A team of Dutch and German researchers under the leadership of Albert Heck and Friedrich Förster from Utrecht University has discovered the operation of one of the oldest biological clocks in the world, which is crucial for life on earth as we know it. The researchers applied a new combination of cutting-edge research techniques. They discovered how the biological clock in cyanobacteria works in detail. Important to understand life, because cyanobacteria were the first organisms on earth producing oxygen via photosynthesis. The results of their research were published in Science.
Ten years ago, researchers discovered that the biological clock in cyanobacteria consists of only three protein components: KaiA, KaiB and KaiC. These are the building blocks - the gears, springs and balances - of an ingenious system resembling a precision Swiss timepiece. In 2005, Japanese scientists published an article in Science showing that a solution of these three components in a test tube could run a 24-hour cycle for days when a bit of energy was added. However, the scientists were not able to uncover the exact operation of the system, despite its relative simplicity.