Regenerative Medicine, Stem Cells & Cancer

Developing possible treatments for destructive diseases in animals and humans

The majority of chronic diseases are characterised by severe tissue damage resulting in painful and often life-threating health conditions. We use stem cells and other innovative technologies, such as biofabrication, to understand and cure destructive diseases. 

Cancer and degenerative diseases
Our interdisciplinary research programme is composed of experts in tissue engineering, stem cells, single cell analysis, metabolomics, cancer biology, pathology and clinical sciences. Together we are generating critical insights into the origin of cancer and the pathobiology of degenerative diseases in bone, cartilage and liver. Intensive and unique collaborations between basic research labs and doctors from the veterinary and human clinics translate the most promising discoveries into novel treatment and prevention strategies for veterinary and human patients.

We want to unravel currently incurable diseases and employ innovative strategies to regenerate organs
Research themes

Tissue Regeneration 
Can we replace damaged tissues using 3D printing technology? Which molecular events are essential for tissue regeneration? How are they altered in bone, joint and liver diseases? What is the impact of inflammation, genome size and fat on regeneration? Read more

Understanding and Suppressing Cancer Which common molecular events cause cancer in animals and humans? Can we target these events for personalised cancer therapy? Which mechanism in the cell suppresses tumor formation? Can we hyper-activate tumor suppressor functions to treat cancer? Read more

Genetic Neuromuscular Disorders
Neuromuscular disorders affect a patient’s ability to move, breathe or eat. They are often caused by mutations in one or more genes that affect the muscle itself, or the nerve cells that control the muscles. We use a combination of stem cell and genome engineering methodologies to better understand the cause of genetic muscle diseases and focus on developing technologies to tackle these debilitating disorders. Read more

Expertise Centres 
We have established a worldwide unique set of expertise on biofabrication, single cell analysis, genome editing, lipid analysis, mouse pathology and treating animal patients. These expertise are available to all national/international  academic and industrial investigators. Read more

News

Dierenarts en wetenschapper Hedwig Kruitwagen aan het werk in het laboratorium
24 July 2019
Two researchers talk about their shared dream of helping both dogs and people with liver diseases.
22 July 2019
Researchers at among others Utrecht University and Universitair Ziekenhuis Leuven published an article on the process in PNAS on July, 22.
13 June 2019
PhD student Nikae te Moller explains her research in an original way: with a dance she talks about osteoarthritis and her research into this disease.
Portret Bart Spee
6 June 2019
Bart Spee gave Adriaan and Sander a tour through the Regenerative Medicine Centre Utrecht, where they talk about growing mini-livers in the lab.
3 April 2019
Dr. Jan van der Valk has won the Björn Ekwall Memorial Foundation Award 2019.

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