Toxicological mechanisms and effects
Utrecht University researchers investigate the cellular and molecular mechanisms of action of toxic substances (food-related products, health products, drugs and environmental contaminants) on the nervous system. Research focuses on adverse effects of toxic substances on neuronal network activity, membrane signaling through membrane receptors and ion channels, and on cellular communication through exocytosis. Additionally, intracellular signaling cascades and neurodevelopment are studied for further hazard characterization of various classes of environmental toxicants.
Projects focus on those exposures that are associated with strong societal concern (e.g., alternative flame retardants, drugs of abuse and electromagnetic fields) and/or neurodegenerative disorders, such as Parkinson's Disease (e.g., pesticides and chemical mixtures) and/or developmental neurological disorders, such as ADHD/ASD (chemical mixtures of pesticides and persistent organic pollutants).
The new Horizon 2020 project RISK-HUNT3R: RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs was launched on 1 June 2021. The five-year project aims to develop a novel and modular framework for animal-free next generation risk assessment.
RIVM National Institute for Public Health and the Environment is involved in this European interdisciplinary collaboration, which unites 37 partners, academic researchers, regulators, safety authorities, and safety scientists from key industry sectors.
IRAS Project Member: Roel Vermeulen
Funded by: European Union’s Horizon 2020 research and innovation programme under grant agreement No 964537.