Innate Antiviral Responses

We study how intracellular RNA sensors (e.g. RIG-I, MDA5, PKR) discriminate viral RNA from host cell RNA and how they signal to activate IFN-α/β responses and stress responses to combat virus infection. Conversely, we investigate how picornaviruses and coronaviruses actively manipulate these intracellular signaling pathways to suppress these infection-limiting innate host responses.