Three NWO ENW Klein grants for Faculty of Science

Three scientists of the Faculty of Science receice a NWO Open Competitie ENW Klein-grant. Overall nineteen applications were approved, with a sum of 7 million euro.

Klein grants are intended for innovative, high-quality, fundamental research or studies involving matters of scientific urgency. The Klein grant offers researchers the opportunity to develop creative, high-risk ideas and scientific innovations that can form the basis for the research themes of the future.

The following research projects were awarded a grant:

A new perspective on the use of instruments by leading mathematicians in early modern times

Constructive mathematics in the classical theory of conic sections
Viktor Blåsjö 

Modern developments in constructive mathematics enable us to appreciate neglected aspects of classical geometry. This could lead to historical insights and a new perspective on the use of instruments by leading mathematicians in early modern times, as well as lost works of antiquity.

Study protein decomposition in brain cells and to manipulate the process so that the protein accumulations are removed

Ginny Farías Galdames
Cell biology

Unravelling the regulatory mechanisms for lysosome formation and aggregate clearance in neurons
Ginny Farías Galdames (together with Judith Klumperman, UMCU)

It is very important for brain cells that the process of production and decomposition of proteins is in balance. An effect of many brain diseases is that proteins are no longer removed, which leads to protein accumulations that kill the brain cell. The researchers will use the latest molecular and advanced microscopy techniques to study protein decomposition in brain cells and to manipulate the process so that the protein accumulations are removed.

Study the influence of the compactness of the DNA on the way genes are expressed

To the next level of transcription regulation: influence of the accessible genome size
Willem Kegel (together with Jocelyne Vreede, UvA)

Gene regulation to the next level. In biological cells, the expression of genes is regulated by a complex interplay between certain parts on the genes and many proteins that move along the DNA. The scientists will study the influence of the compactness of the DNA on the way genes are expressed.