Funded by: ZonMW