Soft Tissue Engineering & Medicine

Lacking efficacy and/or toxic side effects of drugs lead to many new patients (both human and veterinary) every year. Soft Tissue Engineering & Medicine aims to understand hepatic, intestinal, and pancreatic stem cell differentiation in order to bioengineer functional organ systems. These functional tissues are crucial for predictive organ toxicology screens, transplantation purposes, and disease modelling. 

We combine innovation and teamwork to bioengineer highly physiological tissues

 

New ways to treat patients

Soft Tissue Engineering & Medicine is active in the interplay between stem cell biology, tissue engineering, biomaterials, and in vitro-in vivo extrapolation (IVIVE) science. Soft Tissue Engineering & Medicine will lead to more insight into tissue morphogenesis, novel biomaterials, safer and more effective drugs, as well as new ways to treat veterinary and human patients with state-of-the-art bioengineered tissues.

Subthemes

Bone and Cartilage Regeneration
Disorders of the musculoskeletal system are the most important reasons for invalidity in both humans and animals. They are on the increase due to ageing, obesity, an inactive lifestyle and other societal and environmental factors that affect humans and animals alike. Read more

Liver Regeneration
Our work focuses on developing novel regenerative strategies for the treatment of liver diseases in domestic animals and humans. We use 3D liver stem cell cultures, bioprinting technology and cellular reprogramming techniques to try and generate mature hepatocytes and organise these into functional liver structures. Read more

Lipids and Regeneration
Lipid overload is a paramount problem for people in industrial countries due to associated risks of secondary disorders including obesity, diabetes, atherosclerosis and hypertension.The liver plays a crucial role in fat metabolism. We investigate the mechanisms of fat storage in the liver and how stem cells are protected from excess fat exposure. Read more