Seen its complex nature several aspects of the disease, including (heritable) deviating immune responsiveness and options for its modulation, microbiome constitution, barrier lipid constitution/(dys)function and the role of keratinocytes in each of these, are addressed. In the larger context of chronic inflammatory diseases, a focus of the division of Immunology, recently a collaboration has started with dog, cat and human ophthalmologists. In a translational context, we investigateĀ the immunopathogenesis of ocular inflammatory diseases with (suspected) auto-immune causes, aiming at development of immunomodulatory therapies.