Developing possible treatments for destructive diseases in animals and humans

The majority of chronic diseases are characterised by severe tissue damage resulting in painful and often life-threating health conditions. We use stem cells and other innovative technologies, such as biofabrication, to understand and cure destructive diseases. 

Cancer and degenerative diseases
Our interdisciplinary research programme is composed of experts in tissue engineering, stem cells, single cell analysis, metabolomics, cancer biology, pathology and clinical sciences. Together we are generating critical insights into the origin of cancer and the pathobiology of degenerative diseases in bone, cartilage and liver. Intensive and unique collaborations between basic research labs and doctors from the veterinary and human clinics translate the most promising discoveries into novel treatment and prevention strategies for veterinary and human patients.

We want to unravel currently incurable diseases and employ innovative strategies to regenerate organs
Research themes

Tissue Regeneration 
Can we replace damaged tissues using 3D printing technology? Which molecular events are essential for tissue regeneration? How are they altered in bone, joint and liver diseases? What is the impact of inflammation, genome size and fat on regeneration? Read more

Understanding and Suppressing Cancer Which common molecular events cause cancer in animals and humans? Can we target these events for personalised cancer therapy? Which mechanism in the cell suppresses tumor formation? Can we hyper-activate tumor suppressor functions to treat cancer? Read more

Genetic Neuromuscular Disorders
Neuromuscular disorders affect a patient’s ability to move, breathe or eat. They are often caused by mutations in one or more genes that affect the muscle itself, or the nerve cells that control the muscles. We use a combination of stem cell and genome engineering methodologies to better understand the cause of genetic muscle diseases and focus on developing technologies to tackle these debilitating disorders. Read more

Expertise Centres 
We have established a worldwide unique set of expertise on biofabrication, single cell analysis, genome editing, lipid analysis, mouse pathology and treating animal patients. These expertise are available to all national/international  academic and industrial investigators. Read more

News

4 October 2017
Intensified cooperation between UU, UMC Utrecht and UT on micro imaging, biofabrication and bioartifical organs The contract was signed on October 4th.
29 August 2017
Kerstin Schneeberger gets grant from K.F Heinfonds for developing stable liver cells.
14 June 2017
Bart Spee awarded STW grant for development of specialised liver cells to test the toxicity of drugs.
25 April 2017
Veterinary Medicine Honours student Wesley de Wit was presented with the Voorjaarsdagen Research Award at the Voorjaarsdagen event.
10 March 2017
How can we build an organ from scratch? This ambitious question is being solved by Sangeeta Bhatia of Massachusetts Institute of Technology.

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